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Rac1 relieves neuronal injury induced by oxygen-glucose deprivation and re-oxygenation via regulation of mitochondrial biogenesis and function

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Neural Regeneration Research 2020年第10期15卷 1937-1946页

作者： ping-ping Xia Fan Zhang Cheng Chen zhi-Hua Wang Na Wang Long-yan Li Qu-Lian Guo zhi Ye Department of Anesthesiology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Central South UniversityChangshaHunan ProvinceChina Department of Anesthesiology Hainan General HospitalHaikouHainan ProvinceChina

Certain microRNAs(miRNAs)can function as neuroprotective factors after reperfusion/ischemia brain ***-142-3p can participate in the occurrence and development of tumors and myocardial ischemic injury by negatively regulating the activity of Rac1,but it remains unclear whether miRNA-142-3p also participates in cerebral ischemia/reperfusion *** this study,a model of oxygen-glucose deprivation/re-oxygenation in primary cortical neurons was established and the neurons were transfected with miR-142-3p agomirs or miR-142-3p ***-142-3p expression was down-regulated in neurons when exposed to oxygen-glucose deprivation/***-expression of miR-142-3p using its agomir remarkably promoted cell death and apoptosis induced by oxygen-glucose deprivation/re-oxygenation and improved mitochondrial biogenesis and function,including the expression of peroxisome proliferator-activated receptor-γcoactivator-1α,mitochondrial transcription factor A,and nuclear respiratory factor ***,the opposite effects were produced if miR-142-3p was *** reporter assays verified that Rac Family Small GTPase 1(Rac1)was a target gene of ***-expressed miR-142-3p inhibited NOX2 activity and expression of Rac1 and Rac1-GTPase(its activated form).miR-142-3p antagomirs had opposite effects after oxygen-glucose deprivation/*** results indicate that miR-142-3p down-regulates the expression and activation of Rac1,regulates mitochondrial biogenesis and function,and inhibits oxygen-glucose deprivation damage,thus exerting a neuroprotective *** experiments were approved by the Committee of Experimental Animal Use and Care of Central South University,China(approval No.201703346)on March 7,2017.

关键词： biogenesis ischemia/reperfusion injury microRNAs miR-142-3p mitochondria neuroprotection NOX2 oxygen-glucose deprivation Rac1

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Comparison and Relation between Crystal Structures and Magnetic Properties of Two Manganese(Ⅱ)Coordination Polymers Based on(Triazol-1-yl)iso/terephthalic Acid

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Chinese Journal of Structural Chemistry 2021年第11期40卷 1469-1474,1407页

作者： yan Juan-zhi ZHAO Dan LU Li-ping Taiyuan University Taiyuan 030032China Institute of Molecular Science Shanxi UniversityTaiyuan 030006China

One new Mn(Ⅱ)coordination polymer,[Mn(Htia)_(2)(H_(2)O)_(2)]_(n)·2nH_(2)O(1,H_(2)tia=4-(1,2,4-triazol-1-yl)isophthalic acid)has been synthesized in mixed solvents under solvothermal *** characterizations including single-crystal XRD,elemental analysis,IR spectroscopy,thermogravimetric analysis and powder XRD were performed to verify the *** 1 displays a one-dimensional(1D)chain and is similar to a reported Mn(II)complex 2{[Mn(Htta)_(2)(H_(2)O)_(2)]·2H_(2)O}_(n).It crystallizes in triclinic P1 space group,with a=7.5557(3),b=7.5974(3),c=11.8448(4)Å,α=90.088(1)°,β=95.863(1)°,γ=113.668(1)°,V=618.81(4)Å^(3),Z=1,M_(r)=591.36 g/mol,D_(c)=1.587 mg/m^(3),μ=0.609 mm^(-1),F(000)=303,GOOF=1.062,the final R=0.0359and w R=0.0818 for 4272 observed reflections with I>2σ(I).Based on two similar structures,Hirshfeld surface analysis confirmed both structures are mainly stabilized by O···H/H···O and C···H/H···C hydrogen ***,weak ferromagnetic behaviors between adjacent Mn(II)ions in 1D chain are obtained.

关键词： manganese(Ⅱ)complexes (triazol-1-yl)iso/terephthalic acid crystal structure Hirshfeld surface magnetic properties

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Microstructure,tensile properties and free bulge formability of Sr-and Y-containing AZ31 alloy sheet produced by twin-roll casting and sequential hot rolling

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Rare Metals 2020年第10期39卷 1202-1209页

作者： Peng Jiang Luo-Bin Li yan-Dong Yu Wang-ping Wu zhi-zhi Wang Yi Zhang Nai-Ming Miao School of Mechanical Engineering Changzhou High Technology Research Key Laboratory of Mould Advanced ManufacturingChangzhou UniversityChangzhou 213164.China Jiangsu Key Laboratory of Green Process Equipment Changzhou UniversityChangzhou 213164.China School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040China

The effects of Sr and Y on microstructure,tensile property and free bulge formability of AZ31 alloy sheet produced by twin-roll casting and sequential hot rolling were investigated to improve the mechanical properties and formability of the AZ31 *** and Y addition can form Al4 Sr,Al2 Y and Al3 Y phases which can impede dislocation movement and promote dynamic recrystallization during the rolling deformation and decrease the lattice resistance to dislocation motion by decreasing Al solubility in the alloy,resulting in finer grains,lower dislocation density and no twinning generating in the twin-roll casting and sequential hot rolling(TRC-HR)AZ31-1.3 Sr-1.0 Y *** maximum stress and elongation of the alloy increase significantly after adding Sr and *** average cavity and grain sizes of the TRC-HR AZ31-1.3 Sr-1.0 Y alloy are smaller,resulting in higher elongation in the *** addition of Y and Sr can effectively improve the free bulge formability and the thickness uniform of the *** Al4 Sr,Al2 Y and A13 Y phases can inhibit the grain growth by obstructing dislocation motion or grain boundary slip,resulting in smaller grain size of AZ31-1.3 Sr-1.0 Y alloy bulge parts.

关键词： AZ31 alloy Strontium Yttrium Twin-roll casting Tensile properties Free bulge formability

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优质三系杂交粳稻津优29制种技术

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天津农业科学 2002年第3期8卷 24-26页

作者：孙海波牛景邹美智李艳萍天津市水稻研究所天津300112

从父母本花期的预测和调节,提高结实率的技术措施,严格去杂、去劣3个方面阐述了优质杂交粳稻津优29的制种技术。

关键词：优质三次杂交粳稻津优29 制种技术

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Effects of pressure and plastic addition on sticking of fine iron ore particles in fluidized bed reduction

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Journal of Iron and Steel Research International 2021年第2期28卷 140-151页

作者： Qi-yan Xu Zhang-han Gu zhi-ping Li Ying-yi Zhang Hai-chuan Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

The adhesion of fine iron ore particles during fluidized bed reduction was studied using pressurized visible fluidized bed laboratory *** results showed that the optimal operating parameters for pure hydrogen reduction under high pressure were reduction temperature of 1073 K,particle size of 0.18-0.66 mm,pure H_(2) linear velocity of 0.8 m/s,reduction pressure of 200 kPa,and reduction time of 50 *** plastic particles were mixed into the fluidized bed,the optimal parameters were reduction temperature of 973 K,particle size of 0.18-0.66 mm,pure H_(2) linear velocity of 0.8 m/s,reduction pressure of 100 kPa,mass content of plastic particles of 8%,and reduction time of 65 *** chemical reaction resistance is much higher than the inner diffusion resistance at the initial stage of the reaction,whereas,in later stage,the inner diffusion resistance exceeds the chemical reaction *** contact area of iron atoms or iron whiskers gradually decreases with the increase in reduction pressure from 0.20 to 0.45 MPa,and the sticking trend gradually *** plastic particles in the fluidized reduction process of fine iron ore can effectively inhibit the adhesion among fine iron ore particles.

关键词： Fine iron ore Fluidized bed Reduction pressure Plastic particle Sticking Reduction

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Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor

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World Journal of Gastroenterology 2010年第37期16卷 4716-4724页

作者： Yun Zhang Hui Cao Ming Wang Wen-Yi Zhao zhi-Yong Shen Dan-ping Shen Xing-zhi Ni zhi-Yong Wu yan-Ying Shen yan-yan Song Department of General Surgery Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Pathology China Section of Statistics Teaching and Research Shanghai Jiao Tong University School of MedicineShanghai 200025China

AIM: To investigate loss of heterozygosity (LOH) of chromosome 9p21 and the prognostic relevance of p16 expression in gastrointestinal stromal tumor (GIST). METHODS: Fifty-one GIST patients (30 men and 21 women; median age 59 years; range 29-80 years) treated surgically within a 10-year period were grouped by aggressive behavior risk (17 with very low and low, 14 intermediate, and 20 high risk). GISTs were characterized immunohistochemically and evaluated for LOH of 9p21 by microsatellite analysis at D9S1751, D9S1846, D9S942, and D9S1748. LOH of 9p21 and immunohistochemicalexpression of p16 protein encoded at 9p21 were correlated with clinicopathological parameters, and the prognostic significance of p16 alterations was evaluated. RESULTS: Thirty-one (63.3%) cases showed LOH with at least one microsatellite marker. LOH frequency was 37.0% at D9S1751, 37.5% at D9S1846, 42.1% at D9S942, and 24.2% at D9S1748. There was a higher LOH frequency of D9S942 in high-risk than in non-highrisk tumors (P < 0.05, χ 2 = 4.47). Gender, age, tumor size and site were not correlated with allelic loss. Ninety percent (18/20) of the GIST patients in the high risk group showed LOH with at least one of the 9p21 markers, while 57.1% (8/14) in the intermediate risk group and 33.3% (5/15) in the very low and low risk groups, respectively (P < 0.05, χ 2 = 12.16). Eight (28.5%) of 31 patients with LOH and 1 (5.6%) of 18 patients without LOH died of the disease during the follow-up period. Loss of p16 protein expression occurred in 41.2%, but in 60% of the high risk group and 23.5% of the very low and low risk groups (P < 0.05, χ 2 = 4.98). p16 loss was associated with poor prognosis (P < 0.05, χ 2 = 4.18): the 3and 5-year overall survival rates were 84.8% and 70.8% for p16-negative and 100% and 92.0% for p16-positive patients, respectively. CONCLUSION: LOH at 9p21 appears to play an important role in GIST progression; decreased p16 expression in GIST is highly predictive of poor outcome.

关键词： Gastrointestinal stromal tumor Loss of heterozygosity p16 Prognosis Tumor suppressor gene

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Ablation Mechanism of Carbon/Carbon Composites Modified by HfC–SiC in Two Conditions Under Oxyacetylene Torch

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Journal of Materials Science & Technology 2017年第1期33卷 71-78页

作者： Ke-zhi Li Tao Duan Jia-ping Zhang Ning-Kun Liu Mao-yan Zhang State Key Laboratory of Solidification Processing Carbon/Carbon Composites Research Center Northwestern Polytechnical University Xi'an 710072 China

C/C-HfC-SiC composites prepared by precursor infiltration and pyrolysis process were ablated by oxyacetylene torch under two different flame conditions. The ablation performance of the composites was investigated in the heat flux of 2.38 MW/m2 （HF-L） and 4.18 MW/m2 （HF-H） for 60 s. The mechanical denudation in 4.18 MW/m2 （HF-H） was higher than that in 2.38 MW/m2 （HF-L）, while the results indicated that the composites had a similar and good ablation property under two different flame conditions. C/C- HfC-SiC composites can adapt the heat flux from 2.38 MW/m2 to 4.18 MW/m2. The Hf02 was not melted completely in the heat flux of 2.38 MW/m2 （HF-L）. So, both Hf02 and Si02 layers acted as an effective barrier to the transfer of heat and oxidative gases into the underlying carbon substrate. SiO2 was severely consumed in 4.18 MW/m2 （HF-H）, where the HfO2 molten layer played a more important role in protecting the inner composite.

关键词： Carbon/carbon composites Corrosion Ablation performance

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Effect of weld reinforcement on axial plastic buckling of welded steel cylindrical shells

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第2期13卷 79-90页

作者： Chu-lin YU zhi-ping CHEN Ji WANG Shun-juan yan Li-cai yanG Institute of Process Equipment Zhejiang UniversityHangzhou 310027China

The effect of weld reinforcement on axial plastic buckling of welded steel cylindrical shells is investigated through experimental and numerical buckling analysis using six welded steel cylindrical shell specimens. The relationship between the amplitude of weld reinforcement and the axial plastic buckling critical load is explored. The effect of the material yield strength and the number of circumferential welds on the axial plastic buckling is studied. Results show that circumferential weld reinforcement represents a severe imperfect form of axially compressed welded steel cylindrical shells and the axial plastic buckling critical load decreases with the increment of the mean amplitude of circumferential weld reinforcement. The material yield strength and the number of circumferential welds are found to have no significant effect on buckling waveforms; however, the axial plastic buckling critical load can be decreased to some extent with the increase of the number of circumferential welds.

关键词： Cylindrical shells Axial buckling Plastic Weld Reinforcement Geometric imperfections

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Effect of Spark Plasma Sintering Temperature on Electrochemical Properties of La_(0. 82)Mg_(0. 18)Ni_(3. 50)Co_(0. 15) Alloy

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Journal of Iron and Steel Research International 2016年第5期23卷 459-465页

作者： Xiao-ping DONG yan-rong PANG Li-ying yanG Qing WANG zhi-yuan LI Department of Mechanics Hebei University

Electrochemical properties of La_（0. 82）Mg_（0. 18）Ni_（3. 50）Co_（0. 15） alloys synthesized by spark plasma sintering（ SPS） were investigated based on the electrochemical measurements,physical parameters and microstructure observation. The sintering behavior of La_（0. 82）Mg_（0. 18）Ni_（3. 50）Co_（0. 15） alloys at the temperatures of 900,950 and 1 000 ℃ is characterized by four stages,i. e.,initial slight shrinkage,expansion,abrupt shrinkage and slight expansion. The maximum shrinkage displacement increases with increasing sintering temperature. All of the alloys consist of（ La,Mg）_2（ Ni,Co）_7 phase; additionally,temperatures of 900 and 950 ℃ are beneficial to the formation of（ La,Mg）（ Ni,Co）_3 phase,whereas the LaNi_5 phase is easy to form in the alloy synthesized by SPS at 1 000 ℃. The electrochemical measurements indicate an evident change of the electrochemical performance of the alloys associated with increasing the sintering temperature. The discharge capacity of the alloys first increases and then decreases as sintering temperature rises,whereas their cycle stability clearly grows all the ***,the charging-discharging potential difference and discharging efficiency both demonstrate that the electrochemical properties of the alloy electrodes first augment and then decline with increasing sintering temperature.

关键词： spark plasma sintering La-Mg-Ni system microstructure electrochemical property

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Nanometer Stripe Microstructure of Supersaturated Solid Solution in Fe-Cu Alloy

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Journal of Iron and Steel Research International 2007年第1期14卷 64-68页

作者： REN Hui-ping WANG Hai-yan LIU Zong-chang AN zhi-guo College of Material and Metallurgy Engineering Inner Mongolia University of Science and TechnologyBaotou 014010 Inner Mongolia China

Strengthening due to precipitation of Cu in the a-Fe matrix is an important phenomenon utilized in the design of HSLA steels. In the present work, the microstructure of supersaturated solid solution in Fe-1.18%Cu binary alloy was investigated by means of high resolution electron microscopy. The results indicated that the solid solution was heterogeneous, there were lots of Cu atom clusters, which consisted of diffractive stripe microstructure similar to twin crystal. Orientation deviation was observed between two （110）o planes in diffractive stripes, which results in light and shade contrast. Furthermore, formation mechanisms of the nanometre stripe microstructure were discussed in terms of the interaction of Cu and Fe atoms in the Fe-Cu binary alloys.

关键词： Fe-Cu alloy supersaturated solid solution Cu-rich cluster nanometer stripe microstructure high resolution electron microscopy

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