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Antiviral therapy delays esophageal variceal bleeding in hepatitis B virus-related cirrhosis

World Journal of Gastroenterology 2013年第40期19卷 6849-6856页

作者： Chang-Zheng Li Liu-Fang Cheng Qing-Shan Li zhi-qiang wang Jun-Hong Yan Department of Gastroenterology and Hepatology Institute of Hepatobiliary and Gastrointestinal DiseasesChinese Second Artillery General Hospital Department of Gastroenterology and Hepatology Chinese PLA General Hospital

AIM:To investigate the effect of antiviral therapy with nucleoside analogs in hepatitis B virus(HBV)-related cirrhosis and esophageal ***:Eligible patients with HBV-related cirrhosis and esophageal varices who consulted two tertiary hospitals in Beijing,China,the Chinese Second Artillery General Hospital and Chinese PLA General Hospital,were enrolled in the study from January 2005 to December 2009. Of 117 patients,79 received treatment with different nucleoside analogs and 38 served as controls. Bleeding rate,change in variceal grade and non-bleeding duration were analyzed. Multivariate Cox proportional hazard regression was used to identify factors related to esophageal variceal *** group compared to the control group(29.1%vs 65.8%,P < 0.001). Antiviral therapy was an independent factor related to esophageal bleeding in multivariate analysis(HR = 11.3,P < 0.001). The mean increase in variceal grade per year was lower in the antiviral group(1.0 ± 1.3 vs 1.7 ± 1.2,P = 0.003). Nonbleeding duration in the antiviral group was prolonged in the Kaplan-Meier model. Viral load rebound was observed in 3 cases in the lamivudine group and in 1 case in the adefovir group,all of whom experienced bleeding. Entecavir and adefovir resulted in lower bleeding rates(17.2% and 28.6%,respectively) than the control(P < 0.001 and P = 0.006,respectively),whereas lamivudine(53.3%) did not(P = 0.531).CONCLUSION:Antiviral therapy delays the progression of esophageal varices and reduces bleeding risk in HBV-related cirrhosis,however,high-resistance agents tend to be ineffective for long-term treatment.

关键词： Nucleoside analog Esophageal variceal bleeding Hepatitis B virus Cirrhosis Resistance Entecavir Lamivudine Adefovir

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Astrometric Reduction of Saturnian Satellites with Cassini-ISS Images Degraded by Trailed Stars

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Research in Astronomy and Astrophysics 2023年第3期23卷 85-92页

作者： Qing-Feng Zhang Meng-Qi Liu Yan Li Lin-Peng Wu zhi-qiang wang Li-Sha Zhu Zhan Li Department of Computer Science Jinan UniversityGuangzhou 510632China Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China Department of Financial Technology School of ManagementGuangzhou Xinhua UniversityGuangzhou 510520China

The Imaging Science Subsystem(ISS)mounted on the Cassini spacecraft has taken a lot of images,which provides an important source of high-precision astrometry of some planets and ***,some of these images are degraded by trailed ***,these degraded images cannot be used for *** this paper,a new method is proposed to detect and compute the centers of these trailed stars *** method is then performed on the astrometry of ISS images with trailed ***,we provided 658 astrometric positions between 2004 and 2017 of several satellites that include Enceladus,Dione,Tethys,Mimas and *** with the JPL ephemeris SAT427,the mean residuals of these measurements are 0.11 km and 0.26 km in *** decl.,*** standard deviations are 1.08 km and 1.37 km,*** results show that the proposed method performs astrometric measurements of Cassini ISS images with trailed stars effectively.

关键词： stars trail Saturn

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Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy:A systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第12期21卷 3720-3730页

作者： zhi-qiang wang Long-Qi Chen Yong Yuan Wen-Ping wang Zhong-Xi Niu Yu-Shang Yang Jie Cai Department of Thoracic Surgery West China Hospital Sichuan University

AIM: To evaluate the benefit and safety of sivelestat(a neutrophil elastase inhibitor) administration in patients undergoing esophagectomy. METHODS: Online databases including Pub Med, EMBASE, the Cochrane Library, Web of Knowledge, and Chinese databases(Wanfang database, VIP and CNKI) were searched systematically up to November 2013. Randomized controlled trials and high-qualitycomparative studies were considered eligible for inclusion. Three reviewers evaluated the methodological quality of the included studies, and Stata 12.0 software was used to analyze the extracted data. The risk ratio(RR) was used to express the effect size of dichotomous outcomes, and mean difference(MD) or standardized mean difference was used to express the effect size of continuous ***: Thirteen studies were included in this systematic review and nine studies were included in the meta-analysis. The duration of mechanical ventilation was significantly decreased in the sivelestat group on postoperative day 5 [I2 = 76.3%, SMD =-1.41, 95%CI:-2.63-(-0.19)]. Sivelestat greatly lowered the incidence of acute lung injury in patients after surgery(I2 = 0%, RR = 0.27, 95%CI: 0.08-0.93). However, it did not decrease the incidence of pneumonia, intensive care unit stay or postoperative hospital stay, and did not increase the incidence of complications such as anastomotic leakage, recurrent nerve palsy, wound infection, sepsis and catheter-related fever. CONCLUSION: A neutrophil elastase inhibitor is beneficial in patients undergoing esophagectomy. More high quality, large sample, multi-center and randomized controlled trials are needed to validate this effect.

关键词： Neutrophil elastase inhibitor Esophageal cancer Es

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Activity and selectivity of propane oxidative dehydrogenation over VO_3/CeO_2(111) catalysts: A density functional theory study

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Chinese Journal of Catalysis 2018年第9期39卷 1520-1526页

作者： Chang Huang zhi-qiang wang Xue-Qing Gong Key Laboratory for Advanced Materials Centre for Computational Chemistry and Research Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237 China

The oxidative dehydrogenation（ODH） of propane on monomeric VO3 supported by CeO2（111）（VO3/CeO 2（111）） is studied by periodic density functional theory calculations. Detailed energetic, structural, and electronic properties of these reactions are determined. The calculated activation energies of the breaking of the first and second C–H bonds of propane on the VO3/CeO2（111） catalyst are compared, and it is found that both the unique structural and electronic effects of the VO3/CeO2（111） catalyst contribute to the relatively easy rupture of the first C–H bond of the propane molecule during the ODH reaction. In particular, the so-called new empty localized states that are mainly constituted of O2 porbitals of the ceria-supported VO3 species are determined to be crucial for assisting the cleavage of the first C–H bond of the propane molecule. Following this they become occupied and the remaining C–H bonds become increasingly difficult to break owing to the increasing repulsion between the localized 4 felectrons at the Cecations, resulting in the adsorption of more H and other moieties. This work illustrates that CeO2-supported monomeric vanadium oxides can exhibit unique activity and selectivity for the catalytic ODH of alkanes to alkenes.

关键词： Oxidativede hydrogenation Propanetopropylene C–Hbondcleavage Ceria‐support edvanadia Density functional theorycal culations

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Carbon Monoxide Inhibits the Nuclear-cytoplasmic Translocation of HMGB1 in an In Vitro Oxidative Stress Injury Model of Mouse Renal Tubular Epithelial Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 791-795页

作者： Yu JIA Lu wang Guang-yuan ZHAO zhi-qiang wang Song CHEN Gang CHEN Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Key Laboratory of Organ Transplantation Ministry of Education Key Laboratory of Organ Transplantation Ministry of Health Wuhan 430030 China

Carbon monoxide（CO）,as a vital small molecule in signaling pathways,is found to be involved in ischemia-reperfusion injury（IRI） in renal ***-releasing molecule-2（CORM-2）,a CO-releasing molecule,is a type of metal carbonyl complexes which can quickly release CO in *** this study,an in vitro oxidative stress injury model was established to examine the effect of CORM-2 pretreatment on the nuclear-cytoplasmic translocation of high mobility group box 1 protein（HMGB1） in mouse primary renal proximal tubular epithelial cells（RPTECs）.Immunofluorescence staining showed that HMGB1 in the medium-and CORM-2-treated groups was predominantly localized in the nucleus of the cells,whereas higher amounts of HMGB1 translocated to the cytoplasm in the H2O2-and inactive CORM-2（i CORM-2）-treated *** blotting of HMGB1 showed that the total amounts of cytoplasmic HMGB1 in the H2O2-treated（0.59±0.27） and i CORM-2-treated（0.57±0.22） groups were markedly higher than those in the medium-treated（0.19±0.05） and CORM-2-treated（0.21±0.10） groups（P〈0.05）.Co-immunoprecipitation showed that the levels of acetylated HMGB1 in the H2O2-treated（642.98±57.25） and i CORM-2-treated（342.11±131.25） groups were markedly increased as compared with the medium-treated（78.72±74.17） and CORM-2-treated（71.42±53.35） groups（P〈0.05）,and no significant difference was observed between the medium-treated and CORM-2-treated groups（P〉0.05）.In conclusion,our study demonstrated that in the in vitro oxidative stress injury model of primary RPTECs,CORM-2 can significantly inhibit the nuclear-cytoplasmic translocation of HMGB1,which is probably associated with the prevention of HMGB1 acetylation.

关键词： renal tubules epithelial cell oxidative stress HMGB1 protein carbon monoxide acetylation

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Evaluation of bronchoscopic direct vision glottis anesthesia method in bronchoscopy

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World Journal of Clinical Cases 2023年第21期11卷 5108-5114页

作者： Jie Lang zhi-Zhen Guo Shu-Shan Xing Jian Sun Bin Qiu Yu Shu zhi-qiang wang Gui-Xiang Liu Department of Thoracic Surgery Tangshan People’s HospitalTangshan 063000Hebei ProvinceChina Department of Nephrology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Oncology Tangshan Central HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Fibrobronchoscopy is a common adjunct tool that requires anesthesia and is widely used in the diagnosis and treatment of various respiratory ***,current anesthesia methods,such as spray,nebulized inhalation,and cricothyroid membrane puncture,have their own advantages and ***,studies have shown that bronchoscopic direct-view glottis anesthesia is a simple and inexpensive method that shortens the examination time and provides excellent anesthetic *** To evaluate the effectiveness of bronchoscopic direct vision glottis anesthesia for *** The study included 100 patients who underwent bronchoscopy during thoracic surgery.A random number table method was used to divide the patients into control and observation groups(50 patients each).The control and observation groups were anesthetized using the nebulized inhalation and bronchoscopic direct vision glottis method,*** indices[systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),and oxygen saturation(SpO_(2))before(T1),5 min after anesthesia(T2),and at the end of the operation(T3)]serum stress hormone indices[norepinephrine(NE),epinephrine(E),adrenocorticotropic hormone(ACTH),and cortisol(Cor)before and after treatment]were compared between the 2 *** effects were also RESULTS At T2 and T3,SBP,DBP,and HR were lower in the observation group than the control group,whereas SpO_(2) was higher than the control group[(119.05±8.01)mmHg vs(127.05±7.83)mmHg,(119.35±6.66)mmHg vs(128.39±6.56)mmHg,(84.68±6.04)mmHg vs(92.42±5.57)mmHg,(84.53±4.97)mmHg compared to(92.57±6.02)mmHg,(74.25±5.18)beats/min compared to(88.32±5.72)beats/min,(74.38±5.31)beats/min compared to(88.42±5.69)beats/min,(97.36±2.21)%vs(94.35±2.16)%,(97.42±2.36)%vs(94.38±2.69%],with statistically significant differences(all P<0.05).After treatment,NE,E,ACTH,and Cor were significantly higher in both groups than before treatment,but were lower in the obser

关键词： Direct bronchoscopy Glottis anesthesia method Bronchoscopy Airway Sedation

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Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5631-5656页

作者： zhi-qiang wang Zhao-Cong Zhang Yu-Yang Wu Ya-Nan Pi Sheng-Han Lou Tian-Bo Liu Ge Lou Chang Yang Department of Gynecology Oncology Harbin Medical University Cancer HospitalHarbin 150086China School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical UniversityWenzhouChina Department of Colorectal Surgery Harbin Medical University Cancer HospitalHarbinChina

BET proteins,which influence gene expression and contribute to the development of cancer,are epigenetic ***,BET inhibitors represent a novel form of epigenetic anticancer *** preliminary clinical trials have shown the anticancer potential of BET inhibitors,it appears that these drugs have limited effectiveness when used ***,given the limited monotherapeutic activity of BET inhibitors,their use in combination with other drugs warrants attention,including the meaningful variations in pharmacodynamic activity among chosen drug *** this paper,we review the function of BET proteins,the preclinical justification for BET protein targeting in cancer,recent advances in small-molecule BET inhibitors,and preliminary clinical trial *** elucidate BET inhibitor resistance mechanisms,shed light on the associated adverse events,investigate the potential of combining these inhibitors with diverse therapeutic agents,present a comprehensive compilation of synergistic treatments involving BET inhibitors,and provide an outlook on their future prospects as potent antitumor *** conclude by suggesting that combining BET inhibitors with other anticancer drugs and innovative next-generation agents holds great potential for advancing the effective targeting of BET proteins as a promising anticancer strategy.

关键词： drugs holds meaningful

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NOTE ON GROUND STATES OF NONLINEAR SCHRODINGER SYSTEMS

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Journal of Partial Differential Equations 2006年第3期19卷 200-207页

作者： Thomas Bartsch zhi-qiang wang Mathematisches Institut Universitaet Giessen 35392 Giessen Germany Department of Mathematics and Statistics Utah state University Logan UT 84322 USA

We give sufficient and necessary conditions for the existence and nonexistence of positive ground state solutions of a class of coupled nonlinear Schroedinger equations.

关键词： Ground states Schrodinger systems.

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Adjuvant chemotherapy,p53,carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma

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World Journal of Gastroenterology 2014年第1期20卷 264-273页

作者： Ming-Ming He Dong-Sheng Zhang Feng wang zhi-qiang wang Hui-Yan Luo Chao Ren Ying Jin Dong-Liang Chen Rui-Hua Xu State Key Laboratory of Oncology in South China Department of Medical OncologySun Yat-sen University Cancer Center

AIM: To investigate adjuvant chemotherapy, p53 and carcinoembryonic antigen (CEA) expression and prognosis after D2 gastrectomy for stage II/III gastric adenocarcinoma.

关键词： Gastric adenocarcinoma Adjuvant chemotherapy p53 Carcinoembryonic antigen Immunohistochemistry

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A chaotic coverage path planner for the mobile robot based on the Chebyshev map for special missions

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Frontiers of Information Technology & Electronic Engineering 2017年第9期18卷 1305-1319页

作者： Cai-hong LI Yong SONG Feng-ying wang zhi-qiang wang Yi-bin LI College of Computer Science and Technology Shandong University of Technology Zibo 255000 China School of Mechanical Electrical & Information Engineering Shandong University Weihai 264209 China

We introduce a novel strategy of designing a chaotic coverage path planner for the mobile robot based on the Che- byshev map for achieving special missions. The designed chaotic path planner consists of a two-dimensional Chebyshev map which is constructed by two one-dimensional Chebyshev maps. The performance of the time sequences which are generated by the planner is improved by arcsine transformation to enhance the chaotic characteristics and uniform distribution. Then the coverage rate and randomness for achieving the special missions of the robot are enhanced. The chaotic Chebyshev system is mapped into the feasible region of the robot workplace by affine transformation. Then a universal algorithm of coverage path planning is designed for environments with obstacles. Simulation results show that the constructed chaotic path planner can avoid detection of the obstacles and the workplace boundaries, and runs safely in the feasible areas. The designed strategy is able to satisfy the requirements of randomness, coverage, and high efficiency for special missions.

关键词： Mobile robot Chebyshev map Chaotic Affine transformation Coverage path planning

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