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Ultrasonic diagnosis of biliary atresia: A retrospective analysis of 20 patients

World Journal of Gastroenterology 2008年第22期14卷 3579-3582页

作者： Shi-Xing Li Yao Zhang Mei Sun Bo Shi Zhong-Yi Xu Ying Huang zhi-qin mao Department of Ultrasound Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of Internal Medicine for Childhood Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of Pediatric Surgery Shengjing Hospital of China Medical University Shenyang 110004 Liaoning Province China

AIM: To investigate the clinical value of ultrasono-graphic diagnosis of biliary atresia (BA), a retrospective analysis of the sonogram of 20 children with BA was undertaken. METHODS: Ultrasonography (US) was performed in 20 neonates and infants with BA, which was confirmed with cholangiography by operation or abdominoscopy. The presence of triangular cord, the size and echo of liver, the changes in empty stomach gallbladder and postprandial gallbladder were observed and recorded. RESULTS: The triangular cord could be observed at the porta hepatis (thickness: 0.3-0.6 cm) in 10 cases. Smaller triangular cord (0.2-0.26 cm) can be observed in 3 cases. The gallbladder was not observed in 2 cases, and 1 case showed a streak gallbladder without capsular space. The gallbladders of 15 cases were flat and small. The gallbladders of 2 cases were of normal size and appearance, however, there was no postprandial contraction. The livers of all cases showed hepatomegaly and hetreogeneous echogenicity. Statistical analysis was performed to compare the hepatomegaly and hetreogeneous echogenicity and the stage of hepatic fibrosis. CONCLUSION: The presence of the triangular cord atthe porta hepatis is specific. However, it is not the only diagnostic criterion, since flat and small gallbladder and poor contraction are also of important diagnostic and differential diagnostic significance. The degree of hepatomegaly and hetreogeneous echogenicity is proportional with liver fibrosis, and able to indicate the duration of course and prognosis.

关键词： Biliary atresia Ultrasonic diagnosis The triangular cord Maldevelopement of gallbladder Magnetic resonance imaging

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Genetic polymorphism of UL144 open reading frame of human cytomegalovirus DNA detected in colon samples from infants with Hirschsprung's disease

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World Journal of Gastroenterology 2007年第32期13卷 4350-4354页

作者： zhi-qin mao Ying Huang Mei Sun Qiang Ruan Ying Qi Rong He Yu-Jing Huang Yan-Ping Ma Yao-Hua Ji Zheng-Rong Sun Hong Gao Department of Pediatrics Second Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China Department of Pediatric Surgery Second Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China Virus Laboratory Second Affiliated Hospital China Medical University Shenyang 110004 Liaoning Province China

AIM： To explore the genetic diversities of UL144 open reading frame （ORF） of cytomegalovirus DNA detected in colon tissue from infants with Hirschsprung＇s disease （HD） by sequencing UL144 DNA in 23 aganglionic colon tissue and 4 urine samples from 25 HD infants. METHODS： Nest PCR was performed for amplification of the UL144 gene. The UL144 gene was analyzed with soffwares, such as DNAclub, BioEdit, PROSITE database, and DNAstar. RESULTS： The strains from HD patients were distributed among three genotypes of UL144： group 1A （64%）, group 2 （24%）, and group 3 （12%）. The UL144 genotypes between strains from HD and control group were compared by chi square test （x^2 = 1.870, P = 0.393）. Strains from the colon were sporadically distributed in UL144 genotypes. CONCLUSION： There are genetic diversities of UL144 ORF in colon tissue of infants with HD. However, cytomegalovirus UL144 genotypes are not associated with clinical manifestations of HD.

关键词： Hirschsprung's disease Cytomegalovirus UL144 gene Polymorphism

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知识创新与期刊文献的知识活化

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图书馆建设 2001年第6期 4-5页

作者：徐志娟毛琴芳上海大学图书馆 200436

期刊文献资源只有经过有效的梳理和激活，才能真正发挥其特有的知识信息作用，从而采取相应的激活方式及技巧，推动期刊文献的深层次开发和信息化服务。

关键词：知识创新期刊文献知识活化资源开发知识整序信息服务

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饮食教育预防骨科术后病人便秘的研究

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国际护理学杂志 2009年第6期28卷 731-734页

作者：只茂琴天津市静海县医院 301600

目的探讨饮食教育对骨科术后病人进食结构的影响，以及对预防便秘的作用。方法将骨科手术的手术后病人随机分为试验组和对照组，试验组符合纳入标准48例，对照组49例。试验组于术后当日及术后第2天分2次接受专门的饮食教育，对照组接受... 详细信息

目的探讨饮食教育对骨科术后病人进食结构的影响，以及对预防便秘的作用。方法将骨科手术的手术后病人随机分为试验组和对照组，试验组符合纳入标准48例，对照组49例。试验组于术后当日及术后第2天分2次接受专门的饮食教育，对照组接受常规指导。记录病人术后3d内的进食种类、量及排便情况。结果试验组术后2～3d蔬菜进食率均明显高于对照组（Х^2=6．95；7．24；P均〈0．05）：试验组术后1-2d主食进食量均明显高于对照组（t=2．077；3．084；P均〈0．05）；试验组术后2—3d蔬菜进食量均明显高于对照组（t=2．205；2．341；P均〈0．05）；术后便秘症状评分，试验组为6．85±3．32，对照组为8．63±3．27（t=2．660，P〈0．05），两组差异有显著性。结论对病人进行饮食教育能够有效降低骨科术后病人便秘症状评分，即饮食教育能够降低术后便秘的发生；饮食结构不合理主要表现为术后3d内主食类、蔬菜类的量不足。因此，进行饮食教育时应强调术后适宜的主食量和蔬菜量，特别应重视病人术后3d内的进食情况。

关键词：饮食教育骨科病人便秘

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PAF对肠上皮细胞紧密连接的影响及ITF的保护作用

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世界华人消化杂志 2008年第4期16卷 372-378页

作者：许玲芬董亚珞孙梅马力毛志芹中国医科大学附属第二医院(盛京医院)儿科辽宁省沈阳市110004 中国医科大学附属第一医院临床流行病教研室辽宁省沈阳市110001 中国医科大学附属第二医院(盛京医院)感染科实验室辽宁省沈阳市110004

目的:探讨血小板活化因子(PAF)是否会引起肠黏膜屏障的破坏以及这种破坏机制是否与紧密连接相关,并观察肠三叶因子(ITF)的保护作用.方法:培养人结肠腺癌细胞株Caco-2,分别设正常对照组:不加刺激物及干预因素;实验组:加入PAF,终浓度分别... 详细信息

目的:探讨血小板活化因子(PAF)是否会引起肠黏膜屏障的破坏以及这种破坏机制是否与紧密连接相关,并观察肠三叶因子(ITF)的保护作用.方法:培养人结肠腺癌细胞株Caco-2,分别设正常对照组:不加刺激物及干预因素;实验组:加入PAF,终浓度分别为50 ng/L、100 ng/L和200 ng/L;ITF预防组:先加入ITF0.3 g/L,30 min后加入PAF 100 ng/L;ITF治疗组:先加入PAF 100 ng/L,30 min后加入ITF0.3 g/L,24 h后进行实验.MTT比色法检测细胞活力;测定跨上皮电阻TER和荧光黄的透过量反映肠上皮细胞单层通透性;RT-PCR法检测紧密连接蛋白ZO-1和Occludin mRNA表达的变化;免疫荧光染色观察紧密连接蛋白ZO-1和Occludin的形态学.结果:PAF未影响到细胞的增殖和细胞活力.各浓度PAF作用24 h后,细胞单层通透性增加,跨上皮电阻(TER)下降,荧光黄透过增加.ITF治疗组及预防组TER下降值较模型组明显降低(122.2±14.7,100.3±10.9 vs 210.3±26.4,P<0.05),荧光黄透过量减少(10226.1±556.2,9711.2±364.9 vs 11601.2±693.5,P<0.05),预防组作用更明显.PAF作用后,ZO-1和Occludin mRNA表达均有下降,以100 ng/L组改变最为明显,ITF预防组较之表达增加(1.28±0.06 vs 1.07±0.05,1.13±0.07 vs 0.81±0.06,P<0.05),ITF治疗组改变不明显.免疫荧光染色发现ZO-1和Occludin主要分布在细胞内近胞膜处.PAF作用后,ZO-1及Occludin形态学改变,预防性给予ITF后,可明显减轻这种改变.结论:PAF可引起肠黏膜屏障破坏,其机制可能和紧密连接蛋白的破坏相关;ITF可以通过改变紧密连接蛋白的表达而部分恢复肠黏膜正常通透性,起到保护作用.

关键词：紧密连接血小板活化因子肠三叶因子跨上皮电阻 ZO-1 Occludin MTT法逆转录聚合酶链式反应

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早产儿血清表皮生长因子测定的临床意义

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中国当代儿科杂志 2005年第3期7卷 243-244页

作者：毛志芹李军孙梅胡国斌张惠中国医科大学附属第二医院儿科辽宁沈阳110004 辽宁省人民医院儿科辽宁沈阳110015

目的表皮生长因子与胎儿器官发育和功能成熟密切相关,该研究探讨早产儿窒息及早产儿坏死性小肠结肠炎患儿血清中表皮生长因子含量及其临床意义。方法采用放射免疫方法检测10例足月新生儿和35例早产儿生后血清表皮生长因子浓度。结果35... 详细信息

目的表皮生长因子与胎儿器官发育和功能成熟密切相关,该研究探讨早产儿窒息及早产儿坏死性小肠结肠炎患儿血清中表皮生长因子含量及其临床意义。方法采用放射免疫方法检测10例足月新生儿和35例早产儿生后血清表皮生长因子浓度。结果35～37周和28～34周早产儿血清表皮生长因子含量0.617±0.22μg/L,0.540±0.31μg/L明显低于足月新生儿0.723±0.18μg/L,差异有显著性(P<0.01);窒息早产儿与足月儿相比血清表皮生长因子水平降低更为明显0.446±0.24μg/Lvs0.723±0.18μg/L;坏死性小肠结肠炎早产儿与足月儿比较血清表皮生长因子浓度没有明显降低0.771±0.44μg/Lvs0.723±0.18μg/L,差异无显著性。结论血清表皮生长因子水平与胎龄有关;窒息可使表皮生长因子水平降低。

关键词：表皮生长因子坏死性小肠结肠炎窒息早产儿

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-qin Liu Jie Chen zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin qin Xin Tan Xiao-Yan Sun Xu-Fang Ying zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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掺杂对单层石墨烯纳米梁振动频率的影响

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原子与分子物理学报 2025年第3期42卷 67-71页

作者：王志钦王静新疆大学物理科学与技术学院乌鲁木齐830017

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、... 详细信息

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、硼-硼(B-B)掺杂、铍(Be)掺杂和铍-铍(Be-Be)掺杂均会导致单层石墨烯纳米梁的振动频率降低.此外,随着硼(B)/铍(Be)掺杂浓度的增加,单层石墨烯纳米梁的振动频率逐渐降低.且随着掺杂浓度的增加,硼(B)掺杂石墨烯纳米梁的振动频率和铍(Be)掺杂石墨烯纳米梁的振动频率的差异逐渐增大.这对石墨烯纳米机械谐振器、振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：石墨烯振动频率分子动力学

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Pyrolysis-GC/MS of Menthyl Esters of N-Benzoxycarbonyl Amino Acid

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Chemical Research in Chinese Universities 2010年第2期26卷 198-203页

作者： mao mao GU Cheng-zhi YIN Hao SONG qin-hua LI Qlan-rong Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry University of Science and Technology of China Hefei 230026 R R. China Department of Chemistry Shihezi University Shihezi 832003 P. R. China

With the aid of a Pyrolysis-GC/TOF MS technique, the pyrolysis behaviour of two menthyl esters of N-benzoxycarbonyl amino acid was investigated. A clear pattern emerges involving the cleavage of the bond linking the menthyl ring to the carboxy group, followed by further degradation of the fragments. The major pyroproducts were p-menth-l-ene pyrolysed at a higher temperature or p-menth-2-ene pyrolysed at a lower temperature, and various derivatives of cyclohexene pyrolyzed from the menthyl ring. In addition, some of the products were also iden- tified as derivatives of benzene from the pyrolysis of benzyloxyl moiety.

关键词： Menthyl esters of N-benzoxycarbonyl amino acid Py-GC/MS Pyrolysis

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