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World Journal of Gastroenterology 2014年第1期20卷 264-273页

作者： Ming-Ming He Dong-Sheng Zhang Feng wang zhi-qiang wang Hui-Yan Luo Chao Ren Ying Jin Dong-Liang Chen Rui-Hua Xu State Key Laboratory of Oncology in South China Department of Medical OncologySun Yat-sen University Cancer Center

AIM: To investigate adjuvant chemotherapy, p53 and carcinoembryonic antigen (CEA) expression and prognosis after D2 gastrectomy for stage II/III gastric adenocarcinoma.

关键词： Gastric adenocarcinoma Adjuvant chemotherapy p53 Carcinoembryonic antigen Immunohistochemistry

Exact Location of Linear B-cell Epitopes of VP3 Protein of Goose Parvovirus

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畜牧兽医学报 2011年第B12期42卷 34-39页

作者： GUO Lu JU Huan-yu YU Tian-fei JING zhi-qiang MA Bo wang Jun-wei （College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China）

Four monoclonal antibodies (MAbs) against Goose Parvovirus (GPV) VP3 protein already available were used to precisely locate linear B-cell epitopes in VP3 of GPV. The epitopes, recognized by four MAbs, had already been identified at low levels of resolution. Complementary oligonucleotides encoding ten amino acid fragments, with five amino acid overlaps were designed with suitable sticky ends for recombination with pET-32a and subsequent expression as small-fragment fusion proteins. Antigenicity of specific oligopeptides was determined by Western blotting with the MAbs. Using the same methods, amino acids were deleted one by one from the peptides of interest, enabling the two epitopes to be precisely located at amino acids 430-435 (-DRIMNP-) and 643-647 (-VFIKN-).

关键词： VP3基因鹅细小病毒 B细胞表位 VP3蛋白抗原表位线性单克隆抗体位置

A chaotic coverage path planner for the mobile robot based on the Chebyshev map for special missions

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Frontiers of Information Technology & Electronic Engineering 2017年第9期18卷 1305-1319页

作者： Cai-hong LI Yong SONG Feng-ying wang zhi-qiang wang Yi-bin LI College of Computer Science and Technology Shandong University of Technology Zibo 255000 China School of Mechanical Electrical & Information Engineering Shandong University Weihai 264209 China

We introduce a novel strategy of designing a chaotic coverage path planner for the mobile robot based on the Che- byshev map for achieving special missions. The designed chaotic path planner consists of a two-dimensional Chebyshev map which is constructed by two one-dimensional Chebyshev maps. The performance of the time sequences which are generated by the planner is improved by arcsine transformation to enhance the chaotic characteristics and uniform distribution. Then the coverage rate and randomness for achieving the special missions of the robot are enhanced. The chaotic Chebyshev system is mapped into the feasible region of the robot workplace by affine transformation. Then a universal algorithm of coverage path planning is designed for environments with obstacles. Simulation results show that the constructed chaotic path planner can avoid detection of the obstacles and the workplace boundaries, and runs safely in the feasible areas. The designed strategy is able to satisfy the requirements of randomness, coverage, and high efficiency for special missions.

关键词： Mobile robot Chebyshev map Chaotic Affine transformation Coverage path planning

Diagnostic accuracy of a deep learning approach to calculate FFR from coronary CT angiography

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Journal of Geriatric Cardiology 2019年第1期16卷 42-48页

作者： zhi-qiang wang Yu-Jie ZHOU Ying-Xin ZHAO Dong-Mei SHI Yu-Yang LIU Wei LIU Xiao-Li LIU Yue-Ping LI Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Clinical Center for Coronary Heart Disease Capital Medical University

Background The computational fluid dynamics(CFD)approach has been frequently applied to compute the fractional flow reserve(FFR)using computed tomography angiography(CTA).This technique is *** developed the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value out of CTA images in five *** study is to evaluate the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value from CTA images as an efficient *** A single-center,prospective study was conducted and 63 patients were enrolled for the evaluation of the diagnostic performance of *** quantification method for the three-dimensional coronary arterial geometry and the deep learning based prediction of FFR were developed to assess the ischemic risk of the stenotic coronary *** performance of the DEEPVESSEL-FFR was assessed by using wire-based FFR as reference *** primary evaluation factor was defined by using the area under receiver-operation characteristics curve(AUC)*** For per-patient level,taking the cut-off value<0.8 referring to the FFR measurement,DEEPVESSEL-FFR presented higher diagnostic performance in determining ischemia-related lesions with area under the curve of 0.928 compare to CTA stenotic severity ***-FFR correlated with FFR(R=0.686,P<0.001),with a mean di&ference of-0.006士0.0091(P=0.619).The secondary evaluation factors,indicating per vessel accuracy,sensitivity,specificity,positive predictive value,and negative predictive value were 87.3%,97.14%,75%,82.93%,and 95.45%,*** DEEPVESSEL-FFR is a novel method that allows efficient assessment of the functional significance of coronary stenosis.

关键词： Computed tomography angiography Coronary artery Deep learning Fractional flow reserve

PhaseⅡstudy of oxaliplatin combined with S-1 and leucovorin(SOL)for Chinese patients with metastatic colorectal cancer

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Chinese Journal of Cancer 2016年第3期35卷 126-132页

作者： zhi-qiang wang dong-sheng zhang nong xu de-yun luo yan-hong deng feng-hua wang hui-yan luo miao-zhen qiu yu-hong li rui-hua xu Sun Yat‑sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer Medicine510060 GuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road East510060 GuangzhouGuangdongP.R.China Department of Medical Oncology The First Affiliated Hospital of College of MedicineZhejiang University310003 HangzhouZhejiangP.R.China Department of Medical Oncology West China Hospital of Sichuan University610041 ChengduSichuanP.R.China Department of Medical Oncology The Sixth Affiliated Hospital of Sun Yat-sen University510655 GuangzhouGuangdongP.R.China

Background:Fluoropyrimidine and oxaliplatin are widely used for patients with colorectal *** phase II study was conducted to evaluate the efficacy and safety of the combination of S-1,oxaliplatin,and leucovorin(SOL) in the treatment of Chinese patients with metastatic colorectal cancer(mCRC).Methods:Eligible patients with untreated mCRC from four hospitals in China received intravenous oxaliplatin(85 mg/m2) on day 1,oral S-1 twice daily(80-120 mg per day) on day 1-7,and leucovorin twice daily(50 mg per day)simultaneously with S-1,every 2 *** and discussion:Forty patients were enrolled in our *** total,296 cycles of SOL were *** overall response rate was 50.0%.At a median follow-up of 27 months,progression-free survival and overall surviva were 7.0 months(95%confidence interval[CI]6.0-10.6 months) and 22.2 months(95%CI 15.1-29.3 months),*** most common grade 3/4 non-hematological adverse events were diarrhea(n = 8,20.0%),nausea(n = 3,7.5%),and vomiting(n = 3,7.5%).The most common grade 3/4 hematological toxicities were thrombocytopenia(n = 3,7.5%),neutropenia(n = 1,2.5%),and abnormal alanine transaminase/aspartate transaminase levels(n = 1,2.5%).There was one treatment-related ***:The data indicate that the SOL regimen is effective and moderately tolerated in Chinese patients with *** registration:Clinical trial

关键词： Colorectal cancer, Oxaliplatin, S-1, Leucovorin

The efficacy and safety of modified FOLFIRINOX as first-line chemotherapy for Chinese patients with metastatic pancreatic cancer

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Cancer Communications 2019年第1期39卷 245-252页

作者： zhi-qiang wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng-Hua wang Wei wang De-Shen wang Hui-Yan Luo Rui-Hua Xu Yi Ba Yu-Hong Li Department of Medical Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060GuangdongPeople’s Republic of China Department of Gastrointestinal Medical Oncology National Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin Medical University Cancer Institute and HospitalTianjin 300060People’s Republic of China Cancer Center The First People’s Hospital of FoshanFoshan 528000GuangdongPeople’s Republic of China

Background: Oxaliplatin, irinotecan, 5-fluorouracil, and l-leucovorin (FOLFIRINOX) has become one of the first-line treatment options for advanced pancreatic cancer (PC). However, the relatively high rate of grade 3 or 4 adverse events associated with the standard dosage of FOLFIRINOX limits its widespread use in clinical practice. In this study, we were to evaluate the efficacy and safety of a modified FOLFIRINOX regimen as a first-line chemotherapy for Chinese patients with metastatic PC. Methods: Patients with histologically confirmed primary metastatic pancreatic adenocarcinoma with an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 were recruited to receive the modified FOLFIRINOX regimen (intravenous infusion of oxaliplatin, 65 mg/m2;irinotecan, 150 mg/m2;l-leucovorin, 200 mg/ m2;and 5-fluorouracil, 2400 mg/m2, repeated every 2 weeks). The treatment was continued for 12 cycles unless the patient had progressive disease (PD), stable disease (SD) with symptom deterioration, unacceptable adverse events, or requested to terminate the treatment prematurely. The primary endpoint was objective response rate (ORR). Results: Sixty-five patients were enrolled from July 2012 to April 2017 in three institutions, and they all received at least one cycle of chemotherapy, with a median of 8 cycles (range 1-12 cycles). No complete response was observed. Twenty-one (32.3%) patients had partial responses, and 27 (41.5%) had SD. The ORR and disease control rate of the study cohort was 32.3% and 73.8%. The estimated median overall survival and progression-free survival were 11.60 (95% confidence interval [CI] 8.76-14.44) and 5.77 (95% CI 5.00-6.54) months. Major grade 3 or 4 adverse events included neutropenia (12.3%) and diarrhea (6.2%). No treatment-related death was observed. Conclusions: Modified FOLFIRINOX was well-tolerated and might be a promising option as first-line therapy for Chinese patients with metastatic PC.

关键词： Pancreatic cancer Metastatic Chemotherapy FOLFIRINOX Dose modification First-line Multicenter Overall response rate Efficacy Safety

Detection and Ranging System of Flight Aid Lights

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Semiconductor Photonics and Technology 2007年第1期13卷 20-24页

作者： YU zhi-jing wang qiang Research Base of Ground Support Equipment of CAAC Civil Aviation University of China Tianjin 300300 CHN

Dynamic detection based on optics sensors and ranging radars is a new method to detect the luminous intensity of flight aid lights. The optics sensors can get the illumination information of each light, the ranging radar gets the distance information, and then data amalgamation technology is used to compute the luminous intensity of each light. A method to modify the errors of this dynamic detection system is presented. It avoids the accumulation error and measurement carrier’s excursion error by using peak value detection based on optics sensors to estimate the accurate position of each light, then to modify the lights’ lengthways distance information and transverse position information. The performance of the detection and ranging system is validated by some experiments and shown in pictures.

关键词： luminous intensity dynamic detection illumination optics sensor

CRYSTAL STRUCTURE OF SEVEN-COORDINATE ZIRCONOCENE COMPLEX (CH_3C_5H_4) Zr(S_2CNBz_2)_3 (Bz=CH_2C_6H_5)

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Chinese Chemical Letters 1991年第11期2卷 863-864页

作者： zhi qiang wang Shi Wei LU He Fu GUO Niag Hai HU Dalian Institute of Chemical Physics Academia SinicaDalian 116023 Changchun Institute of Applied Chemistry Changchun 130022

(CH_3C_5H_4)Zr(S_2CNBz_2)_3, Mr=987.55, space group P1, a=13.002(4), b=13.659(3), c=29.685(8); α=100.72(2)~o,β=97.23(2)~o, γ=105.36(2)~o; V=4909(2)~3, Z=4, Dc=1.34gcm^(-3), Mo-K(λ=0.71073A) radiation, μ=5.0cm^(-1), R=0.069, Rw=0.078 for 6100 reflections. The title complex has pentagonal bipyramid configuration in which the zirconium atom is coordinated by one CH_3C_5H_4 group and three bidentate dibenzyldithiocarbamate ligands.

关键词： CH3C5H4 CRYSTAL STRUCTURE OF SEVEN-COORDINATE ZIRCONOCENE COMPLEX S2CNBz2 Bz=CH2C6H5 Zr Bz

CRYSTAL STRUCTURE OF FIVE-COORDINATE ZIRCONOCENE COMPLEX CP_2ZrCl(S_2CNBz_2) (Bz=C_6H_5CH_2)

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Chinese Chemical Letters 1991年第11期2卷 865-866页

作者： zhi qiang wang Shi Wei LU He Fu GUO Ning Hai HU Dalian Institute of Chemical Physics Dalian 116023 Changchun Institute of Applied Chemistry Changchun 130022

Cp;ZrCl（S;CNBz;） is a five-coordinate bent zirconocene in which the dibenzyldithiocarbamate is a bidentate ligand (Zr-Cl 2.549（1）A; Zr-C 2.489-2.533; Zr-S 2.667（1）, 2.734（1）; Zr-Cl-S1 137.6（1）;; Zr-Cl-S2 73.... 详细信息

关键词： Bz=C6H5CH2 Zr CP CRYSTAL STRUCTURE OF FIVE-COORDINATE ZIRCONOCENE COMPLEX CP2ZrCl Bz S2CNBz2 CH

Blended coals for improved coal water slurries

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Journal of China University of Mining and Technology 2008年第1期18卷 50-54页

作者： GU Tian-ye WU Guo-guang LI Qi-hui SUN zhi-qiang ZENG Fang wang Guang-you MENG Xian-liang School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Three coal samples of different ranks were used to study the effect of coal blending on the preparation of Coal Water Slurry (CWS). The results show that by taking advantage of two kinds of coal, the coal concentration in slurry made from hard-to-pulp coal can be effectively improved and increased by 3%–5% generally. DLT coal (DaLiuTa coal mine) is very poor in slurryability and the stability and rheology of the resulting slurry are not very good. When the amount of easily slurried coal is more than 30%, all properties of the CWS improve and the CWS meets the requirements for use as fuel. Coalification, porosity, surface oxygenic functional groups, zeta potential and grindability have a great effect on the performance of blended coal CWS. This leads to some differences in performance between the slurry made from a single coal and slurry made from blended coal.

关键词： low rank coal coal water slurry coal blending slurryability zeta potential