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基于改进大脑情感学习模型的车辆纵向跟随

吉林大学学报（工学版） 2022年第12期52卷 2994-3005页

作者：魏民祥杨佳伟陈凯王志浩沙朝南京航空航天大学能源与动力学院南京210016

为提高无人驾驶车辆纵向跟随控制算法的安全性,在大脑情感学习模型的基础上,删除了情感暗示信号,并结合径向基神经网络良好的非线性逼近特性,提出了一种间接自适应脑情绪神经鲁棒控制器(iARBERC)和一种证明该控制系统稳定性的Lyapunov... 详细信息

为提高无人驾驶车辆纵向跟随控制算法的安全性,在大脑情感学习模型的基础上,删除了情感暗示信号,并结合径向基神经网络良好的非线性逼近特性,提出了一种间接自适应脑情绪神经鲁棒控制器(iARBERC)和一种证明该控制系统稳定性的Lyapunov分析方法。将其运用到单级倒立摆仿真中,并与径向基神经网络、ARBENC进行数值比较,仿真结果表明:iARBERC具有最快的响应速度、最小的跟踪误差和最优的鲁棒性能,虽然总控制能量有所提高,但偏差在4%以内。最后,将iARBERC应用到无人驾驶车辆跟随控制系统半物理仿真台架中,结果表明,搭载iARBERC的车辆对频繁变化的纵向速度有较好的跟随能力。

关键词：无人驾驶纵向跟随控制大脑情感学习非线性逼近鲁棒性半物理仿真

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Distributions and Driving Factors of Hydrochemical Compositions in Different Types of Karst Groundwater in Qingjiang River Basin

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1417-1426页

作者： Xie, hao Shen, hao-Yong Zhang, Hai-Dao Lin, Yong-Sheng Li, Jun Liang, Hui-Ya wang, zhi-Heng Zhu, Tian-Long Zou, Sheng-Zhang Key Laboratory of Karst Dynamics Ministry of Natural Resources/Guangxi International Research Center on Karst under the Auspices of United Nations Educational Scientific and Cultural Organization Institute of Karst Geology Chinese Academy of Geological Sciences Guilin541004 China Guangxi Karst Resources and Environment Research Center of Engineering Technology Guilin541004 China Guangxi Pingguo Karst Ecosystem National Field Scientific Observation and Research Station Baise531406 China Hebei Key Laboratory of Water Quality Engineering and Comprehensive Utilization of Water Resources Hebei University of Architecture Zhangjiakou075000 China Zhangjiakou Municipal Water Service Limited Liability Company Zhangjiakou075000 China

The karst groundwater resource is the key water supply for native residents and industrial and agricultural production in karst regions of southwest China and is even the only water supply for rural regions. Understanding the formation mechanism of hydrochemical compositions is practically imperative to the sustainable development and utilization of karst groundwater resources. The hydrochemical ions of 34 karst spring samples and 12 underground river water samples from the Qingjiang River Basin were measured and analyzed in this study. On the basis of investigating the distribution characteristics of hydrochemical components,methods such as hierarchical clustering analysis,Gibbs model,and relationships between hydrochemical components were used to comprehensively reveal the chemical genesis mechanism of karst groundwater from the perspectives of water-rock interaction and anthropogenic activities,especially in the disturbance mechanism of acidic pollutants on the natural dissolution of carbonate rocks. The results showed that the karst groundwater in the Qingjiang River Basin was weakly alkaline(7.12 ≤pH ≤ 8.69),and the overall water quality was good. Only the maximum concentration of NO3− in the karst spring(80.2 mg·L−1) exceeded the maximum acceptable limit for drinking purposes(10 mg·L−1 as N). The Ca2+ and HCO3− were identified as the dominant ions,associated with the main water phrase of HCO3-Ca·Mg in approximately 97.1% of karst spring samples and all underground river water samples. The dominant ions were derived from the strong dissolution of calcite,whereas Mg2+、SO42−,and F− were controlled by the weak dissolution of dolomite,gypsum,and fluorite,respectively. Karst groundwater NO3− was derived from the agricultural fertilizers and rainwater input,whereas the H2SO4 acid rain input was identified as another important source of karst groundwater SO42−. In addition,the carbonate rocks in the study area were mainly naturally dissolved;however,the input of exoge

关键词： Groundwater pollution

An integrative view on the carotid artery alterations in metabolic syndrome

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An integrative view on the carotid artery alterations in met...

The miR172a–SNB module orchestrates both induced and adult-plant resistance to multiple diseases via MYB30-mediated lignin accumulation in rice

山东省医学会第十一次老年医学分会学术会

作者： zhi-hao wang Hui-Ping Gong Yuan-Yuan Shang Meng-Xiong Tang Ning-Ning Fang Gui-Hua Jiang Yun Zhang Ming Zhong Wei Zhang Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Department of CardiologyQilu Hospital of Shandong University Emergency Department Qilu Hospital of Shandong University

Backgrounds Metabolic syndrome(MetS) is a multiple risk factor paradigm widely considered in risk *** aimed to investigate carotid artery alterations in MetS and the underlying risk factors. Materials and methods A total of 400 Chinese subjects were recruited,divided into control(n = 200) and MetS(n = 200) *** and laboratory characteristics were *** subjects underwent carotid ultrasonography. Results Cardiovascular risk profiles were worse in the MetS than control group(all P < 0.05).After adjusting for MetS and age,the MetS group showed significantly increased mean intima-media thickness(IMT) and significantly impaired carotid elastic properties(all P < 0.05),as compared to control *** circumference (WC) was positively correlated with IMT(r = 0.130,P = 0.038),systolic carotid diameter(r = 0.139, P = 0026) and diastolic carotid diameter[r = 0.168,P = 0-007).systolic blood pressure(SBP) and diastolic blood pressure were positively correlated with IMT(r = 0.201,P = 0004;r = 0.168,P = 0.008,respectively),but negatively with arterial compliance coefficient(r =-0.421,P < 0.001;r =-0-230,P < 0.001,respectively). Serum level of high-density lipoprotein(HDL) negatively correlated with IMT(r =-0.195,P = 0.002).Plaque index was positively correlated with fasting blood glucose(r = 0.205,P = 0.001) after adjusting for the other risk *** impaired carotid elastic properties(all P < 0.05) independently correlated with ***, ge(β= 0.255,P < 0.001),SBP(β= 0.224,P < 0.001),WC(β= 0.202,P < 0.001) and high-density lipoprotein cholesterol(HDL-C)(β=-0.163,P = 0.001) were independently associated with IMT. Conclusion Carotid alterations consequent upon MetS ultimately developed subclinical and clinical atherosclerosis, the underlying risk factors for which were abdominal obesity,hypertension,ageing and low level of HDL-C.

关键词： Carotid alterations metabolic syndrome ultrasonography Eur J Clin Invest 2012 42(5)-502

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Molecular Plant 2025年第1期18卷 59-75页

作者： He wang Zhe-Xu wang Hong-Yuan Tian Yu-Long Zeng hao Xue Wan-Ting Mao Lu-Yue Zhang Jun-Ni Chen Xiang Lu Yong Zhu Guo-Bang Li zhi-Xue Zhao Ji-Wei Zhang Yan-Yan Huang Jing Fan Pei-Zhou Xu Xiao-Qiong Chen Wei-Tao Li Xian-Jun Wu Wen-Ming wang Yan Li State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute and Key Lab for Major Crop Diseases Sichuan Agricultural UniversityChengduChina

Plants mount induced resistance and adult-plant resistance against different pathogens throughout the whole growth *** production faces threats from multiple major diseases,including rice blast,sheath blight,and bacterial leaf ***,we report that the miR172a–SNB–MYB30 module regulates both induced and adult-plant resistance to these three major diseases via lignification in ***,pathogen infections induce the expression of miR172a,which downregulates the transcription factor SNB to release its suppression of MYB30,leading to an increase in lignin biosynthesis and disease resistance throughout the whole growth ***,expression levels of miR172a and MYB30 gradually increase and are consistently correlated with lignin contents and disease resistance during rice development,reaching a peak at full maturity,whereas SNB RNA levels are negatively correlated with lignin contents and disease resistance,indicating the involvement of the miR172a–SNB–MYB30 module in adult-plant *** functional domain of SNB protein and its binding sites in the MYB30 promoter are highly conserved among more than 4000 rice accessions,while abnormal expression of miR172a,SNB,or MYB30 compromises yield traits,suggesting artificial selection of the miR172a–SNB–MYB30 module during rice *** together,these results reveal a novel role for a conserved miRNA-regulated module that contributes significantly to induced and adult-plant resistance against multiple pathogens by increasing lignin accumulation,deepening our understanding of broad-spectrum resistance and adult-plant resistance.

关键词： miR172a SNB MYB30 lignin induced resistance adult-plant resistance

Effect of heat treatment on microstructure and mechanical properties of a novel Al-Zn-Mg-Cu alloy

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China Foundry 2025年

作者： Yan-mei Yang Xin-chen Tang Ye-fei Li Xue-wei Fang Da-wei Yi zhi-yun Zhang Qiao-ling Zheng zhi-xi wang Guo-yu Zhang Su Zhang hao Cheng Yang He Yi-bo Liu Zi-han Wu Ya-nan Chen Yi-min Gao State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an Aerospace Precision Electromechanical Institute

Effects of solution and aging treatment on the microstructure and mechanical properties of a novel Al-Zn-Mg-Cu alloy by microalloying rare elements Sc and Er were studied. The results show that solution time has a visible influence on the microstructure and mechanical properties of the alloy. Specifically, as the solution time increases, the area fraction of the residual phase in the alloy decreases, and the shape of the grain becomes more spheroidal and coarser, leading to a decrease in hardness. This is attributed to the dissolution of strengthening phases during the solution treatment, which weakens the solid solution strengthening *** single-stage aging treatment shows an initial increase in strength and hardness of the alloy, followed by a decrease as the aging time is extended, until a steady state is achieved. The optimal single-aging conditions are found to be at 120 ℃ for 24 h, where the alloy exhibits an excellent combination of high strength and good ductility, with an ultimate tensile strength(UTS) of 523 MPa, yield strength(YS) of 482 MPa, and elongation(El)of 1.75%, respectively. Compared to single-stage aging, double-stage aging(120 ℃ for 24 h and then 150 ℃ for 52 h) significantly increases the elongation of the alloy(4.17%), but the UTS reduces to 465.29 MPa, and YS reduces to 410.64 MPa. Transmission electron microscopy(TEM) observations disclose that the grain size, the distribution spacing of precipitates along the grain boundary, and the width of the precipitation-free zone(PFZ) all undergo augmentation as the duration of the second stage aging process elongates.

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Contributions from light level and spectral content on refractive development in young rabbits

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 390-397页

作者： Xiu-Ping Tang zhi-Jin Tang hao-Bo Fan Yun-Chun Zou Department of Ophthalmology the Second Clinical College of North Sichuan Medical College(Nanchong Central Hospital)Nanchong 637000Sichuan ProvinceChina Department of Ophthalmology Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Optometry North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

AIM:To compare the effects of manipulating light levels versus manipulating the spectral content of short wavelengths(blue light)of ambient lighting on refractive development in young ***:A total of 32 healthy 3-week-old rabbits were randomly assigned to one of the four groups with 8 in each group for 12wk:Control group(NC)under low blue light(output ratio of blue light 1.8%)at low illuminance(341 lx),HI group under low blue light(output ratio of blue light 1.6%)at high illuminance(5057 lx),simulating natural light(S-NL)group under high blue light(output ratio of blue light 4.9%)at high illuminance(5052 lx),and MB group under high blue light(output ratio of blue light 5.2%)at low illuminance(342 lx).The lighting in each group were provided by light emitting diode(LED)lamps emitting visible light(range 380-780 nm)in addition to(or not)LED lamps only emitting short wavelength(range 380-500 nm).Refraction,axial length,and corneal curvature radius were assessed by retinoscopy,ultrasonography and keratometry,*** data of both eyes for each animal were used as single values and compared among ***:During the 12-week intervention,all animals had an emmetropization *** decrease of refraction in rabbits in HI group was similar to S-NL group,both slower than that of NC group(P0.05).CONCLUSION:The light levels per se but not the rich in spectral content of short wav

关键词： emmetropization myopia refractive error illuminance short wavelengths

Retrospective analysis of preoperative tumor marker levels in rectal cancer patients: Implications for diagnosis

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 221-228页

作者： Ming Li Da-hao Yuan zhi Yang Teng-Xiang Lu Lei Zhang Clinical Laboratory Linquan County People’s HospitalLinquan 236400Anhui ProvinceChina Hemodialysis Center Linquan County People’s HospitalLinquan 236400Anhui ProvinceChina Department of Gastrointestinal Surgery Linquan County People’s HospitalLinquan 236400Anhui ProvinceChina

BACKGROUND Early detection of rectal cancer poses significant *** diagnostic methods,including colonoscopy,imaging techniques,and fecal tests,have limitations such as invasiveness,cost,and varying *** study evaluated the diagnostic value of preoperative serum tumor markers in rectal cancer *** To investigate the value of a multi-marker approach for the preoperative diagnosis of rectal *** A retrospective analysis of 250 patients diagnosed with rectal cancer between July 2022 and July 2024 was *** alpha-fetoprotein levels,carcinoembryonic antigen(CEA),cancer antigen 125(CA125),CA19-9,CA15-3,and CA72-4 were *** blood samples were collected under standardized conditions,including fasting status and proper storage methods,within two weeks before *** performance was assessed using receiver operating characteristic curve *** among clinicopathological features were also *** CEA demonstrated the highest diagnostic performance among individual tumor markers with an area under the curve(AUC)of 0.78[95%confidence interval(CI):0.73-0.83].However,a combination of CEA,CA19-9,and CA72-4 showed superior performance,achieving an AUC of 0.87(95%CI:0.83-0.91).Significant correlations were observed between CEA levels and several clinicopatho-logical features,including tumor stage(P<0.001),lymph node involvement(P=0.002),and distant metastasis(P<0.001).Furthermore,in a subgroup analysis of patients diagnosed after July 2022,the integration of fecal occult blood testing with the tumor marker panel(CEA+CA19-9+CA72-4)significantly improved diagnostic accuracy,increasing the AUC to 0.91(95%CI:0.86-0.96).CONCLUSION A multimarker approach combining CEA,CA19-9,and CA72-4 with fecal occult blood testing enhances the preoperative assessment of patients with rectal *** findings suggest potential improvements in risk stratification and management of patients with rect

关键词： Rectal cancer Tumor markers Carcinoembryonic antigen Cancer antigen 19-9 Cancer antigen 72-4 Fecal occult blood test Diagnosis

Identification of novel rodent and shrew orthohepeviruses sheds light on hepatitis E virus evolution

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Zoological Research 2025年第01期 103-121页

作者： Fu-Li Li Bo wang Pei-Yu Han Bei Li hao-Rui Si Yan Zhu Hong-Min Yin Li-Dong Zong Yi Tang Zheng-Li Shi Ben Hu Xing-Lou Yang Yun-zhi Zhang Institute of Preventive Medicine School of Public Health Dali University Yunnan Key Laboratory of Screening and Research on Antipathogenic Plant Resources from Western Yunnan Yunnan Key Laboratory of Zoonotic Disease Cross-border Prevention and Quarantine Second People's Hospital of Qujing Programme in Emerging Infectious Diseases Duke-NUS Medical School CAS Key Laboratory of Special Pathogens Wuhan Institute of Virology Chinese Academy of Sciences Key Laboratory of Genetic Evolution & Animal Models Yunnan International Joint Laboratory of Zoonotic Viruses Yunnan Key Laboratory of Biodiversity Information Kunming Institute of Zoology Chinese Academy of Sciences

The family Hepeviridae has seen an explosive expansion in its host range in recent years, yet the evolutionary trajectory of this zoonotic pathogen remains largely unknown. The emergence of rat hepatitis E virus(HEV)has introduced a new public health threat due to its potential for zoonotic transmission. This study investigated2 ?464 wild small mammals spanning four animal orders,eight families, 21 genera, and 37 species in Yunnan Province, China. Using broadly reactive reverse transcription-polymerase chain reaction(RT-PCR), we systematically screened the presence and prevalence of Orthohepevirus and identified 192 positive specimens from10 species, corresponding to an overall detection rate of7.79%. Next-generation sequencing enabled the recovery of 24 full-length genomic sequences from eight host species, including Bandicota bengalensis, Eothenomys eleusis, and Episoriculus caudatus, representing newly reported host species for Orthohepevirus *** and sequence analyses revealed extensive genetic diversity within orthohepeviruses infecting rodents and shrews. Notably, among the identified strains, 20 were classified as Rocahepevirus ratti C1, two as C3, and one as Rocahepevirus eothenomi, while the remaining strain exhibited significant divergence, precluding *** analyses highlighted close associations between orthohepeviruses and their respective host taxa,with distinct phylogenetic clustering patterns observed across different host orders. These findings emphasize the critical roles of co-speciation and cross-species transmission in shaping the evolutionary trajectories of the genera Paslahepevirus and Rocahepevirus.

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Beyond the tumor region:Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer

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World Journal of Gastroenterology 2025年第8期31卷 49-65页

作者： zhi-Ying Liang Mao-Li Yu Hui Yang hao-Jiang Li Hui Xie Chun-Yan Cui Wei-Jing Zhang Chao Luo Pei-Qiang Cai Xiao-Feng Lin Kun-Feng Liu Lang Xiong Li-zhi Liu Bi-Yun Chen Department of Radiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Medical Imaging First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

BACKGROUND The peritumoral region possesses attributes that promote cancer growth and ***,the potential prognostic biomarkers in this region remain relatively underexplored in *** To investigate the prognostic value and importance of peritumoral radiomics in locally advanced rectal cancer(LARC).METHODS This retrospective study included 409 patients with biopsy-confirmed LARC treated with neoadjuvant chemoradiotherapy and *** were divided into training(n=273)and validation(n=136)*** on intratumoral and peritumoral radiomic features extracted from pretreatment axial high-resolution small-field-of-view T2-weighted images,multivariate Cox models for progression-free survival(PFS)prediction were developed with or without clinicoradiological features and evaluated with Harrell’s concordance index(C-index),calibration curve,and decision curve *** stratification,Kaplan-Meier analysis,and permutation feature importance analysis were *** The comprehensive integrated clinical-radiological-omics model(ModelICRO)integrating seven peritumoral,three intratumoral,and four clinicoradiological features achieved the highest C-indices(0.836 and 0.801 in the training and validation sets,respectively).This model showed robust calibration and better clinical net benefits,effectively distinguished high-risk from low-risk patients(PFS:97.2%vs 67.6%and 95.4%vs 64.8%in the training and validation sets,respectively;both P<0.001).Three most influential predictors in the comprehensive ModelICRO were,in order,a peritumoral,an intratumoral,and a clinicoradiological ***,the peritumoral model outperformed the intratumoral model(C-index:0.754 vs 0.670;P=0.015);peritumoral features significantly enhanced the performance of models based on clinicoradiological or intratumoral features or their *** Peritumoral radiomics holds greater prognostic value than intratumoral radiomics for predicting PFS in L

关键词： Rectal cancer Peritumoral radiomics Intratumoral radiomics Prognosis analysis Variable importance analysis Tumor microenvironment