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International Journal of Minerals,Metallurgy and Materials 2020年第11期27卷 1482-1488页

作者： Jing-qun Yin zhi-qiang zou Jun Tian Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang 330029China School of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

Crystalline rare-earth(RE)carbonates having large particle size were prepared from the lixivium of weathered crust elution-deposited rare-earth ores using the precipitation method with ammonium bicarbonate as the *** chemical composition was studied using elemental and thermogravimetric analyses(TGA),and their structure and morphology were characterized using Fourier transform infrared(FTIR)spectroscopy,X-ray diffraction(XRD),and scanning electron microscopy(SEM).The results demonstrate that the crystalline rareearth carbonate is a hydrated basic carbonate or oxycarbonate and not astable intermediate carbonate in the process of thermal *** particle size of crystalline rare-earth carbonates with large particle size is in the range of 50–200μ*** an RE2O3 content of up to 95wt%,the quality of crystalline rare-earth carbonates is higher compared to the Chinese National Standard(GB/T 28882–2012).The quality of the product is superior to the Chinese National Standard.

关键词： rare-earth ores precipitation crystalline rare-earth carbonate large particle size

Crosstalk between innate and adaptive immunity in hepatitis B virus infection

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World Journal of Hepatology 2015年第30期7卷 2980-2991页

作者： Li Wang Kai Wang zhi-qiang zou Infectious Disease Hospital of Yantai Hepatology Department Qilu Hospital Affiliated to Shandong University

Hepatitis B virus(HBV) infection is a major public healthproblem worldwide. HBV is not directly cytotoxic to infected hepatocytes; the clinical outcome of infection results from complicated interactions between the virus and the host immune system. In acute HBV infection, initiation of a broad, vigorous immune response is res-ponsible for viral clearance and self-limited inflammatory liver disease. Effective and coordinated innate and adaptive immune responses are critical for viral clearance and the development of long-lasting immunity. Chronic hepatitis B patients fail to mount efficient innate and adaptive immune responses to the virus. In particular, HBV-specific cytotoxic T cells, which are crucial for HBV clearance, are hyporesponsiveness to HBV infection. Accumulating experimental evidence obtained from the development of animal and cell line models has highlighted the importance of innate immunity in the early control of HBV spread. The virus has evolved immune escape strategies, with higher HBV loads and HBV protein concentrations associated with increasing impairment of immune function. Therefore, treatment of HBV infection requires inhibition of HBV replication and protein expression to restore the suppressed host immunity. Complicated interactions exist not only between innate and adaptive responses, but also among innate immune cells and different components of adaptive responses. Improved insight into these complex interactions are important in designing new therapeutic strategies for the treatment HBV infection. In this review, we summarize the current knowledge regarding the cross-talk between the innate and adaptive immune responses and among different immunocytes in HBV infection.

关键词： Crosstalk Hepatitis B virus Innate immune Adapative immune

Tribology of rotating band and gun barrel during engraving process under quasi-static and dynamic loading

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Friction 2014年第4期2卷 330-342页

作者： Bin WU Jing ZHENG Qing-tao TIAN zhi-qiang zou Xu-hua YU Kai-shuan ZHANG Army Officer Academy PLA No.451 Huangshan RoadHefei CityAnhui Province230031China

The engraving process of a projectile rotating band is one of the most basic research aspects in interior ballistics,which has not been thoroughly understood thus *** understanding of this process is of great importance from the viewpoints of optimal design,manufacturing,use,and maintenance of gun and *** this paper,the interaction of copper and nylon rotating bands with a CrNiMo gun barrel during engraving was studied under quasi‐static and dynamic loading *** quasi‐static engraving tests were performed on a CSS‐88500 electronic universal testing machine(EUTM)and a special gas‐gun‐based test rig was designed for dynamic impact engraving of the rotating *** mechanical behaviors of copper and nylon were investigated under strain rates of 10^(−3) s^(−1) and 2×10^(3) s^(−1) using an MTS 810 and a split Hopkinson pressure bar(SHPB),*** of the worn surfaces and cross‐sectional microstructures were observed with scanning electron microscope(SEM)and optical microscope(OM).It was found that large deformation and severe friction occur during *** surface layer is condensed and correlated with a hardness gradient along the depth from the top worn *** structure of the rotating band and gun bore,band material,and loading rate have great effects on band *** flow stress‐strain of the copper strongly depends on the applied strain *** is suggested that strain rate and temperature play significant roles in the deformation mechanism of rotating bands.

关键词： tribology sliding friction plastic deformation rotating band gun barrel engraving strain rate

Innate immune targets of hepatitis B virus infection

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World Journal of Hepatology 2016年第17期8卷 716-725页

作者： zhi-qiang zou Li Wang Kai Wang Ji-Guang Yu Infectious Disease Hospital of Yantai Hepatology Department Qilu Hospital of Shandong University

Approximately 400 million people are chronically infected with hepatitis B virus(HBV) globally despitethe widespread immunization of HBV vaccine and the development of antiviral therapies. The immunopathogenesis of HBV infection is initiated and driven by complexed interactions between the host immune system and the virus. Host immune responses to viral particles and proteins are regarded as the main determinants of viral clearance or persistent infection and hepatocyte injury. Innate immune system is the first defending line of host preventing from virus invasion. It is acknowledged that HBV has developed active tactics to escape innate immune recognition or actively interfere with innate immune signaling pathways and induce immunosuppression, which favor their replication. HBV reduces the expression of pattern-recognition receptors in the innate immune cells in humans. Also, HBV may interrupt different parts of antiviral signaling pathways, leading to the reduced production of antiviral cytokines such as interferons that contribute to HBV immunopathogenesis. A full comprehension of the mechanisms as to how HBV inactivates various elements of the innate immune response to initiate and maintain a persistent infection can be helpful in designing new immunotherapeutic methods for preventing and eradicating the virus. In this review, we aimed to summarize different branches the innate immune targeted by HBV infection. The review paper provides evidence that multiple components of immune responses should be activated in combination with antiviral therapy to disrupt the tolerance to HBV for eliminating HBV infection.

关键词： Hepatitis B virus Infection Targets Innate immune response Signaling pathway

Analysis of platelet parameters and activation markers in hematologic metastases of lung cancer

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Chinese Medical Journal 2019年第6期132卷 735-737页

作者： Si-Si Zhang Mei Zhang Lei Yuan zhi-qiang zou Department of Thoracic Surgery The 96th Hospital of the People's Liberation Army of China』nan Shandong 250031 China

To the Editor: Although the causes and mechanisms of lung cancer (LC) are still not clear, with the advances in science and technology and the progress in research methods, it has been shown that tumor cells aggregate with platelets (PLTs) and escape being recognized by the immune system. They adhere to distant vascular endothelial cells and continue to metastasize, invade and grow through the blood circulation.[1] Therefore, the hypercoagulable state and enhancement of PLT functions promote tumor growth, invasion, and metastasis.[2,3] Therefore, the effective reduction in PLT counts and their activities can help reduce the progression and prognosis of LC. We conducted this research to explore the effect of the tumor on circulating platelets in patients with LC.

关键词： To the Editor lung cancer Analysis

An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 304-313页

作者： Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang zhi-qiang zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-qiang Mi Yan-Zhong Peng zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-qiang Wang Department of Infectious Disease Center for Liver DiseasePeking University First HospitalBeijingChina Department of Hepatology The Third Hospital of QinhuangdaoQinhuangdaoHebeiChina Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Disease Xinxiang Medical University Affiliated Third HospitalXinxiangHenanChina No.88 Hospital of Chinese People’s Liberation Army(PLA) JinanShandongChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Infectious Disease China-Japan Friendship HospitalBeijingChina Department of Infectious Diseases Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina Department of Gastroenterology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina Department of Infectious Diseases The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Infectious Diseases The People’s Hospital of Henan ProvinceZhengzhouHenanChina Department of Infectious Disease The Third Affiliated Hospital of Sun-Yat Sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Jiangsu Province HospitalThe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Infectious Diseases The Southwest Hospital of Army Medical UniversityChongqingChina Yantai Infectious Diseases Hospital YantaiShandongChina Department of Hepatology Baoding Infectious Diseases HospitalBaodingHebeiChina Department of Integrated Traditional Chinese Medicine(TCM)and Western Medicine Jinan Infectious Diseases HospitalShandong UniversityJinanShandongChina Department of Integrated TCM and Western Medicine in Hepatology The Sixth People’s Hospital of ShenyangShenyangLiaoningChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Department of Infectious Diseases Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdon

Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and *** the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,***,laboratory,and liver histology data before and after 78 weeks of treatment were *** Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after ***:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX *** 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=*** percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=*** regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.

关键词： Chronic hepatitis B Liver fibrosis Regression Randomized controlled trial

Preparation of aluminum bronze rotating band for large caliber projectiles by high velocity arc spraying

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Preparation of aluminum bronze rotating band for large calib...

Unsatisfying antiviral therapeutic effect in patients with mother-tochild transmissed chronic hepatitis B virus infection: a prospective multi-center clinical study

第十一届全国摩擦学大会

作者： Bin Wu Xiao-lei Chen zhi-qiang zou Ling-hui Fang Xu-hua Yu Jing Zheng Army Officer Academy

In this paper,aluminum bronze coatings were fabricated by high velocity arc spraying(HVAS) *** and microharhness of the prepared coatings were ***-on-disc dry sliding wear tests were conducted in an ambient condition to examine the tribological behavior of the ***-static engraving processes of rotating bands made of as-sprayed aluminum bronze coating and bulk copper were studied by using rate-controlled push test methodology on an MTS 810 Material Testing *** results show that the as-sprayed aluminum bronze coatings have dense microstructure with porosity of about 1.6 %.Meanwhile,the as-sprayed coating presents a higher microhardness than pure *** friction coefficient of coatings is about 0.2-0.3 in steady *** mechanisms of the as-sprayed coatings were *** engraving test results show that aluminum bronze rotating band presents high bonding strength and good *** HVAS aluminum bronze coating should be a possible substitution for the state of the art copper rotating band.

关键词： Aluminum bronze Rotating band Large caliber projectile High velocity arc spraying

来源： cnki会议评论

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Chinese Medical Journal 2019年第22期132卷 2647-2656页

作者： Jun Li Xiao-Qin Dong Zhao Wu An-Lin Ma Shi-Bin Xie Xu-Qing Zhang Zhan-Qing Zhang Da-zhi Zhang Wei-Feng Zhao Guo Zhang Jun Cheng Qing Xie Jun Li zhi-qiang zou Ying-Xia Liu Gui-qiang Wang Hong Zhao China Hepatitis B Related Fibrosis Assessment Research Group Department of Infectious Diseases Center for Liver DiseasePeking University First HospitalBeijing 100034China Department of Infectious Diseases Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Infectious Diseases China-Japan Friendship HospitalBeijing 100029China Department of Infectious Diseases The Third Affiliated Hospital Sun Yat-Sen UniversityGuangzhouGuangdong 510000China Department of Infectious Diseases South West Hospital Affiliated to Third Military Medical UniversityChongqing 400038China Department of Hepatology Shanghai Public Health Clinical CenterFudan UniversityShanghai 200083China Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 404000China Department of Infectious Diseases Xinxiang Medical University Third HospitalXinxiangHenan 453003China Department of Infectious Diseases The People's Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi 530021China Department of Infectious Diseases Di Tan Hospital Affiliated to Capital Medical UniversityBeijing 100015China Department of Infectious Diseases Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200090China Department of Infectious Diseases The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 211166China Department of Infectious Diseases Yantai City Hospital for Infectious DiseaseYantaiShandong 264001China Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhenGuangdong 518034China The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang UniversityHangzhouZhejiang 310085China Department of Infectious Diseases Peking University International HospitalBeijing 102206China 不详

Background:Few data are available regarding the progression of liver disease and therapeutic efficacy in chronic hepatitis B(HBV)carriers infected by mother-to-child transmission(MTCT).This study aimed to investigate these two aspects by comparing the adult chronic HBV carriers in MTCT group with those in horizontal transmission ***:The 683 adult chronic HBV patients qualified for liver biopsy including 191 with MTCT and 492 with horizontal transmission entered the multi-center prospective study from October 2013 to May *** results from 217 patients at baseline and 78 weeks post antiviral therapy were ***:Patients infected by MTCT were more likely to have e antigen positive(68.6%vs.58.2%,x^2=-2.491,P=0.012)than those with horizontal ***,in patients with MTCT,levels of alkaline phosphatase(ALP)(P=0.031),Fibroscan(P=0.013),N-terminal propeptide of Type III procollagen(PIIINP)(P=0.014),and Laminin(LN)(P=0.006)were high,in contrast to the patients with horizontal transmission for whom the levels of albumin(ALB)(P=0.041),matrix metalloproteinase-3(MMP-3)(P=0.001)were *** 47.2% of patients with MTCT and 36.8%of those with horizontal transmission had significant liver fibrosis(P=0.013).Following antiviral therapy for 78 weeks,21.2%and 38.0%patients with MTCT and horizontal transmission acquired hepatitis B e antigen(HBeAg)clearance,respectively(P=0.043),and the virological response rates were 54.7%and 74.1%in the MTCT and horizontal groups,respectively(P=0.005).MTCT was a risk factor for HBeAg clearance and virological ***:Adult patients with MTCT were more prone to severe liver diseases,and the therapeutic efficacy was relatively poor,which underlined the importance of earlier,long-term treatment and interrupting perinatal transmission.

关键词： Chronic Hepatitis B virus infection Horizontal transmission Mother-to-child transmission Progression of disease Therapeutic efficacy

A versatile framework for analyzing galaxy image data by incorporating Human-in-the-loop in a large vision model

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Chinese Physics C 2024年第9期48卷 176-187页

作者： Ming-Xiang Fu Yu Song Jia-Meng Lv Liang Cao Peng Jia Nan Li Xiang-Ru Li Ji-Feng Liu A-Li Luo Bo Qiu Shi-Yin Shen Liang-Ping Tu Li-Li Wang Shou-Lin Wei Hai-Feng Yang Zhen-Ping Yi zhi-qiang zou National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Key lab of Space Astronomy and Technology National Astronomical ObservatoriesBeijing 100101China School of Computer Science South China Normal UniversityGuangzhou 510631China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China University of Chinese Academy of Sciences NanjingNanjing 211135China University of Science and Technology Beijing Beijing 100083China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Computer and Information Dezhou UniversityDezhou 253023China Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China School of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 30024China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China Nanjing University of Posts&Telecommunications Nanjing 210023China School of Science University of Science and Technology LiaoningAnshan 114051China

The exponential growth of astronomical datasets provides an unprecedented opportunity for humans to gain insight into the ***,effectively analyzing this vast amount of data poses a significant *** response,astronomers are turning to deep learning techniques,but these methods are limited by their specific training sets,leading to considerable duplicate *** overcome this issue,we built a framework for the general analysis of galaxy images based on a large vision model(LVM)plus downstream tasks(DST),including galaxy morphological classification,image restoration object detection,parameter extraction,and *** the low signal-to-noise ratios of galaxy images and the imbalanced distribution of galaxy categories,we designed our LVM to incorporate a Human-in-the-loop(HITL)module,which leverages human knowledge to enhance the reliability and interpretability of processing galaxy images *** proposed framework exhibits notable fewshot learning capabilities and versatile adaptability for all the abovementioned tasks on galaxy images in the DESI Legacy Imaging *** particular,for the object detection task,which was trained using 1000 data points,our DST in the LVM achieved an accuracy of 96.7%,while ResNet50 plus Mask R-CNN reached an accuracy of 93.1%.For morphological classification,to obtain an area under the curve(AUC)of~0.9,LVM plus DST and HITL only requested 1/50 of the training sets that ResNet18 *** addition,multimodal data can be integrated,which creates possibilities for conducting joint analyses with datasets spanning diverse domains in the era of multi-messenger astronomy.

关键词： artificial intelligence large vision model human-in-the-loop astronomy galaxies

Mode Conversion and Diffraction of Guided Optical Waves from Magnetostatic Waves under Inclined Bias Magnetic Field

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Communications in Theoretical Physics 2001年第10期36卷 497-502页

作者： WU Bao-Jian LIU Gong-qiang zou zhi-qiang Department of Applied Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Applied Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Applied Physics Shanghai Jiao Tong University Shanghai 200030 China

The noncollinear interaction of guided optical waves with magnetostatic waves under inclined bias magnetic field is theoretically studied in detail. Similar approach can also be applied to the collinear interaction. Calculation results indicate that the diffraction efficiency (DE) in magnitude is equal to the mode-conversion efficiency (MCE) under vertical bias magnetic field, but they differ greatly under inclined bias magnetic field. By comparison to the case of vertical magnetization, the DE or the MCE can be greatly increased under inclined magnetic field. The characteristic of the DE curves obtained is basically in agreement with the experimental result.

关键词： guided optical wave, magnetostatic wave, mode conversion, diffraction efficiency