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Significant annealing-induced hardening effect in nanolaminate d-nanotwinne d(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8)me dium-entropy alloy by severe cold rolling

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Journal of Materials Science & Technology 2024年第3期170卷 156-166页

作者： Shuqing Yuan Hui Fu Lei qian Chi Fai Cheung xu-Sheng Yang State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518060China

Due to the easy coarsening caused by poor thermal stability,the verified annealing-induced hardening in nanograined metals can only maintain at a relatively low-temperature *** this study,a nanolam-inated(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8)medium-entropy alloy with an average lamellae thickness of∼20 nm embedded by thinner nanotwins was fabricated by severe cold rolling to achieve superior thermal *** with the conventional nanotwinned CrCoNi with nanotwins inside ultra-fined grains,the hier-archical nanolaminated-nanotwinned(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8) exhibits a significant annealing-induced hard-ening effect,i.e.,hardness increasing from∼250 HV in the original specimen to∼500 HV in the cold-rolled status and finally∼630 HV after annealing at 600℃for 1 *** microstructure characterizations reveal that the reduced dislocation density and formation of L1_(2)ordered domain are mainly responsible for such hardening effect,which is facilitated by the effectively suppressed coarsening with annealing temperature,i.e.,slow detwinning process and well-retained low-angle nanolamellar *** coarsening mechanisms from the cold-rolled nanolamellae to the fully recrystallized micro-equiaxed structures under the annealing temperatures ranging from 400 to 800℃ were also elucidated by atomic observations.

关键词： Annealing-induced hardening Thermal stability Nanolaminated-nanotwinned structure CrCoNi Detwinning Grain boundary migration

Numerical analysis of wind effects on aerodynamic characteristics of a ducted fan

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Chinese Journal of Aeronautics 2024年第5期37卷 263-280页

作者： Yiwei LUO Tianfu AI Yuhang HE Bin xu Yuping qian Yangjun ZHANG State Key Laboratory of Intelligent Green Vehicle and Mobility School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Key Laboratory of Conveyance and Equipment Ministry of Education East China Jiaotong UniversityNanchang 330013China Vehicle Research Center School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

Ducted fans have been extensively used in Unmanned Aerial Vehicles(UAVs)for a variety of missions because of high efficiency,high safety and low ***,as a kind of typical meteorological condition,brings significant aerodynamic interference to the ducted fan,which seriously threatens flight stability and *** this work,the numerical simulation with the Unsteady Reynolds Averaged Navier-Stokes(URANS)method and the sliding mesh technique is performed to evaluate the steady wind *** results show that the wind will lead to serious unsteady effects in the flow field,and the thrust fluctuates at the blade passing frequency of 200 *** the wind speed increases,the rotor thrust increases,the duct thrust decreases,and the total thrust changes *** instability may occur when the wind speed exceeds 8 m/*** the angle of low-speed wind increases,the rotor thrust changes little,the duct thrust increases,and the total thrust *** addition,we figure out that cases with the same crosswind ratio are similar in results,and increasing the rotating speed or fan radius is beneficial to performance improvement in *** findings are essential to the ducted fan design and UAV flight control design for stable and safe operations in wind conditions.

关键词： Unmanned Aerial Vehicle(UAV) Ducted fan Wind effect Thrust fluctuations Computational Fluid Dynamics(CFD)

Causal temporal graph attention network for fault diagnosis of chemical processes

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Chinese Journal of Chemical Engineering 2024年第6期70卷 20-32页

作者： Jiaojiao Luo Zhehao Jin Heping Jin qian Li xu Ji Yiyang Dai School of Chemical Engineering Sichuan UniversityChengdu 610065China China Three Gorges Corporation Beijing 100038China

Fault detection and diagnosis(FDD)plays a significant role in ensuring the safety and stability of chemical *** the development of artificial intelligence(AI)and big data technologies,data-driven approaches with excellent performance are widely used for FDD in chemical ***,improved predictive accuracy has often been achieved through increased model complexity,which turns models into black-box methods and causes uncertainty regarding their *** this study,a causal temporal graph attention network(CTGAN)is proposed for fault diagnosis of chemical processes.A chemical causal graph is built by causal inference to represent the propagation path of *** attention mechanism and chemical causal graph were combined to help us notice the key variables relating to fault *** in the Tennessee Eastman(TE)process and the green ammonia(GA)process showed that CTGAN achieved high performance and good explainability.

关键词： Chemical processes Safety Fault diagnosis Causal discovery Attention mechanism Explainability

Paroxysmal Kinesigenic Dyskinesia:Genetics and Pathophysiological Mechanisms

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Neuroscience Bulletin 2024年第7期40卷 952-962页

作者： Jiao-Jiao xu Hong-Fu Li zhi-Ying Wu Department of Medical Genetics and Center for Rare Diseases The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology in the Second Affiliated Hospital Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310009China

Paroxysmal kinesigenic dyskinesia(PKD),the most common type of paroxysmal movement disorder,is characterized by sudden and brief attacks of choreoathetosis or dystonia triggered by sudden voluntary *** is mainly caused by mutations in the PRRT2 or TMEM151A *** exact pathophysiological mechanisms of PKD remain unclear,although the function of PRRT2 protein has been well characterized in the last *** on abnormal ion channels and disturbed synaptic transmission in the absence of PRRT2,PKD may be channelopathy or synaptopathy,or *** addition,the cerebellum is regarded as the key pathogenic *** depolarization in the cerebellum is tightly associated with dyskinetic ***,in PKD,other than the cerebellum,the role of the cerebrum including the cortex and thalamus needs to be further investigated.

关键词： Paroxysmal kinesigenic dyskinesia PRRT2 TMEM151A Genetics Pathophysiological mechanisms

Towards designing high mechanical performance low-alloyed wrought magnesium alloys via grain boundary segregation strategy:A review

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Journal of Magnesium and Alloys 2024年第5期12卷 1774-1791页

作者： zhi Zhang Jinshu Xie Jinghuai Zhang xu-Sheng Yang Ruizhi Wu Key Laboratory of Superlight Material and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Ultra-Precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518060China

Low-alloyed magnesium(Mg)alloys have emerged as one of the most promising candidates for lightweight ***,their further application potential has been hampered by limitations such as low strength,poor plasticity at room temperature,and unsatisfactory *** address these challenges,grain refinement and grain structure control have been identified as crucial factors to achieving high performance in low-alloyed Mg *** effective way for regulating grain structure is through grain boundary(GB)*** review presents a comprehensive summary of the distribution criteria of segregated atoms and the effects of solute segregation on grain size and growth in Mg *** analysis encompasses both single element segregation and multi-element co-segregation behavior,considering coherent interfaces and incoherent ***,we introduce the high mechanical performance low-alloyed wrought Mg alloys that utilize GB segregation and analyze the potential impact mechanisms through which GB segregation influences materials *** upon these studies,we propose strategies for the design of high mechanical performance Mg alloys with desirable properties,including high strength,excellent ductility,and good formability,achieved through the implementation of GB *** findings of this review contribute to advancing the understanding of grain boundary engineering in Mg alloys and provide valuable insights for future alloy design and optimization.

关键词： Magnesium alloys Grain boundary segregation High strength High plasticity High formability

Channel-bias-controlled reconfigurable silicon nanowire transistors via an asymmetric electrode contact strategy

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Chip 2024年第3期3卷 8-14页

作者： Wentao qian Junzhuan Wang Jun xu Linwei Yu School of Electronic Science and Engineering/National Laboratory of Solid-State Microstructures Nanjing UniversityNanjing 210093China

Reconfigurable field-effect transistors(R-FETs)that can dynamically reconfigure the transistor polarity,from n-type to p-type channel or vice versa,represent a promising new approach to reduce the logic complexity and granularity of programmable *** R-FETs have been successfully demonstrated upon silicon nanowire(SiNW)channels,a pair of extra program gates is still needed to control the source/drain(S/D)*** this work,we propose a rather simple single gate R-FET structure with an asymmetric S/D electrode contact,where the FET channel polarity can be altered by changing the sign of channel bias V_(ds).These R-FETs were fabricated upon an orderly array of planar SiNW channels,grown via in-plane solid-liquid-solid mechanism,and contacted by Ti/Al and Pt/Au at the S/D electrodes,***,this channel-bias-controlled R-FET strategy has been successfully testified and implemented upon both p-typedoped(with indium dopants)or n-type-doped(phosphorus)SiNW channels,whereas the R-FET prototypes demonstrate an impressive high I_(on/off) ratio of>10^(6) and a steep subthreshold swing of 79 mV/*** results indicate a rather simple,compact and generic enough R-FET strategy for the construction of a new generation of SiNW-based programmable and low-power electronics.

关键词： Catalytic Si nanowires Asymmetric electrodes Reconfigure transistor

Systematic review and network meta-analysis of different nonsteroidal anti-inflammatory drugs for juvenile idiopathic arthritis

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World Journal of Clinical Cases 2024年第12期12卷 2056-2064页

作者： Tao Zeng Jian-Zhong Ye Hui Qin qian-qian xu College of Medicine Jingchu University of Technology JingmenJingmen 448000Hubei ProvinceChina

BACKGROUND Various non-steroidal anti-inflammatory drugs(NSAIDs)have been used for juvenile idiopathic arthritis(JIA).However,the optimal method for JIA has not yet been *** To perform a systematic review and network meta-analysis to determine the optimal *** We searched for randomized controlled trials(RCTs)from PubMed,EMBASE,Google Scholar,CNKI,and Wanfang without restriction for publication date or language at August,*** RCTs that comparing the effectiveness of NSAIDs with each other or placebo for JIA were included in this network *** surface under the cumulative ranking curve(SUCRA)analysis was used to rank the treatments.P value less than 0.05 was identified as statistically *** We included 8 RCTs(1127 patients)comparing 8 different instructions including meloxicam(0.125 qd and 0.250 qd),Celecoxib(3 mg/kg bid and 6 mg/kg bid),piroxicam,Naproxen(5.0 mg/kg/d,7.5 mg/kg/d and 12.5 mg/kg/d),inuprofen(30-40 mg/kg/d),Aspirin(60-80 mg/kg/d,75 mg/kg/d,and 55 mg/kg/d),Tolmetin(15 mg/kg/d),Rofecoxib,and *** were no significant differences between any two NSAIDs regarding ACR Pedi 30 *** SUCRA shows that celecoxib(6 mg/kg bid)ranked first(SUCRA,88.9%),rofecoxib ranked second(SUCRA,68.1%),Celecoxib(3 mg/kg bid)ranked third(SUCRA,51.0%).There were no significant differences between any two NSAIDs regarding adverse *** SUCRA shows that placebo ranked first(SUCRA,88.2%),piroxicam ranked second(SUCRA,60.5%),rofecoxib(0.6 mg/kg qd)ranked third(SUCRA,56.1%),meloxicam(0.125 mg/kg qd)ranked fourth(SUCRA,56.1%),and rofecoxib(0.3 mg/kg qd)ranked fifth(SUCRA,56.1%).CONCLUSION In summary,celecoxib(6 mg/kg bid)was found to be the most effective NSAID for treating ***,piroxicam,and meloxicam may be safer options,but further research is needed to confirm these findings in larger trials with higher quality studies.

关键词： Non-steroidal anti-inflammatory drugs Juvenile idiopathic arthritis Network meta-analysis Systematic review

The MRE11–ATM–SOG1 DNA damage signaling pathway confers rice immunity to Xanthomonas oryzae

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Plant Communications 2024年第4期5卷 194-207页

作者： Zhan xu Mingnan Qu Chuanlin Shi Hong Zhang Wu Chen Hongge qian zhipeng Zhang Jiehua Qiu qian qian Lianguang Shang Guangzhou City Academy of Agricultural Sciences Key Laboratory of BiologyGenetics and BreedingGuangzhou 510000China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding College of AgricultureYangzhou UniversityYangzhou 225009China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China These authors contributed equally to this article

Plants are constantly exposed to microbial pathogens in the *** branch of innate plant immunity is mediated by cell-membrane-localized receptors,but less is known about associations between DNA damage and plant immune ***,we show that rice(Oryza sativa)mesophyll cells are prone to DNA double-stranded breaks(DSBs)in response to ZJ173,a strain of Xanthomonas oryzae ***(Xoo).The DSB signal transducer ataxia telangiectasia mutated(ATM),but not the ATM and Rad3-related branch,confers resistance against ***,the MRE11–ATM module phosphorylates suppressor of gamma response 1(SOG1),which activates several phenylpropanoid pathway genes and prompts downstream phytoalexin biosynthesis during Xoo ***,overexpression of the topoisomerase gene TOP6A3 causes a switch from the classic non-homologous end joining(NHEJ)pathway to the alternative NHEJ and homologous recombination pathways atXoo-induced *** enhanced ATM signaling of the alternative NHEJ pathway strengthens the SOG1-regulated phenylpropanoid pathway and thereby boosts Xoo-induced phytoalexin biosynthesis in TOP6A3-OE1 overexpression ***,the MRE11–ATM–SOG1 pathway serves as a prime example of plant–pathogen interactions that occur via host non-specific recogni*** function of TOP6-facilitated ATM signaling in the defense response makes it a promising target for breeding of rice germplasm that exhibits resistance to bacterial blight disease without a growth penalty.

关键词： Oryza sativa Xanthomonas oryzae pv.oryzae DSBs phytoalexins MRE11–ATM–SOG1 TOP6 complex

Mechanism and application of mechanical property improvements in engineering materials by pulsed magnetic treatment:A review

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Friction 2024年第10期12卷 2139-2166页

作者： zhipeng CAI Chengkai qian xu ZHANG Ning DAI Yao WU Wen JI State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Tianjin Research Institute for Advanced Equipment Tsinghua UniversityTianjin 300304China

Pulsed magnetic treatment(PMT)has been adopted as an effective strengthening method for engineering materials and components in recent years,and the development of its application depends on the comprehensive understanding of the nature of *** deep mechanism was thought initially to be the magnetostrictive effect,while further investigation found that the magnetic field could lead to the change of the defect states in the crystal,which is called the magnetoplastic *** to the complexity of the engineering materials,manifestations of the magnetoplastic effect become more diverse,and they were reviewed in the form of microstructure homogenization and interfacial ***,the mechanism of the magnetoplastic effect was discussed,focusing on the changes in the spin states under the external magnetic *** modifications could also alter material performances,especially the residual stress,plasticity,and fatigue ***,PMT with specific parameters can be utilized to obtain an ideal combination of microstructure,residual stress,and mechanical properties for better service performance of different mechanical parts,and its applications on machining tools and bearings are perfect *** work reviews the effect of PMT on the microstructure and properties of different materials and the mechanism,and it also summarizes the fundamental applications of PMT on essential mechanical parts.

关键词： pulsed magnetic treatment wear resistance microstructure modifications mechanical properties magnetoplastic effect