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基于微震监测的双系煤层开采覆岩运动与矿压显现关系

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煤炭学报 2017年第1期42卷 212-218页

作者：汤国水朱志洁韩永亮李志辽宁工程技术大学矿业学院辽宁阜新123000 中煤科工集团西安研究院有限公司陕西西安710054 天地科技建井研究院北京100013

以大同矿区双系煤层开采为研究背景,基于高精度微地震监测技术,研究石炭系特厚煤层8104综放工作面开采过程中上部侏罗系煤层群复杂采空区影响下微震事件时空演化特征,得到双系煤层影响下覆岩运动与矿压显现的关系。结果表明:8104工作面... 详细信息

以大同矿区双系煤层开采为研究背景,基于高精度微地震监测技术,研究石炭系特厚煤层8104综放工作面开采过程中上部侏罗系煤层群复杂采空区影响下微震事件时空演化特征,得到双系煤层影响下覆岩运动与矿压显现的关系。结果表明:8104工作面接近和进入上部侏罗系煤层采空区对应区域,8104工作面覆岩运动加剧,侏罗系煤层的开采是工作面覆岩运动加剧的主要原因;侏罗系煤柱重叠区域微震事件密集分布,在工作面的开采扰动和重叠煤柱应力传递的共同作用下,微震总能量和能量大于10~5J的震动次数均处于较高数值,覆岩运动更加剧烈。临近采空区对8104工作面的强烈覆岩运动起到了关键作用,在临近采空区和侏罗系覆岩共同作用下,工作面超前微震事件集中,矿压显现剧烈。工作面开采扰动、临近采空区覆岩运动和侏罗系重叠煤柱的耦合作用,是石炭系综放工作面矿压显现剧烈的根本原因。

关键词：双系煤层微震监测覆岩运动特厚煤层重叠煤柱

Effects of postmastectomy radiotherapy on prognosis in different tumor stages of breast cancer patients with positive axillary lymph nodes

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Cancer Biology & Medicine 2014年第2期11卷 123-129页

作者： Miao-Miao Jia zhi-jie liang Qin Chen Ying Zheng Ling-Mei Li Xu-Chen Cao The First Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical UniversityMinistry of Education Department of Pathology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center of Cancer

Objective: To explore the effects of postmastectomy radiotherapy(PMRT) on the locoregional failure-free survival(LRFFS) and overall survival(OS) of breast cancer patients under different tumor stages and with one to three positive axillary lymph nodes(ALNs). Methods: We conducted a retrospective review of 527 patients with one to three positive lymph nodes who underwent modified radical or partial mastectomy and axillary dissection from January 2000 to December 2002. The patients were divided into the T1-T2 N1 and T3-T4 N1 groups. The effects of PMRT on the LRFFS and OS of these two patient groups were analyzed using SPSS 19.0, Pearson's χ2-test, Kaplan-Meier method, and Cox proportional hazard model. Results: For T1-T2 N1 patients, no statistical significance was observed in the effects of PMRT on LRFFS [hazard ratio(HR)=0.726; 95% confidence interval(CI): 0.233-2.265; P=0.582] and OS(HR=0.914; 95% CI: 0.478-1.745; P=0.784) of the general patients. Extracapsular extension(ECE) and high histological grade were the risk factors for LRFFS and OS with statistical significance in multivariate analysis. Stratification analysis showed that PMRT statistically improved the clinical outcomes in high-risk patients [ECE(+), LRFFS: P=0.026, OS: P=0.007; histological grade III, LRFFS: P<0.001, OS: P=0.007] but not in low-risk patients [ECE(–), LRFFS: P=0.987, OS: P=0.502; histological grade I-II, LRFFS: P=0.816, OS: P=0.296]. For T3-T4 N1 patients, PMRT effectively improved the local control(HR=0.089; 95% CI: 0.210-0.378; P=0.001) of the general patients, whereas no statistical effect was observed on OS(HR=1.251; 95% CI: 0.597-2.622; P=0.552). Absence of estrogen receptors and progesterone receptors(ER/PR)(–) was an independent risk factor. Further stratification analysis indicated a statistical difference in LRFFS and OS between the high-risk patients with ER/PR(–) receiving PMRT and not receiving PMRT [ER/PR(–), LRFFS: P=0.046, OS: P=0.039]. However, PMRT had a beneficial effe

关键词： Breast cancer positive lymph nodes postmastectomy radiotherapy(PMRT) locoregional failure-free survival(LRFFS) overall survival(OS)

容错控制器在破碎机调速系统应用中的仿真研究

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湖南科技大学学报（自然科学版） 2004年第3期19卷 32-34页

作者：周知进梁洁萍湖南科技大学机电工程学院湖南湘潭411201

针对单输入单输出多回路系统,采取一种简单的容错控制技术,当控制系统中任一传感器失效时,采用邻近回路重构控制律对水下破碎机转速控制器加以补偿,使控制系统仍能稳定且控制质量与传感器失效前相一致,并给出了其仿真结果.图6,参9.

关键词：容错控制器破碎机调速系统仿真故障监测

大鼠脑、肝组织3种RNA相对表达量与死亡时间的关系

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青海医学院学报 2016年第4期37卷 255-262页

作者：董智杰陈亮吴岳青海大学医学院青海省公安厅刑事技术研究管理中心

目的研究大鼠脑、肝脏组织3种RNA相对表达量与死亡时间的关系,比较两组织用于死亡时间推断的适用性。方法将48只Wistar大鼠随机分为6组,断颈处死,分别于死后0、24、48、72、120、168 h取大鼠脑皮质及肝右外叶。提取脑、肝组织总RNA,采... 详细信息

目的研究大鼠脑、肝脏组织3种RNA相对表达量与死亡时间的关系,比较两组织用于死亡时间推断的适用性。方法将48只Wistar大鼠随机分为6组,断颈处死,分别于死后0、24、48、72、120、168 h取大鼠脑皮质及肝右外叶。提取脑、肝组织总RNA,采用实时荧光定量PCR(real-time fluorescence quantitative PCR,RT-qPCR)技术检测两组织中miR(脑特异性miR-124、肝特异性miR-122)及甘油醛-3-磷酸脱氢酶(glyceraldehyde-3-phosphate dehydrogenase,GAPDH)、β-肌动蛋白(β-actin)mRNA的循环阈值(cyclic threshold,Ct)。用Best Keeper程序筛选内参,对目的RNA的Ct值进行2^(-ΔΔC)t转换,用SPSS及Graph Pad软件对其进行单因素方差分析,并对ΔCt值进行曲线回归分析。结果 miR-124和miR-122分别为脑、肝组织的内参。脑组织GAPDH、β-actin mRNA的相对表达量在死后72 h内逐渐增加,并于死后72 h达到峰值,之后逐渐下降(P<0.05);而肝GAPDH、β-actin mRNA的相对表达量从死后48 h开始逐渐下降(P<0.05)。所有分子的最适回归模型均为三次模型,且肝组织的相关系数r大于脑组织。结论大鼠脑、肝组织中GAPDH、β-actin mRNA的相对表达量与死亡时间具有相关性,肝组织比脑组织更适用于死亡时间推断。

关键词：大鼠脑肝脏组织 RNA表达量死亡时间

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong liang Weipeng Li Chengjian Zhu jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词：

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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蒙古野驴的繁殖行为观察

动物学杂志 2016年第5期51卷 717-723页

作者：揭志良毕俊怀何志超陈绍勇付明霞刘睿内蒙古师范大学生命科学与技术学院呼和浩特010022

2014年6月至2015年8月期间，对分布在内蒙古自治区包头市达尔罕茂明安联合旗中蒙边境地区（41°14′～42°40′N，109°16′～110°26′E）和内蒙古自治区巴彦淖尔市乌拉特梭梭林-蒙古野驴国家级自然保护区（41°50′～42°27′N，106... 详细信息

2014年6月至2015年8月期间，对分布在内蒙古自治区包头市达尔罕茂明安联合旗中蒙边境地区（41°14′～42°40′N，109°16′～110°26′E）和内蒙古自治区巴彦淖尔市乌拉特梭梭林-蒙古野驴国家级自然保护区（41°50′～42°27′N，106°15′～108°00′E）的两个野驴群（1艿3早和283早）的繁殖行为进行研究。采用目标取样法以及目标取样法与扫描取样法相结合的方法对蒙古野驴的发情交配、产前反应、生产过程及产后行为进行观察。共记录到4类35种繁殖行为，分别为争斗行为、性行为、分娩行为和母幼联系行为。结果表明，雄驴平均日爬跨（4．2±1．7）次（n=14），射精（3．7±1．3）次（n=13），平均邀配持续时间（从雌雄驴靠近调情始到爬跨或其中一个走开止）为（26．6±22．0）s（n=13），平均抽动持续时间为（10．6±1．9）s（n=14），平均阴茎置入持续时间为（18．3±8．8）s（n=13），平均爬跨间隔为（685．7±569．6）s（n=14），平均射精间隔为（924．0±790．0）s（n=10）。蒙古野驴的交配模式属于Dewsbury分类系统中的第11种（无锁结、有抽动、单次插入、多次射精）类型和Dixon分类系统中的第12种（无锁结、有抽动、单次插入、无单次长时间插入）类型。本研究较完整地建立了蒙古野驴繁殖行为谱，提供了繁殖行为方面的基础资料。

关键词：蒙古野驴繁殖行为繁殖行为谱交配参数

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi liang Wenbo Ji Jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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中国东北地区的盐渍土资源

土壤通报 2004年第5期35卷 643-647页

作者：王春裕武志杰石元亮王汝镛中国科学院沈阳应用生态研究所辽宁沈阳110016

通过长期区域土壤考察,我国东北地区盐渍土资源的面积约为7 66×106hm2,其中松嫩平原的盐渍土面积占39 3%,西辽河沙丘平原占30 3%,辽河冲积平原占12 8%,呼伦贝尔盟高平原占9 3%,滨海平原占7 9%,三江平原仅占0 4%而已,20世纪80年代不同... 详细信息

通过长期区域土壤考察,我国东北地区盐渍土资源的面积约为7 66×106hm2,其中松嫩平原的盐渍土面积占39 3%,西辽河沙丘平原占30 3%,辽河冲积平原占12 8%,呼伦贝尔盟高平原占9 3%,滨海平原占7 9%,三江平原仅占0 4%而已,20世纪80年代不同辖区所获的土壤普查结果与之相接近。在上述的盐渍土资源面积中,其潜在盐渍土的面积约占34%。在开发利用方面,盐渍土的耕地面积已由20世纪50年代的占其总耕地面积的21 4%,增加为80年代的37 8%,呈显著增长之势。水田灌区土壤普遍脱盐,作物高产稳产,已属新型的人工生态系统。在盐渍土旱作区,农作物亦已普遍持续增产,惟局部土壤的脱盐状况尚不甚稳定,其西部地区的盐渍化面积呈明显蔓延之势,主要原因在于大面积天然草场的土壤盐渍度加剧,生产力普遍下降。上述中国东北地区盐渍土资源的面积约占全国盐渍土面积的7.9%,战略地位重要,其实现农业可持续发展的开发利用任务仍然十分艰巨。

关键词：中国东北地区盐渍土资源开发利用