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Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

Tungsten 2025年第1期7卷 100-111页

作者： zhi-qi Zhang Liu Yang Wen Luo Vladimir An Jing Li Bao-Dan Liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

关键词： Low temperature activity Monolithic mesh catalysts NH3-SCR SO2 tolerance V2O5-WO3/TiO2

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Targeting A-type K+ channels in primary sensory neurons for bone cancer pain in a rat model

Targeting A-type K+ channels in primary sensory neurons for ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Kai-Zheng DUAN~(1,*),qian XU~(1,*),Xiao-Meng ZHANG~1,zhi-qi zhao~1,Yan-Ai MEI~2,Yu-qiu ZHANG~(1,*) 1 Institute of Neurobiology,2 School of Life Sciences,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

The treatment of bone cancer pain remains a clinically challenging ***,we report that A-type K channels in primary sensory neurons are involved in the neuropathy of rat bone cancer pain and are a new target for diclofenac,a non-steroidal anti-inflammatory drug that can be used for therapy for this distinct *** injection of diclofenac dose-dependently attenuated bone cancer-induced spontaneous pain,mechanical allodynia and thermal hyperalgesia,all of which were reversed or prevented by administration of the A-type K channel blockers 4-AP or pandinotoxin-Kαor with siRNA targeted against Kv1.4 or ***,diclofenac significantly inhibited action potential firing and rapidly increased A-type K currents in IB4-positive small dorsal root ganglion (DRG) neurons in both normal and bone cancer ***,in bone cancer rats the A-type K currents were significantly increased on post-tumor day 14(PTD 14);they then faded,but they still remained at a higher level on PTD ***,the expression levels of the A-type K channels Kvl.4,Kv3.4,and Kv4.3 showed timedependent changes during bone cancer *** diclofenac administration not only decreased soft tissue swelling adjacent to the tumor but also attenuated bone *** results indicate that A-type K channel modulators may provide a novel mechanism-based therapeutic strategy for bone cancer pain.

关键词： A-type K+ currents bone cancer pain diclofenac dorsal root ganglion rat

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SIP30 in the anterior cingulated cortex contributes to the induction of pain-related negative affect in rat

SIP30 in the anterior cingulated cortex contributes to the i...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mei HAN~1 Yan ZHANG~1 Ru-Yi HUANG~2 zhi-qi zhao~1 Yu-qiu ZHANG~(1 *) 1 Institutes of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China 2 Department of Life Science Fudan University Shanghai 200433 China

＜正＞Objective SNARE complex,including SNAβ-25,syntaxin and VAMP,plays an important role in presynaptic neurotransmitter ***β25 interacting protein of 30kD（SIP30）that was first identified in the cochlear hair cells of guinea pig organ of Corti is expressed in many organs but is most abundant in ***,its functional significance remains *** evidence demonstrates that the anterior cingulated cortex（ACC） is implicated in the affective response to noxious *** present study is to investigate whether SEP30 in the ACC play roles in pain-related negative affect in rat and its possible *** The localization of SEP30 was detected by *** chronic constriction injury（CCI） of sciatic nerve was used for neuropathic pain *** escape/avoidance paradigm （PEAβ） test was used to reflect the pain-related negative *** neural processing relating learning and memory was tested by conditioned place avoidance（CPA） induced by electric foot-shock or *** behavioral pain hypersensitivities were measured by Von Frey test for mechanical allodynia and Hargreves’test for thermal ***-ACC microinjection of SIP30 small interfering（siRNA） by letivirus as vector was used for knockdown the expression of SIP30. The efficiency of SIP30 knockdown in the ACC was tested by Western Blot and ***（1） SIP30 especially expressed on neuron not astrocyte or microglia in the rACC.（2） In the PEAβtest,the percentage of time spent in the light side of the chamber in the CCI group was much higher than that of sham group,which means PEA has occurred. （3） Compared with sham CCI group,SIP30 significantly upregulated in the rACC after PEAβtest in CCI group.（4） SIP30 knockdown in the rACC had no effect on CCI-induced pain hypersensitivities and innocuous stimuli-induced CPA.（5） Following SIP30 siRNA microinjected into the rACC,place escape/avoidance behavior to a noxious mechanical stimuli was attenua

关键词： SIP30 pain-related negative affect rACC rat

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Disrupting P2X7 receptors inhibited induction of long-term potentiation of C-fiber-evoked field potentials and Fos expression in spinal dorsal horn

Disrupting P2X7 receptors inhibited induction of long-term p...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yu-Xia CHU~(1,2),Ning LU~1,Yu-qiu ZHANG~1,zhi-qi zhao~(1,*) 1 Institute of Neurobiology,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China 2 College of Medicine,Jiaxing University,Jiaxing,314001,China

＜正＞Objective It has been shown that tetanically sciatic stimulation induces long-term potentiation（LTP） of C-fiberevoked field potentials in the spinal dorsal horn,which may be the substrate of inflammation- or nerve injury-produced central *** previous study showed that spinal glia was involved in the induction of *** that purinergic P2X7 receptor（P2X7R）is expressed by glia,the present study was to investigate the effects of P2X7R on tetanic stimulation-induced LTP and Fos expression in the dorsal horn of spinal *** The extracellular recording was performed on adult SD rats.C-fiber-evoked field potentials were induced by tetanic stimulation of the sciatic nerve（0.5 ms, 100 Hz,40V,10 trains of 2-s duration at 10-s intervals ）.The tetanic stimulation-induced expression of Fos and the distribution of P2X7R was identified by immunohistochemistry ***（1） Unilaterally tetanic stimuli elicited LTP of C-fiber-evoked field potentials.（2）The induction of spinal LTP was blocked by intrathecal（i.t.） administration of a specific antagonist of P2X7R Brilliant Blue G（20μM/10μl,i.t.） and a less specific oxidized ATP（300μM/10μl,i.t.） 0.5h prior to tetanic stimulation.（3）Intrathecal administration of Brilliant Blue G（20μM/10μl,i.t.） suppressed tetanic stimulation-induced spinal Fos expression.（4） Double immunofluorescence showed co-localization of P2X7R with OX42（microglia marker） and GFAP（astrocyte marker）,but not with NeuN（neuronal marker）.Conclusion Disruption of glial P2X7R may be associated with the inhibition of plastic change in spinal nociceptive *** of glial P2X7R may play an important role in the induction of tetanically sciatic stimulation-induced LTP.

关键词： LTP P2X7 spinal dorsal horn glial cells Fos

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Activation of p38/MAPK in the anterior cingulate cortex contributes to pain-related negative emotion in rats

Activation of p38/MAPK in the anterior cingulate cortex cont...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Hong CAO~(1,2),Gen-Cheng WU~2,zhi-qi zhao~1,Yu-qiu ZHANG~1 1 Institute of Neurobiology 2 Department of Integrative Medicine and Neurobiology,Institutes of Brain Research and State Key Laboratory of Medical Neurobiology Shanghai Medical College,Fudan University,Shanghai 200032,China

＜正＞Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, including a sensory-discriminative and an emotional-affective *** evidence from morphological, electrophysiological,neuroimaging,and behavioral studies as well as early clinical observation indicates that the anterior cingulate cortex（ACC） is involved in pain-related ***,little is known about the molecular and cellular mechanisms underlying pain-related aversion in *** previous studies showed that NMDAR-dependent ERK signaling cascade in rat ACC contributes to pain *** the present study we observed the role of p38,another member of MAP（mitogen-activated protein） kinase family,in ACC in pain-related negative emotion using Western Blot and behavioral ***-plantar injection of 5%formalin produced a robust increase in phosphorylated MKK3/6（pMKK3/6）,upstream of p38/MAPK,and phosphorylated p38（p-p38） in the bilateral rostral ACC（rACC）.Using formalin-induced conditioned place avoidance（F-CPA） in rats,which is believed to reflect the pain-related negative emotion,we found that blockade of p38/MAPK activation in the rACC with p38 inhibitor SB203580（0.1μg,1μg per side） but not low dose（0.01μg per side）,or another kind of p38 inhibitor SB239063（0.1μg,1μg per side） dose-dependently prevented the induction of ***,these blockades affected neither formalin-induced two-phase spontaneous pain nor low-intensity electric foot shock-induced CPA *** together,these results indicate that activation of p38/MAPK contributes to pain-related negative emotion,which will provide new molecule mechanisms underlying pain affect and bring new treatments for relieving emotional pain-related disturbance.

关键词： p38/MAPK formalin-induced conditioned place avoidance pain-related negative emotion anterior cingulate cortex rat

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The MAPK pathway involves in the bone cancer pain

The MAPK pathway involves in the bone cancer pain

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ting-Ting LI~1,Chao BIAN~1,zhi-qi zhao~1,Ru-Rong JI~2,Yu-qiu ZHANG~(1,*) 1 Institute of neurobiology,institutes of brain science and state key laboratory of medical neurobiology,Fudan University, shanghai 200032,China 2 Department of anesthesiology,Brigham and women''s hospital,Harvard medical school,Boston,Massachusetts 02115, USA

＜正＞Objective MAPKs are the evolutionally conserved molecules that play a critival role in intracellular signal transduction and consisit of extracellular signal-regulated protein kinase（ERK）,p38MAPK,c-Jun N-terminal kinase/ stress-activated protein kinase（JNK/SAPK）.It has been demonstrated that phosphorylated p38（p-p38） and phosphorylated extracellular signal-regulated kinasel/2（pERK1/2） are involved in inflammatory pain and neuropathic *** this study we futher investigate the role of two members of MAPKs in the cancer *** Walker256 mammary gland carcinoma cells were injected into the tibia medullary cavity to build a rat bone cancer pain *** method, behavioral test and histochemistry methods were used to test the development of bone cancer pain *** expression of p-p38 and pERK in the spinal dorsal horn of cancer pain model is tested by using immunohistochemistry and western blot ***（1） The significant bone destruction was observed on day 14 after the inoculation and the mechanical allodynia occurred in both hindpaws on day 8 and maintained to day 21 after inoculation.（2） p38 was activated mainly in neurons on the superficial of the spinal dorsal horn at 3 and 7 *** day 14,p-p38 was found in both neurons and microglia,but by day 21 predominantly in microglia.（3） ERK activation was found in neurons and microglia on the superficial of the spinal dorsal horn on day 3 after the ***,by 14 and 21 days after inoculation,all the neurons,astrocytes and microglia expressed pERK.（4） On day 14 after inoculation,the mechanical allodynia could be reduced by the administration of the inhibitors of p-p38 and pERK.（5） Microglia and astrocytes in the spinal dorsal horn were also activated on day 7 and lasted by day *** p-p38 and pERK as well as spinal glia cell activation are involved in bone cancer pain,and p-p38 and pERK may also play a role in spinal glia activation induced by cancer pain.

关键词： MAPK pathway spinal cord glia cells bone cancer pain

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NMDAR-dependent AC-ERK-CREB signaling pathway in the anterior cingulate cortex contributes to pain-related negative emotion

NMDAR-dependent AC-ERK-CREB signaling pathway in the anterio...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Hong CAO~1,Yong-Jing GAO~1,Wen-Hua REN~1,Yihui CUI~2,Ting-Ling LI~1,Xiaohua CAO~2,zhi-qi zhao~1,Ru-Rong JI~1,Yu-qiu ZHANG~1 1 Institute of Neurobiolgoy,Institutes of Brain Science,Fudan University,Shanghai,200032,China 2 Shanghai Institute of Brain Functional Genomics,The key laboratories of MOE and SSTC,East China Normal University, Shanghai,200062,China

＜正＞Pain is a multidimensional conscious experience including sensory and affective *** former has been extensively studied,while the latter is poorly *** evidence from morphological, electrophysiological,neuroimaging,and behavioral studies as well as clinical observations indicated that the anterior cingulated cortex（ACC） is a key structure that contributes to pain negative affect or *** of ERK （extracellular signal-regulated kinase）,a member of MAP（mitogen-activated protein） kinase family,in dorsal horn neurons of the spinal cord by peripheral noxious stimulation contributes to both short-term and long-term pain hypersensitivity. The overall goal of our study is to investigate the activation of ERK in the ACC and its contribution to persistent paininduced negative emotion using formalin-induced conditioned place avoidance（F-CPA） animal *** training, immunohistochemistry,Western blot,immunocytochemistry and eletrophysioloy methods were used in our experiments. Intraplantar（***.） injection of 5%formalin 50μ1 induced a rapid and sustained ERK activation in bilateral ACC neurons. Intra-ACC microinjection of MEK（MAP kinase kinase） inhibitor PD098059（0.2μg,2μg） or U0126（1μg） could significantly block the formation of F-CPA,but failed to affect formalin-induced nociceptive response and S-CPA（electric foot shockinduced conditioned place avoidance）,a fear conditioning *** of ACC slices with NMDA receptor agonist,NMDA（50μM）,Adenylyl cyclase（AC） activator,Forskolin（50μM） or cAMP-dependent protein kinase A（PKA） activator,Sp-cAMP（50μM） produced significant activation of ERK,which was suppressed by preincubation with corresponding respective antagonist APV（50μM） or 7-CK（50μM）,SQ22536（50μM） and Rp-cAMP（50μM）.Similarly,F-CPA was also blocked by premicroinjection in bilateral ACC of SQ22536（0.2μg,2μg） or Rp-cAMP（0.5μg,5μg）.Furthermore,formalin injection also produced significant CREB（cAMP response el

关键词： Anterior cingulate cortex ERK CREB F-CPA Pain emotion Rat

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Plasticity changes of central lateral nuclei by stimulation of the anterior cingulate cortex

Plasticity changes of central lateral nuclei by stimulation ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ling ZHANG~(1,2),Yu-qiu ZHANG~2,zhi-qi zhao~(2*) 1 Shanghai Institute of Brain Functional Genomics,East China Normal University,Shanghai,China 200062 2 Institute of Neurobiology,Fudan University,Shanghai 200032,China

＜正＞The anterior cingulate cortex and intralaminar thalamus are essential components in mediating the affective emotional-aspect of *** the present study,we applied in vivo extracelluar recording technique to examine the effects of tetanically electrical stimulation of the ACC on the nociceptive specific（NS） neurons of centra]lateral（CL） *** results showed that high frequency electrical stimulation of the ACC（200 Hz/2 s/4×） produced long-lasting excitation of the NS neurons in CL.A number of neurons changed their discharge patterns from single to burst after tetanic stimulation of the ***,retrograde tracing the neurons by fluoroglold（FG） showed that the positive neurons were distributed mainly in the bilateral of the *** results suggested that the ACC may exert top-down influences on and plastically changed the NS neurons of the CL,which could be the underline mechanism of pain related negative emotion.

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INTERACTION BETWEEN ELECTROACUPUNCTURE ANALGESIA AND EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS IN RAT WITH UNILATERAL INFLAMMATION OF THE HINDPAW

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神经解剖学杂志 2001年第S1期 122-122页

作者： Yu-qiu ZHANG~1, Guang-Chen JI~2, zhi-qi zhao~1, Gen-Cheng WU~2 ~1Institute of Neurobiology, Fudan University ~2State Key Laboratory of Medical Neurobiology, Medical Center of Fudan University, Shanghai, 200433

The analgesic interaction between electroacupuncture and intrathecal (i. t. ) administration of the non-selective excitatory amino acid receptor antagonist kynurenic acid (KYN) was investigated in a rat model of carrageenan inflammatory pain. The nociceptive threshold of the latency of paw withdraw (PWL) to a noxious thermal stimulation was measured. Electroacupuncture (EA) unilateral (ipsilateral to carrageenan-injected paw) 'Zu-San-Li (St 36) and 'Huantia' (GB30) noints (0.3 ms duration. 2 and 60 Hz alternatelv. 1-2-3 mA. each

关键词： RAT PWL INTERACTION BETWEEN ELECTROACUPUNCTURE ANALGESIA AND EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS IN RAT WITH UNILATERAL INFLAMMATION OF THE HINDPAW ACID

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-zhi Liu Yan-Bo Li qi Zhang Jun-zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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