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Chemical Research in Chinese Universities 2011年第6期27卷 944-948页

作者： GAO qian WANG zhi-zeng WANG qian li Shan-shan li Yu Research Academy of Energy and Environmental Studies North China Electric Power University Beijing 102206 P. R. China

Artificial neural network（ANN） and full factorial design assisted atrazine（AT） multiple regression adsorption model（AT-MRAM） were developed to analyze the adsorption capability of the main components in the surficial sediments（SSs）. Artificial neural network was used to build a model（the determination coefficient square r2 is 0.9977） to describe the process of atrazine adsorption onto SSs, and then to predict responses of the full factorial design. Based on the results of the full factorial design, the interactions of the main components in SSs on AT adsorption were investigated through the analysis of variance（ANOVA）, F-test and t-test. The adsorption capability of the main components in SSs for AT was calculated via a multiple regression adsorption model（MRAM）. The results show that the greatest contribution to the adsorption of AT on a molar basis was attributed to Fe/Mn（–1.993 μmol/mol）. Organic materials（OMs） and Fe oxides in SSs are the important adsorption sites for AT, and the adsorption capabilities are 1.944 and 0.418 μmol/mol, respectively. The interaction among the non-residual components（Fe, Mn oxides and OMs） in SSs interferes in the adsorption of AT that shouldn’t be neglected, revealing the significant contribution of the interaction among non-residual components to controlling the behavior of AT in aquatic environments.

关键词： Back propagation(BP) artificial neural network Full factorial design Fe/Mn oxide Organic material Atrazine Interaction

Regioselective Propargylation of Aldehydes with Propargyl Bromide Mediated by Sn-In in Aqueous Media under Microwave Irradiation

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Chinese Chemical Letters 2005年第12期16卷 1573-1576页

作者： Cheng zhi GU qian Rong li Hao YIN Structure Research Laboratory University of Science and Technology of China Hefei 230026

Tin-indium were employed in the propargylations of various aldehydes with propargyl bromide in the presence of SnCl2 and C6H5（CH3）3NBr under microwave irradiation to afford the corresponding homopropargyl alcohols exclusively in high yields. All the reactions were completed smoothly in predominantly aqueous media in 200 seconds only.

关键词： Propargylation aldehydes tin-indium regioselectivity microwave

CRISPR/Cas9-based mutation reveals Argonaute 1 is essential for pigmentation in Ostrinia fumacalis

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Insect Science 2019年第6期26卷 1020-1028页

作者： Lang You Hong-Lun Bi Yao-Hui Wang Xiao-Wei li Xi-En Chen zhi-qian li CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai China

Ostrinia fumacalis (Lepidoptera: Pyralidae) is one of the most destructive agricultural pests in Asia. Traditional pest-management methods include sex pheromone capture, transgenic crops that produce Bacillus thuringiensis toxin, and pesticides. Although these strategies control pest populations effectively, they also cause negative side effects, including dramatically increased pesticide resistance, severe pollution, and hazards for human health. Recently developed genome editing tools provide new prospects for pest management and have been successfully used in several species. However, few examples have been reported in the agricultural pest O. fumacalis due to a lack in genomic information. In this report, we identified only one transcript of O. fumacalis Argonaute 1 (OfAgo 1) gene from the genome and cloned the open reading frame. OfAgol presented the maximum expression at the embryo stage or in the fat body during the larval stages. To understand its function, an OfAgol mutant was constructed using the Clustered Regularly Interspaced Short Palindromic Repeat/RNA-guided Cas9 nuclease (CRISPR/Cas9). Mutagenesis of OfAgol disrupted cuticle pigmentation by dowregulating micro RNAs and pigmentation-related genes. This is the first report for the cloning and functional analysis of OfAgol, revealing a role of OfAgol in cuticle pigmentation. The current report also established a CRISPR/Cas9 system in O. fumacalisy providing a new insight for pest management.

关键词： Agol CRISPR/Cas9 cuticle pigmentation Ostrinia fumacalis pest management

Transcriptome of Erysiphe necator-infected Vitispseudoreticulata leaves provides insight into grapevineresistance to powdery mildew

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Horticulture Research 2014年第1期1卷 86-97页

作者： Kai Weng zhi-qian li Rui-Qi liu Lan Wang Yue-Jin Wang Yan Xu State Key Laboratory of Crop Stress Biology in Arid Areas(Northwest A&F University) Yanglingshanxi 712100China College of Horticulture Northwest A&F UniversityYanglingshanxi 712100China Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of AgricultureYanglingshanxi 712100China

Powdery mildew(PM),which is caused by the pathogen Erysiphe necator(Schw.)Burr.,is the single most damaging disease of cultivated grapes(Vitis vinifera)***,little is known about the transcriptional response of grapes to infection with ***-seq analysis was used for deep sequencing of the leaf transcriptome to study PM resistance in Chinese wild grapes(*** Baihe 35-1)to better understand the interaction between host and *** than 100 million(M)90-nt cDNA reads were sequenced from a cDNA library derived from PM-infected *** the sequences obtained,6541 genes were differentially expressed(DEG)and were annotated with Gene Ontology terms and by pathway *** significant categories that were identified included the following:defense,salicylic acid(SA)and jasmonic acid(JA)responses;systemic acquired resistance(SAR);hypersensitive response;plant–pathogen interaction;flavonoid biosynthesis;and plant hormone signal *** putative secretory proteins were identified,indicating potential defense responses to *** all,318 putative R-genes and 183 putative secreted proteins were identified,including the defense-related R-genes BAK1,MRH1 and MLO3 and the defense-related secreted proteins GLP and *** expression patterns of 16 genes were further illuminated by *** present study identified several candidate genes and pathways that may contribute to PM resistance in grapes and illustrated that RNA-seq is a powerful tool for studying gene *** RT-qPCR results reveal that effective resistance responses of grapes to PM include enhancement of JA and SAR responses and accumulation of phytoalexins.

关键词： resistance Vitis interaction

QUANTUM CHEMICAL CALCULATIONS ON THE ELECTRONIC STRUCTURE AND SPECTRA OF[Mo_3O_4-nSn]^(4+)(n=O-4)CLUSTER CATIONS

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Chinese Chemical Letters 1992年第1期3卷 43-46页

作者： zhi Ru li qian Shu li Ji Kang FANG zhi Ren ZHENG Jun ZHENG Department of Chemistry,Jilin University,Changchun,130023

The electronic structure and spectra of [Mo3O4-nSn]^(4+)(n=0-4) cations were calculated by means of INDO/CI quantum chemistry method to account for the experimental data of their spectra in water solutions.

关键词： HOMO n=O-4)CLUSTER CATIONS Ho LUMO n QUANTUM CHEMICAL CALCULATIONS ON THE ELECTRONIC STRUCTURE AND SPECTRA OF[Mo3O4-nSn Mo

基于地理坐标的网络舆情节点影响力度量方法改进研究

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情报科学 2017年第8期35卷 33-39,46页

作者：李治张潜李小欢华侨大学工商管理学院福建泉州362021 华侨大学东方企业管理研究中心福建泉州362021

【目的/意义】针对基于地理坐标的社交网络(如微博)信息传播特征,研究复杂网络环境下网络节点影响力识别算法,为某些真实网络拓扑结构中衡量节点传播影响力的模拟仿真和实证分析提供参考。【方法/过程】采用统计分析和计算机仿真方法,... 详细信息

【目的/意义】针对基于地理坐标的社交网络(如微博)信息传播特征,研究复杂网络环境下网络节点影响力识别算法,为某些真实网络拓扑结构中衡量节点传播影响力的模拟仿真和实证分析提供参考。【方法/过程】采用统计分析和计算机仿真方法,在传统的中心性变量基础上,考虑网络社区加权因素,引入LWCS算法;然后对该算法的排序结果以及度、紧密度、介数和k-shell之间的性能进行比较;最后,基于k-shell划分对LWCS算法加以改进并提出LWCS+算法,并通过实证分析对改进算法进行检验。【结果/结论】数据分析结果表明,在识别网络节点传播影响力范围和还原社区加权因素方面,LWCS+具有比LWCS更为明显的优势。

关键词：地理坐标网络舆情 LWCS变量影响力度量

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei Cong Guoyu qian Dong Wang Laishi li Yusheng Wu zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao li qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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跨国公司绿色管理研究脉络梳理

经济管理 2012年第12期38卷 184-193页

作者：薛求知李茜复旦大学管理学院上海200433

企业绿色管理已经成为了全球管理学一个热点研究主题,而跨国公司由于在全球范围内经营,其绿色管理又存在特殊之处。本文梳理了关于跨国公司绿色管理的研究文献,首先回顾了跨国公司对东道国环境的正面和负面影响,接下来就跨国公司绿色管... 详细信息

企业绿色管理已经成为了全球管理学一个热点研究主题,而跨国公司由于在全球范围内经营,其绿色管理又存在特殊之处。本文梳理了关于跨国公司绿色管理的研究文献,首先回顾了跨国公司对东道国环境的正面和负面影响,接下来就跨国公司绿色管理的动机进行了综述,并对跨国公司绿色管理的全球一体化和本土化战略进行了分析。最后,本文对现有跨国公司绿色管理研究进行了评述,指出了不足和未来可能的研究方向。

关键词：跨国公司绿色管理战略动机可持续性综述

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引信微机电安全系统的可靠性分析与改进

兵工学报 2017年第4期38卷 664-672页

作者：涂宏茂孙志礼钱云鹏刘勤东北大学机械工程与自动化学院辽宁沈阳110819 中国兵器科学研究院北京100089

在引信微机电(MEMS)安全系统结构设计与仿真分析的基础上,对其开展了量化的工作可靠性水平评估,并进行设计方案的改进和试验验证。针对小口径弹药引信的工作环境特点,给出MEMS安全系统的设计方案和关键结构的设计要求,并利用有限元仿真... 详细信息

在引信微机电(MEMS)安全系统结构设计与仿真分析的基础上,对其开展了量化的工作可靠性水平评估,并进行设计方案的改进和试验验证。针对小口径弹药引信的工作环境特点,给出MEMS安全系统的设计方案和关键结构的设计要求,并利用有限元仿真分析初步确定设计方案的可行性。同时,为在结构仿真分析的基础上开展定量的可靠性分析,提出基于有限元法的结构可靠性仿真方法及其实现流程,并以ANSYS软件为例提出CAE程序的集成方法和实现步骤,解决可靠性分析程序对有限元软件工具的自动调用问题。综合考虑载荷、结构尺寸和材料参数等因素的随机性,分析关键结构的可靠性水平和主要的影响因素,并据此给出了增加电推冲器装药量、控制关键尺寸的变异系数和取消闭锁机构等改进建议。加工MEMS安全系统的实物样机,并通过试验验证了该设计方案的可行性。

关键词：兵器科学与技术引信微机电安全系统可靠性分析可靠度灵敏度