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Sexual,physical and overall adverse effects in patients treated with 5a-reductase inhibitors:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 390-397页

作者： Jun-Jie Zhang Xiao Shi Ting Wu Meng-Da Zhang Jin Tang Guang-Ming Yin zhi long Le-Ye He Lin qi long Wang Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha 410008China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastroenterology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Cardiovascular Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China

Postfinasteride syndrome(PFS)is a term coined to characterize a constellation of reported undesirable sexual,physical,and neuropsychiatric side *** the present study,we conducted the meta-analysis to demonstrate whether the use of 5α-reductase inhibitors(5ARIs)increases the risk of PFS-like adverse effects.A search of studies published until May 10,2020,was performed using PubMed,EMBASE,and the Cochrane *** included randomized controlled trials with at least one comparison between male patients receiving 5ARIs versus placebo for the treatment of benign prostatic hyperplasia(BPH)or androgenetic alopecia(AGA),and identified 34 studies from 28 articles that met our eligibility *** the random-effects model,the overall use of 5ARIs exhibited a 1.87-fold risk of PFS-like adverse effects during the trial(95%confidence interval[CI]:1.64-2.14).Regarding specific types of adverse effects,the use of 5ARIs had a 1.89-fold risk of sexual adverse effects(95%CI:1.74-2.05)and was associated with an increased risk of physical adverse effects(relative risk[RR]:1.31,95%CI:0.80-2.15),albeit without statistical *** meta-analysis helped to better define the adverse effects caused by *** concluded that the overall use of 5ARIs significantly increased the risk of PFS-like adverse effects in men with AGA or BPH during *** awareness of and education on the PFS-like adverse effects are necessary for clinicians.

关键词： 5α-reductase inhibitors adverse effects androgenetic alopecia benign prostatic hyperplasia postfinasteride syndrome

Synthesis and biological evaluation of novel tanshinone IIA derivatives for treating pain

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Chinese Journal of Natural Medicines 2018年第2期16卷 113-124页

作者： LI qi-Nan HUANG zhi-Peng GU qin-Lan zhi Zhuo-Er YANG Yu-Han HE long CHEN Kai-Li WANG Jin-Xin Jiangsu Key Laboratory of Drug Design and Optimization China Pharmaceutical University Nanjing 211009 China Higher Vocational School of Pharmacy，China Pharmaceutical University Nanjing 211009 China

Due to ineffectiveness and side effects of existing analgesics, chronic pain has become one of the most complex and difficult problems in the clinic. Monoacylglycerol lipase(MAGL) is an essential hydrolase in the endocannabinoid system and has been identified as a potential target for the treatment of pain. In the present study, we designed and synthesized twelve tanshinone IIA analogs and screened their activity against MAGL. Selected compounds were tested for analgesic activity in vivo, with the acetic acid writhing test model. Among the test compounds, compound Ⅲ-3(IC_(50) 120 nmol·L^(-1)) showed significant activity against MAGL and ameliorated the clinical progression in the mouse pain model. Additionally, compound Ⅲ-3, substitution with N-methyl-2-morpholinoacetamide, demonstrated improved solubility relative to tanshinone IIA.

关键词： Tanshinone IIA:MAGL inhibitors Analgesic activity

An improved boundary element method for modelling a self-reacting point absorber wave energy converter

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Acta Mechanica Sinica 2018年第6期34卷 1015-1034页

作者： qian-long Xu Ye Li zhi-Liang Lin State Key Laboratory of Ocean Engineering Collaborative Innovation Center for Advanced Ship and Deep-Sea ExplorationMuti-function Towing TankKey Laboratory of Hydrodynamics(Ministry of Education)School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

A numerical model based on a boundary element method (BEM) is developed to predict the performance of two-body selfreacting floating-point absorber (SRFPA) wave energy systems that operate predominantly in *** key numerical issues in applying the BEM are systematically *** particular,some improvements and simplifications in the numerical scheme are developed to evaluate the free surface Green's function,which is a main element of difficulty in the *** a locked SRFPA system,the present method is compared with the existing experiment and the Reynolds-averaged NavierStokes (RANS)-based method,where it is shown that the inviscid assumption leads to substantial over-prediction of the heave *** the unlocked SRFPA model we study in this paper,the additional viscous damping primarily induced by flow separation and vortex shedding,is modelled as a quadratic drag force,which is proportional to the square of body *** inclusion of viscous drag in present method significantly improves the prediction of the heave responses and the power absorption performance of the SRFPA system,obtaining results excellent agreement with experimental data and the RANS simulation results over a broad range of incident wave periods,except near resonance in larger wave height *** is found that the wave overtopping and the re-entering impact of out-of-water floating body are observed more frequently in larger waves,where these non-linear effects are the dominant damping sources and could significantly reduce the power output and the motion responses of the SRFPA system.

关键词： Boundary element method Floating-point absorber Heave Green's function Viscous drag

Will male semen quality improve with environmental quality?

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Asian Journal of Andrology 2023年第2期25卷 252-258页

作者： Xu-Chao Dai Meng-qi Zhang Gang Chen Kun Mei Yan-long Liu Hong Huang zhi-Gang Wu School of Public Health and Management Wenzhou Medical UniversityWenzhou 325035China School of Geography Science and Geomatics Engineering Suzhou University of Science and TechnologySuzhou 215009China School of Mental Health Wenzhou Medical UniversityWenzhou 325035China Research Center for Healthy China Wenzhou Medical UniversityWenzhou 325035China Zhejiang Provincial Key Laboratory of Watershed Sciences and Health Wenzhou 325035China Department of Urology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Reproductive Health Research Center Health Assessment Center of Wenzhou Medical UniversityWenzhou 325000China

Wenzhou has improved its environmental quality because of comprehensive environmental remediation;nevertheless,the semen quality of infertile males remains *** study determined whether better environmental quality improved semen quality in this *** recorded semen quality data from 22962 infertile males from January 2014 to November 2019 at the Center for Reproductive Health of The First Affiliated Hospital of Wenzhou Medical University(Wenzhou,China).Patients were predominantly 30–35 years old(33.1%)and workers(82.0%),with high school education or lower(77.6%);more than a half of the patients(52.6%)were Wenzhou household registration;and most patients(77.5%)had abnormal semen *** who were older than 40 years and workers,and those with Wenzhou household registration,had significantly worse semen quality(all P<0.05).From 2014 to 2019,progressive sperm motility,total sperm motility,and semen volume showed increasing linear trends in all patients(P=0.021,0.030,and 0.005,respectively),yet normal sperm morphology showed a linearly decreasing trend(P=0.046).Sensitivity analyses for subgroups yielded similar *** conclusion,the improvement of environmental quality and better function of the accessory glands are associated with progressive sperm motility,total sperm motility,and semen *** sperm morphology is influenced by occupational exposures and personal lifestyle and does not improve with environmental quality.

关键词： environmental quality male infertility semen quality time trend

Heterosis Expression of Hybrid Rice in Natural-and Short-Day Length Conditions

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Rice science 2015年第2期22卷 81-88页

作者： HUANG zhi-yuan ZHAO Bing-ran LV qi-ming FU Xi-qin XIN Ye-yun YUAN long-ping State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research Center

Development of hybrid rice is an important strategy to increase yields of irrigated rice in China. Day length is a highly important environmental factor for hybrid rice adaptability, productivity and quality. Heterosis of hybrid rice has been utilized under natural- （long） day length conditions in the middle and lower reaches plain of Yangtze River Valley in China for a long time. However, whether the hybrid rice can show heterosis under short-day length conditions is unknown. In this study, we analyzed plant height, grain number per panicle, and other yield related traits of hybrid rice Liangyoupeijiu （LYP9） and its parents （Pei＇ai 64S and 93-11） under natural- and short-day length conditions and compared the respective heterosis. Results showed that earlier heading, reduced plant height, and reduced grain number per panicle were found in these three varieties under short-day length conditions relative to those under natural-day length conditions. In either natural- or short-day length conditions, heterosis of LYP9 was mainly displayed in grain number per panicle and plant height. This study may help in breeding and selectina suitable hybrid rice for different re qions with natural- or short-day length.

关键词： hybrid rice heterosis photoperiod short-day length

西北绿洲灌区玉米叶片衰老特征对不同地膜覆盖利用方式的响应

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作物学报 2025年第1期51卷 233-246页

作者：王丽萍李盼赵连豪樊志龙胡发龙范虹何蔚柴强殷文甘肃农业大学农学院/省部共建干旱生境作物学国家重点实验室甘肃兰州730070

西北绿洲灌区玉米传统生产模式中大量使用地膜伴随着生态环境污染严重,且在极端高温下玉米出现叶片早衰。针对该现象,通过免耕一膜2年覆盖利用技术探讨延缓玉米叶片衰老并增加玉米产量的可行性,以期为构建西北绿洲灌区地膜减量玉米高效... 详细信息

西北绿洲灌区玉米传统生产模式中大量使用地膜伴随着生态环境污染严重,且在极端高温下玉米出现叶片早衰。针对该现象,通过免耕一膜2年覆盖利用技术探讨延缓玉米叶片衰老并增加玉米产量的可行性,以期为构建西北绿洲灌区地膜减量玉米高效生产技术提供理论支撑。2013年在西北绿洲灌区设置免耕一膜2年覆盖利用(NTP)、秋免耕春覆膜(RTP)和传统每年覆新膜(对照, CTP) 3种处理(本文采用2021-2023数据),探究玉米叶片光合源、持绿特性、细胞抗氧化酶活性和渗透调节物质含量对不同地膜覆盖利用方式的响应。结果表明,NTP和RTP可有效调节玉米生育期内光合源和叶片持绿性能的动态关系,维持生育后期较大的叶面积指数(LAI)、光合势(LAD)、叶片持绿性(SG)和叶绿素相对含量(SPAD),有利于延缓叶片衰老。与CTP相比, NTP玉米出苗后75~120 d的LAI、LAD、SG和SPAD分别提高15.1%~16.1%、14.8%~15.5%、7.2%~9.2%和11.3%~11.7%,RTP分别提高12.4%~13.0%、11.5%~12.4%、10.0%~17.6%和6.0%~6.7%。同时,通过单株绿色叶面积的拟合,发现NTP和RTP较CTP叶片衰老时间平均推迟了5.8~7.0d和6.2~7.7d,这可能是由于NTP和RTP有助于增强玉米大喇叭口期-灌浆期叶片的抗氧化能力和细胞渗透调节作用。玉米出苗后60~105 d, NTP较CTP叶片抗氧化酶(SOD、POD、CAT和APX)活性分别提高17.6%~20.0%、28.4%~34.4%、6.7%~8.4%和8.3%~10.9%, RTP较CTP分别提高11.3%~11.7%、16.9%~18.2%、4.4%~6.1%和5.8%~7.7%。此外,与CTP相比,NTP与RTP可溶性蛋白和脯氨酸含量分别提高35.9%~43.9%和29.5%~31.8%,20.7%~31.7%和17.4%~20.4%,丙二醛含量分别降低26.0%~27.8%和17.5%~25.9%。NTP对抗氧化酶和渗透调节物质的影响更大,NTP较CTP增产5.2%~6.0%。免耕一膜2年覆盖利用技术是西北灌区在实现资源减投条件下,有效延缓玉米叶片衰老且增加产量的适宜措施。

关键词：地膜覆盖光合源抗氧化酶活性细胞渗透调节能力籽粒产量

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Weak Poincaré Inequalities,Decay of Markov Semigroups and Concentration of Measures

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Acta Mathematica Sinica,English Series 2005年第4期21卷 937-942页

作者： Feng Yu WANG qi zhi ZHANG School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

For a reasonable class of weak Poincaré inequalities, the decay of the corresponding Markov semigroups obtained earlier by Rockner and the first named author is improved by removing an extra L^2-norm. Next, a concentration estimate of the reference measure is presented for the weak Poincaré inequality, which is sharp as illustrated by some examples of one-dimensional diffusion processes.

关键词： Weak Poincaré inequality Markov semigroup Concentration of measures

On the longest Length of Consecutive Integers

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Acta Mathematica Sinica,English Series 2011年第2期27卷 329-338页

作者： Min zhi ZHAO qi-Man SHAO Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China Department of Mathematics Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong P. R. China

Choose m numbers from the set {1,2,... ,n} at random without replacement. In this paper we first establish the limiting distribution of the longest length of consecutive integers and then apply the result to test rand... 详细信息

关键词： Sampling without replacement consecutive integers limit distribution test of randomness

Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate

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Asian Journal of Andrology 2022年第5期24卷 525-532页

作者： qi-Liang Teng Xin-Rui Yang Shuang Wen zhi-Hong Dai Hong-long Wang Tian-qing Liu Liang Wang Bo Fan zhi-Yu Liu Department of Urology Second Affiliated Hospital of Dalian Medical UniversityDalian 116023China Department of Clinical Imaging Second Affiliated Hospital of Dalian Medical UniversityDalian 116023China Department of Pathology Dalian Friendship HospitalDalian 116001China

Primary signet ring cell carcinoma(SRCC)of the prostate is a rare ***,its potential tumorigenic mechanism,clinicopathological features,and prognostic outcome have not been systematically *** determine the pathogenic mechanism,we detected distributions of programmed cell death-ligand 1(PD-L1),programmed death 1(PD-1),and cellular components in the tumor microenvironment,including tumor-infiltrating lymphocytes(CD4 and CD8),tumor-associated macrophages(TAMs;CD163 and CD68),and tumor-associated fibroblasts(vimentin and alpha-smooth muscle actin[α-SMA]),in tumor tissues from four patients with primary prostatic SRCC compared with corresponding adjacent tissues and tumor tissues from 30 patients with prostate adenocarcinoma(PCa)by immunohistochemical *** found higher expression of PD-L1,CD163,and CD68 in primary SRCC specimens than that in both corresponding adjacent nontumor specimens and PCa specimens with different Gleason scores,indicating that TAMs may participate in the malignant biological behavior of primary SRCC of the *** further analysis,we searched electronic journal databases and Surveillance,Epidemiology,and End Results(SEER)to identify 200 eligible patients including our four *** to Kaplan–Meier survival curve analysis,patientslonger overall survival(OS).Moreover,Cox multivariate analysis indicated that race(hazard ratio[HR]=1.422),surgical approach(HR=1.654),and Gleason score(HR=2.162)were independent prognostic factors for ***,primary SRCC of the prostate represents a distinct and aggressive subtype of prostate cancer associated with a higher distribution of PD-L1 and TAMs,which warrants further clinical investigation.

关键词： clinical features immunohistochemistry infiltrating immune cells primary signet ring cell carcinoma of the prostate tumor microenvironment