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Core and variable antimicrobial resistance genes in the gut microbiomes of Chinese and European pigs

Zoological Research 2024年第1期45卷 189-200页

作者： Cui-Hong Tong zhi-peng huo Lu Diao Dan-Yu Xiao Ruo-Nan Zhao Zhen-Ling Zeng Wen-Guang Xiong Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation South China Agricultural UniversityGuangzhouGuangdong 510642China National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria College of Veterinary MedicineSouth China Agricultural UniversityGuangzhouGuangdong 510642China National Laboratory of Safety Evaluation(Environmental Assessment)of Veterinary Drugs South China Agricultural UniversityGuangzhouGuangdong 510642China National Reference Laboratory of Veterinary Drug Residues South China Agricultural UniversityGuangzhouGuangdong 510642China

Monitoring the prevalence of antimicrobial resistance genes(ARGs)is vital for addressing the global crisis of antibiotic-resistant bacterial *** its importance,the characterization of ARGs and microbiome structures,as well as the identification of indicators for routine ARG monitoring in pig farms,are still lacking,particularly concerning variations in antimicrobial exposure in different countries or ***,metagenomics and random forest machine learning were used to elucidate the ARG profiles,microbiome structures,and ARG contamination indicators in pig manure under different antimicrobial pressures between China and *** showed that Chinese pigs exposed to high-level antimicrobials exhibited higher total and plasmid-mediated ARG abundances compared to those in European pigs(P<0.05).ANT(6)-Ib,APH(3')-IIIa,and tet(40)were identified as shared core ARGs between the two pig ***,the core ARGs identified in pig populations were correlated with those found in human populations within the same geographical *** and Prevotella were identified as the dominant genera in the core microbiomes of Chinese and European pigs,*** ARG markers and 43 biomarkers were able to differentiate between the Chinese and European pig manure samples with accuracies of 100%and 98.7%,*** for assessing ARG contamination in Chinese and European pigs also achieved high accuracy(r=0.72-0.88).Escherichia flexneri in both Chinese and European pig populations carried between 21 and 37 *** results of this study emphasize the importance of global collaboration in reducing antimicrobial resistance risk and provide validated indicators for evaluating the risk of ARG contamination in pig farms.

关键词： Metagenomic Pig manure Antimicrobial pressure Antimicrobial resistance genes Microbiome

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Method for identifying effective carbonate source rocks:a case study from Middle-Upper Ordovician in Tarim Basin,China

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Petroleum Science 2020年第6期17卷 1491-1511页

作者： Jun-Qing Chen Xiong-Qi Pang Song Wu Zhuo-Heng Chen Mei-Ling Hu Luo-Fu Liu Kui-You Ma Bo Pang zhi-peng huo State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of PetroleumBeijing 102249China College of Geoscience China University of PetroleumBeijing 102249China Geological Survey of Canada CalgaryAB T2L 2A7Canada Research Institute of Petroleum Exploration and Development PetroChina Huabei Oilfi eld CompanyRenqiu 062550HebeiChina China University of Geosciences Beijing 100083China

Hydrocarbon expulsion occurs only when pore fluid pressure due to hydrocarbon generation in source rock exceeds the force against migration in the adjacent carrier *** the Middle-Upper Ordovician carbonate source rock of Tarim Basin in China as an example,this paper proposes a method that identifies effective carbonate source rock based on the principles of mass *** from the Well YW2 indicate that the Middle Ordovician Yijianfang Formation contains effective carbonate source rocks with low present-day *** and geochemical analysis suggests that the hydrocarbons in the carbonate interval are likely self-generated and *** steranes from GC-MS analysis of oil extracts in this interval display similar features to those of the crude oil samples in Tabei area,indicating that the crude oil probably was migrated from the effective source *** applying to other wells in the basin,the identified effective carbonate source rocks and non-source rock carbonates can be effectively identified and consistent with the actual exploration results,validating the *** the contribution from the identified effective source rocks with low present-day TOC(TOC_(pd))is considered,the long-standing puzzle between the proved 3 P oil reserves and estimated resources in the basin can be reasonably explained.

关键词： Effective carbonate source rock Mass balance approach Low present-day TOC Ordovician Tarim Basin

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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Shear band evolution and acoustic emission characteristics of sandstone containing non-persistent flaws

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 497-513页

作者： Shuting Miao peng-zhi Pan Chuanqing Zhang Lei huo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China CASIC Research Institute of Intelligent Decision Engineering Wuhan430040China

Direct shear tests were conducted on sandstone specimens under different constant normal stresses to study the coalescence of cracks between non-persistent flaws and the shear sliding characteristics of the shear-formed *** image correlation and acoustic emission(AE)techniques were used to monitor the evolution of shear bands at the rock bridge area and microcracking *** experimental results revealed that the shear stresses corresponding to the peak and sub-peak in the stressdisplacement curve are significantly affected by the normal *** localization bands emerged at both the tip of joints and the rock bridge,and their extension and interaction near the peak stress caused a surge in the AE hit rate and a significant decrease in the AE b *** and curvilinear strain bands were detected at low normal stress,while high normal stress generally led to more microcracking events and longer coplanar cracks at the rock bridge ***,an increase in normal stress resulted in a higher AE count rate and more energetic AE events during friction sliding along the shearformed *** was observed that the elastic energy released during the crack coalescence at the prepeak stage was much greater than that released during friction sliding at the post-peak *** than 75%of AE events were located in the low-frequency band(0e100 kHz),and this proportion continued to rise with increasing normal ***,more AE events of low AF value and high RA value were observed in specimens subjected to high normal stress,indicating that greater normal stress led to more microcracks of shear nature.

关键词： Shear band evolution Acoustic emission(AE) Crack coalescence Normal stress Shear sliding

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不同体系金属加工液表面性能研究

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润滑油 2017年第5期32卷 33-35页

作者：郎需进张杰尤龙刚陈志忠火鹏飞中国石油兰州润滑油研究开发中心甘肃兰州730060

研究了油基金属加工液的运动黏度及水基金属加工液的表面张力变化对产品沉降性能和浸润性能的影响。结果表明,低黏度油基金属加工液浸润性能优于高黏度油基金属加工液,有利于金属碎屑的沉降;含有表面活性剂的乳化型金属加工液、微乳型... 详细信息

研究了油基金属加工液的运动黏度及水基金属加工液的表面张力变化对产品沉降性能和浸润性能的影响。结果表明,低黏度油基金属加工液浸润性能优于高黏度油基金属加工液,有利于金属碎屑的沉降;含有表面活性剂的乳化型金属加工液、微乳型金属加工液的沉降性能、浸润性能大幅提高。

关键词：金属加工液黏度沉降性能浸润性能

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Sulfite as the substrate of C-sulfonate metabolism ofα,β-unsaturated carbonyl containing andrographolide:analysis of sulfite in rats'intestinal tract and the reaction kinetics of andrographolide with sulfite

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Chinese Journal of Natural Medicines 2021年第9期19卷 706-712页

作者： huo zhi-peng FENG Xin-Chi WANG Yu TIAN Yu-Ting QIU Feng School of Chinese Materia Medica and State Key Laboratory of Component-based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China ~TCM Research Center Tasly AcademyTasly Holding Group Co.Ltd.Tianjin 300402China State Key Laboratory of Critical Technology in Innovative Chinese Medicine Tasly Pharmaceutical Co.Ltd.Tianjin 300402China Institute of Pharmacy China Pharmaceutical UniversityNanjing 210009China Institute of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300072China

One-sixth of the currently known natural products containα,β-unsaturated carbonyl *** previous studies reported a rare C-sulfonate metabolic *** groups were linked to theβ-carbon ofα,β-unsaturated carbonyl-based natural compounds through this ***,the mechanism of this type of metabolism is still not fully understood,especially whether it is formed through enzyme-mediated biotransformation or direct sulfite *** this work,the enzyme-mediated and non-enzymatic pathways were ***,the sulfite content in rat intestine was determined by LC-MS/*** results showed that the amount of sulfite in rat intestinal contents was from 41.5 to 383μg·g^(-1),whereas the amount of sulfite in rat feed was lower than the lower limit of quantitation(20μg·g^(-1)).Second,the reaction kinetics of sulfite-andrographolide reactions in phosphate buffer solutions(pH 6-8)was *** half-lives of andrographolide ranged from minutes to *** was suggested that the C-sulfonate reaction of andrographolide was very ***,the C-sulfonate metabolites of andrographolide were both detected when andrographolide and L-cysteine-S-conjugate andrographolide were incubated with the rat small intestine contents or sulfite,indicating that the sulfite amount in rat intestine contents was high enough to react with andrographolide,which assisted a significant portion of andrographolide ***,the comparison of andrographolide metabolite profiles among liver homogenate(with NADPH),liver S9(with NADPH),small intestine contents homogenate(with no NADPH),and sulfite solution incubations showed that the C-sulfonate metabolites were predominantly generated in the intestinal tract by non-enzymatic *** summary,sulfite can serve as a substrate for C-sulfonate metabolism,and these results identified non-enzymatically nucleophilic addition as the potential mechanism for C-sulfonate metabolism of compounds containingα,β-unsaturated carbonyl moie

关键词： Sulfite C-Sulfonate metabolites α,β-Unsaturated carbonyl Reaction kinetics Andrographolide Non-enzymatic

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Tailoring Morphology of PVDF-HFP Membrane via One-step Reactive Vapor Induced Phase Separation for Efficient Oil-Water Separation

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Chinese Journal of Polymer Science 2021年第5期39卷 610-619,I0007页

作者： peng huo Cheng-Tang Zhong Xiao-peng Xiong Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China

Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)receives increasing attention in membrane separation field based on its advantages such as high mechanical strength,thermal and chemical ***,controlling the microporous structure is still *** this work,we attempted to tailor the morphology of PVDF-HFP membrane via a one-step reactive vapor induced phase separation ***,PVDF-HFP was dissolved in a volatile solvent and then was cast in an ammonia water vapor *** complete evaporation of solvent,membranes with adjustable porous structure were prepared,and the microstructures of the membranes were analyzed by scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and X-ray diffraction *** on the results,a mechanism of dehydrofluorination induced cross-linking of PVDF-HFP has been suggested to understand the morphology *** our knowledge,this is the first report of one-step reactive vapor induced phase separation strategy to tailor morphology of PVDF-HFP *** addition,the membranes prepared in the ammonia water vapor exhibited enhanced mechanical strength and achieved satisfactory separation efficiency for water-in-oil emulsions,suggesting promising potential.

关键词： PVDF-HFP Membrane Tailoring Vapor induced phase separation Oil-water separation

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HPLC-ELSD法测定壳寡糖降解液中氨基葡萄糖盐酸盐

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广州化工 2017年第19期45卷 93-96页

作者：张志鹏活泼李成平叶露单海峰饶桂维浙江树人大学生物与环境工程学院浙江杭州310015 杭州民生药业有限公司质检中心浙江杭州311199 瑞安市人民医院制剂室浙江瑞安325200

建立HPLC-ELSD测定壳寡糖降解液中氨基葡萄糖含量的分析方法。用单因素和正交试验对壳寡糖微波条件进行优化,确定最佳降解条件:30%盐酸,功率300 W,时间60 min,料液比1∶20。色谱条件:Prevail Carbohydrate ES柱(4.6 mm×250 mm,5μm),... 详细信息

建立HPLC-ELSD测定壳寡糖降解液中氨基葡萄糖含量的分析方法。用单因素和正交试验对壳寡糖微波条件进行优化,确定最佳降解条件:30%盐酸,功率300 W,时间60 min,料液比1∶20。色谱条件:Prevail Carbohydrate ES柱(4.6 mm×250 mm,5μm),流动相乙腈-水(75∶25),流速1.0 m L·min^(-1)。ELSD漂移管温度:60℃;载气流量:1.5 L/min;进量样5μL,柱温30℃。氨基葡萄糖盐酸盐的质量浓度对数在0.1~0.8 mg/m L与色谱峰面积对数呈良好线性关系,相关系数为r=0.9987,回收率在83.3%~95.5%之间,相对标准偏差为3.9%(n=9)。

关键词： HPLC-ELSD 壳寡糖微波降解氨基葡萄糖盐酸盐

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Friction of graphene on a substrate with a cavity defect

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Science China(Technological Sciences) 2024年第9期67卷 2834-2841页

作者： ZHOU peng huo ZhanLei CHANG TienChong Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China The Center for Computational Mechanics and Engineering Applications Provincial Mechanics Experimental Teaching Demonstration CenterSchool of Civil EngineeringHebei University of EngineeringHandan 056038China Shanghai Institute of Aircraft Mechanics and Control Tongji UniversityShanghai 200092China Joint-Research Center for Computational Materials Zhejiang LaboratoryHangzhou 311100China

The frictional behavior of supported graphene is known to be influenced by the physical properties and surface morphologies of the underlying substrate. However, it is unclear how a surface defect on the substrate affects the friction of supported graphene,and it is even unknown how to define the defect-induced friction force in this context. Here we conduct molecular dynamics(MD) simulations to investigate the friction between a square diamond slider and a graphene sheet supported by a copper substrate with a surface cavity defect. Our results demonstrate that the defect-induced friction exhibits a nonlinear increase with cavity size, while it decreases nonlinearly with slider size. We propose that the definition of defect-induced friction can be linked to the increase in friction work over the length of the slider, and is closely correlated to the defect-induced relative change in indentation depth and the ratio of the cavity area to the contact area. These findings provide a comprehensive evaluation of the impact of a substrate cavity defect on the friction of supported graphene and offer insights that may have broader implications for understanding defect-induced friction in other two-dimensional materials.

关键词： friction graphene underneath substrate cavity defect

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