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Predicting the electromechanical properties of small caliber projectile impact igniter using PZT dynamic damage constitutive model considering crack propagation

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Defence Technology（防务技术） 2023年第10期28卷 121-135页

作者： Rui-zhi Wang zhi-qiang Wang En-ling Tang Lei li Guo-lai Yang Chun Cheng li-ping He Ya-fei Han Key Laboratory of Transient Physical Mechanics and Energy Conversion Materials of liaoning Province Shenyang Ligong UniversityShenyang110159LiaoningChina School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina Key Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo315211ZhejiangChina

Block piezoelectric ceramics(PZTs)are often used in impact igniters to provide activation energy for electric *** the action of strong impact stress,PZTs release electric energy accompanied by crack initiation,propagation and *** present,the electrical output performance of PZTs in projectile is usually calculated by quasi-static piezoelectric equation without considering the dynamic effect caused by strong impact and the influence of crack propagation on material *** the ignition parameters are always not accurately *** tackle this,a PZT dynamic damage constitutive model considering crack propagation is established based on the dynamic impact test and the crack propagation theory of brittle *** model is then embedded into the ABAQUS subroutine and used to simulate the electromechanical response of the impact igniter during the impact of a small caliber projectile on the ***,the experiments of projectile with impact igniter impact on the target are carried *** comparison between experimental and numerical simulation results show that the established dynamic damage model can effectively predict the dynamic electromechanical response of PZTs in the missile service environment.

关键词： Piezoelectric ceramics Impact Igniter Dynamic damage constitutive model Electromechanical response

大成散对成纤维细胞增殖活性及鞘氨醇激酶/1-磷酸鞘氨醇通路的影响

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中国中西医结合杂志 2024年第6期44卷 733-737页

作者：陈慧玲江莉官美龄陈艺玲翁慧兰黄宁北京中医药大学厦门医院医疗美容科福建361006 福建中医药大学附属第二人民医院皮肤科、中西医结合皮肤病福建省高校重点实验室福建350001

目的研究大成散对体外培养人皮肤成纤维细胞(HFF-1)增殖及鞘氨醇激酶/1-磷酸鞘氨醇(SPHK/S1P)通路的影响,并初步探讨其作用机制。方法制备大成散药液,采用CCK-8法检测不同浓度大成散药液对HFF-1细胞增殖活性的影响,确定最佳干预时间与... 详细信息

目的研究大成散对体外培养人皮肤成纤维细胞(HFF-1)增殖及鞘氨醇激酶/1-磷酸鞘氨醇(SPHK/S1P)通路的影响,并初步探讨其作用机制。方法制备大成散药液,采用CCK-8法检测不同浓度大成散药液对HFF-1细胞增殖活性的影响,确定最佳干预时间与浓度进行后续实验,Western Blot法检测大成散药液对HFF-1细胞转化生子因子-β1(TGF-β1)、SPHK1、SPHK2、S1P蛋白表达的影响,qRT-PCR法检测大成散药液对HFF-1细胞TGF-β1、SPHK1、SPHK2 mRNA表达的影响。结果5×10^(-2)g/L的大成散干预48h可促进HFF-1细胞的增殖,提高细胞活力;与对照组比较,大成散可以增加HFF-1细胞中TGF-β1、SPHK1、SPHK2、S1P蛋白表达水平(P<0.05),提高HFF-1细胞中TGF-β1、SPHK1、SPHK2 mRNA表达水平(P<0.05)。结论大成散可通过促进成纤维细胞增殖,上调TGF-β1表达,激活SPHK1/S1P通路,促进血管新生,发挥抗炎效应,或通过激活SPHK2,催化产生S1P,启动缺氧预处理机制,从而保护皮肤成纤维细胞,提高成纤维细胞的增殖能力,进而加速创面愈合。

关键词：创面愈合大成散成纤维细胞鞘氨醇激酶/1-磷酸鞘氨醇信号通路中药复方

Grain size and surface micro-texture characteristics and their paleoenvironmental significance of Holocene sediment in southern margin of the Gurbantunggut Desert,China

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Journal of Arid Land 2024年第5期16卷 632-653页

作者： MA Yunqiang li zhizhong TAN Dianjia ZOU Xiaojun TAO Tonglian School of Geographical Sciences Fujian Normal UniversityFuzhou 350117China Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China Institute of Geography Fujian Normal UniversityFuzhou 350117China

The southern margin of the Gurbantunggut Desert,China,is characterized by alternating layers of aeolian and alluvial *** the characteristics of arenaceous sediment in this area is of significant importance for understanding the interactive processes of wind and water forces,as well as the provenance of ***,there are relatively few investigations on the characteristics of such sediment at *** this study,we researched three aeolian-alluvial interactive stratigraphic profiles and different types of surface sediment on the desert-oasis transitional zone of southern margin of the Gurbantunggut *** on the optically stimulated luminescence(OSL)dating of aeolian sand and analyses of quartz sand grain size and surface micro-texture,we explored the aeolian-alluvial environmental change at southern margin of the desert in Holocene,as well as the provenance of *** results indicated that the grain size characteristics of different types of sediment in the stratigraphic profiles were similar to those of modern dune sand,interdune sand,muddy desert surface soil,and riverbed *** frequency curves were unimodal or bimodal,and cumulative probability curves were two-segment or three-segment,mainly composed of suspension load and saltation *** quartz sand in the sediment at southern margin of the desert had undergone alternating transformation of various exogenic forces,with short transportation distance and time,and sedimentary environment was relatively *** Holocene,southern margin of the desert primarily featured braided river deposits,and during intermittent period of river activity,there were also aeolian deposits such as sand sheet deposits,stabilized dune deposits,and mobile dune *** provenance for Holocene alluvial deposits at southern margin of the desert remains relatively constant,with the debris of the Tianshan Mountains being the primary *** sand is mainly near-source recharge,

关键词： aeolian-alluvial deposition grain size surface micro-texture sedimentary environment Holocene

Dietary Supplementation of β-Carotene Reveals miRNAs Involved in the Regulation of Carotenoid Metabolism in Crassostrea gigas

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Journal of Ocean University of China 2024年第4期23卷 1045-1053页

作者： SUN Dongfang WAN Sai YU Hong KONG lingfeng li Qi Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266237China

Carotenoids play crucial physiological roles in animals.A comprehensive investigation into the mechanism of carotenoid metabolism in oysters will establish a theoretical foundation for further development of its carotenoid-rich ***,the information on the function of miRNA in β-carotene metabolism in oysters is *** elucidate the mechanisms underlying miRNA regulation of carotenoid metabolism in oysters,we compared the expressions of miRNA in digestive gland tissues of Pacific oyster(Crassostrea gigas)fed with aβ-carotene supplemented diet and a normal diet,respectively.A total of 690 candidate miRNAs in the Pacific oyster digestive gland tissues were identified,including 590 known miRNAs and 111 unknown *** differentially expressed miRNAs were obtained in the carotenoid-fed and normal groups,associated to 137 differentially expressed target ***,the GO enrichment analysis revealed that the differentially expressed target genes were mainly involved in transmembrane transport *** enrichment showed that the differentially expressed target genes were involved in ABC *** of the mRNA-miRNA network revealed that novel0025 played a central role in carotenoid metabolism,and it was negatively correlated with the expression of 46 *** addition,down-regulated expression of novel0025 upregulated the expression of the lipoprotein gene LOC105342186,suggesting a potential regulatory role in carotenoid *** results provide useful information for elucidating the miRNA regulation mechanism during carotenoids metabolism in the Pacific oyster.

关键词： Crassostrea gigas β-carotene microRNA carotenoid metabolism

Diffusionmodels for time-series applications: a survey

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 19-41页

作者： Lequan liN Zhengkun li Ruikun li Xuliang li Junbin GAO Discipline of Business Analytics The University of Sydney Business SchoolCamperdownNSW 2006Australia Postdoctoral Programme of Zhongtai Securities Co. Ltd.Jinan 250000China

Diffusion models, a family of generative models based on deep learning, have become increasinglyprominent in cutting-edge machine learning research. With distinguished performance in generating samples thatresemble the observed data, diffusion models are widely used in image, video, and text synthesis nowadays. Inrecent years, the concept of diffusion has been extended to time-series applications, and many powerful models havebeen developed. Considering the deficiency of a methodical summary and discourse on these models, we providethis survey as an elementary resource for new researchers in this area and to provide inspiration to motivate futureresearch. For better understanding, we include an introduction about the basics of diffusion models. Except forthis, we primarily focus on diffusion-based methods for time-series forecasting, imputation, and generation, andpresent them, separately, in three individual sections. We also compare different methods for the same applicationand highlight their connections if applicable. Finally, we conclude with the common limitation of diffusion-basedmethods and highlight potential future research directions.

关键词： Diffusion models Time-series forecasting Time-series imputation Denoising diffusion probabilistic models Score-based generative models Stochastic differential equations

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

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Genes & Diseases 2024年第2期11卷 597-613页

作者： Yu Zhang Xinliang Gu Yang li Yuejiao Huang Shaoqing Ju Medical School of Nantong University Nantong UniversityNantongJiangsu 226001China Department of Laboratory Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Department of Medical Oncology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China

With the development of sequencing technology,transfer RNA(tRNA)-derived small RNAs(tsRNAs)have received extensive attention as a new type of small noncoding *** on the differences in the cleavage sites of nucleases on tRNAs,tsRNAs can be divided into two categories,tRNA halves(tiRNAs)and tRNA-derived fragments(tRFs),each with specific subcellular ***,the biogenesis of tsRNAs is tissue-specific and can be regulated by tRNA *** this review,we first elaborated on the classification and biogenesis of *** summarizing the latest mechanisms of tsRNAs,including transcriptional gene silencing,post-transcriptional gene silencing,nascent RNA silencing,translation regulation,rRNA regulation,and reverse transcription regulation,we explored the representative biological functions of tsRNAs in ***,this review summarized the clinical value of tsRNAs in cancers,thus providing theoretical support for their potential as novel biomarkers and therapeutic targets.

关键词： Biogenesis Biological function Cancer Mechanism Therapeutic strategy tsRNAs

Considerations of advanced aqueous batteries recycling:A perspective

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Journal of Energy Chemistry 2024年第6期93卷 46-54,I0002页

作者： Yun Zhao Yuqiong Kang Hao Du Feiyu Kang Baohua li Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina

*** Battery technology,serving as a basis for a rechargeable society,has developed rapidly over a century[1].The progress can be roughly divided into three stages,with the initial two mainly focusing on aqueous battery *** to 1859,research primarily focused on the conceptualization of batteries and the development of primary(non-rechargeable)cells[2].In the subsequent150 years,rechargeable battery technology emerged。

关键词： battery Battery primarily

Industry-Oriented Detection Method of PCBA Defects Using Semantic Segmentation Models

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1438-1446页

作者： Yang li Xiao Wang zhifan He Ze Wang Ke Cheng Sanchuan Ding Yijing Fan Xiaotao li Yawen Niu Shanpeng Xiao Zhenqi Hao Bin Gao Huaqiang Wu Department of Internet of Things Technology and Application China Mobile Research InstituteBeijing 100053China Beijing Advanced Innovation Center for Integrated Circuits the School of Integrated CircuitTsinghua UniversityBeijing 100084China SigmaStar Technology limited Xiamen 361199China IEEE

Automated optical inspection(AOI)is a significant process in printed circuit board assembly(PCBA)production lines which aims to detect tiny defects in *** AOI equipment has several deficiencies including low throughput,large computation cost,high latency,and poor flexibility,which limits the efficiency of online PCBA *** this paper,a novel PCBA defect detection method based on a lightweight deep convolution neural network is *** this method,the semantic segmentation model is combined with a rule-based defect recognition algorithm to build up a defect detection *** improve the performance of the model,extensive real PCBA images are collected from production lines as *** optimization methods have been applied in the model according to production demand and enable integration in lightweight computing *** results show that the production line using our method realizes a throughput more than three times higher than traditional *** method can be integrated into a lightweight inference system and pro-mote the flexibility of *** proposed method builds up a general paradigm and excellent example for model design and optimization oriented towards industrial requirements.

关键词： Automated optical inspection(AOI) deep learning defect detection printed circuit board assembly(PCBA) semantic segmentation.

Improving the value of molecular testing:current status and opportunities in colorectal cancer precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 21-28页

作者： Haiyun li linwei Guo Chenchen Wang Xin Hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Precision Cancer Medical Center Affiliated with Fudan University Shanghai Cancer Center Shanghai 201315China

Colorectal cancer(CRC)is the second leading cause of cancer-related deaths *** radical resection with adjuvant chemotherapy remains the primary treatment choice for CRC,but the 5-year postoperative survival rate is only approximately 60%,and approximately one-third of patients with CRC experience recurrence within 2 years of ***,the transformation of high-throughput sequencing has accelerated the development of precision *** example,KRAS mutations indicate resistance to anti-epidermal growth factor receptor(EGFR)-targeted therapies in ***,molecular-guided individualized therapy has brought new promise in major clinical areas and challenges,such as novel biomarkers predicting sensitivity and resistance to immunotherapy for microsatellite stable(MSS)CRC.

关键词： cancer chemotherapy colorectal