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Development and validation of a machine learning-based early prediction model for massive intraoperative bleeding in patients with primary hepatic malignancies

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 90-101页

作者： Jin li Yu-Ming Jia zhi-Lei Zhang Cheng-Yu liu Zhan-Wu Jiang zhi-Wei Hao li pen. Department of Hepatological Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of General Surgery II Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Surgical resection remains the primary treatment for hepatic malignancies,and intraoperative bleeding is associated with a significantly increased risk of ***,accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective *** To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and *** The retrospective analysis enrolled patients diagnosed with primary hepatic malignancies who underwent surgery at the Hepatobiliary Surgery Department of the Fourth Hospital of Hebei Medical University between 2010 and *** regression analysis was performed to identify potential risk factors for intraoperative bleeding.A prediction model was developed using Python programming language,and its accuracy was evaluated using receiver operating characteristic(ROC)curve *** Among 406 primary liver cancer patients,16.0%(65/406)suffered massive intraoperative *** regression analysis identified four variables as associated with intraoperative bleeding in these patients:ascites[odds ratio(OR):22.839;Plirubin score(OR:2.361;Plity to predict intraoperative bleeding were 0.844 in the training set and 0.80 in the prediction *** The developed and validated model predicts significant intraoperative blood loss in primary hepatic malignancies using four preoperative clinical factors by considering four preoperative clinical factors:ascites,history of alcohol consumption,TNM staging,and albumin-bilirubin ***

关键词： Primary liver cancer Intraoperative bleeding Machine learning Model

Interface strengthening for thermal sprayed WC-10Co4Cr coating subjected to pulsed magnetic treatment

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Rare Metals 2024年第2期43卷 780-795页

作者： Cheng-Kai Qian Qu liu Heng Wang Ke-Jian li zhi-pen. Cai Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Tianjin Research Institute for Advanced Equipment Tsinghua UniversityTianjin300304China State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China

The reliability of the coated industry components demands ideal fatigue properties of the coating,and it is mainly determined by the performance of the *** this study,pulsed magnetic treatment(PMT)was applied to the thermal sprayed WC-10Co4Cr coating,and the fatigue lifetime of the coated bolt increased by 219.82%under an imitation of the operating mode *** tests further proved that both the adhesion and cohesion strength were improved after PMT,and they benefit from the interface strengthening *** formation of coherent WC/Co interfaces was characterized by in-situ transmission electron microscopy(TEM),and the molecular dynamic simulations indicate that the work of separation of these interfaces is much higher than the original disordered *** stress was relaxed and distributed more homogeneously after PMT,and it mainly contributes to the coating/substrate *** work provides a new post-treatment method focusing on the interfaces in the WC-based coating and gives insight into its mechanism so that it is hopeful to be applied to other kinds of coatings.

关键词： Cemented carbide coating Pulsed magnetic treatment Interface strengthening Fatigue properties Adhesion strength

Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-Qiang Zhang Qing-lin Cheng Wei Sun Yi Zhao zhi-Min li Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu zhi-Hao Xie Jun li Shi Tao Fang-li Ren Yin-Yin Wang zhi-Jie Chang Xin-Bao Hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya Beijing Med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease: A multi-centre,randomised, double-blind, placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi li liang-ji liu Jia-bing Tong zhi-hui Lan Shu-guang Tian Qiao li Xiang-li Tong Ji-feng Wu Zhen-gang Zhu Su-yun li Jian-sheng li Department of Respiratory Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine Graduate School Anhui University of Traditional Chinese Medicine Department of Respiratory Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese Medicine Department of Respiratory and Critical Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western Medicine Department of Respiratory Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province

Background: Chronic obstructive pulmonary disease(COPD), a common respiratory disease, can be effectively treated by traditional Chinese medicine(TCM). Qingfei Huatan, a TCM formula, has been reported to effectively alleviate the clinical symptoms of COPD patients. However, there is a lack of multi-centre,randomised, double-blind, controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective: This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD, thereby providing high-quality clinical ***, setting, participants and interventions: A total of 276 patients with AECOPD were included in this multi-centre, randomised, double-blind, placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:1. Patients in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day, for 14 days, in addition to Western medicine treatment. All patients were followed up for 3 *** outcome measures: The primary outcome was time taken to symptom stabilisation. The secondary outcomes included duration of antibiotic use, clinical symptom and sign score, TCM syndrome score, dyspnoea score, and quality of life(QOL) score. Meanwhile, the safety of the formula was assessed through routine urine and stool tests, electrocardiograms, liver and kidney function tests, and the observation of adverse events throughout the ***: The time taken for effective stabilisation(P lisation(P linical symptom and sign score decreased in both groups,particularly in the treatment group(P < 0.01). On days 9, 12 and 14 of treatment, the TCM syndrome scores of both groups were reduced(P

关键词： Acute exacerbation of chronic obstructive pulmonary disease Clinical trial Syndrome of phlegm-heat congesting lung Qingfei Huatan formula Traditional Chinese medicine

Metallurgy and Solidification Microstructure Control of Fusion-Based Additive Manufacturing Fabricated Metallic Alloys:A Review

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 29-53页

作者： Qiang li Xing-Ran li Bai-Xin Dong Xiao-Long Zhang Shi-li Shu Feng Qiu Lai-Chang Zhang zhi-Hui Zhang Key Laboratory of Bionic Engineering(Ministry of Education) and College of Bionic Science and EngineeringJilin UniversityChangchun130022China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun130025China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130025China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

The metal-based additive manufacturing(AM),also referred to as metal 3D printing,has drawn particular interest because it enables direct creation,aided by computationally-directed path design,of intricate components with site-specific compositions and geometrical requirements as well as low buy-to-fly *** the last two decades,the objective of this revolutionary technology has been shifting from only“rapid prototyping”to advanced manufacturing of special high-end products or devices,which,in many aspects,outperform conventional manufacturing *** fusion-based AM,significant progress has been achieved in understanding the processing window of macroscopic scales,non-equilibrium metallurgy of mesoscale scales,and grain evolution of microscopic *** the versatile capacity of AM facilitates new avenues for discovering advanced materials and structures,their potential has still not been fully *** the unique non-equilibrium solidification during the AM process,coarse columnar grains with strong textures are usually developed along the build direction,which downgrades the mechanical *** push the limits of this digital manufacturing,this review attempts to provide in-depth and comprehensive overviews of the recent progress in understanding the evolution and control of the as-built microstructure that has been made recently and the challenges encountered during the AM process.

关键词： Additive manufacturing Temperature field Microstructure control Nanoparticles Functionally graded materials

Constraints on Characteristics and Distribution of Gas Hydrate and Free Gas Using Broad-Band Processing of Three-Dimensional Seismic Data

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Journal of Ocean University of China 2024年第5期23卷 1233-1247页

作者： WANG Xiujuan ZHOU Jilin li Sanzhong li lixia li Jie li Yuanping WANG linfei SU Pibo JIN Jiapen. GONG zhi State Key Laboratory of Offshore Natural Gas Hydrate Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Submarine Geosciences and Prospecting Techniques MOE and College of Marine Geosciences Ocean University of China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology Center CNOOC Research Institute Co. Ltd. CNOOC China limited Shenzhen Branch Guangzhou Marine Geological Survey China Geological Survey

Gas hydrate drilling expeditions in the Pearl River Mouth Basin, South China Sea, have identified concentrated gas hydrates with variable thickness. Moreover, free gas and the coexistence of gas hydrate and free gas have been confirmed by logging, coring, and production tests in the foraminifera-rich silty sediments with complex bottom-simulating reflectors(BSRs). The broad-band processing is conducted on conventional three-dimensional(3D) seismic data to improve the image and detection accuracy of gas hydratebearing layers and delineate the saturation and thickness of gas hydrate-and free gas-bearing sediments. Several geophysical attributes extracted along the base of the gas hydrate stability zone are used to demonstrate the variable distribution and the controlling factors for the differential enrichment of gas hydrate. The inverted gas hydrate saturation at the production zone is over 40% with a thickness of 90 m, showing the interbedded distribution with different boundaries between gas hydrate-and free gas-bearing layers. However, the gas hydrate saturation value at the adjacent canyon is 70%, with 30-m-thick patches and linear features. The lithological and fault controls on gas hydrate and free gas distributions are demonstrated by tracing each gas hydrate-bearing layer. Moreover, the BSR depths based on broad-band reprocessed 3D seismic data not only exhibit variations due to small-scale topographic changes caused by seafloor sedimentation and erosion but also show the upward shift of BSR and the blocky distribution of the coexistence of gas hydrate and free gas in the Pearl River Mouth Basin.

关键词： broad-band processing free gas gas hydrate shift of BSR

On the Viability of Solutions to Conformable Stochastic Differential Equations

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Journal of Partial Differential Equations 2024年第1期37卷 47-58页

作者： XU liping li zhi School of Information and Mathematics Yangtze UniversityJingzhou 434023China.

The viability of the conformable stochastic differential equations is *** necessary and sufficient conditions in terms of the distance function to K are *** addition,when the boundary of K is sufficiently smooth,our necessary and sufficient conditions can reduce to two relations just on the boundary of ***,an example is given to illustrate our main results.

关键词： Viability conformable derivatives conformable stochastic differential equation.

Cone-beam computed tomography noise reduction method based on U-Net with convolutional block attention module in proton therapy

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Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan Xiu-Fang li Meng-Ya Guo Mei Chen Ming Lv Rui li zhi-ling Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index