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Nano Research 2017年第10期10卷 3285-3294页

作者： Wenjing zhang zhi-ping zhang Xian-En zhang Feng Li State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China National Laboratory ofBiomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Protein nanocages are ideal templates for the bio-inspired fabrication of nanomaterials due to several advantageous properties. During the mineralization of nanoparticles （NPs） inside protein nanocages, most studies have employed a common strategy： seed formation inside protein nanocages followed by seeded NP growth. However, the seed formation step is restricted to gentle reaction conditions to avoid damage to the protein nanocages, which may greatly limit the spectrum of seed materials used for NP growth. We put forward a simple route to circumvent such a limitation： encapsulation of a preformed NP as the seed via self-assembly, followed by the growth of an outer metal layer. Using such a method, we succeeded in mineralizing size-tunable Au NPs and Au@Ag core-shell NPs （〈10 nm in diameter） with narrow size distributions inside the virus-based NPs of simian virus 40. The present route enables the utilization of NPs synthesized under any conditions as the starting seeds for nanomaterial growth inside protein nanocages. Therefore, it potentially leads to novel bioinorganic chimeric nanomaterials with tailorable components and structures.

关键词： protein nanocages mineralization gold nanoparticles gold-silver core-shellnanoparticles self-assembly

A New Periodic Solution to Jacobi Elliptic Functions of MKdV Equation and BBM Equation

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Acta Mathematicae Applicatae Sinica 2012年第2期28卷 409-415页

作者： Hong-cai MA zhi-ping zhang Ai-ping DENG Department of Applied Mathematics College of Science Donghua University Shanghai 201620 China School of Mathematics and Information Sciences Henan University Kaifeng 475000 China

Based on the homogeneous balance method, the Jacobi elliptic expansion method and the auxiliary equation method, the first elliptic function equation is used to get a new kind of solutions of nonlinear evolution equations. New exact solutions to the Jacobi elliptic function of MKdV equations and Benjamin-Bona-Mahoney （BBM） equations are obtained with the aid of computer algebraic system Maple. The method is also valid for other （l＋l）-dimensional and higher dimensional systems.

关键词： (1+1)-dimensional MKdV equation BBM equation auxiliary equation method traveling wavesolution nonlinear

Synthesis,structure and property of serial p-carboxylphenoxyacetate-lanthanide coordination polymers

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Chinese Science Bulletin 2009年第23期54卷 4296-4302页

作者： CHEN zhi CUI ping zhang Yang ZHAO Bin Department of Chemistry Nankai University Tianjin 300071 China

Four novel lanthanide-based coordination polymers, [Ln(PBDC)(HPBDC)(H2O)3] (H2PBDC=p-carboxylphenoxyacetate; Ln = La (1), Pr (2), Nd (3)) and [La2(PBDC)3(H2O)4] (4), have been prepared through hydrothermal synthetic methods. Compounds 1―3 are isomorphous and exhibit one-dimensional (1D) chain-like motifs, while compound 4 features a complicated three-dimensional (3D) architecture, which is designed and synthesized based on the inspiration from the structure characterization of compound 1. Under the similar reaction conditions, the carboxyl in compound 1 may be further deprotonated by adding the organic base of 2,2'-bipyridine. This subtle change caused a significant difference in the structures, from 1D chain of 1 to a 3D structure of 4. In addition, IR, UV-Vis, TGA and magenetic properties are also investigated in this paper.

关键词：配位聚合物合成方法结构特性稀土财产序列三维结构化合物

Photoregulation of protein plasmid expression in vitro and in vivo using BHQ caging group

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Chinese Chemical Letters 2011年第3期22卷 338-341页

作者： zhi ping zhang Ming Li Xiao Yun Chen Qing Xiang Guo Department of Chemistry University of Science and Technology of China Hpfei 230026 China Department of Chemistry Tsinghua University Beijing 100084 China

Green fluorescent protein（GFP） plasmid was caged by 8-bromo-7-hydroxyquinolinyl chromophore（BHQ） for controlling its expression with exact spatiotemporal *** vitro and in vivo experiments clearly verified that,comparing with Bhc caging, the expression level of caged GFP plasmid was dramatically decreased and then efficiently restored after subsequent photolysis.

关键词： Photoregulation Caging(uncaging) BHQ Green fluorescent protein plasmid Photolysis

Strategies for Precise Engineering and Conjugation of Antibody Targeted-nanoparticles for Cancer Therapy

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Current Medical Science 2020年第3期40卷 463-473页

作者： Yuan-yuan GUO Lu HUANG zhi-ping zhang De-hao FU Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430077China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Improvements in the diagnosis and treatment of cancer are urgently needed for use in ***(NPs)can reduce the side effects of traditional chemotherapy by sustained release of loaded drugs and increase therapeutic *** can also enhance endothelial permeation retention by size effect and its accumulation in tumor cells through passive ***,it is critical to treat cancer with a controlled targeted drug which can be specifically delivered into tumor cells and released there,resulting in a targeted therapy to eradicate tumor cells while sparing normal *** this end,antibody-mediated targeting therapy has been developed,but imperfections in antibodies(Abs)limit this ***,the combination of NPs and Abs has been highly valued in recent years,because conjugating special Abs on the surface of NPs can increase targeting efficiency,enabling selective delivery of anti-cancer drugs to tumor *** this mini-review,we would like to enumerate the strategies for the conjugation of Abs to the surface of the NPs as well as the precise engineering of targeted *** application of targeting antibody fragments in this drug delivery system will also be discussed.

关键词： cancer drug delivery nanoparticle antibody conjugation

Photoinduced Electron Transfer in Dumbbell-type Fullerene Dyad

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Chinese Journal of Chemical Physics 2006年第5期19卷 433-437页

作者： Hui-yuan Hu Man-zhou Zhu zhi-ping zhang Guo-tao Wen Yao Fu Qing-xiang Guo Department of Chemistry University of Science and Technology of China Hefei 230026 China

1,3-Dipolar cycloaddition of DTE-azomethine ylides （DTE： dithienyl-ethene） to C60 in refluxed toluene was used to synthesize novel dumbbell-type fullerene dimer 1. For the sake of comparison, the monoadduct 2 were also synthesized. The molecular geometries of these two compounds were determined by theoretical calculations with HF-3/21G method. UV-Vis and fluorescence experiments were carried out in solvents with different polarity at the room temperature. All the results indicated the existence of a photoinduced intramolecular electron transfer process between the donor and acceptor moieties.

关键词： Fullerene Photophysical properties Photoinduced intramolecular electron transfer

Extracorporeal Membrane Oxygenation Support for Incessant Tachyarrhythmia-lnduced Severe Cardiogenic Shock

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Chinese Medical Journal 2018年第17期131卷 2139-2140页

作者： zhi-ping zhang Xi Su Jiang-You Wang Cheng-Wei Liu Department of Cardiology Wuhan Asia Heart Hospital Affiliated to Wuhan University of Science and Technology Wuhan Hubei 430022 China

To the Editor： Junctional ectopic tachycardia is uncommon; however, it is one of the most serious incessant supraventricular tachycardia. This tachyarrhythmia has a high association with tachycardia-induced cardiomyo... 详细信息

关键词： JUNCTIONAL ECTOPIC TACHYCARDIA DEFECTS

Arabidopsis AT-hook Protein TEK Positively Regulates the Expression of Arabinogalactan Proteins for Nexine Formation

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Molecular Plant 2015年第2期8卷 251-260页

作者： Qi-Shi dia Jun Zhu Xiao-Feng Xu Yue Lou Zhan-Lin zhang zhi-ping zhang Zhong-Nan Yang College of Life and Environment Sciences Shanghai Normal University Shanghai 200234 China National Key Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China College of Agriculture Henan University of Science and Technology Luoyang 471003 China

Nexine is a conserved layer of the pollen wall. We previously reported that the nexine layer is absent in the knockout mutant of Arabidopsis TRANSPOSABLE ELEMENT SILENCING VIA AT-HOOK （TEK） gene. In this study, we investigated the molecular regulatory functions of TEK in pollen development and identified the genes encoding Arabinogalactan proteins （AGPs） as direct targets of TEK, which are essential for nexine formation. Phenotypic similarity between tek and the TEK-SRDX transgenic lines suggest that TEK plays a role in transcriptional activation in anther development. Microarray analysis identified a total of 661 genes downregulated in tek, including four genes encoding AGPs, AGP6, AGP11, AGP23, and AGP40. Electrophoretic mobility shift assays showed that TEK could directly bind the nuclear matrix attachment region （MAR） and the promoter of AGP6. Chromatin immunoprecipitation followed by PCR analysis demonstrated that TEK is enriched in the promoters of the four AGP genes. Expression of AGP6 driven by the TEK promoter in tek partially rescued both nexine formation and plant fertility. These results indicate that TEK directly reg- ulates AGP expression in the anther to control nexine layer formation. We also proposed that glycoproteins might be essential components of the nexine laver in the oollen wall.

关键词： cell walls development pollen development nexine

Photoinduced Electron Transfer in Host-Guest Complexes of Naphthalene Derivatives with p-NBCD and m-NBCD

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Chinese Chemical Letters 2006年第3期17卷 333-336页

作者： Hui Yuan HU Man Zhou ZHU zhi ping zhang Guo Tao WEN Qing Xiang GUO Department of Chemistry University of Science and Technology of China Hefei 230026

A number of naphthalene derivatives containing adamantanamine binding moiety and an （CH2）. （n = 2, 3, 4, 5, 6） spacer were prepared as electron donor. A supramolecular assembly was fabricated by the inclusion complexation of the donor substrates with the host molecules, mono-6-O-p-nitrobenzoyl-β-cyclodextrin （p-NBCD） and mono-6-O-m-nitrobenzoyl-β-cyclodextrin （m-NBCD）, in water. The fluorescence quenching in these systems was studied and detailed Stern-Volmer constants were measured. It revealed that an efficient photoinduced electron transfers （PET） between the naphthalene donors and the cyclodextrin acceptors occurred.

关键词： Cyclodextrin fluorescence quenching photoinduced electron transfer supramolecule.

Continuous Mechanical Chest Compression-assisted Percutaneous Coronary Intervention in a Patient with Cardiac Arrest Complicating Acute Myocardial Infarction

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Chinese Medical Journal 2015年第6期128卷 846-848页

作者： zhi-ping zhang Xi Su Cheng-Wei Liu Dan Song Jian Peng Hua Yan Department of Cardiology Wuhan Asia Heart Hospital Wuhan Hubei 430022 China

Cardiac arrest with ventricular tachycardia or ventricular fibrillation in the catheterization laboratory is not uncommon, but patients who suffered cardiac arrest requiring prolonged cardiopulmonary resuscitation is not infrequent and still a major problem, because it is essentially impossible to perform effective manual chest compressions during percutaneous coronary interventions （PCIs）.

关键词： Cardiac Arrest Cardiopulmonary Resuscitation Myocardial Infarction Percutaneous Coronary Intervention