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Next-generation antibody-drug conjugates revolutionize the precise classification and treatment of HER2-expressing breast cancer

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Cancer Biology & Medicine 2023年第10期20卷 689-694页

作者： Lei-Jie Dai Yu-Wei Li Ding ma zhi-ming Shao Yi-Zhou Jiang Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China

The concept of antibody±drug conjugations(ADCs)can be tracked back to the early 20^(th) century when the renowned immunologist,Paul Ehrlich,proposed the idea of a"magic bullet",which utilizes ADCs for targeted destruction of microorganisms and tumor cells^(1).After nearly one century of development,ADCs have emerged as a rather promising approach in the treatment of cancer,especially breast cancer,which is the most common malignant tumor in women^(2).

关键词： breast Ehrlich treatment

Effect of increasing rainfall on the thermal–moisture dynamics of permafrost active layer in the central Qinghai–Tibet Plateau

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Journal of Mountain Science 2021年第11期18卷 2929-2945页

作者： ZHOU zhi-xiong ZHOU Feng-xi ZHANG ming-li LEI Bing-bing ma Zhao College of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environmental and ResourcesChinese Academy of SciencesLanzhou 730000China Geological Hazards Prevention Institute Gansu Academy of SciencesLanzhou 730000China

In the past several decades,the trend of rainfall have been significantly increasing in the Qinghai–Tibet Plateau,which inevitably leads to a change in the surface energy balance processes and thermal-moisture status of the permafrost active ***,the influence of mechanisms and associated effects of increasing rainfall on active layers are still poorly ***,in this study,a validated coupled numerical water–vapor–heat model was applied for simulating the surface energy components,liquid and vapor water migration,and energy transfer within the permafrost active layer under the action of increasing rainfallin the case of an especially wet *** obtained results demonstrate that the surface heat flux decreaseswith the increase in rainfall,and the dominant form of energy exchange between the ground and atmospherebecomes the latent heatflux,which is beneficial for the preservation of *** increasing rainfall will also cause the migration of liquid and vapor water,and the migration of liquid will be more *** liquid and vapor water migrationcaused by the increasing rainfallis also accompanied by energy *** the increase in rainfall,the decrease in total soil heat flux directly leads to a cooling effect on the soil,and then the upper limit of the frozen soil rises,which alleviates the degradation of *** results provide further insights into engineering structures,regional ecological climate change,hydrology,and environmental issues in permafrost regions.

关键词： Active layer Rainfall Qinghai–Tibet Plateau(QTP) Thermal–moisture dynamics Numerical modeling

Factors associated with early recurrence after curative surgery for gastric cancer

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World Journal of Gastroenterology 2015年第19期21卷 5934-5940页

作者： Wei-ming Kang Qing-Bin Meng Jian-Chun Yu zhi-Qiang ma zhi-Tian Li Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Department of Gastrointestinal Surgery First Hospital of Wuhan City

AIM: To characterize patterns of gastric cancer recurrence and patient survival and to identify predictors of early recurrence after ***: Clinicopathological data for 417 consecutive patients who underwent curative resection for gastric cancer were retrospectively analyzed. Tumor and node status was reclassified according to the 7th edition of the American Joint Committee on Cancer tumor-node-metastasis classification for carcinoma of the stomach. Survival data came from both the patients' follow-up records and telephone *** gastric cancer was diagnosed based on clinical imaging, gastroscopy with biopsy, and/or cytological examination of ascites, or intraoperative findings in patients who underwent *** of early recurrence were compared in patients with pT1 and pT2-4a stage tumors. Pearson's χ 2 test and Fisher's exact test were used to compare differences between categorical variables. Survival curves were constructed using the Kaplan-Meier method and compared via the log-rank test. Variables identified as potentially important for early recurrence using univariate analysis were determined by multivariate logistic regression ***: Of 417 gastric cancer patients, 80(19.2%)were diagnosed with early gastric cancer and the remaining 337(80.8%) were diagnosed with locally advanced gastric cancer. After a median follow-up period of 56 mo, 194 patients(46.5%) experiencedrecurrence. The mean time from curative surgery to recurrence in these 194 patients was 24 ± 18 mo(range, 1-84 mo). Additionally, of these 194 patients,129(66.5%) experienced recurrence within 2 years after surgery. There was no significant difference in recurrence patterns between early and late recurrence(P < 0.05 each). For pT1 stage gastric cancer, tumor size(P = 0.011) and pN stage(P = 0.048) were associated with early recurrence of gastric *** age, pT stage, pN stage, Lauren histotype,lymphovascular invasion, intraoperative chemothe

关键词： Stomach neoplasms Gastrectomy D2lymphadenectomy Recurrence Chemotherapy

The endoparasitoid Psyllaephagus arenarius benefits from ectoparasitic venom via multiparasitism with the ectoparasitoid Tamarixia lyciumi

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Insect Science 2020年第4期27卷 815-825页

作者： Peng-Xiang Wu Bao-Xu ma Feng-ming Wu Jing Xu Run-zhi Zhang State Key Laboratory of Integrated management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina

As solitary nymphal parasitoids of Pamtrioza sinica,the ectoparasitoid Tamarixia lyciumi and the endoparasitoid Psyllaephagus arenarius act as effective biocontrol ***,it is necessary to facilitate mass productions of both *** showing an excellent parasitic ability,*** is often trapped fatally inside 5th-instar nymphs of *** due to strong host *** improve the emergence rate of ***,we evaluated whether *** could utilize *** venom via multiparasitism,so the parasitism characteristics of both species were examined between separate-existence(monoparasitism only)and co-existence(mono-and multiparasitism)***,the parasitism characteristics of *** on venom-injected hosts with/without *** eggs were tested to further identify the *** results showed the parasitism rate of *** was increased while that of *** did not change from separate-existence to co-existence *** intrinsic performances of two species in monoparasitism did not differ between separate-and co-existence *** monoparasitism(separate-existence)to multiparasitism(co-existence),no differences were detected in the intrinsic performances of ***,but those of *** were greatly *** *** venom injection,the parasitism characteristics of *** did not differ between venom-injected hosts with *** eggs and those without,further indicating *** benefited from the venom of *** females rather than *** egg/larval *** of negative effects,multiparasitism with ectoparasitoids improves endoparasitoids due to ectoparasitic *** study increases host resource utilization and provides creative ways for mass production of endoparasitoids.

关键词： biocontrol agent host resource utilization intrinsic performance mass production parasitism characteristics

Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity

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Neural Regeneration Research 2022年第1期17卷 178-184页

作者： Chong Sun Xin-Cheng Cao zhi-Yang Liu Chao-Lin ma Bao-ming Li Laboratory of Cognitive Function and Disorder Institute of Life ScienceNanchang UniversityNanchangJiangxi ProvinceChina Institute of Brain Science and Department of Psychology School of EducationHangzhou Normal UniversityHangzhouZhejiang ProvinceChina

Excess extracellular glutamate leads to excitotoxicity,which induces neuronal death through the overactivation of N-methyl-D-aspartate receptors(NMDARs).Excitotoxicity is thought to be closely related to various acute and chronic neurological disorders,such as stroke and Alzheimer’s *** F(PGSF)is a triterpenoid saponin monomer that can be isolated from Polygala japonica,and has been reported to protect cells against *** investigate the mechanisms underlying the neuroprotective effects of PGSF against glutamateinduced cytotoxicity,PGSF-pretreated hippocampal neurons were exposed to glutamate for 24 *** results demonstrated that PGSF inhibited glutamate-induced hippocampal neuron death in a concentration-dependent manner and reduced glutamate-induced Ca^(2+)overload in the cultured *** addition,PGSF partially blocked the excess activity of NMDARs,inhibited both the downregulation of NMDAR subunit NR2A expression and the upregulation of NMDAR subunit NR2B expression,and upregulated the expression of phosphorylated cyclic adenosine monophosphate-responsive element-binding protein and brain-derived neurotrophic *** findings suggest that PGSF protects cultured hippocampal neurons against glutamate-induced cytotoxicity by regulating *** study was approved by the Institutional Animal Care Committee of Nanchang University(approval No.2017-0006)on December 29,2017.

关键词： BDNF Ca^(2+)homeostasis excitotoxicity glutamate hippocampal neurons pCREB polygalasaponin F neuroprotection NR2A NR2B

Visible-light-induced novel cyclization of 2-(2-(arylethynyl)benzylidene)-malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol to bridged spirocyclic compounds

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Chinese Chemical Letters 2022年第12期33卷 5069-5073页

作者： Xiaofei Xie Lei Wang Quan Zhou Yongmin ma zhi-ming Wang Pinhua Li Advanced Research Institute and Department of Chemistry Taizhou UniversityTaizhou 318000China Department of Chemistry Anhui Polytechnic UniversityWuhu 241000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryShanghai 200032China

A green and highly efficient strategy for the preparation of bridged spirocyclic compounds via visible-light-induced cyclization of 2-(2-(arylethynyl)benzylidene)malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol(BHT)at room temperature was *** photoinduced radical reactions generated the corresponding products in good yields under simple and mild reaction conditions.

关键词： 2-(2-(Arylethynyl)benzylidene)malononitriles 2,6-Di(tert-butyl)-4-methylphenol Bridged spirocyclic compounds Visible-light-induced organosynthesis

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng ma Chuanlei Zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

A multi-mechanism numerical simulation model for CO_(2)-EOR and storage in fractured shale oil reservoirs

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Petroleum Science 2024年第3期21卷 1814-1828页

作者： Yuan-Zheng Wang Ren-Yi Cao zhi-Hao Jia Bin-Yu Wang ming ma Lin-Song Cheng College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China John&Willie Leone Department of Energy&Mineral Engineering The Pennsylvania State UniversityUniversity Park16802PA.USA

Under the policy background and advocacy of carbon capture,utilization,and storage(CCUS),CO_(2)-EOR has become a promising direction in the shale oil reservoir *** multi-scale pore structure distribution and fracture structure lead to complex multiphase flow,comprehensively considering multiple mechanisms is crucial for development and CO_(2) storage in fractured shale *** this paper,a multi-mechanism coupled model is developed by *** to the traditional Eclipse300 and maTLAB Reservoir Simulation Toolbox(MRST),this model considers the impact of pore structure on fluid phase behavior by the modified Peng—Robinson equation of state(PR-EOS),and the effect simultaneously radiate to maxwell—Stefan(M—S)diffusion,stress sensitivity,the nano-confinement(NC)***,a modified embedded discrete fracture model(EDFM)is used to model the complex fractures,which optimizes connection types and half-transmissibility calculation approaches between non-neighboring connections(NNCs).The full implicit equation adopts the finite volume method(FVM)and Newton—Raphson iteration for discretization and *** model verification with the Eclipse300 and MRST is *** results show that the interaction between the mechanisms significantly affects the production performance and storage *** effect of molecular diffusion may be overestimated in oil-dominated(liquid-dominated)shale *** well spacing and injection gas rate are the most crucial factors affecting the production by sensitivity ***,the potential gas invasion risk is *** model provides a reliable theoretical basis for CO_(2)-EOR and sequestration in shale oil reservoirs.

关键词： CO_(2)-EOR CO_(2)storage Shale oil reservoir Complex fracture model Multiple mechanisms

Blind adaptive constrained constant modulus algorithms based on unscented Kalman filter for beamforming

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Journal of Central South University 2017年第10期24卷 2342-2352页

作者： QIAN Hua-ming LIU Ke JIAO zhi-bo ma Jun-da College of Automation Harbin Engineering UniversityHarbin 150001China Hainengda Communication Co. Ltd.Shenzhen 518000China

This work proposes constrained constant modulus unscented Kalman filter(CCM-UKF) algorithm and its low-complexity version called reduced-rank constrained constant modulus unscented Kalman filter(RR-CCM-UKF) algorithm for blind adaptive beamforming. In the generalized sidelobe canceller(GSC) structure, the proposed algorithms are devised according to the CCM criterion. Firstly, the cost function of the constrained optimization problem is transformed to suit the Kalman filter-style state space model. Then, the optimum weight vector of the beamformer can be estimated by using the recursive formulas of UKF. In addition, the a priori parameters of UKF(system and measurement noises) are processed adaptively in the implementation. Simulation results demonstrate that the proposed algorithms outperform the existing methods in terms of convergence speeds, output signal-tointerference-plus-noise ratios(SINRs), mean-square deviations(MSDs) and robustness against steering mismatch.

关键词： constrained constant modulus criterion blind beamforming unscented Kalman filter generalized sidelobe canceller