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Performance Evaluation for SDN Deployment: an Approach Based on Stochastic Network Calculus

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China Communications 2016年第S1期13卷 98-106页

作者： lin Changting WU Chunming HUANG min WEN Zhenyu ZHENG Qiuhua Next Generation Network Laboratory College of Computer Science and Technology Zhejiang University Centre for Intelligent Systems and their Applications University of Edinburgh School of Computer Science and Technology Hangzhou Dianzi University

The Open Flow implementations(SDNs) have been deployed increasingly on varieties of networks in research institutions as well as commercial institutions. To develop an Open Flow implementation, it is required to understand the performance of the network. A few benchmark tools(e.g., Cbench and OFlops) can be used to measure the network performance, while these tools take considerable time to simulate traffic behaviors and generate the required results,therefore extending the development time. In this paper, we present an analytical model, which is based on stochastic network calculus theory, for evaluating the performance of switch to *** previous studies show that stochastic network calculus can provide realistic emulation of real network traffic behaviors. Our model is evaluated by using both simulation tool and realistic *** results show the stochastic network calculus based analysis model can realistically measure the network performance of the end-to-end properties between controller and switch.

关键词： software-defined networking endto-end performance stochastic network calculus

Stem cell transplantation for spinal cord injury： a meta-analysis of treatment effectiveness and safety

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Neural Regeneration Research 2017年第5期12卷 815-825页

作者： Xiao Fan Jin-zhao Wang Xiao-min lin Li Zhang Fujian University of Traditional Chinese Medicine Fuzhou Fujian Province China Xiamen Medical College Xiamen Fujian Province China

OBJECTIVE： The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury（SCI）.DATA SOURCES： PubM ed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and Sino Med databases were systematically searched by computer to select clinical randomized controlled trials using stem cell transplantation to treat SCI, published between each database initiation and July 2016. DATA SELECTION： Randomized controlled trials comparing stem cell transplantation with rehabilitation treatment for patients with SCI. Inclusion criteria：（1） Patients with SCI diagnosed according to the American Spinal Injury Association（ASIA） International standards for neurological classification of SCI;（2） patients with SCI who received only stem cell transplantation therapy or stem cell transplantation combined with rehabilitation therapy;（3） one or more of the following outcomes reported： outcomes concerning neurological function including sensory function and locomotor function, activities of daily living, urination functions, and severity of SCI or adverse effects. Studies comprising patients with complications, without full-text, and preclinical animal models were excluded. Quality of the included studies was evaluated using the Cochrane risk of bias assessment tool and Rev Man V5.3 software, provided by the Cochrane Collaboration, was used to perform statistical analysis. OUTCOME MEASURES： ASIA motor score, ASIA light touch score, ASIA pinprick score, ASIA impairment scale grading improvement rate, activities of daily living score, residual urine volume, and adverse ***： Ten studies comprising 377 patients were included in the analysis and the overall risk of bias was relatively low level. Four studies did not detail how random sequences were generated, two studies did not clearly state the blinding outcome assessment, two studies lacked blinding outcome assessment, one study

关键词： nerve regeneration spinal cord injury stem cells cell transplantation bone marrow mesenchymalstem cells umbilical cord blood stem cells neural stem cells human embryonic stem cells paraplegia meta-analysis neural regeneration

Optimizing Locations and Scales of Emergency Warehouses Based on Damage Scenarios

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Journal of the Operations Research Society of China 2020年第3期8卷 437-456页

作者： Bo-Chen Wang Miao Li Yi Hu lin Huang Shu-min lin School of Management Shanghai UniversityShanghai 200444China

Choosing the locations and the capacities of emergency warehouses for the storage of relief materials is critical to the quality of services provided in the wake of a largescale emergency such as an *** paper proposes a stochastic programming model to determine disaster sites’locations as well as their scales by considering damaged scenarios of the facility and by introducing seismic resilience to describe the ability of disaster sites to resist *** objective of the model is to minimize fixed costs of building emergency warehouses,expected total transportation costs under uncertain demands of disaster sites and penalty costs for lack of relief materials.A local branching(LB)based solution method and a particle swarm optimization(PSO)based solution method are proposed for the *** numerical experiments are conducted to assess the efficiency of the heuristic according to the real data of Yunnan province in China.

关键词： Emergency warehouse location Damage scenario Disaster resilience Stochastic programming

质子交换膜燃料电池退化机制及寿命预测方法综述

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洁净煤技术 2024年第1期30卷 265-276页

作者：章雷其林沁刘敏吴启亮张雪松赵波胡亮杨志宾国网浙江省电力有限公司电力科学研究院浙江杭州310014 中国矿业大学(北京)固体氧化物燃料电池中心北京100083

故障诊断与寿命预测是解决质子交换膜燃料电池(PEMFC)系统寿命短、成本高的有效方法。综述了PEMFC系统的退化机制,包括质子交换膜、催化层、扩散层等各个组件的退化机理。从本征因素和外部因素两方面总结了影响PEMFC系统老化的影响因素... 详细信息

故障诊断与寿命预测是解决质子交换膜燃料电池(PEMFC)系统寿命短、成本高的有效方法。综述了PEMFC系统的退化机制,包括质子交换膜、催化层、扩散层等各个组件的退化机理。从本征因素和外部因素两方面总结了影响PEMFC系统老化的影响因素,特别是在运行管理过程中操作不当会加速PEMFC系统老化。介绍了表征PEMFC老化程度的常用退化性能指标,退化性能指标的选择对寿命预测方法的研究有重要意义,介绍了不同指标的优缺点以及适用情况。从模型驱动方法、数据驱动方法和混合驱动方法3方面介绍了常见的PEMFC系统寿命预测方法。模型驱动和数据驱动方法各有优缺点,混合方法可结合二者优点并提高预测的精度和准确性。最后展望了预测研究的未来发展方向。

关键词：质子交换膜燃料电池故障分析与寿命预测剩余使用寿命退化机制退化性

An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases

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Science China Life Sciences 2024年

作者： Yudai Xu Zijian Wang Shumin Li Jun Su Lijuan Gao Junwen Ou Zhanyi lin Oscar Junhong Luo Chanchan Xiao Guobing Chen Department of Microbiology and Immunology School of Medicine Institute of Geriatric Immunology School of Medicine Jinan University Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University) Ministry of Education Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory School of Medicine Jinan University First Affiliated Hospital Jinan University Anti Aging Medical Center Clifford Hospital Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Department of Systems Biomedical Sciences School of Medicine Jinan University The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital) Jinan University Zhuhai Institute of Jinan University Jinan University

T cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly examined the existing studies on the characteristics of immune organ aging. Furthermore, we elucidated the changes and potential mechanisms that occur in T cells during the aging process. Additionally, we have discussed the latest research advancements pertaining to T-cell agingrelated diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.

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Design,Synthesis,and Biological Evaluation of 5H-Thiazolo[3,2-a]pyrimidine-6-carboxylic Acid Ethyl Ester Derivatives as a Novel Series of Acetylcholinesterase Inhibitors

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Chemical Research in Chinese Universities 2009年第3期25卷 332-337页

作者： zhi Hui CHEN Lan-mei ZHANG lin-lin LIU Si-jie David Chi Cheong WAN lin Huang-quan HU Chun School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China Department of Biochemistry The Chinese University of Hong Kong Hong Kong SAR P. R. China

Acetylcholinesterase inhibitors are the most frequently prescribed anti-Alzheimer＇s drugs. A series of 5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester derivatives as the novel acetylcholinesterase inhibitors was designed based on virtual screening methods. The target compounds were synthesized with Biginelli reaction and Hantzsch-type condensation of dihydropyrimidines with substituted phenacyl chlorides, and were characterized with elemental analysis, IR, MS, ^1H NMR, and ^13C NMR. The biological evaluation against human acetylcholinesterase in vitro indicated all the target compounds show more than 50% inhibition at 10μmol/L by means of the Ellman method. The results provide a starting point for the development of novel drugs to treat Alzheimer＇s disease and lay the foundation of searching for improved acetylcholinesterase inhibitors with the novel scaffolds.

关键词： Acetylcholinesterase inhibitor Docking screening Heterocycle Biological activity 5H-Thiazolo[3,2-a] pyrimidine-6-carboxylic acid ethyl ester derivative

Effects of certain phenolic acids on advanced glycation end products formation in glucose-lysine Maillard reaction models

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Food Science and Human Wellness 2024年

作者： He Li Meng-Yao Jin Zi-Ze Liang Dan Li Jia-Hao Ji lin Kong Zi-Qing Zhao Rui-Jie Wu School of Chemistry and Chemical Engineering， North University of China Shanxi Jinshuo Biomedical Technology Co.Ltd.

Advanced glycation end products (AGEs)， a group of complex compounds generated by nonenzymatic interactions between amino acids， proteins and reducing sugars or lipids， accumulate in vivo and activate various signaling pathways closely related to the occurrence of various chronic metabolic diseases. This study aims to explore the structure-activity relationship between phenolic acids with different structure and affecting the AGEs generation， and to provide data support for AGEs control. Phenolic acids (4-hydroxybenzoic， protocatechuic， gallic， ρ-coumaric， caffeic， ferulic and sinapic acids) were employed to indicate the AGEs formation condition in Maillard reaction performed in the glucose-lysine model system. Three 1，2-dicarbonyl compounds were reacted with phenolic acids and then tested by liquid chromatography-mass spectrometry. The results showed that Nε-carboxy-methyl-lysine (CML)， Nε-carboxy-ethyl-lysine (CEL)， and pyrraline formation inhibited by phenolic acids varied from (8.7 ± 2.5)% to (33.2 ± 2.5)%， (10.5 ± 0.8)% to (57.1 ± 3.2)% and (1.3 ± 0.3)% to (23.3 ± 0.8)%， respectively. The ρ-coumaric acid has no inhibitory effect on CML and CEL formation. Gallic acid shows the best inhibitory effect on CML formation due to its strong antioxidant activity. Sinapic acid showed the best glyoxal (GO) trapping rate and thus had the stronger inhibitory effect on CML formation. Ferulic acid can react with mono-， di- tri-methylglyoxal (MGO) to form adduct products， showing the best MGO scavenging rate and a good inhibitory effect on CEL formation. The main role of phenolic acid is an antioxidant agent to inhibit pyrraline formation. The glucose itself or ammonia-induced degradation and ARP oxidation were lowered by protocatechuic， gallic and caffeic acids due to their antioxidant activities to form AGEs， while AGEs inhibited by ferulic and sinapic acids were mainly dependent on their trapping ability on 1，2-dicarbonyl compounds.

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The prospects of using gravitational waves for constraining the anisotropy of the Universe

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Chinese Physics C 2019年第7期43卷 112-117页

作者： zhi-Chao Zhao Hai-Nan lin Zhe Chang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China

The observation of GW150914 gave a new independent measurement of the luminosity distance of a gravitational wave event. In this paper, we constrain the anisotropy of the Universe by using gravitational wave *** simulate hundreds of events of binary neutron star merger that may be observed by the Einstein Telescope. Full simulation of the production process of gravitational wave data is employed. We find that 200 binary neutron star merging events with the redshift in (0,1) observed by the Einstein Telescope may constrain the anisotropy with an accuracy comparable to that from the Union2.1 supernovae. This result shows that gravitational waves can be a powerful tool for investigating cosmological anisotropy.

关键词： gravitational wave anisotropic space-time gravitational wave detector

GC-ECNI-MS法检测纺织品中氯化松节油

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针织工业 2024年第1期 85-88页

作者：林金美福建省纤维检验中心福建福州350026 福建省纺织产品检测技术重点实验室福建福州350026

用气相色谱-电子捕获负化学离子源-质谱法(GC-ECNI-MS)对纺织品中的氯化松节油进行定性和定量分析。通过对分子离子峰和脱氯离子峰的加和与浓度之间的关系转化,实现对氯化松节油的定量分析。对纺织品常用棉贴衬布样品进行加标试验,回收... 详细信息

用气相色谱-电子捕获负化学离子源-质谱法(GC-ECNI-MS)对纺织品中的氯化松节油进行定性和定量分析。通过对分子离子峰和脱氯离子峰的加和与浓度之间的关系转化,实现对氯化松节油的定量分析。对纺织品常用棉贴衬布样品进行加标试验,回收率和相对标准偏差分别在83.55%~95.73%和2.81%~4.10%,定量限为0.2 mg/kg,符合日常检测要求。对10个实际样品进行检测,未发现氯化松节油残留。本研究确定的检测氯化松节油的方法具有前处理简单、灵敏度高和回收率高的优点,为生态纺织品标准中氯化松节油的检测提供了技术支持。

关键词：氯化松节油纺织品检测气相色谱-负化学源质谱法检测方法