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Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy

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World Journal of Gastroenterology 2017年第36期23卷 6733-6740页

作者： Jing-Xian Sun Ke-Yun Bai Yan-Feng Liu Gang Du zhi-hao fu hao Zhang Jin-Huan Yang Ben Wang Xiu-Yu Wang Bin Jin Department of Anorectal Surgery Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011 Shandong Province China Department of Hepatobiliary Surgery Qilu Hospital of Shandong UniversityJinan 250012 Shandong Province China Department of Anesthesiology Qilu Hospital of Shandong UniversityJinan 250012 Shandong Province China

AIM To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open *** A total of 56 patients undergoing open hepatectomy were randomly divided into two groups:a ropivacaine group(wound infiltration with ropivacaine solution)and a control group(infiltration with isotonic saline solution).A visual analog scale(VAS)at rest and on movement was used to measure postoperative pain for the first 48 h after *** arterial pressure(MAP),heart rate(HR),time to bowel recovery,length of hospitalization after surgery,cumulative sufentanil consumption,and incidence of nausea and vomiting were compared between the two *** stress hormones(epinephrine,norepinephrine,and cortisol)were detected using enzyme-linked immunosorbent assay,and the results were compared. RESULTS VAS scores both at rest and on movement at 24 h and48 h were similar between the two *** lower VAS scores were detected at 0,6,and 12 h in the ropivacaine group compared with the control group(P<0.05 for all).MAP was significantly lower at 6,12,and 24 h(P<0.05 for all);HR was significantly lower at 0,6,12,and 24 h(P<0.05 for all);time to bowel recovery and length of hospitalization after surgery(P<0.05 for both)were significantly shortened;and cumulative sufentanil consumption was significantly lower at 6,12,24,and 36 h(P<0.05 for all)in the ropivacaine group than in the control group,although the incidence of nausea and vomiting showed no significant difference between the two *** levels of epinephrine,norepinephrine,and cortisol were significantly lower in the ropivacaine group than in the control group at 24 and 48 h(P<0.01 for all). CONCLUSION Local wound infiltration with ropivacaine after open hepatectomy can improve postoperative pain relief,reduce surgical stress response,and accelerate postoperative recovery.

关键词： Local wound infiltration Ropivacaine Open hepatectomy Postoperative pain Surgical stress

A novel alternative for pyrogen detection based on a transgenic cell line

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： Qing He Chuan-Fei Yu Gang Wu Kai-Qin Wang Yong-Bo Ni Xiao Guo zhi-hao fu Lan Wang De-Jiang Tan Hua Gao Can Wang Gang Chen Xu-Hong Chen Bo Chen Jun-zhi Wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

Study of Self-Similarity in Variable Bit Rate Video Sources

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Wuhan University Journal of Natural Sciences 1999年第2期4卷 60-63页

作者： ZHU Qiu ping, FANG zhi hao, LUO Juan,fu Liang College of Electronic Information,Wuhan University,Wuhan 430072,China Wuhan University College of Electronic Information Wuhan China (GRID:grid.49470.3e) (ISNI:***)

Variable bit rate(VBR)video will be the predominant application in the future's multimedia communication *** the characteristics of VBR video is important for us to utilize network resources effectively.A brief description of MPEG 1 video sources is *** essentials of self similarity and long range dependence are also ***,some methods of estimating Hurst parameter are described in *** analyze an hour long MPEG 1 video trace,and the details of statistical results are *** results highlight that the trace generated by MPEG 1 code has both the short range dependence and long range dependence structures.

关键词： self similarity long range dependence VBR video sources

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地下水系统数值模拟的研究现状和发展趋势

水利水电科技进展 2006年第1期26卷 77-81页

作者：郝治福康绍忠中国农业大学中国农业水问题研究中心北京100083

综述近几年国内外地下水系统数值模拟领域在思维方法、数学工具和计算机软件技术等方面的研究现状,分析了国内外在确定地下水系统数值模拟模型的不确定因素、应用3S技术和数值模拟软件的情况,提出了存在的问题,强调多学科模型的耦合及... 详细信息

综述近几年国内外地下水系统数值模拟领域在思维方法、数学工具和计算机软件技术等方面的研究现状,分析了国内外在确定地下水系统数值模拟模型的不确定因素、应用3S技术和数值模拟软件的情况,提出了存在的问题,强调多学科模型的耦合及对水文地质参数研究和基础资料获取的重要性,指出计算机技术的深入应用、三维数值模型的建立和多种模型的耦合是未来发展方向。

关键词：地下水系统地下水资源数值模拟

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan Zhang Cheng hao Tongtong fu Dian Yu Jane Howe Kaiwen Chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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数字阅读环境下公共图书馆的服务创新

农业图书情报学刊 2013年第3期25卷 165-167页

作者：刘莉郝志福黑龙江省图书馆哈尔滨150090

网络数字阅读以势不可当之势袭击而来,面对社会的发展和读者的需求,公共图书馆如何克服自身发展的障碍,创新服务理念和服务内容,推进公共图书馆数字阅读化发展的进程,结合现阶段图书馆数字阅读发展所面临的问题指出公共图书馆服务创新... 详细信息

网络数字阅读以势不可当之势袭击而来,面对社会的发展和读者的需求,公共图书馆如何克服自身发展的障碍,创新服务理念和服务内容,推进公共图书馆数字阅读化发展的进程,结合现阶段图书馆数字阅读发展所面临的问题指出公共图书馆服务创新之路。

关键词：数字阅读公共图书馆服务创新

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腰椎小关节退变的CT诊断价值

实用放射学杂志 2004年第12期20卷 1107-1109页

作者：殷好治梁福民王希林傅晓芹梁付奎山东省昌乐县人民医院CT室山东省昌乐县人民医院CT室山东昌乐262400

目的　引起临床与影像医学界对关节突关节病的重视。方法　用本组病例结合文献对关节突关节病的发病与CT表现进行综合研究。结果　通过 94例关节突关节病的CT所见 ,总结出 5项主要征象 :①关节增生肥大及骨赘形成 ;②关节间隙狭窄或宽... 详细信息

目的　引起临床与影像医学界对关节突关节病的重视。方法　用本组病例结合文献对关节突关节病的发病与CT表现进行综合研究。结果　通过 94例关节突关节病的CT所见 ,总结出 5项主要征象 :①关节增生肥大及骨赘形成 ;②关节间隙狭窄或宽窄不等 ;③关节间隙内真空现象 ;④关节囊肥厚或钙化 ;⑤关节不稳。结论　关节突关节病是一种发病率很高的疾病 ,CT扫描对本病具有重要意义。

关键词：关节突关节病关节囊真空现象