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Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： Yang Yang zhi-gang Liu Yan-Qi Yang zhi-gang zhang Xiao-Li Wang Yu-Long Li Rui-Fang Sun School of Public Health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of Pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various tumors.However,a systematic pan-cancer analysis of TNFAIP6 is lacking.Here we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon cancer.Methods:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor types.GEPIA2 was used to evaluate the effect of TNFAIP6 on clinical cancer prognosis.cBioportal was used to assess TNFAIP6 mutations.The correlation between TNFAIP6 and cancer immune infiltrates was explored using TIMER2.0.The CancerSEA database was used to perform functional analysis of TNFAIP6.Metascape was used to identify TNFAIP6-related gene enrichment pathways.Immunohistochemistry was performed to detect TNFAIP6 protein expression in the colon cancer.In addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with TNFAIP6.Results:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer prognosis.TNFAIP6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial cells.TNFAIP6 and similar genes may also be involved in the PID_VEGF_VEGFR_pathway.Immunohistochemistry revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer tissues.Several known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics Database.These results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.Conclusions:TNFAIP6 may function as an oncogene

关键词： Cancer IHC Mutation Survival TNFAIP6

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Sb nanoparticles encapsulated in N-doped carbon nanotubes as freestanding anodes for high-performance lithium and potassium ion batteries

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Rare Metals 2023年第2期42卷 449-458页

作者： Xiao-Ping Lin Fang-Fang Xue zhi-gang zhang Qiu-Hong Li Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen361005China

Sb-based materials with high specific capacity have targeted as an alternative anode material for alkali metal ion batteries.Herein,Sb nanoparticles embedded in hollow porous N-doped carbon nanotubes(Sb@N-C nanotubes)are used as freestanding anode for Li-ion batteries(LIBs)and K-ion batteries(PIBs).The Sb@N-C nanotubes demonstrate exceptional reversible capacity of643 mAh·g^(-1)at 0.1 A·g^(-1)with long cycle stability,as well as outstanding rate performance(219.6 mAh·g^(-1)at10 A·g^(-1))in LIBs.As the anode material of PIBs,they reveal impressive capacity of 325.4 mAh·g^(-1)at 0.1 A·g^(-1).The superior electrochemical properties mainly originate from the novel structure.To be specific,the obtained 3D connected network allows for quick ion and electron migration,and prevents the aggregation of Sb nanoparticles.The hollow porous nanotubes can not only accommodate the volume expansion of Sb nanoparticles during cycling,but also facilitate the infiltration of the electrolyte and reduce the ion diffusion length.This work provides a new insight for designing advanced Sb-based anodes for alkali metal ion batteries.

关键词： Alkali metal ion batteries Freestanding electrode Hollow porous nanotube Sb@N-C nanotubes

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Hologenomic insights into mammalian adaptations to myrmecophagy

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National Science Review 2023年第4期10卷 24-36页

作者： Shao-Chen Cheng Chun-Bing Liu Xue-Qin Yao Jing-Yang Hu Ting-Ting Yin Burton K.Lim Wu Chen Guo-Dong Wang Cheng-Lin zhang David M.Irwin zhi-gang zhang Ya-Ping zhang Li Yu State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life SciencesYunnan University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Department of Natural History Royal Ontario Museum Guangzhou Zoo Center for Excellence in Animal Evolution and Genetics Kunming Institute of ZoologyChinese Academy of Sciences Beijing Zoo Department of Laboratory Medicine and Pathobiology University of Toronto

Highly specialized myrmecophagy(ant-and termite-eating) has independently evolved multiple times in species of various mammalian orders and represents a textbook example of phenotypic evolutionary convergence. We explored the mechanisms involved in this unique dietary adaptation and convergence through multi-omic analyses, including analyses of host genomes and transcriptomes, as well as gut metagenomes, in combination with validating assays of key enzymes’ activities, in the species of three mammalian orders(anteaters, echidnas and pangolins of the orders Xenarthra, Monotremata and Pholidota, respectively) and their relatives. We demonstrate the complex and diverse interactions between hosts and their symbiotic microbiota that have provided adaptive solutions for nutritional and detoxification challenges associated with high levels of protein and lipid metabolisms, trehalose degradation, and toxic substance detoxification. Interestingly, we also reveal their spatially complementary cooperation involved in degradation of ants’ and termites’ chitin exoskeletons. This study contributes new insights into the dietary evolution of mammals and the mechanisms involved in the coordination of physiological functions by animal hosts and their gut commensals.

关键词： myrmecophagy adaptive evolution hologenome genomics metagenomics convergent evolution

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Introducing an antibiotic stewardship program in a pediatric center in China

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World Journal of Pediatrics 2018年第3期14卷 274-279页

作者： zhi-gang zhang Fei Chen Jian-Zhong Chen Department of Pharmacology Liaocheng People's Hospital of Shandong ProvinceLiaocheng 252000China

Background This study aimed to investigate the eff ect of antibiotic stewardship programs (ASP) on reducing antimicrobial resistance rate, antibiotics consumption and multi-drug resistance bacterial infections in the pediatric patients. Methods This study was carried out in the Pediatric Center of a tertiary hospital of Shandong Province, China. The study duration was separated into two periods according to introduction of ASP (began from April 2011). Before intervention: from April 2009 to March 2011;after intervention: from April 2012 to March 2014. The consumption of antibiotics, defi ned daily dose (DDD), isolation of multidrug-resistant organisms (MDRO) and resistance rate of antibiotics were analyzed and compared between the two study periods. Results Total antibiotics consumption (DDDs) reduced from 56,725 in 2011 to 31,380 in 2014;antibiotic use density (AUD) reduced from 93.8 to 43.5;mean (± SD) antibiotic costs per patient (per quarter) decreased from 637 (± 29) RMB to 462 (± 49) RMB;and the mean total drug consumption (g)/DDD (DDDs) for inpatients decreased from 90.4 (± 3.3) to 56.4 (± 9.5). Multidrug-resistant microorganisms isolation reduced signifi cantly from 463 (20.0) to 216 (6.9%). Resistance rate of general spectrum antibiotics reduced remarkably after intervention. The proportion of patients colonized or infected with Carbapenems-resistantAcinetobacter baumannii was correlated with DDDs of carbapenem. Conclusions Implementation of ASP leads to reduced medical expense, decrease of improper and abuse of antibiotics, and reduced antibiotics resistance rate and MDRO isolation. Continuous eff orts to improve antibiotic use are required.

关键词： Antimicrobial resistance Antibiotic stewardship program (ASP) Defined daily dose (DDD) Isolation of multidrug-resistant organisms (MDRO)

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The genomic,transcriptomic,and immunological profiles of perineural invasion in pancreatic ductal adenocarcinoma

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Science China(Life Sciences) 2023年第1期66卷 183-186页

作者： Shu-Heng Jiang Rong-Kun Li De-Jun Liu Jun-Li Xue Min-Hao Yu Shan zhang Li-Min Liu Jun-Feng zhang Rong Hua Yong-Wei Sun Xu Wang Qin Yang zhi-gang zhang State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Institute of Oncology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001China Department of Biliary-Pancreatic Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200217China Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Gastrointestinal Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200217China Department of Oral Pathology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011China State Key Laboratory of Oncogenes and Related Genes Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Institute of Precision Medicine Shanghai 200125China

Dear Editor,Cancer neuroscience is an emerging topic in cancer research(Monje et al.,2020;Shi et al.,2022).Perineural invasion(PNI),defined as the neoplastic invasion of tumor cells into or surrounding the different layers of nervous fibers(epineural,perineural,and endoneural spaces of the neuronal sheath),is associated with aggressive tumor behavior.

关键词： invasion neural

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Phase-Division-Based Dynamic Optimization of Linkages for Drawing Servo Presses

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Chinese Journal of Mechanical Engineering 2017年第6期30卷 1426-1437页

作者： zhi-gang zhang Li-Ping Wang Yan-Ke Cao JIER Machine-Tool Group Co. Ltd Department of Mechanical Engineering Tsinghua University

Existing linkage-optimization methods are designed for mechanical presses; few can be directly used for servo presses, so development of the servo press is limited. Based on the complementarity of linkage opti- mization and motion planning, a phase-division-based linkage-optimization model for a drawing servo press is established. Considering the motion-planning principles of a drawing servo press, and taking account of work rating and efficiency, the constraints of the optimization model are constructed. Linkage is optimized in two modes： use of either constant eccentric speed or constant slide speed in the work segments. The performances of optimized link- ages are compared with those of a mature linkage SL4- 2000A, which is optimized by a traditional method. The results show that the work rating of a drawing servo press equipped with linkages optimized by this new method improved and the root-mean-square torque of the servo motors is reduced by more than 10%. This research pro- vides a promising method for designing energy-saving drawing servo presses with high work ratings.

关键词： Drawing servo press Linkage optimization Phase-division Motion planning

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Zoonotic origins of human coronavirus 2019(HCoV-19/SARS-CoV-2):why is this work important?

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Zoological Research 2020年第3期41卷 213-219页

作者： Gary Wong Yu-Hai Bi Qi-Hui Wang Xin-Wen Chen zhi-gang zhang Yong-gang Yao CAS Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Department of Microbiology-Infectiology and Immunology Laval UniversityQuebec G1V 4G2Canada CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China State key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life SciencesYunnan UniversityKunmingYunnan 650091China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic.

关键词： origin why is this work important HCoV-19/SARS-CoV-2 Zoonotic origins of human coronavirus 2019

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Development of a Loop-Mediated Isothermal Amplification Assay for Porcine Circovirus Type 2

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Virologica Sinica 2011年第3期26卷 214-220页

作者： Ye-bing Liu Lei zhang Qin-hong Xue Yi-bao Ning zhi-gang zhang China Institute of Veterinary Drug Control Beijing 100081 China College of Veterinary Medicine Northwest Agriculture ＆ Forestry University Yangling 712100 Chinat

In this study, the loop-mediated isothermal amplification (LAMP) method was used to develop a rapid and simple detection system for porcine circovirus type 2 (PCV2). According to the PCV2 sequences published in GenBank, multiple LAMP primers were designed targeting conserved sequences of PCV2. Using the DNA extracted from PCV2 isolates HUN-09 and SD-09 as the template, LAMP reactions in a PCV2 LAMP system was performed, the amplification products were detected by adding SYBR Green I and could be observed directly by the naked eye. The results showed highly-efficient and specific amplification in 30 min at 63°C with a LAMP real-time turbidimeter. Furthermore, PCV2 DNA templates, with a detection limit of 5.5×10-5 ng of nucleic acid, indicated that this assay was highly sensitive. The results obtained with the naked eye after SYBR Green I staining were consistent with those detected by the real-time turbidimeter, showing the potential simplicity of interpretation of the assay results. The LAMP assay appeared to have greater accuracy than PCR and virus isolation for the analysis of 18 clinical samples. In addition it offers higher specificity and sensitivity, shorter reaction times and simpler procedures than the currently available methods of PCV2 detection. It is therefore a promising tool for the effective and efficient detection of PCV2.

关键词：猪圆环病毒2型实验等温介导 DNA模板 PCV2 GenBank 检测系统

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An alternative approach to match field production data from unconventional gas-bearing systems

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Petroleum Science 2020年第5期17卷 1370-1388页

作者： zhi-gang zhang Yan-Bao Liu Hai-Tao Sun Wei Xiong Kai Shen Quan-Bin Ba National Key Laboratory of Gas Disaster Detecting Preventing and Emergency ControllingChongqing 400037China Chongqing Research Institute of China Coal Technology and Engineering Group Crop. Chongqing 400037China School of Resources and Safety Engineering Chongqing UniversityChongqing 400045China

Nowadays,the unconventional gas-bearing system plays an increasingly important role in energy market.The performances of the current history-matching techniques are not satisfied when applied to such systems.To overcome this shortfall,an alternative approach was developed and applied to investigate production data from an unconventional gas-bearing system.In this approach,the fluid flow curve obtained from the field is the superposition of a series of Gaussian functions.An automatic computing program was developed in the MATLAB,and both gas and water field data collected from a vertical well in the Linxing Block,Ordos Basin,were used to present the data processing technique.In the reservoir study,the automatic computing program was applied to match the production data from a single coal seam,multiple coal seams and multiple vertically stacked reservoirs with favourable fitting results.Compared with previous approaches,the proposed approach yields better results for both gas and water production data and can calculate the contributions from different reservoirs.The start time of the extraction for each gas-containing unit can also be determined.The new approach can be applied to the field data prediction and designation for the well locations and patterns at the reservoir scale.

关键词： Gaussian function Flow rate Unconventional gas Ordos Basin Gas-bearing reservoirs

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Transcatheter Closure of Atrial Septal Defects Improves Cardiac Remodeling and Function of Adult Patients with Permanent Atrial Fibrillation

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Chinese Medical Journal 2015年第6期128卷 780-783页

作者： Liang Chen Yuan Bai Fei-Yu Wang zhi-gang zhang Xing-Hua Shan Tao Chen Xian-Xian Zhao Yong-Wen Qin Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Cardiology Fuzhou General Rospital of Nanjing Military Command I:uzhou-Fujian 350025 China Standardized Base for Trainin'gResidents Changhai 'Hospital Second Mil~ary Medical University Shanghai 200433 China

Background:Permanent atrial fibrillation (AF) is the most common form of dysrhythmia associated with atrial septal defects (ASDs) in patients older than 40 years.However,little is known about cardiac remodeling after transcatheter closure in patients with permanent AF.This study was designed to compare cardiac events and remodeling effects after transcatheter closure in such patients.Methods:Clinical data of 289 adult patients older than 40 years who underwent ASD closure at our center were analyzed retrospectively.Of them,63 patients with permanent AF were assigned to the case group,and the other 226 patients without permanent AF were assigned to the control group.Cardiac events and changes in left and right cardiac cavity dimensions before the procedure and 6 months after the procedure were compared between the two groups.Results:Patients in the case group were significantly older than those in the control group.The right ventricular (RV) volume and right atrial (RA) volume were decreased significantly in both the groups during a median follow-up period of 6 months after closure (P ＜ 0.001).The left atrial dimensions,left ventricular end-systolic dimensions,left ventricular end-diastolic dimensions and left ventricular ejection fraction showed no significant change before and after the procedure in both the groups.Changes of the RV volume and RA volume in the case group were significantly smaller than those in the control group (P =0.005 and P ＜ 0.001).The New York Heart Association cardiac function was improved in both the groups during the 6 months follow-up period.Conclusions:The transcatheter closure of ASD can improve the cardiac remodeling and cardiac function in patients with or without AF.

关键词： Atrial Fibrillation Cardiac Catheterization Heart Septal Defects Atrial

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