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White Matter“Matters”in Alzheimer’s Disease

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Neuroscience Bulletin 2022年第3期38卷 323-326页

作者： Man-Yu xu zhi-qiang xu Yan-Jiang Wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China The Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China

Alzheimer's disease(AD)is a neurodegenerative disease that increasingly burdens many families *** AD is generally thought to be closely associated with gray matter,many studies have identified significant changes in white matter as well,including demyelination and function alterations in oligodendrocytes in the AD *** addition,Ap plaques,the most important pathological characteristic in AD,are deposited in late-myelinating regions such as the prefrontal and temporal lobes,where myelin is prone to damage[1].All the evidence hints that the changes in myelin are closely associated with the onset and progression of AD,prompting scientists to outline the process of changing myelin in AD and develop novel strategies for the treatment of AD.

关键词： Alzheimer alterations damage

Preparation of calcium ferrite by flue gas desulfurization gypsum

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Journal of Iron and Steel Research International 2021年第11期28卷 1357-1365页

作者： Lin-cheng Liu Hai-bin Zuo Wen-guo Liu zhi-qiang xu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

At present,the continuous accumulation of the flue gas desulfurization(FGD)gypsum in steel plants leads to the serious environmental issues and resource *** achieve green and sustainable development for the steel industry,it is significant to improve the usage of by-product *** the sintering FGD gypsum,ferric oxide,and graphite carbon as raw materials,the effects of the carbon content,reaction time,and molar ratio of CaO to Fe_(2)O_(3)on the desulfurization rate of gypsum were studied based on the orthogonal *** results show that the order of the three influencing factors on the desulfurization rate of FGD gypsum is:molar ratio of CaO to Fe_(2)O_(3)>reaction time>carbon *** the optimal conditions of 20 wt.%carbon content,4 h reaction time,and 1:1 molar ratio of CaO to Fe_(2)O_(3),the desulfurization rate of desulfurization gypsum is 95.79%,and 97.57 wt.%of calcium ferrite appears in the solid product,which can be used as sintering additive to increase the economic benefits of enterprises and realize the green ecological development mode of internal generation and internal digestion of solid waste in iron and steel enterprises.

关键词： Flue gas desulfurization gypsum Desulfurization rate Calcium ferrite Sintered ore Green production

Effect of Oscillation Parameters to Flow Field in the Pool during the Oscillating Twin-Roll Strip Casting Process

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Chinese Journal of Mechanical Engineering 2018年第6期31卷 187-194页

作者： zhi-qiang xu Zhe-Ru Meng Shun-Hui xue De-Quan Zhang Feng-Shan Du School of Mechanical Engineering Yanshan University Qinhuangdao 066004 China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University Qinhuangdao 066004 China Shanghai XZS Heavy Machinery Integration Co. Ltd Shanghai 201900 China

During the oscillating twin?roll strip casting process, the quality of final products is directly influenced by the flow field distribution of molten metal in the pool. The variation in the flow field is caused by oscillating roller benefits, for homogeneous distribution of strip impurity, and decreasing the grain size. Thus, the quality of the strip could be improved. A numerical model was developed using the multiphase flow technology, coupled with heat transfer, fluid flow, solidification, and oscillation. Furthermore, a transient algorithm was adopted for simulating the oscillating twin?roll strip casting process of AlSi9Cu3 and 3104 aluminum alloy. This paper focuses on the flow distribution in the pool, in comparison with the traditional vertical twin?roll strip casting process, while the amplitude or frequency is chang?ing with the definite value of casting velocity, roller diameter, nozzle angle, and the strip thickness. Consequently, the conclusions were experimentally validated by oscillating twin?roll 3104 aluminum alloy strip casting. Vibrating casting technology can change the flow field in the pool by vibration, which can improve the quality of the strip core.

关键词： Flow field Oscillating twin?roll strip casting Solidification Twin?roll strip casting

Phase noise sensitivity analysis of lattice constellation

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The Journal of China Universities of Posts and Telecommunications 2010年第2期17卷 36-40页

作者： YU Guang-wei NIU Kai HE zhi-qiang WANG xu-zhen LIN Jia-ru Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

Based on the assumption of large number of constellation points and high signal-to-noise ratio （SNR）, phase noise sensitivity of lattice constellation is analyzed. The upper bound of symbol error rate （SER） in additive white Gaussian noise （AWGN） channel is derived from pairwise error probability. For small phase noise, phase noise channel is transformed to AWGN channel. With the aid of Wiener model, the obtained upper bound can be extended to phase noise channel. The proposed upper bound can be used as performance criterion to analyze the sensitivity of phase noise in multi-dimensional lattice constellation. Simulation results show that with the same normalized spectral efficiency, higher dimensional lattice constellations are more sensitive than lower ones in phase noise channel. It is also shown that with the same dimension of constellation, larger normalized spectral efficiency means more performance loss in phase noise channel.

关键词： lattice constellation symbol error rate (SER) phase noise

Intermittent disturbance mechanical behavior and fractional deterioration mechanical model of rock under complex true triaxial stress paths

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International Journal of Mining Science and Technology 2024年第1期34卷 117-136页

作者： zhi Zheng Hongyu xu Kai Zhang Guangliang Feng qiang Zhang Yufei Zhao State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100080China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing ***,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is *** triaxial static compression and intermittent disturbance tests are carried out on *** effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture *** increases in microseismic parameters during rock loading can be precursors for intermittent rock *** on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental *** sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are *** study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads.

关键词： True triaxial static and disturbance test Mechanical properties Failure mechanism and precursor Intermittent disturbance effect Fractional mechanical model

Multi-dimensional versions of a formula of Popoviciu

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Science China Mathematics 2007年第2期50卷 285-291页

作者： zhi-qiang xu Institute of Computational Math and Sci/Eng Computing, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100080, China Institute of Computational Math and Sci/Eng Computing Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing China

In this paper, an explicit formulation for multivariate truncated power functions of degree one is given firstly. Based on multivariate truncated power functions of degree one, a formulation is presented which counts the number of non-negative integer solutions of s×(s + 1) linear Diophantine equations and it can be considered as a multi-dimensional versions of the formula counting the number of non-negative integer solutions of ax + by = n which is given by Popoviciu in 1953.

关键词： multivariate splines discrete truncated power linear Diophantine equations 41A15 05A15

Peripheral Delivery of Ganglioside GM1 Exacerbates the Pathogenesis of Alzheimer’s Disease in a Mouse Model

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Neuroscience Bulletin 2022年第1期38卷 95-98页

作者： Chuang-Chuang Yang Yuan Cheng Hai-Mei Yang Yang Chen Yan-Jiang Wang zhi-qiang xu Ye-Ran Wang Department of Neurology and Clinical Center for Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China

Dear Editor,Alzheimer’s disease(AD)is the most common cause of dementia among the older population,and is characterized by amyloid-beta(Aβ)accumulation,hyperphosphorylation of tau,and finally neurodegeneration in the brain[1].Aβ is the major pathological agent in AD,thus currently most efforts in developing therapies for AD target this *** most promising therapy for this disease is immunotherapy.

关键词： GM1 Alzheimer Aβ tau

A New Chromone Glycoside from Cassia siamea Lam.

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Chinese Chemical Letters 2001年第8期12卷 703-704页

作者： Tai Sheng LU Yang Hua YI Shi Long MAO Da Zheng ZHOU qiang zhi xu Hai Feng TANG Shu Yu ZHANG Center of Marine Drug Research School of PharmacySecond Military Medical UniversityShanghai 200433

2-methyl-5-propyl-7, 12-dihydroxy chromone-12-O-β-D-glucopyranoside was isolated from the stem of Cassia siamea. The structure was elucidated by chemical and spectral evidences.

关键词： Cassia siamea 2-methyl-5-propyl-7 12-dihydroxy-chromone-12-O-β-D-glucopyrano-side

Exploring deep learning for landslide mapping:A comprehensive review

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China Geology 2024年第2期7卷 330-350页

作者： zhi-qiang Yang Wen-wen Qi Chong xu Xiao-yi Shao College of Surveying and Geo-Informatics Tongji UniversityShanghai 200092China National Institute of Natural Hazards Ministry of Emergency ManagementBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China

A detailed and accurate inventory map of landslides is crucial for quantitative hazard assessment and land *** methods relying on change detection and object-oriented approaches have been criticized for their dependence on expert knowledge and subjective *** advancements in highresolution satellite imagery,coupled with the rapid development of artificial intelligence,particularly datadriven deep learning algorithms(DL)such as convolutional neural networks(CNN),have provided rich feature indicators for landslide mapping,overcoming previous *** this review paper,77representative DL-based landslide detection methods applied in various environments over the past seven years were *** study analyzed the structures of different DL networks,discussed five main application scenarios,and assessed both the advancements and limitations of DL in geological hazard *** results indicated that the increasing number of articles per year reflects growing interest in landslide mapping by artificial intelligence,with U-Net-based structures gaining prominence due to their flexibility in feature extraction and ***,we explored the hindrances of DL in landslide hazard research based on the above research *** such as black-box operations and sample dependence persist,warranting further theoretical research and future application of DL in landslide detection.

关键词： Landslide Mapping Quantitative hazard assessment Deep learning Artificial intelligence Neural network Big data Geological hazard survery engineering