检索结果-南通市图书馆

Epidural Spinal Cord Stimulation Promotes Motor Functional Recovery by Enhancing Oligodendrocyte Survival and Differentiation and by Protecting Myelin after Spinal Cord Injury in Rats

引用

Neuroscience Bulletin 2020年第4期36卷 372-384页

作者： Gang Li Zhong-Kai Fan Guang-Fei Gu zhi-qiang jia qiang-qiang Zhang Jun-Yu Dai Shi-Sheng He Department of Orthopedics Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Spinal Pain Research Institute Tongji University School of MedicineShanghai 200072China Department of Orthopaedics The First Affiliated HospitalJinzhou Medical UniversityJinzhou 121001China Department of Spinal Surgery The Second Affiliated HospitalHenan University of Science and TechnologyLuoyang 471003China

Epidural spinal cord stimulation (ESCS) markedly improves motor and sensory function after spinal cord injury (SCI), but the underlying mechanisms are ***, we investigated whether ESCS affects oligodendrocyte differentiation and its cellular and molecular mechanisms in rats with SCI. ESCS improved hindlimb motor function at 7 days, 14 days, 21 days, and 28 days after *** also significantly increased the myelinated area at 28days, and reduced the number of apoptotic cells in the spinal white matter at 7 days. SCI decreased the expression of 20,30-cyclic-nucleotide 30-phosphodiesterase (CNPase,an oligodendrocyte marker) at 7 days and that of myelin basic protein at 28 days. ESCS significantly upregulated these markers and increased the percentage of Sox2/CNPase/DAPI-positive cells (newly differentiated oligodendrocytes) at 7 days. Recombinant human bone morphogenetic protein 4 (rh BMP4) markedly downregulated these factors after ESCS. Furthermore, ESCS significantly decreased BMP4 and p-Smad1/5/9 expression after SCI,and rh BMP4 reduced this effect of ESCS. These findings indicate that ESCS enhances the survival and differentiation of oligodendrocytes, protects myelin, and promotes motor functional recovery by inhibiting the BMP4-Smad1/5/9 signaling pathway after SCI.

关键词： Spinal cord injury Epidural spinal cord stimulation Oligodendrocyte Differentiation Remyelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel pricing model for spectrum leasing in secondary spectrum market

引用

The Journal of China Universities of Posts and Telecommunications 2010年第5期17卷 12-19页

作者： WANG Lei XU Xing-kun XU Wen-jun HE zhi-qiang LIN jia-ru Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

According to the property rights model of cognitive radio,primary users who own the spectral resource have the right to lease or trade part of it to secondary users in exchange for appropriate *** this paper,an implementation of this framework is investigated,where a primary link can lease the owned spectrum to secondary nodes in exchange for cooperation （relaying）.A novel pricing model is proposed that enables the trading between spectrum and *** on the demand of secondary nodes,the primary link attempts to maximize its quality of service （QoS） by setting the price of *** the price asked by primary link,the secondary nodes aim to obtain most profits by deciding the amount of spectrum to buy and then pay for it by cooperative *** investigated model is conveniently cast in the framework of seller/buyer （Stackelberg） *** and numerical results show that our pricing model is effective and practical for spectrum leasing based on trading spectral resource for cooperation.

关键词： cognitive radio property rights cooperative transmission spectrum leasing secondary spectrum market

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RESID HYDROCONVERSION—A NEW APPROACH IN PROCESSING INFERIOR RESIDUAL OILS

引用

石油学报（石油加工） 2001年第1期17卷 35-41页

作者： LI zhi qiang, LIU jia ming, SUN Li li (Beijing Design Institute, SINOPEC, Beijing 100724, China) 中国石油化工公司北京设计所北京 100724 中国石油化工总公司北京设计所北京 100724

In order to meet the market demands for more premium distillates and the more stringent requirements of environment protection, China refineries should find a better way for deep processing of residues. This paper describes the necessity, overview and application of the resid hydroconversion process in China. Qilu Petrochemical Co. built the first vacuum resid hydrodesulfurization (VRDS) unit with a capacity of 840 kt/a of Gudao vacuum residue in 1986. And Dalian West Pacific Petrochemical Co. Ltd. built the first atmospheric resid hydrodesulfurization (ARDS) unit with the capacity of 2 Mt/a in 1992. Beijing Design Institute SINOPEC did the engineering design of these two units. Some modifications on the units were carried out, which gives the adaptability and flexibility in processing inferior crudes such as high sulfur crudes.

关键词：加氢裂化残油市场需求环境保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Time representation of mitochondrial morphology and function after acute spinal cord injury

引用

Neural Regeneration Research 2016年第1期11卷 137-143页

作者： zhi-qiang jia Gang Li Zhen-yu Zhang Hao-tian Li Ji-quan Wang Zhong-kai Fan Gang Lv Department of Orthopedics First Affiliated Hospital of Liaoning Medical University

Changes in mitochondrial morphology and function play an important role in secondary damage after acute spinal cord injury. We recorded the time representation of mitochondrial morphology and function in rats with acute spinal cord injury. Results showed that mitochondria had an irregular shape, and increased in size. Mitochondrial cristae were disordered and mitochondrial membrane rupture was visible at 2–24 hours after injury. Fusion protein mitofusin 1 expression gradually increased, peaked at 8 hours after injury, and then decreased to its lowest level at 24 hours. Expression of dynamin-related protein 1, amitochondrial fission protein, showed the opposite kinetics. At 2–24 hours after acute spinal cord injury, malondialdehyde content, cytochrome c levels and caspase-3 expression were increased, but glutathione content, adenosine triphosphate content, Na＋-K＋-ATPase activity and mitochondrial membrane potential were gradually reduced. Furthermore, mitochondrial morphology altered during the acute stage of spinal cord injury. Fusion was important within the first 8 hours, but fission played a key role at 24 hours. Oxidative stress was inhibited, biological productivity was diminished, and mitochondrial membrane potential and permeability were reduced in the acute stage of injury. In summary, mitochondrial apoptosis is activated when the time of spinal cord injury is prolonged.

关键词： nerve regeneration spinal cord injury mitochondria fusion fission oxidative damage bioenergy mitochondrial permeability cytochrome c Caspase-3 apoptosis NSFC neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Virtual reality system for diagnosis and therapeutic planning of cerebral aneurysms

引用

Chinese Medical Journal 2010年第16期123卷 2206-2210页

作者： MO Da-peng BAO Sheng-de LI Liang YI zhi-qiang ZHANG jia-yong ZHANG Yang Department of Neurosurgery Peking University First HospitalBeijing 100034 China

Background The virtual reality （VR） system can provide the neurosurgeon to intuitively interact with and manipulate the three dimensional （3-D） image similarly to manipulate a real *** was seldom reported that the system was used in diagnosis and treatment of cerebral *** study aimed to investigate the application of VR system in diagnosis and therapeutic planning of cerebral *** A total of 24 cases of cerebral aneurysms were enrolled in this study from 2006 to 2008, which diagnosed by 3-D digital subtraction angiography （3D-DSA） or VR-based computed tomography angiographies （CTA）.The VR system and 3D-DSA system were used to observe and measure aneurysms and the adjacent *** data of observation and measurements were compared between VR image and 3D-DSA *** the patients underwent surgical plan and simulated neurosurgical procedures in the VR *** There were 28 aneurysms detected in VR system and 3D-DSA *** VR system generated clear and vivid 3-D virtual images which clearly displayed the location and size of the aneurysms and their precise anatomical spatial relations to the parent arteries and *** location, size and shape of the aneurysms and their anatomical relationship with the adjacent vessels were similar between 3-D virtual image and 3D-DSA, but the spatial relationship between aneurysms and skull only been displayed by VR *** VR system also could simulate simple surgical procedures and surgical *** The VR system can provide a highly effective way to provide precise imaging details as same as 3D-DSA system and assist the diagnosis of cerebral aneurysms with virtual 3-D data based on *** significantly enhances the chosen therapeutic strategy of cerebral aneurysms.

关键词： intracranial aneurysm angiography, digital subtraction computed tomographic angiography virtual reality images, surgical planning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

引用

Tungsten 2025年第1期7卷 152-160页

作者： zhi-Jun Xie jia-Lin Li Ling Gong Xiang-Li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于B-Rep的三维有限元网格高效消隐技术

引用

计算机辅助设计与图形学学报 1998年第2期10卷 118-123页

作者：王志强洪嘉振上海交通大学工程力学系

利用三维有限元网格图的性质和数据结构的特点，结合实体造型的边界表示模式，提出了一种高效的空间立体网格图的消隐方法．该方法根据Ｂ－Ｒｅｐ将单元面归于不同的子集，充分利用拓扑面的性质，采用一系列优化消隐策略，从而减少计算... 详细信息

利用三维有限元网格图的性质和数据结构的特点，结合实体造型的边界表示模式，提出了一种高效的空间立体网格图的消隐方法．该方法根据Ｂ－Ｒｅｐ将单元面归于不同的子集，充分利用拓扑面的性质，采用一系列优化消隐策略，从而减少计算量，较好地提高了消隐处理的效率．

关键词：拓扑信息 B-Rep 消隐算法有限元法图形处理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

科学发展观:社会发展的新范式

引用

安徽大学学报（哲学社会科学版） 2009年第1期33卷 12-16页

作者：钱之佳萧玲南京大学哲学系江苏南京210093

所谓发展观,是关于发展的总的看法。中国在社会主义建设现阶段提出的"科学发展观",针对的是片面的"增长发展观"。新社会发展观的提出,体现了历史与逻辑的统一,既是"历史再现",又是对社会发展规律的"理性重建"。科学发展观作为社会发展... 详细信息

所谓发展观,是关于发展的总的看法。中国在社会主义建设现阶段提出的"科学发展观",针对的是片面的"增长发展观"。新社会发展观的提出,体现了历史与逻辑的统一,既是"历史再现",又是对社会发展规律的"理性重建"。科学发展观作为社会发展的新范式,体现了社会成员共同认可并且共同遵守的信念、理论和方式。这一新范式的确立,有其生存论、伦理观及动力基础,"以人为本"是其生存论的基础,"和谐社会"是其伦理观的基础,科学技术是其动力基础。

关键词：发展观科学发展观以人为本和谐社会

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

机群出动能力的Markov模型

引用

系统仿真学报 2008年第22期20卷 6278-6281页

作者：岳奎志侯志强韩维贾忠湖海军航空工程学院烟台264001

以往在评估武器装备的效能时,只注重其基本性能和作战能力,而忽视了包括出动能力在内的可用性指标,而作战仿真中这类指标往往是决定仿真真实性的关键。建立了有备份飞机条件下机群出动能力的Markov模型。根据故障率和所需出动飞机的数量... 详细信息

以往在评估武器装备的效能时,只注重其基本性能和作战能力,而忽视了包括出动能力在内的可用性指标,而作战仿真中这类指标往往是决定仿真真实性的关键。建立了有备份飞机条件下机群出动能力的Markov模型。根据故障率和所需出动飞机的数量,确定了备份飞机数量和维修组数,所模拟得到的数据曲线符合实际情况,可应用于陆基或舰基机群出动能力的评估和分析,其分析方法对优化飞机装备配备和保障资源配置具有重要意义。

关键词：机群出动能力作战效能 Markov链仿真

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

引用

IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li zhi-Xin Liu jia-Wei Su Ya-Zhou Yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：