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Reciprocal translocation experiments reveal gut microbiome plasticity and host specificity in a qinghai-Xizang Plateau lizard

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Zoological Research 2025年第01期 139-151页

作者： Wei Yu Jing Yang Li-Wei Teng Xiao-long Zhao Ze-Yu Zhu Shuang Cui Wei-Guo Du Zhen-Sheng Liu zhi-Gao Zeng College of Wildlife and Protected Area Northeast Forestry University Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Key Laboratory of Conservation Biology National Forestry and Grassland Administration School of Ecological and Environmental Sciences Institute of Eco-Chongming Shanghai Institute of Wildlife Epidemics East China Normal University

Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition. The gut microbiome, highly responsive to external environmental factors, plays a crucial role in host adaptability and may facilitate local adaptation within species. Concurrently, the genetic background of host populations influences gut microbiome composition,highlighting the bidirectional relationship between host and microbiome. Despite this, our understanding of gut microbiome plasticity and its role in host adaptability remains limited, particularly in reptiles. To clarify this issue,we conducted a reciprocal translocation experiment with gravid females of the qinghai toad-headed lizards(Phrynocephalus vlangalii) between high-altitude(2?600 m a.s.l.) and superhigh-altitude(3?600 m a.s.l.) environments on Dangjin Mountain of the qinghai-Xizang Plateau,China. One year later, we assessed the phenotypes and gut microbiomes of their offspring. Results revealed significant plasticity in gut microbiome diversity and structure in response to contrasting elevations. Highaltitude conditions increased diversity, and maternal effects appeared to enable high-altitude lizards to maintain elevated diversity when exposed to superhigh-altitude environments. Additionally, superhigh-altitude lizards displayed distinct gut microbiome structures with notable host specificity, potentially linked to their lower growth rates. Overall, these findings underscore the importance of the gut microbiome in facilitating reptilian adaptation to rapid environmental changes across altitudinal ***, this study provides critical insights into microbial mechanisms underpinning local adaptation and adaptative plasticity, offering a foundation for future research on host-microbiome interactions in evolutionary and ecological contexts.

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Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

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Science China Chemistry 2025年第2期68卷 492-498页

作者： Hailong Xiong Chunyu qi Lantian Xue Ling Zhang Hanyu Liu Zhen-An qiao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Mesoporous metals with large surface area,high pore volume,and uniform pore structure hold excellent advantages for various ***,the state-of-the-art synthesis methods are still limited to wet chemistry,which requires excessive solvents and a time-consuming drying ***,we report a facile and general mechanochemical coordination self-assembly strategy to prepare mesoporous metals(e.g.,Rh,Ru,Ir,Pt,Pd,Ag,Co,and Ni)with remarkable porous properties by using metal chlorides and cationic polymer *** with the wet chemistry process,this method proceeds without solvents and does not need complicated experimental conditions and long synthetic periods,which not only greatly reduces the consumption of cost and energy and environmental pollution,but also improves the synthesis efficiency and yield of target *** believe the developed approach will provide a general pathway for the scalable preparation of advanced porous materials.

关键词： mechanochemistry self-assembly mesoporous materials mesoporous metals electrocatalysis

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新疆布尔津县冲乎尔盆地地热资源水化学特征及地下热水成因分析

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地下水 2024年第1期46卷 52-55页

作者：喜英张同良齐志龙新疆地质矿产勘查开发局第一水文工程地质大队新疆乌鲁木齐830091 新疆工程学院地热研究中心新疆乌鲁木齐830023

以冲乎尔镇为中心,探明新疆布尔津县冲乎尔盆地地热资源,运用舒卡列夫分类和派珀三线图解分类,通过对比和分析不同区域地下水组分和化学特征,探讨了地热水的来源和成因。结果表明,冲乎尔盆地水化学类型为HCO_(3)-Ca·Mg、HCO_(3)·SO_(4... 详细信息

以冲乎尔镇为中心,探明新疆布尔津县冲乎尔盆地地热资源,运用舒卡列夫分类和派珀三线图解分类,通过对比和分析不同区域地下水组分和化学特征,探讨了地热水的来源和成因。结果表明,冲乎尔盆地水化学类型为HCO_(3)-Ca·Mg、HCO_(3)·SO_(4)-Mg·Ca·Na、HCO_(3)-Ca·Mg型;地下水的δ^(18)O和δD值均在大气降水线附近,说明其补给源均为大气降水;根据对冲乎尔盆地水点进行碳-14年代测定,发现地下水年龄在95~1460 a之间,属于深循环地下水;热储属于带状热储,热交换温度为68.9℃~73.9℃,说明研究区基础温度较高具有较大的开发潜力。冲乎尔盆地地下水通过大气降水入渗水后必然顺构造裂隙向深部运动,经过深循环大地热流加热密度降低,再通过深大断裂上涌,形成地热水。

关键词：冲乎尔盆地水文地球化学特征地热水热储成因分析

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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： qi-Hong Zhong Jiang-Shan Huang Fei-long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang zhi-Cheng Zhang qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin qin Xin Tan Xiao-Yan Sun Xu-Fang Ying zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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一种2FSK非相干盲解调系统设计

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无线电工程 2015年第4期45卷 29-31页

作者：李帅李辉漆志龙陈祎电子科技大学电子工程学院四川成都611731 国家电网四川省电力公司泸州供电公司四川泸州646000

针对复杂电磁环境下通信侦察接收机侦收的通信信号难以被准确解调的问题,在传统差分解调算法的基础上设计出一种2FSK信号非相干盲解调算法。该算法利用估计的载波频率将信号下变频到准基带,通过差分解调算法解调出基带信号,利用基于码... 详细信息

针对复杂电磁环境下通信侦察接收机侦收的通信信号难以被准确解调的问题,在传统差分解调算法的基础上设计出一种2FSK信号非相干盲解调算法。该算法利用估计的载波频率将信号下变频到准基带,通过差分解调算法解调出基带信号,利用基于码元跳变点的定时同步算法完成实时解调处理。仿真结果表明,该算法抗噪声与载频估计误差性能好,当SNR≥4 d B时,解调算法的误码率(BER)小于1%。

关键词：通信侦察 2FSK盲解调位同步误码率

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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新疆锑矿区域成矿规律探讨

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世界有色金属 2020年第6期45卷 119-122页

作者：郭利张同良齐志龙陈波新疆地矿局第一区域地质调查大队新疆乌鲁木齐830000 新疆工程学院新疆乌鲁木齐830000 新疆地矿局第一水文工程地质大队新疆乌鲁木齐830000 新疆地矿局第二区域地质调查大队新疆昌吉831100

新疆地跨古中亚洲成矿域、秦祁昆成矿域及特提斯成矿域等三大成矿域,是中国重要的锑矿产地之一,近年来在锑矿资源勘查方面取得了一系列的突破。笔者多年来一直从事新疆锑矿评价工作,基于近年来新疆锑矿的研究成果,从新疆锑矿的物质结构... 详细信息

新疆地跨古中亚洲成矿域、秦祁昆成矿域及特提斯成矿域等三大成矿域,是中国重要的锑矿产地之一,近年来在锑矿资源勘查方面取得了一系列的突破。笔者多年来一直从事新疆锑矿评价工作,基于近年来新疆锑矿的研究成果,从新疆锑矿的物质结构、时空分布、成矿地质演化及区域成矿演化模式等方面入手,针对新疆锑矿区域成矿规律进行了探讨。

关键词：锑矿区域成矿规律新疆

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Taurine: A Comprehensive Review of Its Origin， Pharmacological Properties， Potential Health Benefits， Therapeutic Applications， and Safety Profile

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Food Science and Human Wellness 2025年

作者： Pengfei Zhao Ying qi Department of Pharmacology， School of Pharmacy， China Medical University (Shenyang) Department of Radiology， Shengjing Hospital of China Medical University

Taurine， a multifunctional sulfur-containing amino acid and conditionally essential nutrient for humans， plays a key role in various biological processes and has attracted significant attention for its therapeutic potential. Originally isolated from ox bile， taurine has broad applications， but a comprehensive understanding of its pharmacological properties， health benefits， and safety profile remains incomplete. In this review， we critically evaluate the existing evidence on taurine’s effects based on an extensive literature search of multiple databases， including PubMed， Web of Science， Scopus， ScienceDirect， Google Scholar， CNKI， and Baidu Scholar， up to May 2024. Taurine demonstrates a range of beneficial effects， including antioxidant and anti-inflammatory activities， modulation of lipid metabolism， neuroprotection， and cardiovascular protection. It has shown substantial impacts on anti-tumor activity， immune system modulation， blood pressure and lipid regulation， glycemic control， hepatobiliary protection， and potential anti-aging effects. However， the precise regulatory pathways underlying these benefits are not yet fully understood. Epidemiological studies indicate a correlation between high taurine dosage and a reduced risk of diseases. However， direct evidence from interventional studies remains insufficient， and existing clinical trials require further in-depth investigation. Concerns about improper use and potential health risks also highlight the need for thorough safety assessments. To address these gaps， we recommend conducting well-designed， long-term randomized controlled trials to establish effective doses for disease prevention and assess taurine’s potential as a primary or adjunct therapy. This review aims to guide future research and support public health efforts， ultimately improving health outcomes.

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The long noncoding RNA ALEX1 confers a functional phase state of ARF3 to enhance rice resistance to bacterial pathogens

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Molecular Plant 2025年第1期18卷 114-129页

作者： Meng-qi Lei Rui-Rui He Yan-Fei Zhou Lu Yang Zhen-Fei Zhang Chao Yuan Wen-long Zhao Yu Cheng Jian-Ping Lian Yu-Chan Zhang Wen-Tao Wang Yang Yu Yue-qin Chen Guangdong Provincial Key Laboratory of Plant Stress Biology State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275P.R.China Guangdong Key Laboratory of Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China Plant Protection Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China

Rice bacterial blight is a devastating disease worldwide,causing significant yield *** how plants defend against microbial infection is critical for sustainable crop *** this study,we show that ALEX1,a previously identified pathogen-induced long noncoding RNA,localizes to the nucleus and directly binds AUXIN RESPONSE FACTOR 3(ARF3).We showed that ARF3 forms the condensates in the nucleus via its intrinsically disordered middle region(MR),and that these ARF3 condensates display solid-like *** further revealed that ALEX1 directly binds the MR of ARF3 to regulate ARF3 condensate dynamics and promote ARF3 *** dispersed,dimeric form of ARF3,referred to as its functional phase state,enhances its ability to transcriptionally repress the expression of downstream target genes such as JAZ13,thereby modulating the jasmonic acid signaling pathway and enhancing pathogen resistance in ***,this study reveals the role of a long noncoding RNA in regulating protein condensation and complex assembly,thus contributing to plant pathogen resistance.

关键词： lncRNA Xoo ARF3 protein condensates

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