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Numerical simulation during vacuum sublimation purification of metal Tm(Ⅱ):Effect of Operation Conditions

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Numerical simulation during vacuum sublimation purification ...

改良FOLFIRINOX方案一线化疗中国转移性胰腺癌患者的疗效与安全性研究

2016全国稀土冶炼与环境保护技术交流会

作者： Xiao-wei ZHANG Qiong ZHU Rui-ying MIAO Dao-gao WU De-hong CHEN zhi-qiang wang Shi-hong YAN National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous Metalsand Grirem Advanced Materials Co.LTD.

Two important operating parameters of heater temperature and the thickness of solid metal Tm has been considered,and the temperature distribution in the sublimation furnace has been simulated by a 2-D axis-symmetric heat transfer *** simulation results indicate that,the temperature increases gradually in the solid metal and metallic vapor in the lower part of the crucible,reaches the maximum approximately in the middle of the crucible,and the temperature profiles are similar with various heater temperature;the mean temperature at upper surface of solid metal is about 30℃ lower than heater temperature in the beginning of sublimation purification process,the sublimation velocity calculated by simulation is lower than the value calculated by heater temperature,and the dimensionless ratio increases 54.3%to 83.3%with the heater temperature increasing;as the purification continues,the thickness of solid metal decreases correspondingly,the temperature difference of mean temperature at upper surface of solid metal to the heater temperature increases gradually,the maximum temperature difference is up to 98.4 ℃ when the heater temperature is1400℃ and thickness is 10 mm;the temperature difference between the upper and lower surface of solid metal increases with the heater temperature increasing,and it decreases as the sublimation purification continues,it decreases the range of 2.1-5.3℃ when the thickness is 10 mm;the sublimation velocity calculated by simulation results is lower than that calculated by the heater temperature,and it further decreases with the sublimation purification.

关键词： sublimation purification numerical simulation meal Tm temperature field sublimation velocity

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癌症 2019年第8期38卷 377-384页

作者： zhi‑qiang wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng‑Hua wang Wei wang De‑Shen wang Hui‑Yan Luo Rui‑Hua Xu Yi Ba Yu‑Hong Li 肿瘤内科华南肿瘤学国家重点实验室肿瘤医学协同创新中心中山大学肿瘤防治中心广东广州510060 消化肿瘤内科国家临床肿瘤医学研究中心天津市肿瘤防治重点实验室天津医科大学肿瘤医院天津300060 肿瘤中心佛山市第一人民医院广东佛山528000

背景与目的奥沙利铂(oxaliplatin)、伊立替康(irinotecan)、5-氟尿嘧啶(5-fluorouracil)和1-醛氢叶酸(l-leucovorin)联合用药(即FOLFIRINOX方案)已成为晚期胰腺癌(pancreatic cancer,PC)的一线治疗方案之一。然而,与FOLFIRINOX标准剂量相关的3级或4级不良事件的较高发生率限制了该方案在临床上的广泛应用。在本研究中,我们对改良FOLFIRINOX方案一线化疗中国转移性PC患者的疗效和安全性进行了评价。方法将组织学证实为原发转移性胰腺癌,且东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)体能状态评分为0-2的患者纳入本研究。所有患者均接受改良FOLFIRINOX方案治疗(静脉滴注奥沙利铂65 mg/m^2、伊立替康150 mg/m^2、l-醛氢叶酸200 mg/m^2、5-氟尿嘧啶2400 mg/m^2,每2周重复1次)。治疗持续12个周期,除非患者出现疾病进展(progressive disease,PD)、症状恶化的疾病稳定(stable disease,SD)、不可耐受的不良事件或要求提前终止治疗。主要终点为客观缓解率(objective response rate,ORR)。结果2012年7月至2017年4月期间,共有来自3个机构的65例患者被纳入本研究。所有患者均接受了至少1个周期化疗,化疗周期中位数为8个周期(范围:1-12个周期)。本研究中未观察到完全缓解。21(32.3%)例患者为部分缓解,27(41.5%)例表现为SD。总体人群的ORR和疾病控制率(diseasecontrol rate,DCR)分别为32.3%和73.8%。中位总生存期和无进展生存期分别为11.60[95%置信区间(confidence interval,CI):8.76-14.44]个月和5.77(95%CI:5.00-6.54)个月。主要的3级或4级不良事件包括中性粒细胞减少(12.3%)和腹泻(6.2%)。未观察到与治疗相关的死亡。结论改良FOLFIRINOX具有良好的耐受性,可作为中国转移性PC中国患者的一线治疗方案。

关键词：胰腺癌转移化疗 FOLFIRINOX 剂量调整一线多中心总体缓解率疗效安全性

MAGE-A1,-A4基因在大肠肿瘤中的表达及临床意义

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世界华人消化杂志 2005年第5期13卷 657-661页

作者：梁锐王芳王开昕高倩王志强杨耘昆明医学院病理学教研室云南省昆明市650031 广东医学院附属南山医院病理科广东省深圳市518052 昆明医学院第三附属医院肿瘤外科云南省昆明市650031

目的:探讨MAGE—A1,-A4基因在大肠肿瘤中的表达及临床意义. 方法:采用免疫组化S-P法,检测正常人大肠黏膜38 例,大肠腺瘤31例,大肠腺癌组织83例中MAGE- A1,-A4蛋白的表达和定位特点. 结果:MAGE—A1蛋白定位于胞质,MAGE—A4蛋白定位于胞... 详细信息

目的:探讨MAGE—A1,-A4基因在大肠肿瘤中的表达及临床意义. 方法:采用免疫组化S-P法,检测正常人大肠黏膜38 例,大肠腺瘤31例,大肠腺癌组织83例中MAGE- A1,-A4蛋白的表达和定位特点. 结果:MAGE—A1蛋白定位于胞质,MAGE—A4蛋白定位于胞质及胞核;二者在正常大肠黏膜组织中几乎均不表达,在大肠肿瘤(大肠腺瘤、大肠腺癌)中均有较高水平的表达;但在大肠腺瘤与大肠腺癌中的表达差异均无显著性;二者在大肠腺瘤中的表达与患者的性别、年龄、组织学类型、是否复发及癌变之间差异均无显著性;二者在大肠腺癌中的表达均与患者的性别、年龄、组织学分级、侵袭深度、有无肝转移之间无统计学意义,均与有无淋巴结转移之间有统计学意义(P<0.01),且均呈正相关关系(PA1<0.01,rsA1=0.287;PA4<0.01,rsA4=0.312). 在有淋巴结转移的大肠腺癌中,MAGE—A1与A4蛋白表达呈正相关关系(P<0.05,rs=0.247). 结论:MAGE-A1,-A4基因可能在大肠肿瘤的发生、发展(尤其是淋巴结转移)中起作用,有望成为诊断大肠肿瘤及其发生淋巴结转移的分子生物学标记物之一.

关键词： MAGE 大肠肿瘤临床意义 4基因表达及分子生物学标记物大肠腺瘤大肠腺癌组织无淋巴结转移蛋白定位相关关系组织学类型组织学分级免疫组化大肠黏膜黏膜组织表达差异 0.05 蛋白表达显著性统计学正常人高水平

Research on Quality Markers of Moutan Cortex: Quality Evaluation and Quality Standards of Moutan Cortex

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Chinese Herbal Medicines 2017年第4期9卷 307-320页

作者： zhi-qiang wang Jie Shen Pei Li Shuang-shuang Liu Fan Yi Hai-bo Liu Fan-rong Wu Chun-nian He Fei-hu Chen Pei-gen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical College Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education School of Pharmacy Anhui Medical University

Objective To identify the quality markers of Moutan Cortex（MC） and establish the quality evaluation methods for multi-component assay and fingerprinting of MC. Methods The chemical constituents in MC were identified by HPLC-QTOF-MS. UPLC was employed for the multi-component assay and fingerprinting of MC. Furthermore, text mining was carried out to review the biosynthesis pathways and pharmacological and pharmacokinetic studies related to MC, and in silico target fishing was conducted to construct compound-target networks for MC. Results Sixteen compounds were clearly identified in MC and their structures were confirmed through comparison with literature data. In addition, the biosynthetic pathways and component specificities of the identified compounds were summarized and confirmed by text *** activities, including traditional usage and modern pharmacological studies were summarized. A total of 282 targets from Homo sapiens were fished for 13 compounds. In addition, pharmacokinetic studies of different compounds were synopsized. Finally, multi-component assay and fingerprint of MC were established. Conclusion Eight major components are selected as quality markers of MC, such as oxypaeoniflorin, apiopaeonoside, albiflorin, paeonolide, paeoniflorin, 1,2,3,4,6-penta-O-galloyl-β-D-glucose, mudanpioside C and paeonol. These eight quality markers are successfully applied to the quality evaluation of MC, and could be useful in improving the current quality standards of MC.

关键词： Moutan Cortex multi-component assay network pharmacology quality evaluation quality marker

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三层干扰下的最优无线电信道问题的研究

数学的实践与认识 2003年第10期33卷 9-15页

作者：张志强王陵东南大学数学系南京210096

研究了 2 0 0 0年 MCM— B题 ,将问题推广到有三层干扰的复杂情况 ,给出并严格证明了 ( k,1,1)

关键词：三层干扰无线电信道最优解周期可行解

A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta(POLE/POLD1)mutation

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4543-4553页

作者： Ying Jin Run-Jie Huang Wen-Long Guan zhi-qiang wang Zong-Jiong Mai Yu-Hong Li Jian Xiao Xing Zhang Qi Zhao Shi-Fu Chen Ming Liu Yan-Xia Shi Feng wang Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou510060People’s Republic of China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhou510060People’s Republic of China Department of Oncology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai519000People’s Republic of China Department of Medical Oncology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510100People’s Republic of China Department of Medical Melanoma and Sarcoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen UniversityGuangzhou510060People’s Republic of China Bioinformatic Platform Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen UniversityGuangzhou510060People’s Republic of China HaploX Biotechnology Shenzhen518000People’s Republic of China

Patients carrying mutations in polymerase epsilon/polymerase delta have shown positive responses to immune checkpoint ***,prospective trials exploring the efficacy in those with polymerase epsilon/polymerase delta mutations are still lacking.A phase II clinical trial was initiated to evaluate the efficacy of toripalimab,a humanized IgG4K monoclonal antibody to human PD-1,in patients with advanced solid tumors with unselected polymerase epsilon/polymerase delta mutations but without microsatellite instability-high.A total of 15 patients were enrolled,14 of whom were assessed for treatment *** was a 21.4%overall response rate,with a disease control rate of 57.1%.The median overall survival and median progression-free survival were 17.9(95%CI 13.5-not reach)months and 2.5(95%CI 1.4-not reach)months,*** patients with exonuclease domain mutations,the objective response rate was 66.7%(2/3),with a disease control rate of 66.7%(2/3).For those with non-exonuclease domain mutations,the rates were 9.1%(1/11)and 54.5%(6/11),***,patients with PBRM1 gene mutations exhibited a high response rate to toripalimab at 75.0%(3/4).This study showed that neither the exonuclease domain mutations nor non-exonuclease domain mutations could fully predict the efficacy of immunotherapy,urging the need for more investigations to clarify potential immune sensitization differences within polymerase epsilon/polymerase delta mutation variants.

关键词： delta phase neither

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城市交通网络客流疏散安全评估方法仿真

计算机仿真 2018年第10期35卷 226-229,308页

作者：陈之强王辛岩西藏大学继续教育学院西藏拉萨850000 西藏大学工学院西藏拉萨850000

对城市交通网络客流疏散安全性进行评估,能够实现城市交通安全稳定运行,对客流疏散安全的评估,需要分析交通网络客流参数以及它们之间的关系,并对其进行计算。传统方法采用背景差法获取交通背景和前景,对轨迹跟踪获得的交通流参数之间... 详细信息

对城市交通网络客流疏散安全性进行评估,能够实现城市交通安全稳定运行,对客流疏散安全的评估,需要分析交通网络客流参数以及它们之间的关系,并对其进行计算。传统方法采用背景差法获取交通背景和前景,对轨迹跟踪获得的交通流参数之间的映射关系,但忽略了对基本交通网络客流参数的分析,导致评估精度低。提出一种城市交通网络客流疏散安全评估方法。上述方法对影响评估结果的基本交通网络客流参数以及它们之间的关系进行分析和计算。将城市交通网络客流疏散安全评估问题看做支持向量机最佳超平面求解问题。对于交通网络客流参数同类样本采用相同的权值,给出两类样本数的比例关系并确定城市交通网络客流疏散数据样本重要度权值,实现客流疏散安全评估。仿真结果表明,所提方法评估精度高,对城市交通网络客流疏散安全状态的评估结果与实际调查结果相吻合。

关键词：城市交通客流疏散交通事件评估

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真空集热管中吸收涂层的半球向发射率的确定

太阳能学报 1989年第2期10卷 208-214页

作者：吴家庆殷志强王德晓清华大学无线电电子学系

以两同心圆管辐射换热方程为基础,采用电加热法实现了真空集热管中吸收涂层半球向发射率的测定。实验表明,它与分光光度计和太阳光照法所得结果符合良好。本文给出了Al、Al-C-F/渐变SS-C/Al、渐变Al-N/Al吸收涂层和硼硅玻璃的测试结果,... 详细信息

以两同心圆管辐射换热方程为基础,采用电加热法实现了真空集热管中吸收涂层半球向发射率的测定。实验表明,它与分光光度计和太阳光照法所得结果符合良好。本文给出了Al、Al-C-F/渐变SS-C/Al、渐变Al-N/Al吸收涂层和硼硅玻璃的测试结果,并对测试精度进行了分析。

关键词：真空集热管涂层发射率集热管

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新生儿自发性胃穿孔临床病理特点和病因探讨

中华儿科杂志 2010年第10期48卷 779-782页

作者：王志强谢丽微吴红芳王宗敏温州医学院附属育英儿童医院病理科 325000

目的探讨新生儿自发性胃穿孔的病因和临床病理特点.方法对本院自2001至2009年,治疗的15例胃穿孔新生儿进行回顾性分析,全部病例采用免疫组织化学方法进行研究.结果本病典型的临床表现有呕吐、腹胀、呼吸窘迫等,腹部立位X线平片显示... 详细信息

目的探讨新生儿自发性胃穿孔的病因和临床病理特点.方法对本院自2001至2009年,治疗的15例胃穿孔新生儿进行回顾性分析,全部病例采用免疫组织化学方法进行研究.结果本病典型的临床表现有呕吐、腹胀、呼吸窘迫等,腹部立位X线平片显示膈下游离气体及腹腔积液.穿孔部位大多在胃大弯,本组8例死亡,病死率53.33%,其中6例为出生后1 d内出现症状.镜下观察胃壁肌层变薄、缺损,ICC减少.结论新生儿自发性胃穿孔与胃壁结构异常和ICC减少有关.预后与发病时间、手术时间等关系更为密切.

关键词：胃疾病胃破裂婴儿,新生