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中华肿瘤防治杂志 2017年第13期24卷 906-911页

作者：许振刘志强郭庆枝孙莉滨州医学院附属医院妇科山东滨州256600

目的宫颈癌新辅助化疗(neoadjuvant chemotherapy,NACT)的疗效一直存在争议,PI3K/AKT通路在肿瘤细胞增殖、迁移、侵袭及抗凋亡都起到举足轻重的作用。本研究探讨NACT对宫颈鳞状细胞癌AKT通路中AKT及P-AKT的表达对肿瘤微淋巴管生成的影响... 详细信息

目的宫颈癌新辅助化疗(neoadjuvant chemotherapy,NACT)的疗效一直存在争议,PI3K/AKT通路在肿瘤细胞增殖、迁移、侵袭及抗凋亡都起到举足轻重的作用。本研究探讨NACT对宫颈鳞状细胞癌AKT通路中AKT及P-AKT的表达对肿瘤微淋巴管生成的影响,并分析其变化与NACT临床疗效的关系。方法采用免疫组化SP法分别检测2011-03-01-2016-03-31滨州医学院附属医院收治的47例ⅠB2~ⅡB期宫颈鳞癌患者行NACT前后AKT和P-AKT的表达情况及肿瘤微淋巴管密度(lymphatic microvessel density,LMVD)的变化。结果免疫组化检测结果显示,NACT前AK和P-AKT的阳性率分别为93.6%和72.3%,化疗后阳性率分别为44.7%和36.2%,NACT前后比较,AKT和P-AKT表达差异有统计学意义,P<0.001。化疗前宫颈鳞癌组织中LMVD计数为20.87±3.31,化疗后宫颈鳞癌组织中LMVD计数为16.47±3.44,化疗后宫颈鳞癌组织中LMVD明显降低,t=6.32,P<0.001。化疗前宫颈鳞癌AKT阳性的LMVD为21.14±3.19,高于阴性组(17.00±3.00)。Spearman相关分析显示,化疗前后LMVD的表达(r_s=0.39,P=0.007)与化疗前后P-AKT的表达(r_s=0.66,P<0.001)均呈正相关。化疗后LMVD与化疗后AKT的表达呈正相关,r_s=0.58,P<0.001。淋巴结转移与化疗前后LMVD均呈正相关(r_s=0.44,P<0.001;r_s=0.36,P=0.013)。淋巴结转移的患者化疗前化疗后LMVD均高于淋巴结未转移者。结论化疗前P-AKT的表达及化疗后AKT和P-AKT的表达与肿瘤微淋巴管生成呈正相关,LMVD与淋巴结的转移呈正相关,化疗前P-AKT的表达有可能作为预测宫颈癌新辅助化疗疗效的指标。

关键词：宫颈癌新辅助化疗 AKT P-AKT 微淋巴管密度

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印章结构对微接触印刷制备导电网格的影响

无机材料学报 2017年第7期32卷 713-718页

作者：辛智青李修姬磊李泽涛项飞翔刘世丽李路海北京印刷学院印刷与包装工程学院北京市印刷电子工程技术研究中心北京102600

为了在PET基底上制备精细的透明网格状导电图案,本工作利用微接触印刷高精度的优势,分别采用线条结构和网格结构的印章转印银纳米粒子导电油墨,分析了其转印过程,并讨论了印章结构对网格图案性能的影响。结果表明:采用线条结构的印章可... 详细信息

为了在PET基底上制备精细的透明网格状导电图案,本工作利用微接触印刷高精度的优势,分别采用线条结构和网格结构的印章转印银纳米粒子导电油墨,分析了其转印过程,并讨论了印章结构对网格图案性能的影响。结果表明:采用线条结构的印章可真实还原印章设计尺寸,避免了线条的扩展,有利于提高网格图案的透光率;同时,在交叉处墨层较厚可提高导电性。而采用网格结构印章可一次转移快速获得网格图案,但由于印章网格上相邻线条之间液桥的形成会使图案线宽增加,降低其透光率;采用间距较大的印章可使液桥断裂,得到边缘光滑的网格图案,但间距增大导致单位面积导电路径减少,降低其导电性。总之,采用线条结构印章有利于获得性能较好的网格图案,但两次转移过程相对复杂,需用时间较长。

关键词：微接触印刷网格图案导电油墨银纳米粒子

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei Cong Guoyu Qian Dong Wang Laishi li Yusheng Wu zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

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基于数据特征的内核恶意软件检测

软件学报 2016年第12期27卷 3172-3191页

作者：陈志锋李清宝张平丁文博解放军信息工程大学河南郑州450001 数学工程与先进计算国家重点实验室河南郑州450001

内核恶意软件对操作系统的安全造成了严重威胁.现有的内核恶意软件检测方法主要从代码角度出发,无法检测代码复用、代码混淆攻击,且少量检测数据篡改攻击的方法因不变量特征有限导致检测能力受限.针对这些问题,提出了一种基于数据特征... 详细信息

内核恶意软件对操作系统的安全造成了严重威胁.现有的内核恶意软件检测方法主要从代码角度出发,无法检测代码复用、代码混淆攻击,且少量检测数据篡改攻击的方法因不变量特征有限导致检测能力受限.针对这些问题,提出了一种基于数据特征的内核恶意软件检测方法,通过分析内核运行过程中内核数据对象的访问过程,构建了内核数据对象访问模型;然后,基于该模型讨论了构建数据特征的过程,采用动态监控和静态分析相结合的方法识别内核数据对象,利用EPT监控内存访问操作构建数据特征;最后讨论了基于数据特征的内核恶意软件检测算法.在此基础上,实现了内核恶意软件检测原型系统MDS-DCB,并通过实验评测MDS-DCB的有效性和性能.实验结果表明:MDS-DCB能够有效检测内核恶意软件,且性能开销在可接受的范围内.

关键词：内核恶意软件数据特征内核数据对象恶意软件检测

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： zhi-Wei Fu Yue-Jing li Ran Yu Rui-qing Guo li-Xia Gao Sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all Plinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun Wang qing Shi Guofan Zhang Yuxuan Zhu Binbin li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

窄带成像技术对胃黏膜高级别上皮内瘤变患者临床疗效的影响

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中国内镜杂志 2017年第3期23卷 74-78页

作者：李庆芝庄天彦山东省菏泽市立医院消化内科山东菏泽274031

目的探究窄带成像技术(NBI)对胃黏膜高级别上皮内瘤变(HGIN)患者临床疗效的影响。方法选取2006年6月-2016年6月该院接收治疗的96例胃黏膜HGIN患者为研究对象,采用随机数表法将患者分为对照组和观察组,各48例。对照组患者采用内镜黏膜下... 详细信息

目的探究窄带成像技术(NBI)对胃黏膜高级别上皮内瘤变(HGIN)患者临床疗效的影响。方法选取2006年6月-2016年6月该院接收治疗的96例胃黏膜HGIN患者为研究对象,采用随机数表法将患者分为对照组和观察组,各48例。对照组患者采用内镜黏膜下剥离术(ESD)治疗,观察组患者采用NBI联合ESD治疗。比较两组患者的各项手术情况、术后病理分型和并发症发生情况。结果观察组患者的手术时间、切缘阳性率均低于对照组,病灶直径、一次性整块切除率和治愈性切除率均高于对照组,差异具有统计学意义(P0.05)。观察组与对照组患者的并发症总发生率分别为6.25%和22.92%,观察组明显低于对照组,差异具有统计学意义(P<0.05)。结论采用NBI联合内镜治疗胃黏膜HGIN患者能够显著提高病灶的整块完整切除率和治愈性切除率,缩短手术时间,降低并发症发生率。

关键词：窄带成像技术内镜黏膜下剥离术高级别胃黏膜上皮内瘤变

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披碱草胚和胚乳的发育

中国草地学报 2016年第6期38卷 98-101页

作者：李造哲谢菲马青枝李月强内蒙古农业大学草原与资源环境学院内蒙古呼和浩特010019 内蒙古阿拉善盟林木种苗站内蒙古巴彦浩特750306 内蒙古农业大学生命科学学院内蒙古呼和浩特010019 内蒙古包头市达茂旗林业局内蒙古014500

采用常规石蜡切片法,对披碱草(Elymus dahuricus Turcz.)胚和胚乳发育过程进行了观察。结果表明:披碱草花后6h卵细胞受精形成合子,合子休眠期长约6h。花后12h,合子进行第一次分裂。花后1d,形成了四细胞原胚,胚胎发生属紫菀型。花后第9d... 详细信息

采用常规石蜡切片法,对披碱草(Elymus dahuricus Turcz.)胚和胚乳发育过程进行了观察。结果表明:披碱草花后6h卵细胞受精形成合子,合子休眠期长约6h。花后12h,合子进行第一次分裂。花后1d,形成了四细胞原胚,胚胎发生属紫菀型。花后第9d,在梨形原胚偏上一侧出现小凹沟,器官开始分化。花后第18d时,胚的结构基本发育成熟。披碱草有异常胚发生的现象。胚乳发育早,胚发育晚,胚乳的类型属于核型胚乳。

关键词：披碱草胚胚乳发育

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牵引变电所固定并联电容补偿有效性评价

铁道学报 2004年第3期26卷 41-45页

作者：贺建闽黄治清李群湛西南交通大学电气工程学院四川成都610031

为使负荷功率因数达到供电部门所规定的相关标准,牵引变电所安装了固定并联电容补偿装置。本文讨论这种固定补偿方式的有效性问题,给出适合工程计算的评估方法,对泸沽牵引变电所的实测和仿真结果证实了本文所给方法的正确性。

关键词：电气化铁道牵引变电所固定并联电容补偿有效性