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A GPU-Accelerated In-Memory Metadata Management Scheme forLarge-Scale Parallel File Systems

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Journal of Computer Science & Technology 2021年第1期36卷 44-55页

作者： zhi-guang chen Yu-Bo Liu Yong-Feng Wang Yu-Tong Lu School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China

Driven by the increasing requirements of high-performance computing applications,supercomputers are prone to containing more and more computing *** running on such a large-scale computing system are likely to spawn millions of parallel processes,which usually generate a burst of I/O requests,introducing a great challenge into the metadata management of underlying parallel file *** traditional method used to overcome such a challenge is adopting multiple metadata servers in the scale-out manner,which will inevitably confront with serious network and consistence *** work instead pursues to enhance the metadata performance in the scale-up ***,we propose to improve the performance of each individual metadata server by employing GPU to handle metadata requests in *** proposal designs a novel metadata server architecture,which employs CPU to interact with file system clients,while offloading the computing tasks about metadata into *** take full advantages of the parallelism existing in GPU,we redesign the in-memory data structure for the name space of file *** new data structure can perfectly fit to the memory architecture of GPU,and thus helps to exploit the large number of parallel threads within GPU to serve the bursty metadata requests *** implement a prototype based on BeeGFS and conduct extensive experiments to evaluate our proposal,and the experimental results demonstrate that our GPU-based solution outperforms the CPU-based scheme by more than 50%under typical metadata *** superiority is strengthened further on high concurrent scenarios,e.g.,the high-performance computing systems supporting millions of parallel threads.

关键词： GPU-accelerated in-memory metadata management parallel file system

Synthesis and Antitumor Activity of an Analog of Phthalascidin

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Chinese Chemical Letters 2006年第10期17卷 1279-1282页

作者： Ye WANG Yan Li ZHOU Zhan Zhu LIU Shi zhi chen Xiao guang chen Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050

An analog of phthalascidin （Pt-650） was synthesized with an improved synthetic route. With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor test of this Pt-650 analog showed that it possessed strong toxicity against a number of tumor cell lines including A2780, A549, Bel-7402, BGC-823, HELA, KB, KeTr3 and HCT-8.

关键词： Ecteinascidin phthalascidin tetrahydroisoquinoline antitumor.

Lesion discrimination with breath-hold hepatic diffusionweighted imaging:A meta-analysis

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World Journal of Gastroenterology 2015年第5期21卷 1621-1627页

作者： zhi-guang chen Li Xu Si-Wei Zhang Yan Huang Rui-Huan Pan Department of Radiology Guangdong Provincial Traditional Chinese Medicine Hospital Department of Neurology Guangdong Provincial Traditional Chinese Medicine Hospital

AIM:To investigate the diagnostic capability of breathhold diffusion-weighted imaging(DWI) for differentiation between malignant and benign hepatic ***:A total of 614 malignant liver lesions(132 hepatocellular carcinomas,468 metastases and 14 intrahepatic cholangiocarcinomas) and 291 benign liver lesions(102 hemangiomas,158 cysts,24 focal nodular hyperplasia,1 angiomyolipoma and 6 hepatic adenomas) were included from seven studies(eight sets of data).RESULTS:The pooled sensitivity and specificity of breath-hold DWI were 0.93 [95% confidence interval(CI):0.91-0.95] and 0.87(95%CI:0.83-0.91),*** positive likelihood ratio and negative likelihood ratio were 7.28(95%CI:4.51-11.76) and 0.09(95%CI:0.05-0.17),*** P value for χ2 heterogeneity for all pooled estimates was 0.05).CONCLUSION:Breath-hold DWI is useful for differentiating between malignant and benign hepatic *** diffusion characteristics of benign lesions that mimic malignant ones have rarely been investigated.

关键词： Breath-hold imaging Diffusion-weighted imaging Hep

On efficiency of sand-controlling system along the Tarim Desert Highway in Taklimakan Desert

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Journal of Geographical Sciences 2000年第2期10卷 141-150页

作者： WANG Xun-ming, DONG zhi-bao, chen guang-ting, HAN zhi-wen (Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China)

As the longest desert highway in China. the 447-kin-long Taklimakan Desert Highway which goes across the Taklimakan Desert was fully opened to traffic in 1996~[1]. The sand-controlling system along the Desert Highway enables the Highway itself to operate properly and creates enormous socio-economic benefits. However, due to delivery time pressure, the sand-controlling system was built in a haste. Lack of studies on sand-controlling system brought deficiencies on design and construction of the sand-controlling system. And with the lapse of time, troubles such as sand deposition on the roadbeds and erosion on roadsides came to surface and caused more serious problems for the traffic routes[1.2]. This paper discusses two forms of the sand-controlling system-the upright fence and the send-covered sand barrier, then analyzes the general benefits of the sandcontrolling system along the Desert Highway.

关键词： sand-controlling system, desert highway Taklimakan Desert

Relationships between use of statins and arterial stiffness in normotensive and hypertensive patients with coronary artery disease

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Chinese Medical Journal 2013年第16期126卷 3087-3092页

作者： WANG zhi-guang chen Bing-wei L(U) Na-qiang chenG Yan-mei DANG Ai-min State Key Laboratory of Cardiovascular Disease Department ofCardiology Fuwai Hospital National Center for CardiovascularDiseases Chinese Academy of Medical Sciences and Peking UnionMedical College Beijing 100037 China

Background Statins improve arterial stiffness in patients with coronary artery disease （CAD）.Hypertension is a predominant contributor of arterial ***,the influence of hypertension on the effect of statins for improving arterial stiffness in CAD patients has seldom been ***,in this study,we investigated the relationships between statin use and arterial stiffness in normotensive and hypertensive CAD *** Brachial-ankle pulse wave velocity （ba-PWV） was measured in 437 patients,including 220 hypertensive CAD patients （121 used statins,99 did not） and 217 normotensive CAD patients （105 used statins,112 did not）.The normotensive and hypertensive CAD patients were matched according to age,sex,and body mass index （BMI）.Results In the normotensive and hypertensive CAD patients,lipid profiles were significantly improved in the statin group compared with the non-statin *** significant differences in the administered statins （i.e.,atorvastatin,simvastatin,rosuvastatin,and pravastatin） and statin therapy duration were found between normotensive and hypertensive CAD patients （all P＞0.05）.No significant correlation of ba-PWV and statin therapy duration was found in all CAD patients,normotensive CAD patients,or hypertensive CAD patients （all P＞0.05）.ba-PWV in the statin group was significantly lower than that in the non-statin group in normotensive CAD patients （（1331.68±167.52） cm/s vs.（1468.61±244.54） cm/s,P=0.002） but not in hypertensive CAD patients （P＞0.05）.In multiple linear regression analyses,statin therapy was significantly associated with ba-PWV after adjusting for confounding variables in normotensive CAD patients （P=0.018） but not in hypertensive CAD patients （P＞0.05）.Conclusions Statins may significantly improve arterial stiffness in CAD patients,and hypertension may probably influence the effectiveness of statin therapy in improving arterial stiffness in this *** studies are required to investigate the

关键词： arterial stiffness statins hypertension coronary artery disease

KIAA0305, a FYVE domain protein, is invoved in TGFb signaling transduction

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KIAA0305, a FYVE domain protein, is invoved in TGFb signalin...

Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma

中国细胞生物学学会2005年学术大会、青年学术研讨会

作者： zhi Wang, Ye-guang chen Tsinghua University, Beijing 100084

KIAA0305 is a member of the FYVE domain protein family, which has about 50% identity in the carboxyl-terminal 800 amino acid region related to SARA (Smad anchor for receptor activation). Both KIAA0305 and SARA are mainly targeted to the early endosome mediated by the FYVE domain. It is well known that SARA can interact with Smad2, Smad3 and TbR I receptor and is an important component in TGFb signal transduction. To date, no relationship in KIAA0305's function with TGFb signal pathway has been identified. In our research, we found that KIAA0305 colocalizes partially with SARA and TbR I receptor and it can interact with SARA, TbR I receptor and Smad4. Mutations in KIAA0305 cause mislocalization of this protein , inhibit TGFb-dependent transcriptional responses. Furthermore, using small interfering RNAs (siRNAs) specifically inhibit KIAA0305 expression can also reduce TGFb-dependent transcriptional responses. These results collectively suggested that KIAA0305 may play a functional role in TGFb signal transduction.

关键词： domain KIAA0305 a FYVE domain protein is invoved in TGFb signaling transduction

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Chinese Medical Journal 2013年第3期126卷 482-487页

作者： chen Bo-bin XU Xiao-ping SHEN Lin HAN Tian-jie LIN zhi-guang chen Zi KANG Hui HUANG Bo LIN Guo-wei Department of Hematology Huashan Hospital Shanghai Medical College Fudan University Shanghai 200040 China

Background Clinical outcome in patients with primary central nervous lymphoma （PCNSL） is variable and poorly predictable. This study investigated the association of clinical features and immune markers with prognosis of patients with PCNSL. Methods One hundred and fifteen newly diagnosed PCNSL patients at the study institution were considered eligible for this study. Clinical characteristics and biochemical assay data were collected. Immunohistochemical staining of Cyclin D3, Cyclin E, Foxpl, and LMO2 were performed. All cases were followed-up regularly. Results The common sites of involvement were frontal lobe （54.8%） and thalamus （16.5%）. Diffuse large B-cell lymphoma composed of 96.5% of the cases. The median overall survival was 22 （4-41） months, and the 5-year survival rate was 22.8%. Age 〉65 years, serum globulin 〉40 g/L, large size of tumor, lymphocyte count ≥1×10^9/L, and expression of Cyclin D3 and Cyclin E were associated with poor prognosis of PCNSL. Expressions of Foxpl, LMO2, and CD44 were not related to the survival. Expression of Cyclin E, large tumor size, and high serum globulin were independent prognostic factors for PCNSL. Conclusions PCNSL prognosis is relatively poor. Age, high tumor burden, higher lymphocyte count, expression of Cyclin D3, and Cyclin E are inferior prognostic factors for PCNSL.

关键词： primary central nervous system lymphoma prognosis, immunochemohistorical marker, Cyclin D3 Cyclin E

Sensitized photorehox reaction——Ⅴ.The complcxation of zincte traphenylporphyrin sulfonate with viologens and its role in the sensitized photoreduction of methyl viologen

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Acta Chimica Sinica(English Edition) 1987年第4期 349-351页

作者： WANG Xiu-zhi LIANG Xiao-guang chen Yu-Yi Institute of Photographic Chemistry,Academia Sinica,Beijing

Photolysis of water to yield molecular hydrogen and oxygen is one of the most promis-ing means converting solar energy to chemical *** has been demonstrated that in thepresence of a catalyst,methyl viologen cation radical（MV+）,a product derived from the sen-sitized photoreduction of methyl viologen(MV2+),can reduce water successfully to yield hy-drogen *** aqueous solution,the efficiency of zinc tetramethylpyridylporphyrin（ZnTMPyP）in sensitizing photoreduction of MV2+ is much higher as compared with zinc te-traphenylporphyrin sulfonate（ZnTPPS）.This phenomenon can best be explained by *** of a photo-inert complex between the negatively charged ZnTPPS and the positively

关键词： Sensitized photorehox reaction The complcxation of zincte traphenylporphyrin sulfonate with viologens and its role in the sensitized photoreduction of methyl viologen MV

Solutions to Steady State Generalized Smoluchovski Equation with Reinforced Source

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Advances in Manufacturing 2000年第3期4卷 204-209页

作者： Yu Xue guang-zhi chen Institute of Applied Mathematics and Mechanics Shanghai University Shanghai China Department of Physics Guangxi University Nanning China

The generalized Smoluchovski equation with reinforced source is analysed. The asymptotic expression of the size distribution of cluster C m(t) is obtained by seeking the steady state solution and post gel solution of the generalized Smoluchovski equation with reinforced source. The result can be verified by Friedlander's experiment.

关键词： coagulation kernel generalized Smoluchovski equation clustering process