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丹龙口服液对肺间质纤维化小鼠肺组织病变的影响

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天津中医药 2024年第9期41卷 1161-1166页

作者：马悦宁郭思佳李云辉天津中医药大学第一附属医院感染疾病科天津300381 国家中医针灸临床医学研究中心天津300381 天津中医药大学第二附属医院天津300250

[目的]观察中成药丹龙口服液对小鼠肺间质纤维化的影响,并对比其与西药吡非尼酮作用效果的差异,探讨丹龙口服液干预肺间质纤维化疗效及可能存在的机制。[方法]通过博来霉素鼻腔滴入法建立肺间质纤维化昆明小鼠模型,造模14 d后开始灌胃给... 详细信息

[目的]观察中成药丹龙口服液对小鼠肺间质纤维化的影响,并对比其与西药吡非尼酮作用效果的差异,探讨丹龙口服液干预肺间质纤维化疗效及可能存在的机制。[方法]通过博来霉素鼻腔滴入法建立肺间质纤维化昆明小鼠模型,造模14 d后开始灌胃给药,治疗28 d。观察小鼠一般情况、肺功能、肺组织形态学染色、羟脯氨酸(HYP)及促纤维化因子水平等。[结果]丹龙口服液在各指标中均可与吡非尼酮治疗肺间质纤维化呈现相似或更佳水平。在体质量变化及一般情况中中成药较西药治疗更佳,肺功能水平中成药与西药改善情况相似;苏木精-伊红(HE)染色结果显示中成药与西药减轻肺泡炎症结果相似;masson染色显示西药较中成药更佳;在肺组织HYP及血清、肺泡灌洗液中促纤维化因子表达水平中,两组呈现相似水平。[结论]丹龙口服液可以对防治小鼠肺间质纤维化中起到一定的作用,其作用与抑制肺组织炎症及降低促纤维化因子水平相关。

关键词：丹龙口服液肺间质纤维化实验研究

Genotypic variations in the accumulation of Cd exhibited by different vegetables

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Journal of Environmental Sciences 2010年第8期22卷 1246-1252页

作者： Junxing Yang Haitao guo Yibing ma Liqun Wang Dongpu Wei Luo Hua Ministry of Agriculture Key Laboratory of Plant Nutrition and Nutrient Cycling Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China The Key Laboratory of Resource Environment and GIS College of Resource Environment and Tourism Capital Normal University Beijing 100037 China

It is an important approach to use the Cd-contaminated soils properly by growing low accumulator or excluder plants for Cd to produce safe foods. To find the suitable vegetable species for growing in Cd-contaminated soils, in the present study the variations in the Cd accumulation for twenty eight vegetable species and several cultivars of five common vegetables （cowpea, kidney pea, bitter gourd, cucumber and squash） were investigated in two soil Cd levels （1 and 2 mg/kg Cd）. Experimental results showed that highly significant differences in Cd concentration were evident among 28 vegetables. For example, spinach Cd concentrations were 110-fold and 175-fold higher than that of sweet pea under the 1 and 2 mg/kg Cd exposures, respectively. For Cd accumulation, the order of vegetable species was： leafy vegetables solanaceous vegetables kale vegetables root vegetables allimus melon vegetables legumes. Distinctive differences were also identified when comparing different cultivars of the five common vegetables with an average range of 0.003–0.094 mg/kg Cd. Our results indicated that a large genotypic variation existed among vegetable species or cultivars when subjected to Cd exposure. Therefore, it is important and feasible to elect/breed vegetable species/cultivars with low accumulation of Cd, especially in mildly Cd-contaminated soils.

关键词： vegetables cadmium accumulation genotypic variations

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氟化氨银预防及抑制龋齿的Meta分析

现代口腔医学杂志 2024年第2期38卷 123-127页

作者：马思雨郭欣欣荆雪李涛河北医科大学口腔医学院·口腔预防科河北省口腔医学重点实验室河北省口腔疾病临床医学研究中心石家庄050017

目的全面系统评价氟化氨银(Silver diamine fluoride,SDF)的临床应用效果,为氟化氨银应用于临床龋病防治提供依据。方法检索知网、万方、维普、CBM数据库、PubMed、Web of Science、Cochrane library、Science Direct,收集自建库至2023... 详细信息

目的全面系统评价氟化氨银(Silver diamine fluoride,SDF)的临床应用效果,为氟化氨银应用于临床龋病防治提供依据。方法检索知网、万方、维普、CBM数据库、PubMed、Web of Science、Cochrane library、Science Direct,收集自建库至2023年5月关于氟化氨银预防及抑制龋齿的随机对照试验文章。纳入的结局指标包括:龋失补牙面数、新发龋齿牙面数、静止龋牙面数。本Meta分析运用satat17.0软件进行数据分析。结果从数据库中共检索出1532篇相关文献,并根据纳入及排除标准,最终纳入10篇文献。Meta分析结果显示,应用氟化氨银和氟化钠相比,新发龋齿牙面数无显著性差异(SMD=-0.133,95%CI=-0.28~0.01,P=0.503);应用氟化氨银后静止龋牙面数较多(SMD=0.626,95%CI=0.42~0.83,P=0.915)。应用氟化氨银和安慰剂相比,龋失补牙面数无显著性差异(SMD=-0.519,95%CI=-1.18~0.14,P=0);应用氟化氨银后新发龋齿牙面数较少(SMD=-0.448,95%CI=-0.62~-0.28,P=0.085);应用氟化氨银后静止龋牙面数较多(SMD=0,95%CI=0.62~0.86,P=0.34)。结论应用氟化氨银有利于预防及抑制龋齿,建议在临床上广泛应用。

关键词：龋齿氟化氨银预防静止龋 Meta分析

BHONEM:Binary High-Order Network Embedding Methods for Net worked-Guarantee Loans

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Journal of Computer Science & Technology 2019年第3期34卷 657-669页

作者： Da-Wei Cheng Yi Tu Zhen-Wei ma zhi-Bin Niu Li-Qing Zhang Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of mathematical Science Shanghai Jiao Tong University.Shanghai 200240China School of Computer Software Tianjin UniversityTianjin 300354China

Networked-guarantee loans may cause systemic risk related concern for the government and banks in *** prediction of the default of enterprise loans is a typical machine learning based classification problem, and the networked guarantee makes this problem very difficult to solve. As we know, a complex network is usually stored and represented by an adjacency matrix. It is a high-dimensional and sparse matrix, whereas machine-learning methods usually need lowdimensional dense feature representations. Therefore, in this paper, we propose a binary higher-order network embedding method to learn the low-dimensional representations of a guarantee network. We first set vertices of this heterogeneous economic network by binary roles (guarantor and guarantee), and then define high-order adjacent measures based on their roles and economic domain knowledge. Afterwards, we design a penalty parameter in the objective function to balance the importance of network structure and adjacency. We optimize it by negative sampling based gradient descent algorithms,which solve the limitation of stochastic gradient descent on weighted edges without compromising efficiency. Finally, we test our proposed method on three real-world network datasets. The result shows that this method outperforms other start-of-the-art algorithms for both classification accuracy and robustness, especially in a guarantee network.

关键词： networked-guarantee loan high-order network embedding representative learning gradient descent

CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison

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Genomics, Proteomics & Bioinformatics 2018年第4期16卷 226-233页

作者： Rui Dong Xu-Kai ma guo-Wei Li Li Yang CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University

Circular RNAs （circRNAs） from back-splicing of exon（s） have been recently identified to be broadly expressed in eukaryotes, in tissue-and species-specific manners. Although functions of most circRNAs remain elusive, some circRNAs are shown to be functional in gene expression regulation and potentially relate to diseases. Due to their stability, circRNAs can also be used as biomarkers for diagnosis. Profiling circRNAs by integrating their expression among different samples thus provides molecular basis for further functional study of circRNAs and their potential application in clinic. Here, we report CIRCpedia v2, an updated database for comprehensive circRNA annotation from over 180 RNA-seq datasets across six different species. This atlas allows users to search, browse, and download circRNAs with expression features in various cell types/tissues, including disease samples. In addition, the updated database incorporates conservation analysis of circRNAs between humans and mice. Finally, the web interface also contains computational tools to compare circRNA expression among samples. CIRCpedia v2 is accessible at http：//***/rnomics/circpedia.

关键词： Circular RNACircRNA Back-splicing Database CIR Cpedia

Neoproterozoic–Early Paleozoic Tectonic Evolution of the South China Craton： New Insights from the Polyphase Deformation in the Southwestern Jiangnan Orogen

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1700-1727页

作者： ZHAO Zhongbao XU zhiqin ma Xuxuan LIANG Fenghua guo Peng Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China State Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210046 China School of Earth Science and Resources China University of Geosciences Beijing 100083 China

A 〉1500–km–long northeast–southwest trending Neoproterozoic metamorphic belt in the South China Craton（SCC） consists of subduction mélange and extensional basin deposits. This belt is present under an unconformity of Devonian–Carboniferous sediments. Tectonic evolution of the Neoproterozoic rocks is crucial to determining the geology of the SCC and further influences the reconstruction of the Rodinia supercontinent. A subduction mélange unit enclosed ca.1000–850–ma mafic blocks, which defined a Neoproterozoic ocean that existed within the SCC, is exposed at the bottom of the Jiangnan Orogen（JO） and experienced at least two phases deformation. Combined with new（detrital） zircon U–Pb ages from metasandstones, as well as igneous rocks within the metamorphic belt, we restrict the strongly deformed subduction mélange as younger than the minimum detrital age ca. 835 ma and older than the ca. 815 ma intruded granite. Unconformably overlying the subduction mélange and the intruded granite, an intra–continental rift basin developed 〈800 ma that involved abundant mantle inputs, such as mafic dikes. This stratum only experienced one main phase deformation. According to our white mica ^40Ar/^（30）Ar data and previously documented thermochronology, both the Neoproterozoic mélange and younger strata were exhumed by a 490–400–ma crustal–scale positive flower structure. This orogenic event probably induced the thick–skinned structures and was accompanied by crustal thickening, metamorphism and magmatism and led to the closure of the pre–existing rift basin. Integrating previously published data and our new results, we agree that the SCC was located on the periphery of the Rodinia supercontinent from the Neoproterozic until the Ordovician. Furthermore, we prefer that the convergence and dispersal of the SCC were primarily controlled by oceanic subduction forces that occurred within or periphery of the SCC.

关键词： Rodinia supercontinent South China Craton Jiangnan Orogen intra–continental rifting intra–continental orogen

复杂环境下基于自适应极线约束的AGV视觉SLAM算法

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中国惯性技术学报 2024年第3期32卷 234-241页

作者：崔岸张新颖马耀辉吉林大学汽车工程学院长春130025 吉林大学汽车仿真与控制国家重点实验室长春130025

针对传统视觉同步定位与地图构建(SLAM)算法不能有效处理复杂环境中的动态及潜在动态目标而影响定位与建图性能的问题,提出一种基于mask R-CNN神经网络以及ORB-SLAM3算法改进的视觉SLAM方法。针对动态目标,提出一种基于语义信息的运动... 详细信息

针对传统视觉同步定位与地图构建(SLAM)算法不能有效处理复杂环境中的动态及潜在动态目标而影响定位与建图性能的问题,提出一种基于mask R-CNN神经网络以及ORB-SLAM3算法改进的视觉SLAM方法。针对动态目标,提出一种基于语义信息的运动一致性检验算法,使用自适应阈值的极线约束方法实现图像中动态特征点的精确剔除;针对潜在动态目标,提出一种改进的长期数据关联方法,通过增大关键帧选取密度及优化关键帧中的潜在动态目标信息,对算法的回环优化和地图融合过程进行改进,提高回环优化效果与地图复用性。在TUM数据集和真实场景中进行验证,实验结果表明与ORB-SLAM3算法相比,采用TUM数据集在低动态场景和高动态场景中的绝对轨迹均方根误差分别减小8.5%和65.6%;在真实场景下测试,所提算法的定位精度提高了62.5%。

关键词：同步定位与地图构建复杂环境语义信息自适应阈值极线约束

Thermal and Optoelectronic Properties of Anthracene and Dibenz[a,c]Anthracene

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Chemical Research in Chinese Universities 2013年第1期29卷 110-115页

作者： MUDDASIR Hanif WANG zhi-ming YANG Bing LU Ping ma Yu-guang State Key Laboratory of Supramolecular Structure and materials Jilin University Changchun 130012 P. R. China School of Petrochemical Engineering Shenyang University of Technology Liaoyang 111003 P. R. China

The basic characteristics of anthracene（AN） and dibenz[a,c]anthracene（D[a,c]A） derivatives, important semiconductors, were systematically studied. Differential scanning calorimetry（DSC） shows that D[a,c]A has the reversibility of solid and liquid phases. Thermalgravimetric analysis（TGA） shows that D[a,c]A exhibits higher Td（decomposition temperature）, which indicates D[a,c]A, as active layers, should be more suitable to being made into stable devices. D[a,c]A shows blue-shifted UV-Vis absorption and emission despite increased conjugation compared to anthracene due to different symmetries. Both the compounds are planar and show weak blue fluorescence in the tetrahydrofuran（THF） solution and higher fluorescence in the solid-state, due to different energy levels in solution and solid-state, explained via Jablonski diagram.

关键词： Anthracene Dibenz[a,c]anthracene Molecular property Thermal Electrochemistry

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再生细骨料自密实混凝土试验研究

山西建筑 2024年第8期50卷 111-113页

作者：张少峰杨凯郭俊珍马颉内蒙古自治区住房和城乡建设绿色研究发展中心内蒙古呼和浩特010050 兴泰建设集团有限公司内蒙古呼和浩特010050

基于全计算法配合比设计方法设计了再生细骨料自密实混凝土的配合比。通过研究其工作性能,在满足工作性能的情况下,确定最终配合比,并对力学性能进行了测试。试验结果表明,通过合理调整砂率和外加剂的用量,能够利用建筑垃圾再生细骨料... 详细信息

基于全计算法配合比设计方法设计了再生细骨料自密实混凝土的配合比。通过研究其工作性能,在满足工作性能的情况下,确定最终配合比,并对力学性能进行了测试。试验结果表明,通过合理调整砂率和外加剂的用量,能够利用建筑垃圾再生细骨料制备出满足要求的自密实混凝土;短龄期的再生细骨料自密实混凝土的抗压强度和劈裂抗拉强度要低于普通天然砂自密实混凝土,但经过长龄期标准养护后,再生细骨料自密实混凝土的强度和强度增长率均有提高。在90 d龄期下,再生细骨料自密实混凝土基本接近普通混凝土。

关键词：再生细骨料自密实混凝土配合比设计工作性能力学性能