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Lp范数约束下的最大化L1范数主成分分析

模式识别与人工智能 2013年第2期26卷 211-218页

作者：梁志贞李勇夏士雄周勇中国矿业大学计算机科学与技术学院徐州221116

针对主成分分析在处理污染数据时的敏感性且其投影向量非稀疏的特性,提出一种鲁棒主成分分析的优化模型.该模型的目标函数采用L1范数且投影向量受Lp范数约束.范数约束下的主成分分析算法被用来求解该模型且其理论分析表明该算法可取得... 详细信息

针对主成分分析在处理污染数据时的敏感性且其投影向量非稀疏的特性,提出一种鲁棒主成分分析的优化模型.该模型的目标函数采用L1范数且投影向量受Lp范数约束.范数约束下的主成分分析算法被用来求解该模型且其理论分析表明该算法可取得局部最优解.另外把核函数嵌入到线性模型并给出核方案.通过在UCI数据集和人脸库上的实验表明该算法的可行性和有效性.

关键词：主成分分析 Lp范数敏感性核函数

Investigation and control of a Plasmodium falciparum malaria outbreak in Shan Special Region II of Myanmar along the China-Myanmar Border from June to December 2014

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Infectious Diseases of Poverty 2016年第1期5卷 277-287页

作者： Hui Liu Jian-Wei Xu Heng-Lin Yang Mei Li Cheng-De Sun Yi-Jie Yin zhi-liang zheng Guang-Yun Zhang Ai-Shui Yu Yong-Hui Yang Chun-Hui Li Shui Ai Yunnan Institute of Parasitic Diseases Yunnan Provincial Center of Malaria ResearchYunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and ControlYunnan Provincial Key Laboratory of Vector-borne Diseases Control and ResearchPuer 665000China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025China Wa State Department of Health PangsangShan Special Region IIMyanmar Wa State Office of Health Poverty Action PangsangShan Special Region IIMyanmar Menglian Center for Disease Control and Prevention Menglian 665800China Wa State Center for Disease Control and Prevention PangsangShan Special Region IIMyanmar

Background:From 2007 to 2013,intensive control measures reduced malaria burden by 90%along the China-Myanmar ***,despite these measures a *** malaria outbreak was reported in the Shan Special Region II of Myanmar in June of ***:Epidemiological,parasitological and entomological investigations were *** piperaquine(DAPQ)was immediately administered to treat parasite positive *** lasting insecticidal nets(LLIN),indoor residual spraying(IRS)with insecticides and behavior change communication(BCC)were also provided for outbreak *** embedded efficacy study was conducted evaluating *** genotyping via polymerase chain reaction(PCR)was performed on the Kelch gene on chromosome ***:All infections were identified as Plasmodium falciparum by RDT and *** fatalities resulted from the *** attack rate was 72.8%(67/92)and the incidence density rate was 14.2 per 100 *** positive rate of rapid diagnostic test(RDT)was 72.2%(65/90)and microscopically-determine parasite rate 42.2%(38/90).Adjusted odds ratio(OR)of multivariate logistic regression analysis for aged<15 years,15–45 years,inappropriate treatment from a private healer and lack of bed nets were 13.51(95%confidence interval,2.21–105.89),7.75(1.48–44.97),3.78(1.30–46.18)and 3.21(1.21–15.19)*** the six surrounding communities of the outbreak site,positive RDT rate was 1.2%(4/328)and microscopically-determine parasite rate 0.6%(2/328).Two light traps collected a total of 110 anopheline mosquitoes including local vectors,***,*** and *** intensive control,the detection of malaria attacks,parasites and antigen were reduced to zero between July 1 and December 1,*** cure rate of *** patients at day 42 was 94.3%(95%CI,80.8–99.3%).The PCR did not detect K13-propeller ***:Imported *** caused the ***,seeking inappropriate treatment

关键词： Malaria outbreak Plasmodium falciparum Investigation Control Chinese-Myanmar borde

The protective effect of tenegnin in SY5Y cells induced by 6-OHDA

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The protective effect of tenegnin in SY5Y cells induced by 6...

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： zhi-Gang liang,Yi-zheng WANG,Fang SHI,Xiao-Min WANG~* Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education,Capital Medical University,Beijing 100069,China

Objective:To examine the neuroprotective effects of Tenegenin(TEN) on 6-hydroxydopamine(6- OHDA) induced neurotoxicity in SY5Y ***:Neurotoxicity was induced by 25μm 6-OHDA in SY5Y cells and different doses of TEN were administered 60 min before addition of 6-OHDA into S Y5 Y cell *** viability was measured by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS),lactate dehydrogenase(LDH) in 12 h,24 h and 36 h after SY5Y cell induced by *** the effect of TEN on glutathione(GSH) and the activity of caspase-3 were *** mitochondrial mem- brane potential(MMP) was observed with Confocal ***:The cell viability of SY5Y cells damaged by 6-OHDA for 24h was 50%of control group in MTS *** addition,6-OHDA increased release of LDH and the activity of caspase-3,reduced GSH and MMP of *** with 10,10 and 10 mol/L TEN significantly increased cell *** parallel,protreatment with 10 mol/L TEN significantly reduced 6-OHDA induced LDH release and protected the MMP then reduced the activity of caspase-3,and increased the GSH of the ***:The results suggest that pretreatment of TEN protects SY5Y cells induced by *** protective mechanism of TEN may be antioxidant.

关键词： tenegenin SY5Y cell 6-hydroxydopamine antioxidant

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song zheng-zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

实时二维剪切波弹性成像评估慢加急性肝衰竭患者的预后

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中山大学学报（医学科学版） 2017年第5期38卷 774-779页

作者：金洁玚郑玉宝郑剑郭欢仪吴莉莉高志良郑荣琴中山大学附属第三医院超声科广东广州510630 中山大学附属第三医院肝脏疾病研究重点实验室广东广州510630 中山大学附属第三医院感染科广东广州510630 中山大学附属东华医院超声科广东东莞523110

【目的】探讨实时二维剪切波弹性成像(2D SWE)评估慢加急性乙型肝炎肝衰竭(ACLF-HBV)患者预后的临床应用价值。【方法】入组对象为2013年10月1日至2015年12月31日我院感染科确诊的312例慢加急性乙型肝炎肝衰竭患者。观察终点为90 d,根... 详细信息

【目的】探讨实时二维剪切波弹性成像(2D SWE)评估慢加急性乙型肝炎肝衰竭(ACLF-HBV)患者预后的临床应用价值。【方法】入组对象为2013年10月1日至2015年12月31日我院感染科确诊的312例慢加急性乙型肝炎肝衰竭患者。观察终点为90 d,根据临床结局分为好转组192例和恶化组120例。入组后3 d内,应用2D SWE进行肝脏硬度测量,收集患者血常规、凝血、生化等血清学指标,观察患者肝实质回声均匀度、肝包膜光滑度、右肝厚度、胆囊壁厚度、脾脏指数、腹水指数、门静脉主干内径、附脐静脉是否重开,计算终末期肝病评分(MELD)、CTP评分(CTP)、皇家医学院医院评分(KCH),入组后每2-4周动态检测2D SWE,直至患者出院或死亡\肝移植。【结果】恶化组的2D SWE高于好转组[(44.0±7.5)k Pa vs(36.8±10.3)k Pa,t=-6.5,P=0.000],39.2 k Pa可作为预后不良的阈值。2D SWE评估ACLF-HBV患者预后的受试者操作特征曲线下面积(AUROC)为0.73,预后效能高于KCH(AUROC:0.65,z=2.1,P=0.033)。动态检测2D SWE,好转组维持在40 k Pa以下,恶化组则一直高于40 k Pa,并有升高趋势。【结论】2D SWE评估ACLF-HBV患者预后的准确性较高,测值高于39.2 k Pa的患者预后较差,反之预后较好;动态检测2D SWE的变化对于ACLF-HBV患者的预后评估也有潜在价值。

关键词：剪切波弹性成像慢加急性肝衰竭预后超声检查

黄芩素在溃疡性结肠炎模型大鼠肝、肠微粒体中酶促反应动力学研究

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中南药学 2016年第12期14卷 1302-1307页

作者：梁志强郑彤高兴旺解放军第四五八医院广州510602

目的考察黄芩素在正常和溃疡性结肠炎大鼠肝、肠微粒体中的酶促反应动力学差异。方法采用3%葡聚糖硫酸钠连续自由饮用10 d,诱导溃疡性结肠炎大鼠模型,分别制备正常和溃疡性结肠炎大鼠肝、肠微粒体,通过建立大鼠肝、肠微粒体体外孵育体... 详细信息

目的考察黄芩素在正常和溃疡性结肠炎大鼠肝、肠微粒体中的酶促反应动力学差异。方法采用3%葡聚糖硫酸钠连续自由饮用10 d,诱导溃疡性结肠炎大鼠模型,分别制备正常和溃疡性结肠炎大鼠肝、肠微粒体,通过建立大鼠肝、肠微粒体体外孵育体系对黄芩素代谢进行研究,采用HPLCDAD检测方法对代谢产物黄芩苷进行定量测定,应用Graph Pad Prism 5.0软件分析数据,对比黄芩素在正常和溃疡性结肠炎模型中的酶促反应动力学常数最大反应速率(Vmax)和米氏常数(Km)。结果黄芩素(5~150μmol·L^(-1))在正常和溃疡性结肠炎大鼠肝微粒体中的代谢属于经典的米氏方程,Km分别为(59.13±7.756)、(57.45±6.699)μmol·L^(-1),Vmax分别为(6.086±0.3234)、(7.447±0.347)μmol/(min·mg),而在肠微粒体中符合底物抑制动力学特征,抑制速率(Ki)分别为(166.4±58.31)、(141.7±41.17)μmol·L^(-1),Vmax分别为(4.130±0.6035)、(5.797±0.7903)μmol/(min·mg)。不管是正常组还是模型组,黄芩素在肝脏中的代谢速率要显著高于肠微粒体;与正常组相比,溃疡性结肠炎大鼠肝、肠微粒体中黄芩素葡萄糖醛酸化反应的速率显著升高,同时发现了黄芩素的一个新代谢产物,可能为黄芩苷的同分异构体。结论溃疡性结肠炎疾病状态能够显著升高葡萄糖醛酸化转移酶的活性,可能是导致黄芩苷在疾病状态下体内暴露强度增加的因素之一。

关键词：黄芩素溃疡性结肠炎葡萄糖醛酸转移酶肝肠微粒体酶促反应动力学

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou Ying Mo Biao zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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具有行业特色的《数字图像处理》教学改革

现代计算机 2015年第23期21卷 22-24,31页

作者：梁志贞江海峰杨小冬中国矿业大学计算机科学与技术学院徐州22116

根据卓越计划下人才培养的目标,修改原有数字图像处理课程的教学目标,在新的课程建设中,从教学内容、教学方法、培养团队意识、考核方面等方面论述煤矿行业下计算机专业的数字图像处理教学改革过程。实践表明这一系列的教学改革对于提... 详细信息

根据卓越计划下人才培养的目标,修改原有数字图像处理课程的教学目标,在新的课程建设中,从教学内容、教学方法、培养团队意识、考核方面等方面论述煤矿行业下计算机专业的数字图像处理教学改革过程。实践表明这一系列的教学改革对于提高学生的学习兴趣和学习效果有明显作用,为培养学生实践能力和创新能力打下较好的基础。

关键词：卓越工程师课程改革创新能力数字图像处理