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Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke

Stroke & Vascular Neurology 2024年第4期9卷 367-379,I0022-I0031页

作者： Tianchi Tang Li-bin hu Chao Ding zhihua Zhang Ning Wang Tingting Wang Hang Zhou Siqi Xia Linfeng Fan Xiong-jie Fu Feng Yan Xiangnan Zhang gao Chen Jianru Li Department of Neurosurgery Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 2NeurosurgeryZhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 3Zhejiang University School of MedicineHangzhouZhejiangChina 4Zhejiang University Department of PharmacologyHangzhouZhejiangChina

Background Ischaemic stroke triggers neuronal mitophagy,while the involvement of mitophagy receptors in ischaemia/reperfusion(I/R)injury-induced neuronal mitophagy remain not fully ***,we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1(FUNDC1)and its modulation in neuronal mitophagy induced by I/R *** Wild-type and FUNDC1 knockout mice were generated to establish models of neuronal I/R injury,including transient middle cerebral artery occlusion(tMCAO)in vivo and oxygen glucose deprivation/reperfusion in *** outcomes of mice with two genotypes were *** mitophagy was analysed both in vivo and in *** of FUNDC1 and its regulator Src were *** impact of Src on FUNDC1-mediated mitophagy was assessed through administration of Src antagonist *** To our surprise,FUNDC1 knockout mice subjected to tMCAO showed stroke outcomes comparable to those of their wild-type *** neuronal mitophagy could be activated by I/R injury,FUNDC1 deletion did not disrupt neuronal *** activation of FUNDC1,represented by dephosphorylation of Tyr18,was detected in the early stages(within 3hours)of neuronal I/R injury;however,phosphorylated Tyr18 reappeared and even surpassed baseline levels in later stages(after 6hours),accompanied by a decrease in FUNDC1-light chain 3 *** inactivation of FUNDC1 was associated with Src activation,represented by phosphorylation of Tyr416,which changed in parallel with the level of phosphorylated FUNDC1(Tyr18)during neuronal I/R ***,FUNDC1-mediated mitophagy in neurons under I/R conditions can be rescued by pharmacological inhibition of *** FUNDC1 is inactivated by Src during the later stage(after 6hours)of neuronal I/R injury,and rescue of FUNDC1-mediated mitophagy may serve as a potential therapeutic strategy for treating ischaemic stroke.

关键词： FUNDC1 involvement injury

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On Representation Theorem of G-Expectations and Paths of G-Brownian Motion

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Acta Mathematicae Applicatae Sinica 2009年第3期25卷 539-546页

作者： Ming-shang hu Shi-ge Peng Institute of Mathematics Shandong University Jinan 250100 China

We give a very simple and elementary proof of the existence of a weakly compact family of probability measures {Pθ ： θ∈θ} representing an important sublinear expectation- G-expectation E[·]. We also give a concrete approximation of a bounded continuous function X（ω） by an increasing sequence of cylinder functions Lip（Ω） in order to prove that Cb（Ω） belongs to the completion of Lip（Ω） under the natural norm E[｜·｜].

关键词： Probability and distribution uncertainty G-normal distribution G-Brownian motion continuous paths

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ASPPR: active single-image piecewise planar 3D reconstruction based on geometric priors

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Science China(Information Sciences) 2023年第7期66卷 297-299页

作者： Wei WANG Qiulei DONG Zhanyi hu School of Network Engineering Zhoukou Normal University National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences University of Chinese Academy of Sciences

Single-image piecewise planar reconstruction aims at recovering piecewise planar structures of a building from an image. Considering the intrinsic spatial ambiguity in a single image, it is an enormous challenge for existing geometry and learning-based methods [1, 2] to obtain reliable results on complex building structures. To address the problem,

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Preparation and Tribological Properties of Onion-like Carbon/Waterborne Polyurethane Coatings

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 108-120页

作者： Fei Xingpeng Jiang Wuhao Wen Maosheng Xu Yong hu Kunhong hu Enzhu Department of Energy Materials and Chemical Engineering Hefei UniversityHefei 230601China Anhui Province Key Laboratory of Critical Friction Pair for Advanced Equipment Hefei 230088China

Rice husk powder was used as a carbon source in a high-temperature carbonization reaction for the production of rice husk ash(RHA).Under the catalysis of ferric nitrate,onion-like carbon(OLC)nanomaterial with a particle size of approximately 200 nm was successfully prepared and incorporated into waterborne polyurethane(WPU).The tribological properties of the coatings were determined using a controlled-atmosphere tribometer(WMT-2E)under dry-friction *** the friction test,the friction mechanism was investigated by characterizing the abrasive spot surfaces of the test samples using 3D laser microscopy and scanning electron microscopy/energy dispersive *** final results demonstrated that the thermal stability of WPU composite coatings containing various concentrations of OLC nanoparticles was significantly enhanced,binding forces between coatings and steel sheets increased,and hardness improved compared to pure WPU *** tests revealed a notable enhancement in the anti-wear properties of WPU coatings due to the presence of OLC ***,the wear rate of the 1.5%OLC/WPU coating was reduced by 45.3%.The coating’s anti-wear mechanism was attributed to the improvement in the mechanical properties of WPU due to OLC,as well as OLC’s participation in the formation of a transfer film under induced friction,which protected the matrix.

关键词： biomass carbon onion-like carbon waterborne polyurethane wear transfer films

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Genetic Modification of Baculovirus Expression Vectors

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Virologica Sinica 2012年第2期27卷 71-82页

作者： Shu-fen Li hua-lin Wang zhi-hong hu Fei Deng State Key Laboratory of Virology and Joint-Lab of Invertebrate Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China

As a protein expression vector, the baculovirus demonstrates many advantages over other vectors. With the development of biotechnology, baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells. These modifications include utilization of different promoters and signal peptides, deletion or replacement of viral genes for increasing protein secretion, integration of polycistronic expression cassette for producing protein complexes, and baculovirus pseudotyping, promoter accommodation or surface display for enhancing mammalian cell targeting gene delivery. This review summarizes the development and the current state of art of the baculovirus expression system. Further development of baculovirus expression systems will make them even more feasible and accessible for advanced applications.

关键词： Baculovirus Protein expression Promoters Signal peptides Gene delivery

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Financial performance evaluation and forecasting of enterprises by the combination of PCA and CNN deep learning

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Frontiers of Computer Science 2023年第6期17卷 155-157页

作者： Ruisong LI Hongjiu LIU Yanrong hu School of Mathematics and Computer Science Zhejiang A&F UniversityHangzhou 311300China

1 Introduction Financial evaluation focuses on pursuing sustainable financial development under the“New Normal”of China’s *** is of great practical significance to explore innovative methods based on established financial evaluation indexes and systems[1,2].The joint strategy of PCA methods and Deep Learning models seems to have a scientific basis and a good fusion mechanism in earlier studies[3-5].The innovation of our research is to combine evaluation method,unsupervised learning,with supervised *** on the PCA method,the selected data is dimensionally reduced and comprehensively scored,then the unsupervised learning K-means clustering method is used to divide the sample into five evaluation levels according to the performance ***,combined with the Convolutional Neural Network(CNN)framework,the company’s financial performance can be profiled and *** one hand,the theoretical significance of this study is to combine the traditional PCA method with the Deep Learning method to predict the performance level for the performance portrait of enterprises.

关键词： Deep learning CNN

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On summer stratification and tidal mixing in the Taiwan Strait

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Frontiers of Earth Science 2013年第2期7卷 141-150页

作者： Jia Zhu Jianyu hu zhiyu LIU State Key Laboratory of Marine Environmental Science College of Ocean & Earth Sciences Xiamen University Xiamen 361005 China

On continental shelves, a front that separates the sea into well-mixed and stratified zones is usually formed in warm seasons due to spatial variations of tidal mixing. In this paper, using eight years of in situ hydrographic observations, satellite images of sea surface temperature （SST） and chlorophyll-a （Chl-a） concentration, and results of a tidal model, we investigate summer stratification in the Taiwan Strait and its dependence on tidal mixing, upwelling, and river diluted water plumes. In most regions of the strait the dominant role of tidal mixing in determining the thermohaline structure is confirmed by the correlation between the two; there are some regions, however, where thermohaline structure varies in different ways owing to significant influences ofupwelling and river diluted water plumes. The well-mixed regions are mainly distributed on the Taiwan Bank and in the offshore regions off the Dongshan Island, Nanao Island, and Pingtan Island, while the northern and central Taiwan Strait and the region south of the Taiwan Bank are stratified. The critical Simpson-hunter parameter for the region is estimated to be 1.78.

关键词： Taiwan Strait stratification tidal mixing coastal upwelling river plume

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Quadratic Bent and Semi-bent Functions over Finite Fields of Odd Characteristic

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Chinese Journal of Electronics 2014年第4期23卷 767-772页

作者： ZHENG Dabin YU Long hu Lei Faculty of Mathematics and Statistics Hubei University School of Mathematics and Statistics Central China Normal University State Key Laboratory of Information Security Institute of Information Engineering CAS

Let n=me and p be an odd prime. Let Fp be a finite field and Fpn be its n th field extension. By some polynomial GCD computations, this paper characterize the bentness and semi-bentness of two classes of p-ary quadratic functions from Fpn to Fp with coefficients in Fpe. Moreover, the enumeration formulas of constructed bent functions are obtained for some special cases of m. The results generalize some previous related work.

关键词： Quadratic bent function Quadratic semibent function Greatest common divisor Block cyclic matrix

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Development of a groundwater flow and reactive solute transport model in the Yongding River alluvial fan,China

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Frontiers of Earth Science 2019年第2期13卷 371-384页

作者： Haizhu hu Xiaomin MAO Qing YANG Inner Mongolia River and Lake Ecology Laboratory School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China Center for Agricultural Water Research in China College of Water Resources & Civil EngineeringChina Agricultural UniversityBeijing 100083China Beijing Institute of Hydrogeology and Engineering Geology Beijing 100195China

The Yongding River in the western suburbs of Beijing has been recharged with reclaimed water since 2010 for the purpose of ecological *** the reclaimed water is not well treated,it poses a danger to the aquifer underneath the *** provide a reliable tool which could be used in future research to quantify the influence of reclaimed water in the Yongding River on the local groundwater environment,a transient groundwater flow and reactive solute transport model was developed using FEFLOW^TM in the middle-upper part of the Yongding River Alluvium *** numerical model was calibrated against the observed groundwater levels and the concentrations of typical solutes from June 2009 to May 2010 and validated from June 2010 to December *** average RMSE and R2 of groundwater level at four observation wells are 0.48 m and 0.61,*** reasonable agreement between observed and simulated results demonstrates that the developed model is reliable and capable of predicting the behavior of groundwater flow and typical contaminant transport with *** budget analysis indicates that the water storage in this aquifer had decreased by 43.76×10^6m^3 distributions of typical solutes suggest that the middle and southern parts of the unconfined aquifer have been polluted by previous discharge of industrial and domestic *** results underscore the necessity of predicting the groundwater response to reclaimed water being discharged into the Yongding *** study established a coupled groundwater flow and reactive solute transport model in the middle-upper part of the Yongding River Alluvium Fan,one of the drinking water supply sites in Beijing *** model would be used for risk assessment when reclaimed water was recharged into Yongding River.

关键词： Yongding River alluvium fan groundwater flow reactive solute transport FEFLOW ecological restoration

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Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4341-4378页

作者： Weiyi Yao Xinting hu Xin Wang Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong250021China Department of Hematology Shandong Provincial HospitalShandong UniversityJinanShandong250021China Taishan Scholars Program of Shandong Province JinanShandong250021China

Histone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases and their potential as targeted therapeutic agents. Advances in high-throughput molecular tools and the abundance of bioinformatics data have led to the discovery of novel HPTMs which similarly affect gene expression, metabolism, and chromatin structure. Furthermore, a growing body of research has demonstrated that novel histone modifications also play crucial roles in the development and progression of various diseases, including various cancers, cardiovascular diseases, infectious diseases, psychiatric disorders, and reproductive system diseases. This review defines nine novel histone modifications: lactylation, citrullination, crotonylation, succinylation, SUMOylation, propionylation, butyrylation, 2-hydroxyisobutyrylation, and 2-hydroxybutyrylation. It comprehensively introduces the modification processes of these nine novel HPTMs, their roles in transcription, replication, DNA repair and recombination, metabolism, and chromatin structure, as well as their involvement in promoting the occurrence and development of various diseases and their clinical applications as therapeutic targets and potential biomarkers. Moreover, this review provides a detailed overview of novel HPTM inhibitors targeting various targets and their emerging strategies in the treatment of multiple diseases while offering insights into their future development prospects and challenges. Additionally, we briefly introduce novel epigenetic research techniques and their applications in the field of novel HPTM research.

关键词： diseases metabolism epigenetic

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