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Commissioning of a high-resolution collinear laser spectroscopy apparatus with a laser ablation ion source

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Nuclear Science and techniques 2022年第1期33卷 98-106页

作者： Shi-wei Bai Xiao-Fei yang Shu-Jing Wang Yong-Chao liu Peng Zhang yin-Shen liu Han-Rui Hu yang-Fan Guo Jin Wang Ze-yu Du Zhou yan yun-Kai Zhang yan-lin ye qi-te li yu-cheng ge Chuang-ye He School of Physics and State Key Laboratory of Nuclear Physics and technology Peking UniversityBeijing 100871China China Institute of Atomic Energy(CIAE) P.O.Box 275(10)Beijing 102413China

Collinear laser spectroscopy is a powerful tool for studying the nuclear spins,electromagnetic moments,and charge radii of exotic *** study the nuclear properties of unstable nuclei at the Beijing Radioactive Ion-beam Facility(BRIF)and the future High Intensity Heavy-ion Accelerator Facility(HIAF),we developed a collinear laser spectroscopy apparatus integrated with an offline laser ablation ion source and a laser *** overall performance of this state-of-the-art technique was evaluated,and the system was commissioned using a bunched stable ion *** high-resolution optical spectra for the 4s ^(2)S_(1/2)→4p^(2)P_(3/2)(D2)ionic transition of ^(40;42;44;48)Ca isotopes were successfully *** extracted isotope shifts relative to ^(40)Ca showed excellent agreement with the literature *** system is now ready for use at radioactive ion beam facilities such as the BRIF and paves the way for the further development of higher-sensitivity collinear resonance ionization spectroscopy techniques.

关键词： Nuclear properties Collinear laser spectroscopy Laser-ablation ion source Photon detection Isotope shift

Sperm acrosin activity may be a useful factor in choosing between ICSI and IVF for infertile male patients

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Asian Journal of Andrology 2024年第1期26卷 85-90页

作者： ye-Na Hu liang Hu Xin-yu yin huan Zhang yang-qin Peng Gang liu ge lin wei-Na li The Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410008China Department of Andrology Reproductive and Genetic Hospital of CITiC-XiangyaChangsha 410013China Clinical Research Center for Reproduction and genetics in Hunan Province Changsha 410013China Hunan Guangxiu Hi-tech life technology Co. Ltd.Changsha 410013China

The clinical applications of acrosin activity are *** analyzed 61578 male partners in infertile couples who visited the outpatient department of the Reproductive and genetic Hospital of CITIC-Xiangya(Changsha,China)between August 2014 and December 2019 to determine the reference ranges and thresholds for acrosin activity in infertile Chinese men;to determine whether correlations exist between acrosin activity and age,sperm concentration,sperm morphology,or sperm motility;and to evaluate whether acrosin activity could serve as an effective prognostic indicator for choosing between in vitro fertilization(IvF)and intracytoplasmic sperm injection(icsl)in the *** cut-off value for the normal reference range of acrosin activity for male partners in infertile couples was 24.78μlU per 106 *** was no significant association between acrosin activity and age,sperm concentration,semen volume,total sperm count,progressive motility,or total motile spermatozoa.A weak positive correlation was found between acrosin activity and normal sperm *** was a statistically significant difference in abnormal acrosome morphology between the group with high acrosin activity(>24.78μlU per 106 sperm)and the group with low acrosin activity(lization rate had a high index of abnormal acrosomal morphology at 21.2%,while the group with a high IVF fertilization rate had a low index of 0.2%.At an acrosin activity oflization rate,normal fertilization rate,and good-quality embryo rate for Icsl were significantly higher than those for ***,the most promising application of acrosin activity could be in the selection of IcsI over IVF for infertile male patients with complete fertilization failure or a low fertilization rate.

关键词： acrosin activity fertilization rate ICSI IVF semen parameters

Investigation of the near-threshold cluster resonance in ^14C

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Chinese Physics C 2018年第7期42卷 41-46页

作者： Hong-liang Zang yan-lin ye zhi-huan li jian-Song Wang jian-ling lou qi-te li yu-cheng ge Xiao-Fei yang Jing li wei jiang Jun Feng qiang liu Biao yang zhi-qiang Chen yang liu Hong-Yi Wu Chen-yang Niu Chen-Guang li Chun-Guang Wang Xiang Wang wei liu jian Gao Han-Zhou yu Jun-Bin Ma Peng Ma zhen Bai yan-yun yang Shi-Lun Jin Fei Lu School of Physics and State Key Laboratory of Nuclear Physics and technology Peking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of ScienceLanzhou 730000China Argonne National Laboratory 9700 S Cass Ave B109LemontIllinois 60439USA Institute of High Energy Physics CASBeijing 100049China RIKEN Nishina Center 2-1 HirosawaWakoSaitama 351-0198Japan Shanghai Institute of Applied Physics Chinese Academy of ScienceShanghai 200000China

An experiment for m p（14C},14C＊→10Be＋α）p inelastic excitation and decay was performed in inverse kinematics at a beam energy of 25.3 MeV/u. A series of 14C excited states, including a new one at 18.3（1） MeV, were observed which decay to various states of the final nucleus of 10Be. A specially designed telescope system, installed around zero degrees, played an essential role in detecting the resonant states near the α-separation threshold. A state at 14.1（1） MeV is clearly identified, being consistent with the predicted band-head of the molecular rotational band characterized by the π-bond linear chain configuration. Further clarification of the properties of this exotic state is suggested by using appropriate reaction tools.

关键词： cluster decay linear-chain-state high detection efficiency inelastic excitation

Novel evidence for the σ-bond linear-chain molecular structure in ^(14)C

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Chinese Physics C 2021年第8期45卷 71-75页

作者： Han-zhou yu Jing li yan-lin ye Biaoyang cheng-jianlin Hui-Ming Jia jian-ling lou Xiao-Fei yang T.Baba qi-te li yu-cheng ge zhi-huan li Hui Hua Jin-yan Xu Zai-Hong yang Jun Feng Hong-liang Zang qiang liu wei jiang yang liu Jing-Jing li wei liu Shi-wei Bai Jie Chen Jia-Xing Han Jia-Hao Chen Kai Ma Dong-Xi Wang Lei yang Nan-Ru Ma li-Jie Sun School of Physics and State Key Laboratory of Nuclear Physics and technology Peking UniversityBeijing 100871China FRIB/NSCL Laboratory Michigan State UniversityEast LansingMichigan 48824USA China Institute of Atomic Energy Beijing 102413China Kitami Institute of technology 090-8507 KitamiJapan Research Center for Nuclear Physics(RCNP) Osaka University10-1 MihogaokaIbarakiOsaka 567-0047Japan Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China

A multi-nucleon transfer and cluster decay experiment,^(7)li(^(11)B,^(14)C^(*)→α+^(10)Be)α,is conducted at an incident beam energy of 55 *** reaction channel has a significantly large 0-value,which favors populating the high lying resonant states in ^(14)*** decay paths,from these resonances to various states of the final nucleus ^(10) Be,can be selected,owing to the experimentally achieved optimal resolution of the Q-value spectrum.A number of resonant states are reconstructed from the forward emitting 10Be+α fragments,and their major molecular structures can be detected according to the selective decay paths and relative decay widths.A state at 22.4(2)MeV validates the previously measured and theoretically predicted band head of the positive-parity σ-bond linear-chain mo-lecular *** additional resonances at 22.9(2)and 24.2(2)MeV are identified and consistent with the predicted 2^(+) and 4^(+) members of the same molecular band,thus providing novel evidences for the existence of the exotic clustering chain structure in neutron-rich carbon isotopes.A few high energy resonances,which also indicate the presence of the σ-bond molecular structure,are observed;however,further studies are still required to clarify their ascription in band systematics.

关键词： linear-chain state reaction 0-value transfer reaction cluster decay relative branching ratio

Two annular CsI(Tl) detector arrays for the charged particle telescopes

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Nuclear Science and techniques 2023年第10期34卷 158-165页

作者： Hong-yu Zhu jian-ling lou yan-lin ye li-Sheng yang Bo-Long Xia Kang wei ying Chen wei-liang Pu Zi-Yao Hu Hao-yu ge Jia-Hao Chen Kai Ma Wen-Wu Wan Hooi-Jin Ong yan-yun yang Shi-wei Xu Kang Wang Fang-Fang Duan Jun-Bin Ma zhen Bai Peng Ma Ruo-Fu Chen School of Physics and State Key Laboratory of Nuclear Physics and technology Peking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy SciencesLanzhou 730000China

In this study,we constructed two annular detector arrays comprising 24 wedge-shaped CsI(Tl) crystals,and tested them using anαsource and radioactive beams of ^(14-16) Con a CD_2 *** compared the properties of a CsI(Tl) crystal encapsulated with various reflectors,revealing that using the 80-μm-thick ESR film to pack the CsI(Tl) crystal yielded the largest light output with the smallest non-uniformity in light output (ΔLO).For the 24 CsI(Tl) detectors with the 80-μm-thick ESR films,the average energy resolution improved as the average light output increased;however,it deteriorated as theΔLO value *** form two annular Si-CsI(Tl) telescopes for identifying the light-charged particles,theΔLO value and energy resolution of each CsI(Tl) detector were maintained under 20%and 7.7%,*** telescopes were tested for the first time in a direct nuclear reaction experiment using ^(14-16) C+*** results demonstrated that the Z=1 and Z=2 charged particles were adequately discriminated by the telescopes using the standardΔE-E method.

关键词： Wedge-shaped CsI(Tl)detector light output non-uniformity Si-CsI(Tl)telescope Particle identification

Peptide Cy_(RL-QN15)accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor

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Zoological Research 2024年第6期45卷 1287-1299页

作者： yu-Tong Wu Ze-qiong Ru ying Peng zhe Fu qiu-ye Jia Zi-jian Kang yuan-Sheng li yu-Bing huang Sai-ge yin Kun Guo Nai-Xin liu cheng-An Feng Jing Tang Bai-yu Zhang zhi yang ying Wang Xin-Wang yang Department of Anatomy and Histology&Embryology Faculty of Basic Medical ScienceKunming Medical UniversityKunmingYunnan 650500China Key Laboratory of Chemistry in Ethnic Medicinal Resources&Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes State Ethnic Affairs Commission&Ministry of EducationSchool of Ethnic MedicineYunnan Minzu UniversityKunmingYunnan 650504China Department of Biochemistry and Molecular Biology Faculty of Basic Medical ScienceKunming Medical UniversityKunmingYunnan 650500China Department of Urology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650500China Dermatology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650500China yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunmingYunnan 650500China

Individuals with diabetes frequently face serious challenges,including delayed wound healing and increased risk of ***,the regeneration of hair follicles plays a crucial role in accelerating diabetic skin damage repair,reducing the risk of infection,and enhancing overall skin *** has predominantly emphasized the re-epithelialization of diabetic wounds,with a paucity of in-depth studies on hair follicle *** the current study,we explored the effects of a bioactive amphibian-derived peptide,Cy_(RL-QN15),on promoting hair regeneration in a diabetic skin *** vivo experiments demonstrated that local treatment with Cy_(RL-QN15)not only accelerated wound healing of scalded skin on the backs of diabetic Kunming(KM)mice but also improved growth of damaged hair ***,back-shaved diabetic C57BL/6 mice showed a significant increase in the growth of newly formed hair after 28 days of continuous Cy_(RL-QN15)*** analysis indicated that the hairregenerating effects of Cy_(RL-QN15)were closely associated with the proliferation and migration of hair follicle stem cells(HFSCs).Cy_(RL-QN15)enhanced intracellularβ-catenin expression by binding to the Frizzled-7 receptor on the surface of *** up-regulation inβ-catenin modulated the levels of downstream proteins,such as cMYC,Cyclin D1,and Lef1,ultimately inducing hair *** study not only reveals the robust effects of the bioactive peptide Cy_(RL-QN15)in hair follicle regeneration but also provides novel avenues for the development of more targeted and effective therapeutics for diabetic wound healing in the future.

关键词： CyRL-QN15 Hair follicle stem cells(HFSCs) β-catenin Frizzled-7

A New Measurement of ^11Be(p,d) Transfer Reaction

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Chinese Physics Letters 2018年第8期35卷 14-18页

作者： ying jiang jian-ling lou yan-lin ye Dan-yang Pang Jie Chen zhi-huan li yu-cheng ge qi-te li Jing li wei jiang ye-Lei Sun Hong-liang Zang yun Zhang wei liu gen li N.Aoi E.Ideguchi H.J.Ong J.Lee Jin Wu Hong-Na liu Chao Wen Y.Ayyad K.Hatanaka D.T.Tran T.Yamamoto M.Tanaka T.Suzuki T.T.Nguyen School of Physics and State Key Laboratory of Nuclear Physics and technology Peking University Beijing 100871 School of Physics and Nuclear Energy Engineering Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing 100191 Research Centre for Nuclear Physics Osaka university Osaka 567-0047 Japan Institute of Physical and Chemical Research Saitama 351-0198 Japan

A new ^11Be（p,d） transfer reaction experiment is performed in inverse kinematics with a radioactive11 Be beam at26.9 MeV. Three low-lying states, namely the 0＋ground state, the 2^＋ state at Ex = 3.37 MeV, and the multiplet at around 6 MeV in10 Be, are populated by this one-neutron transfer reaction. These three states in10 Be are clearly discriminated from the -value spectrum, which is rebuilt from energies and angles of the recoil deuterons in coincidence with10 Be. A spectroscopic factor for each state is extracted by comparing the experimental differential cross sections to the theoretical calculation results using the finite range adiabatic distorted wave approximation method with different global nucleon-nucleus potentials. It is found that the newly extracted spectroscopic factors for the 0＋and 2＋states are consistent with the previous ones, but the factor for the multiplet is smaller than the value in the reference, and the possible reason is discussed.

关键词： Be A New Measurement of p,d

Possibility of women treated with fertility-sparing surgery fornon-epithelial ovarian tumors to safely and successfully becomepregnant--a Chinese retrospective cohort study among 148cases

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Frontiers of Medicine 2018年第5期12卷 509-517页

作者： Bin yang yan yu Jing Chen yan Zhang ye yin Nan yu ge Chen Shifei Zhu Haiyan huang Yongqun yuan Jihui Ai Xinyu Wang Kezhen li Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430000 China Department of Gynecologic Oncology Women's Hospital Zhejiang University Hangzhou 310006China Department of Gynecologic Oncology Women 's Hospital Zhongxiang 431900 China

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P ted adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.

关键词： fertility fertility-sparing surgery malignant germ cell tumors ovarian sex cord-stromal tumors prognosis

SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-Ming li li-Ren Shen Hai-Rong Zhang zhi-ling Chen Han-Wen Du Ming Gu Rui li De-Kang liu yue-Hu Pu Jun-Feng yu jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo ge-yang jiang zhi-qiang jiang lin Jin Wen-Jing li Xiu-Fang li ye lin Ming liu Yong-Hao liu Ya-Juan liu Ming Lv qing-Ru Mi lian-Hua Ouyang wei-Guo Shi Hang Shu qi-Sheng Tang Kun Wang zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-qiang Xu Wen-zhen Xu Chong-Xian yin cheng yu Ren-Xian yuan qi-Bing yuan Hai-Qun Zhang Miao Zhang Wen-zhi Zhang li-ying Zhao wei-Min Zhou Shou-Xian Fang Xi-Dong Sun zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system