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Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression,activity,and stability

Journal of Pharmaceutical Analysis 2024年第1期14卷 69-85页

作者： Chen Hong Yifan Zhang Lili Yang Haoyang Xu kang Cheng zhi Lv Kaixian Chen Yiming Li Huali Wu Department of TCM Chemistry School of PharmacyShanghai University of Traditional Chinese MedicineShanghai200000China Department of Dermatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200000China International Education College Shanghai University of Traditional Chinese MedicineShanghai200000China Shanghai Inoherb Cosmetics Co. Ltd.Shanghai200000China

Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in *** previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain ***,as an extension to our previous investigation,we provide comprehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and *** results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glycogen synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin ***,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and ***,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis *** data conclude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries.

关键词： Epimedin B Melanosome Tyrosinase Melanogenesis

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Dry eye disease in systemic lupus erythematosus: a cross sectional study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1255-1261页

作者： Sui-Fang kang Ying-Xue Wang Qi-Chen Zhang zhi-Lun Wang Guo-Ling Chen Department of Ophthalmology the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Department of Rheumatology the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina

AIM:To explore ocular surface manifestations of dry eye disease(DED)and its influencing factors in systemic lupus erythematosus(SLE)***:Ophthalmological examinations were conducted in SLE patients(n=43)and controls(n=41),including Ocular Surface Disease Index(OSDI),objective scatter index(OSI),tear meniscus height(TMH),lipid layer thickness(LLT),non-invasive Keratograph tear breakup time(NIKBUT),corneal fluorescein score(CFS),Schirmer I *** was diagnosed according to the Tear Film and Ocular Surface Society Dry Eye Workshop II *** patients were further divided into DED group and non-DED group,the disease activity,clinical manifestations and laboratory investigations were compared between the two *** disease activity was evaluated by Systemic Lupus Erythematosus Disease Activity Index 2000(SLEDAI-2K).Receiver operative characteristic(ROC)curve and multiplefactor binary logistic regression were ***:SLE patients showed higher OSDI[9.1(2.8-15.9)vs 6.3(2.2-7.5),P=0.035],higher OSI[1.67(1.09-2.60)vs 0.96(0.87-1.60),P=0.001],higher CFS[1(0-2)vs 0(0-1),P=0.001],lower LLT[65(42-100)vs 100(79.5-100),P=0.010],and lower NIKBUT[8.03(4.02-9.73)vs 9.67(5.26-12.71),P=0.030]than *** 32.6%of SLE patients had DED,which was higher than 12.2%of healthy *** group showed higher SLEDAI-2K score[9.7±6.1 vs 5.4±3.4,P=0.025],higher anti-cardiolipin antibody(ACL)[8.7(3.5-13.2)vs 3.6(2.0-6.9),P=0.035],and higher proportion of patients with cutaneous eruption[42.9%vs 6.9%,P=0.015]than non-DED *** to multiple-factor binary logistic regression analysis,the SLEDAI-2K score(OR=1.194,P=0.041)and cutaneous eruption(OR=7.094,P=0.045)could be consider as risk factors for DED in SLE *** ROC curve of the combined factors including age,disease duration,SLEDAI-2K score,ACL,and cutaneous eruption was analyzed,with a sensitivity of 0.786,a specificity of 0.793,and an area under curve of ***:Ocular surface affec

关键词： autoimmune disease systemic lupus erythematosus dry eye disease

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Hydrothermal synthesis of polyimide-linked covalent organic frameworks towards ultrafast and stable cathodic sodium storage

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Science China Chemistry 2024年第4期67卷 1300-1310页

作者： Xiya Yang Lei Gong zhixin Liu Qianjun zhi Baoqiu Yu Xin Chen kang Wang Xiaofeng Li Dongdong Qi Jianzhuang Jiang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline MaterialsDepartment of Chemistry and Chemical EngineeringSchool of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Redox-active organic materials are capturing growing attention as cathode materials for sustainable alkaline metal ion ***,the storage of Na+in most organic materials-based cathodes is plagued by low capacity and unsatisfying rate performance due to their low active site densities and limited exposed active ***,two polyimide-linked covalent organic frameworks(COFs),namely HATN-PD-COF and HATN-TAB-COF,were fabricated from hydrothermal synthesis with redoxactive triphenylene-2,3,6,7,10,11-hexacarboxylic acid and aromatic amines as starting *** X-ray diffraction and electron microscopy analysis indicate the high crystalline nature of these COFs with AA stacking configuration and orderly mesoporous tunnel.N_(2) sorption measurement discloses the permanent porosity of these two COFs with a Brunauer-EmmettTeller surface area of 1,065-1,200 m^(2)g^(-1)and a large pore size of 2.0-3.1 *** intermittent titration technique and density functional theory calculations reveal the facile Na+ion diffusion along the mesoporous tunnel of these COFs with a small energy barrier of 0.13-0.40 e *** particular,the as-prepared COFs based-cathodes show ultrafast and stable Na+storage associated with their conjugated electronic structure,highly ordered mesoporous tunnel,robust structure,and redox-active C=N/C=O-rich framework as exemplified by the high reversible capacity of 210 m A h g^(-1)at 200 m A g^(-1),record-high rate performance(195 m A h g^(-1)at a high current density of 10,000 m A g^(-1))among organic electrodes and the capacity retention of nearly 91%at 10,000 m A g^(-1)after 7,000 cycles for HATN-PD-COF.

关键词： covalent organic framework sodium ion battery cathode high rate organic electrode

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OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1- p62/SQSTM1 complex

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World Journal of Gastroenterology 2024年第15期30卷 2155-2174页

作者： Nan Wang Chao-Yang Li Teng-Fei Yao Xiao-Dan kang hui-Shu Guo Clinical Laboratory Medicine The First Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina The Institute of Integrative Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina The Institute of Laboratory Medicine Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Central Laboratory The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Necroptosis has emerged as a novel molecular pathway that can be targeted by chemotherapy agents in the treatment of ***-1,which is derived from the bulbs of Ornithogalum saundersiae Baker,exerts a wide range of pharmaco-logical *** To explore whether OSW-1 can induce necroptosis in colorectal cancer(CRC)cells,thereby expanding its range of clinical *** We performed a sequence of functional experiments,including Cell Counting Kit-8 assays and flow cytometry analysis,to assess the inhibitory effect of OSW-1 on CRC *** utilized quantitative proteomics,employing tandem mass tag label-ing combined with liquid chromatography-tandem mass spectrometry,to analyze changes in protein *** bioinformatic analysis was conducted to elucidate the biological processes associated with the identified *** electron microscopy(TEM)and immunofluorescence studies were also performed to examine the effects of OSW-1 on ***,western blotting,siRNA experiments,and immunoprecipitation were employed to evaluate protein interactions within CRC *** The results revealed that OSW-1 exerted a strong inhibitory effect on CRC cells,and this effect was accompanied by a necroptosis-like morphology that was observable via ***-1 was shown to trigger necroptosis via activation of the RIPK1/RIPK3/MLKL ***,the accumulation of p62/SQSTM1 was shown to mediate OSW-1-induced necroptosis through its interaction with *** We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway,and that this effect is mediated by the RIPK1-p62/SQSTM1 complex,in CRC *** results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.

关键词： OSW-1 Necroptosis RIPK1 P62/SQSTM1 Colorectal cancer

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： zhiyuan Yin Jiahui kang Xuan Cheng hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第1期15卷 43-52页

作者： Sha-Sha Cai Teng-Ye Zheng kang-Yao Wang hui-Ping Zhu Department of Nephrology The First People’s Hospital of WenlingWenling 317500Zhejiang ProvinceChina

BACKGROUND Among older adults,type 2 diabetes mellitus(T2DM)is widely recognized as one of the most prevalent *** nephropathy(DN)is a frequent com-plication of DM,mainly characterized by renal microvascular *** detection,aggressive prevention,and cure of DN are key to improving *** a diagnostic and predictive model for DN is crucial in auxiliary *** To investigate the factors that impact T2DM complicated with DN and utilize this information to develop a predictive *** The clinical data of 210 patients diagnosed with T2DM and admitted to the First People’s Hospital of Wenling between August 2019 and August 2022 were retrospectively *** to whether the patients had DN,they were divided into the DN group(complicated with DN)and the non-DN group(without DN).Multivariate logistic regression analysis was used to explore factors affecting DN in patients with *** data were randomly split into a training set(n=147)and a test set(n=63)in a 7:3 ratio using a random *** training set was used to construct the nomogram,decision tree,and random forest models,and the test set was used to evaluate the prediction performance of the model by comparing the sensitivity,specificity,accuracy,recall,precision,and area under the receiver operating characteristic *** Among the 210 patients with T2DM,74(35.34%)had *** validation dataset showed that the accuracies of the nomogram,decision tree,and random forest models in predicting DN in patients with T2DM were 0.746,0.714,and 0.730,*** sensitivities were 0.710,0.710,and 0.806,respectively;the specificities were 0.844,0.875,and 0.844,respectively;the area under the receiver operating characteristic curve(AUC)of the patients were 0.811,0.735,and 0.850,*** Delong test results revealed that the AUC values of the decision tree model were lower than those of the random forest and nomogram models(P<0.05),whereas the differ

关键词： Type 2 diabetes mellitus Diabetic nephropathy Random forest Decision-making tree Nomogram Forecast

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Separation of halogens and recovery of heavy metals from secondary copper smelting dust

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2686-2701页

作者： zhi-lou LIU zhi-kang CHEN Fu-ze SUN zhi-heng ZHANG kang YAN Shui-ping ZHONG hui LIU Rui-xiang WANG Jia-yuan LI zhi-feng XU School of Metallurgy Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Chemistry and Environmental Science Xiangnan UniversityChenzhou 423000China Ganzhou Engineering Technology Research Centre of Green Metallurgy and Process Intensification Ganzhou 341000China Key Laboratory of Ionic Rare Earth Resources and Environment Ministry of Natural ResourcesGanzhou 341000China

The separation of halogens and recovery of heavy metals from secondary copper smelting(SCS)dust using a sulfating roasting−water leaching process were *** thermodynamic analysis results confirm the feasibility of the phase transformation to metal sulfates and to gaseous HF and *** the sulfating roasting conditions of the roasting temperature of 250℃ and the sulfuric acid excess coefficient of 1.8,over 74 wt.%of F and 98 wt.%of Cl were volatilized into flue *** 98.6 wt.%of Zn and 96.5 wt.%of Cu in the roasting product were dissolved into the leaching solution after the water leaching process,while the leaching efficiencies of Pb and Sn were only 0.12%and 0.22%,*** mechanism studies indicate the pivotal effect of roasting temperature on the sulphation reactions from various metal species to metal sulfates and the salting out reactions from various metal halides to gaseous hydrogen halides.

关键词： secondary copper smelting dust sulfating roasting water leaching halogen volatilization heavy metal separation

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Tungsten pnictides for water electrolysis:advances and perspectives

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Tungsten 2024年第4期6卷 675-695页

作者： Xue kang Xi-Han Tan Ning Han Jian-Feng Hou Chen-Min Yao zhi-Jie Chen Bing-Jie Ni Department of Chemistry and Chemical Engineering Lyuliang University Department of Materials Engineering State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Wuhan University School of Civil and Environmental Engineering The University of New South Wales

Hydrogen fuel is recognized as a promising energy carrier for the sustainable development of global energy system and the green hydrogen production via water electrolysis attracts great *** development of cost-effective electrocatalysts for water electrolysis is important for enhancing green hydrogen production ***,tungsten pnictides(phosphides and nitrides) have emerged as promising catalysts for water electrolysis,and efficient tungsten pnictide-based catalysts with different nanostructures,compositions,and surface chemical properties have been *** this review,recent progress in the design of tungsten pnictide-based electrocatalysts for water electrolysis is comprehensively *** synthesis of tungsten pnictide-based electrocatalysts are discussed ***,current achievements in developing efficient tungsten pnictide electrocatalysts for water electrolysis are detailed,and four key catalyst design strategies(i.e.,nanostructure control,heteroatom doping,defect engineering,and heterostructure design) are *** physicochemical properties-catalytic performance relationship of tungsten pnictide-based electrocatalysts is also *** last,perspectives in this field are put forward for guiding further research on the design and application of high-performance tungsten pnictide-based electrocatalysts.

关键词： Electrocatalysts Hydrogen evolution reaction Oxygen evolution reaction Tungsten nitrides Tungsten phosphides

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Amorphous Sb/C composite with isotropic expansion property as an ultra-stable and high-rate anode for lithium-ion batteries

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Rare Metals 2024年第5期43卷 2039-2052页

作者： Ze-Zhou Yang Cheng-Yi Zhang Yu-Qing Ou zhi-kang Su Yan Zhao Heng-Jiang Cong Xin-Ping Ai Jiang-Feng Qian Hubei Key Laboratory of Electrochemical Power Sources College of Chemistry and Molecular SciencesWuhan UniversityWuhan430072China Institute of Technological Sciences Wuhan UniversityWuhan 430072China

Antimony(Sb)is an intriguing anode material for Li-ion batteries(LIBs)owing to its high theoretical capacity of 660 m Ah·g^(-1)and appropriate working potential of~0.8 V(***^(+)/Li).However,just like all alloying materials,the Sb anode suffers from huge volume expansion(230%)during repeated insertion/extraction of Li+ions,resulting in structural deterioration and rapid capacity *** this work,a novel amorphous Sb/C composite with atomically dispersed Sb particles in carbon matrix is prepared via a straightforward high-energy ball milling *** intimate intermixing of amorphous Sb with C provides homogeneous element distribution and isotropic volume expansion during cycling,resulting in persistent structural ***,the disordered structure of amorphous material shortens the diffusion distance of lithium ions/electrons,promoting fast reaction kinetics and rate *** from the aforementioned effects,the amorphous Sb/C exhibits a high reversible capacity of537.4 m Ah·g^(-1)at 0.1 A·g^(-1)and retains 201.0 m Ah·g^(-1)at an ultrahigh current rate of 10.0 A·g^(-1).Even after 1500deep cycles at 2.0 A·g^(-1),the amorphous Sb/C electrode still maintains 86.3%of its initial capacity,which outperforms all existing Sb-based anodes reported so *** analysis further reveals a greatly reduced volume variation of merely 34.6%for the amorphous Sb/C electrode,much lower than that of 223.1%for crystalline Sb *** study presents a new approach to stabilizing Sb-based alloy anodes and contributes to the construction of high-performance amorphous anode materials for LIBs,enabling advanced energy storage.

关键词： Amorphous Sb/C anode Homogeneous element distribution Isotropic volume expansion Ultra-long cycle stability High-rate capability Lithium-ion battery

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Efficient piezo-catalytic dye degradation using piezoelectric 6H-SiC under harsh conditions

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Rare Metals 2024年第7期43卷 3173-3184页

作者： Lin-Lin Zhou Tao Yang kang Wang Lai-Pan Zhu En-hui Wang Kuo-Chih Chou Hai-Long Wang Xin-Mei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110000China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing University of Science and TechnologyBeijing 100083China

The development of novel piezoelectric catalysts against harsh conditions is indeed crucial for improving the piezo-catalytic degradation efficiency of colored organic dyes in *** this work,6H-SiC nanoparticles(NPs)are utilized to piezo-catalytic degrade rhodamine B(RhB)and methylene blue(MB)under ultrasonic vibration for the first *** degradation efficiency of RhB and MB reaches 98.8%and 98.7%within 80 *** piezoelectricity of 6H-SiC is comprehensively analyzed by the piezoresponse force microscope(PFM)and finite element method(FEM).The strong oxidizing active free radicals generated by the continuous piezoelectric polarized electric field of 6H-SiC,i.e.,·O_(2)^(-)and·OH,induce the decomposition reactions of colored organic dyes in *** the dyes are proven to degrade to harmless or less-harmful products gradually during the piezo-catalysis process by high-performance liquid chromatography tandem mass spectrometry(HPLC-MS).Moreover,RhB is also decomposed efficiently by 6HSiC NPs under acidic and alkaline *** results prove the feasibility of 6H-SiC for decomposing common water pollutants under harsh conditions and provide a new perspective for water purification.

关键词： Piezo-catalytic degradation 6H-SiC Rhodamine B(RhB) Methylene blue(MB) Harsh conditions

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