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The androgen receptor in hormone-refractory prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 69-73页

作者： Hai-Lei Mao zhi-qi zhu Charlie Degui Chen State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Andrology Institute of Biochemistry and CellBiology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Affiliated Hospital of Nantong University Nantong 226001 China

Advanced prostate cancer is responsive to hormone therapy that interferes with androgen receptor （AR） signalling. However, the effect is short-lived, as nearly all tumours progress to a hormone-refractory （HR） state, a lethal stage of the disease. Intuitively, the AR should not be involved because hormone therapy that blocks or reduces AR activity is not effective in treating HR tumours. However, there is still a consensus that AR plays an essential role in HR prostate cancer （HRPC） because AR signalling is still functional in HR tumours. AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens. Therefore, drugs targeting AR signalling could still be effective in treating HRPC.

关键词： prostate cancer hormone therapy androgen receptor hormone-refractory prostate cancer

Sequence-specific Assignment of ~1H-NMR Resonance and Determination of the Secondary Structure of Jingzhaotoxin-I

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Acta Biochimica et Biophysica Sinica 2005年第8期37卷 567-572页

作者： Xiong-zhi ZENG qi zhu Song-Ping LIANG~* College of Life Sciences,Hunan Normal University,Changsha 410081,China College of Life Sciences Hunan Normal UniversityChangsha 410081 China

Jingzhaotoxin-I（JZTX-I）purified from the venom of the spider Chilobrachys jingzhao is anovel neurotoxin preferentially inhibiting cardiac sodium channel inactivation by binding to receptor site *** structure of this toxin in aqueous solution was investigated using 2-D 1H-NMR *** completesequence-specific assignments of proton resonance in the 1H-NMR spectra of JZTX-I were obtained byanalyzing a series of 2-D spectra,including DQF-COSY,TOCSY and NOESY spectra,in H2O and *** backbone protons except for Gln4 and more than 95% of the side-chain protons were identified by dαN,dαδ.dβN and dNN connectivities in the NOESY *** studies provide a basis for the furtherdetermination of the solution conformation of JZTX-Ⅰ.Furthermore,the secondary structure of JZTX-Ⅰwas identified from NMR *** consists mainly of a short triple-stranded antiparallel [3-sheet with Trp7-Cys9,Phe20-Lys23 and *** characteristics of the secondary structure of JZTX-Ⅰ are similarto those of huwentoxin-Ⅰ（HWTX-Ⅰ）and hainantoxin-Ⅳ（HNTX-IV）,whose structures in solution havepreviously been reported.

关键词： Jingzhaotoxin-I(JZTX-I) 2-D nuclear magnetic resonance(NMR) sequence-specific assignment secondary structure

Experimental investigation of an adjustable ejector for CO_2 heat pump water heaters

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第11期10卷 1678-1682页

作者： Guang-ming CHEN Li-xia LIANG Li-ming TANG Xiao-xiao XU zhi-jiang zhu qi CHEN State Key Laboratory of Clean Energy Utilization Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China

An adjustable ejector expansion device for a CO2 heat pump water heater (HPWP) is proposed to improve the system performance. It has been designed to investigate experimentally the effects of the motive nozzle throat area of the ejector, entrained flow pressure, back pressure and primary flow pressure on the entrainment ratio. Experiments based on different motive nozzle throat areas were conducted and the results of the prototype ejector using CO2 as working fluid are presented. The results show that an adjustable ejector can achieve high performance and work well in a wide range of working conditions.

关键词： Adjustable elector System nerformance CO2 heat oumo water heater (HPWH) Entrainment ratio

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Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

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Tungsten 2025年第1期7卷 100-111页

作者： zhi-qi Zhang Liu Yang Wen Luo Vladimir An Jing Li Bao-Dan Liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

关键词： Low temperature activity Monolithic mesh catalysts NH3-SCR SO2 tolerance V2O5-WO3/TiO2

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu zhu Huanyu Liang Ping Li Chenglong qiu Jingyi Wu Jingwei Chen Weiqian Tian Yue zhu zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms

2-Pyrrole Carboxylic Acid Nitro-Phenylamide: New Colorimetric Sensor for Anion

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有机化学 2003年第Z1期23卷 184-184页

作者： YIN Zhen-Ming YANG Wen-zhi HE Jia-qi zhu Xiao-qing CHENG Jin-Pei Department of Chemistry Nankai University Tianjin 300071 Department of Chemistry Nankai University Tianjin 300071 Department of Chemistry Nankai University Tianjin 300071 Department of Chemistry Nankai University Tianjin 300071 Department of Chemistry Nankai University Tianjin 300071

　　Due to the role played by anions in the field of biology and environmental chemistry, the development of selec tive and sensitive chemosensor for anion sensing is a topic of current attention. Colorimetric anion sensor, which does not require the use of a potentiostate or spectrometer to detect redox or optical perturbation, can give immediate qualitative anion sensing information by visual detection and therefore has advantages over other molecular *** the anion binding ability of some pyrrolic amides reported by Schmuck and Gale, we linked the color reporter group of nitroanile to pyrrole moiety and synthesized two 2-pyrrole carboxylic acid nitro-phenylamides (1 and 2).……

关键词： Carboxylic Acid carboxylic acid binding ability

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基于染料吸收的光导纤维SO2传感器

化学学报 1987年第5期45卷 497-499页

作者：张志琪章竹君陕西师范大学化学系陕西师范大学化学系西安

建立于气液两相平衡的气敏电极已为人们所熟知。近年来研究了气液两相平衡的光纤化学传感器。作者之一曾报道了CO2荧光传感器。本文在文献基础上对基于染料吸收的光纤SO2传感器进行了探讨性的研究。光纤SO2传感器在其结构上与气敏电极相... 详细信息

建立于气液两相平衡的气敏电极已为人们所熟知。近年来研究了气液两相平衡的光纤化学传感器。作者之一曾报道了CO2荧光传感器。本文在文献基础上对基于染料吸收的光纤SO2传感器进行了探讨性的研究。光纤SO2传感器在其结构上与气敏电极相似,所不同是采用感应膜光信号变化的特征而不用指示电极进行测定。由于测定方法不同才使它具有光纤化学传感器的特殊优点。

关键词：传感器换能器电子技术 SO2 感应膜气敏电极隔膜电极光导纤维导光纤维光学纤维染料染剂

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任意着陆状态下的飞机起落架模型仿真研究

系统仿真学报 2009年第13期21卷 3867-3871,3875页

作者：张雯张智朱齐丹贡鸣哈尔滨工程大学自动化学院哈尔滨150001

为支持舰载机的甲板降落研究而建立了一个任意着陆状态下的飞机起落架模型。为使该模型可以体现出飞机降落时的复杂姿态变化和每个起落架的反复压缩过程,采用了一种反向受力传递的分析方法,并将飞机的六自由度运动方程与三个起落架微分... 详细信息

为支持舰载机的甲板降落研究而建立了一个任意着陆状态下的飞机起落架模型。为使该模型可以体现出飞机降落时的复杂姿态变化和每个起落架的反复压缩过程,采用了一种反向受力传递的分析方法,并将飞机的六自由度运动方程与三个起落架微分方程联立。通过仿真分析得到此模型可以准确的体现飞机的任意着陆过程,而且基本上与实际物理过程相符。

关键词：任意着陆状态仿真起落架模型飞机的六自由度运动模型舰载机

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2-Pyrrole Carboxylic Acid Nitro-Phenylamide: New Colorimetric Sensor for Anion

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2-Pyrrole Carboxylic Acid Nitro-Phenylamide: New Colorimetri...