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Simulation of open channel flows by an explicit incompressible mesh-free method

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Journal of Hydrodynamics 2023年第2期35卷 287-298页

作者： zhi-jian huang Ti-bing Xu David Z.Zhu Song-da Zhang School of Civil and Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China Department of Civil and Environmental Engineering University of AlbertaAlbertaCanada Ningbo River Management Center Ningbo315303China

In this study,to simulate open channel flows,an explicit incompressible mesh-free method is employed in which the pressure field is obtained by explicitly solving the pressure Poisson *** capture the velocity information in open channel flows,the source term in the pressure Poisson equation is modified while the spatial discretization of gradient and Laplacian models is based on the moving particle semi-implicit(MPS)*** inflow boundary condition is treated by injecting fluid particles into the domain according to the inlet discharge,and the outflow condition is handled by prescribing the pressure distribution and removing the fluid particles beyond the *** explicit incompressible mesh-free method is then used to simulate open channel flows,including weir flow,hydraulic jump,and flow over an *** the simulations,velocity distribution and flow pattern are *** simulated results are compared to available experimental measurements and other numerical *** is a good agreement between the simulated results and the experimental *** shows that the explicit incompressible mesh-free method can reproduce the flow characteristics in the open channel flows.

关键词： Mesh-free method explicit scheme weir flow hydraulic jump velocity distribution

Quantum Information Splitting Based on Current Cavity QED Techniques

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Communications in Theoretical Physics 2008年第5期49卷 1165-1168页

作者： WU Huai-zhi YANG Zhen-Biao SU Wan-Jun ZHONG zhi-Rong huang jian-Min Department of Electronic Science and Applied Physics Fuzhou University Fuzhou 350002 China

We propose two schemes for quantum information splitting via W-class state. The first scheme is based on the interaction of single atom with single-mode field, while the second scheme is based on the simultaneous interaction of two atoms with single-mode cavity. For the first scheme, the difIiculty of two atoms required to be simultaneously sent through one cavity is avoid. For the second scheme, it is immune to thermal field. Both schemes are experimentally feasible based on current cavity QED techniques.

关键词： resonant interaction thermal field information splitting

Pentraxin 3 contributes to neurogenesis after traumatic brain injury in mice

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Neural Regeneration Research 2020年第12期15卷 2318-2326页

作者： Chao Zhou Hong Chen jian-Feng Zheng Zong-Duo Guo zhi-jian huang Yue Wu jian-Jun Zhong Xiao-Chuan Sun Chong-Jie Cheng Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Emerging evidence indicates that pentraxin 3 is an acute-phase protein that is linked with the immune response to *** is also a newly discovered marker of anti-inflammatory A2 reactive astrocytes,and potentially has multiple protective effects in stroke;however,its role in the adult brain after traumatic brain injury is *** the present study,a moderate model of traumatic brain injury in mice was established using controlled cortical *** models were intraventricularly injected with recombinant pentraxin 3(the recombinant pentraxin 3 group)or an equal volume of vehicle(the control group).The sham-operated mice underwent craniotomy,but did not undergo the controlled cortical *** potential neuroprotective and neuroregenerative roles of pentraxin 3 were investigated on days 14 and 21 after traumatic brain *** blot assay showed that the expression of endogenous pentraxin 3 was increased after traumatic brain injury in ***,the neurological severity test and wire grip test revealed that recombinant pentraxin 3 treatment reduced the neurological severity score and increased the wire grip score,suggesting an improved recovery of sensory-motor *** Morris water maze results demonstrated that recombinant pentraxin 3 treatment reduced the latency to the platform,increased the time spent in the correct quadrant,and increased the number of times traveled across the platform,thus suggesting an improved recovery of cognitive *** addition,to investigate the effects of pentraxin 3 on astrocytes,specific markers of A2 astrocytes were detected in primary astrocyte cultures in vitro using western blot *** results demonstrated that pentraxin 3 administration activates A2 *** explore the protective mechanisms of pentraxin 3,immunofluorescence staining was *** injection of recombinant pentraxin 3 increased neuronal maintenance in the peri-injured cortex and ipsilateral hippocampus,inc

关键词： brain injury brain trauma cells neurogenesis plasticity protein recovery regeneration

Different outcomes of serpiginous choroiditis with or without ocular and systemic treatment

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 535-538页

作者： Zhong-Shan Chen Qin Ding Yan-Ping Song Li Zhu zhi-jian huang and Ming Yan Department of Ophthalmology Wuhan General Hospital of Guangzhou Military Command Wuhan 430070 Hubei Province China

Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury

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Neural Regeneration Research 2022年第3期17卷 577-586页

作者： Wei Tang Zong-Duo Guo Wei-Na Chai Dong-Lin Du Xiao-Min Yang Lang Cao Hong Chen Chao Zhou Chong-Jie Cheng Xiao-Chuan Sun zhi-jian huang jian-Jun Zhong Department of Neurosurgery First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Ophthalmology First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Micro RNA-491-5 p(miR-491-5 p) plays an important role in regulating cell proliferation and migration;however,the effect of miR-491-5 p on neovascularization after traumatic brain injury remains poorly *** this study,a controlled cortical injury model in C57 BL/6 mice and an oxygen-glucose deprivation model in microvascular endothelial cells derived from mouse brain were established to simulate traumatic brain injury in vivo and in vitro,*** the in vivo model,quantitative real-time-polymerase chain reaction results showed that the expression of miR-491-5 p increased or decreased following the intracerebroventricular injection of an miR-491-5 p agomir or antagomir,respectively,and the expression of miR-491-5 p decreased slightly after traumatic brain *** detect the neuroprotective effects of miR-491-p,neurological severity scores,Morris water maze test,laser speckle techniques,and immunofluorescence staining were assessed,and the results revealed that miR-491-5 p downregulation alleviated neurological dysfunction,promoted the recovery of regional cerebral blood flow,increased the number of lectin-stained microvessels,and increased the survival of neurons after traumatic brain *** the in vitro experiments,the potential mechanism of miR-491-5 p on neovascularization was explored through quantitative real-time-polymerase chain reaction,which showed that miR-491-5 p expression increased or decreased in brain microvascular endothelial cells after transfection with an miR-491-5 p mimic or inhibitor,***-luciferase reporter and western blot assays verified that metallothionein-2 was a target gene for miR-491-5 *** counting kit 8(CCK-8) assay,flow cytometry,and 2′,7′-dichlorofluorescein diacetate(DCFH-DA) assay results confirmed that the downregulation of miR-491-5 p increased brain microvascular endothelial cell viability,reduced cell apoptosis,and alleviated oxidative stress under oxygen-glucose deprivation conditions.C

关键词： brain injury cell migration cell proliferation endothelial cell hypoxia-inducible factor-1 alpha metallothionein 2 microRNA neovascularization neurons vascular endothelial growth factor

Standards of care for Kasabach-Merritt phenomenon in China

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World Journal of Pediatrics 2021年第2期17卷 123-130页

作者： Wei Yao Ke-Lei Li Zhong-Ping Qin Kai Li Jia-Wei Zheng Xin-Dong Fan Lin Ma De-Kai Zhou Xue-jian Liu Li Wei Li Li Mao-Zhong Tai Jin-Hu Wang Yi Ji Lin Zhou Hai-Jin huang Xiao-Yun Gao zhi-jian huang Song Gu He-Ying Yang Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Special Department of Vascular Anomalies Tumor Hospital of Linyi CityLinyi 276001China Department of Oral and Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011.China Department of Intervention Therapy Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Dermatology Beijing Children's Hospital Affiliated to Capital Medical UniversityBeijing 100045China Department of Infantile Hemangioma Gastrointestinal and Neonatal SurgeryChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Oncology People’s Hospital of Linyi Economic Development ZoneLinyi 276023China Department of Pediatric Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pediatric Surgery West China HospitalSichuan UniversityChendu 610041China Department of Pediatric Surgery People’s Hospital of Xinjiang Uygur Autonomous RegionUrumchi 830001China Department of Pediatric Surgery First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Department of Pediatric Surgery Fujian Provincial HospitalFuzhou 350001China Department of Pediatric Surgery Children's Hospital of Soochow UniversitySuzhou 215025China Department of Pediatric Surgery Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Kasabach-Merritt phenomenon(KMP)is a rare disease that is characterized by severe thrombocytopenia and consumptive coagulation dysfunction caused by kaposiform hemangioendothelioma or tufted *** condition primarily occurs in infants and young children,usually with acute onset and rapid *** review article introduced standardized recommendations for the pathogenesis,clinical manifestation,diagnostic methods and treatment process of KMP in China,which can be used as a reference for clinical practice.

关键词： Kasabach-Merritt phenomenon Kaposiform hemangioendothelioma Tufted hemangioma

Expression of protein kinase C isoforms in retinoic acid-induced differentiation of mouse embryonic stem cells into neuron-like cells

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Chinese Medical Journal 2007年第18期120卷 1639-1642页

作者： GAO Qian-ying WU Jun-shu WANG zhi-chong GE jian huang Dan-ping State Key Laboratory of Ophthalmology Zhongshan OphthalmicCenter Sun Yat-sen University Guangzhou 510060 China

Protein kinases C （PKCs）, a big family including 12 isoenzymes, are divided into three major groups according to the variability of their regulatory domains^1.2 The classical PKCs （cPKC） including PKCα, PKCβI, PKCβ2, and PKC7 need calcium, phosphatidylserine, and diacylglycerol or phorbol esters for full activation. The novel PKCs （nPKC） including PKCδ, PKCε, PKCη, PKCθ, and PKC, do not require calcium for their activation. The third group is the atypical PKCs （aPKC） including PKCζ, PKCλ and PKC~ whose activation depends on phosphatidylserine but not on diacylglycerol, calcium or phorbol esters. The differences in function of specific PKC isoforms are mainly due to their different subcellular localization, activation or inhibition by different stimuli, and transcriptional regulation.

关键词： embryo stem cells protein kinase C retinoic acid

巩膜外加压术后视网膜下液厚度与脉络膜厚度的变化

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国际眼科杂志 2021年第6期21卷 952-957页

作者：黄志坚中国人民解放军中部战区总医院全军眼科中心中国湖北省武汉市430070

目的:观察黄斑区孔源性视网膜脱离巩膜外加压术后视网膜下液厚度与脉络膜厚度的变化。方法:回顾性非随机临床研究。共23例23眼黄斑区孔源性视网膜脱离患者成功采用巩膜外加压术联合冷冻,排除复发性视网膜脱离和增殖性视网膜前膜患者。采... 详细信息

目的:观察黄斑区孔源性视网膜脱离巩膜外加压术后视网膜下液厚度与脉络膜厚度的变化。方法:回顾性非随机临床研究。共23例23眼黄斑区孔源性视网膜脱离患者成功采用巩膜外加压术联合冷冻,排除复发性视网膜脱离和增殖性视网膜前膜患者。采用OCT检测黄斑中心凹下视网膜下液厚度、中心凹下脉络膜厚度。对比观察分析患眼术前,术后1wk,1,3,6、12mo平均最佳矫正视力(BCVA,LogMAR)、黄斑中心凹下视网膜下液厚度、中心凹下脉络膜厚度的变化情况,分析视网膜下液厚度与脉络膜厚度的变化。结果:术后1wk所有患者均有视网膜下液。术后黄斑中心凹下视网膜下液厚度逐渐下降。术后1wk,中心凹下脉络膜厚度增加,随后中心凹下脉络膜厚度逐渐下降。术后1wk BCVA为0.60±0.35,与术前BCVA比较,差异有统计学意义(t=6.35,P<0.01)。结论:视网膜下液随时间逐渐吸收,脉络膜厚度早期增厚后期逐渐下降。视网膜脱离巩膜外加压术治疗累及黄斑区孔源性视网膜脱离,早期提高患者的视力。

关键词：孔源性视网膜脱离黄斑中心凹下视网膜下液厚度中心凹下脉络膜厚度视网膜脱离巩膜外加压术

基于车辆运动模型辅助的智能手机平台车载组合导航算法

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中国惯性技术学报 2017年第2期25卷 203-208页

作者：许建新熊智刘建业黄欣张苗南京航空航天大学导航研究中心南京211106

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台... 详细信息

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台中所采用的消费级MEMS惯性传感器模块其精度很低,通常难以满足车载DR导航算法的性能需求;同时在车辆行驶过程中,不可避免会经过高架、隧道等路径,也会导致GPS信号受到遮挡和屏蔽从而无法定位。针对以上问题,设计了适用于智能手机平台的基于车辆运动模型辅助的车载DR/GPS组合导航方案,推导建立了基于车辆侧向速度约束的组合导航算法模型,并以智能手机作为验证平台,测试验证了所设计的算法在无GPS环境下,采用智能手机平台中的消费级MEMS惯性测量组件,仍然可以在短时间内维持较高的导航定位性能。

关键词：车载导航车辆运动模型组合导航卡尔曼滤波