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Investigation on the mechanism of Qiangxinhuoli prescription in the treatment of chronic heart failure based on p38-MAPK signaling pathway

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Traditional Medicine Research 2024年第7期9卷 13-24页

作者： Di Guo Qiu-Han zheng Di Wang zhi Pan Xiao-Ling Shang College of Basic Medicine Changchun University of Chinese MedicineChangchun 130117China. Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130117China.

Background:The aim of this study is to investigate the mechanism of action underlying the therapeutic effects of the national patent Chinese medicine compound“Qiangxinhuoli prescription(QXHLF)”on chronic heart failure(CHF).Methods:In vitro,the H_(9)C_(2) cell model was induced by ANGII,and cell proliferation and related protein expression were detected by Cell Counting Kit-8 and Western *** vivo,A rat model of CHF was prepared by ligation of the left anterior descending coronary *** effects of QXHLF on cardiac function in CHF rats were evaluated by cardiac index,hemodynamic changes,enzyme-linked immunosorbent assay,hematoxylin-eosin staining,immunohistochemistry,Western blot and *** expression of pro-apoptotic factors and anti-apoptotic factors,as well as TGFβ1,p-p38,TAK 1 mRNA,and protein,were ***:In vitro,QXHLF has a significant inhibitory effect on the proliferation of H_(9)C_(2) *** can reduce the expression levels of TAK 1,TGFβ1,p-p38,Caspase3 and BAX proteins in H_(9)C_(2) cells,and increase the expression level of BCL_(2) *** vivo,QXHLF has the potential to increase left ventricular systolic pressure,m aximum rate of change in left ventricular pressure while decreasing left ventricular end diastolic pressure,and inhibiting the serum levels of brain natriuretic ***,QXHLF exhibits significant improvements in the pathological alterations of myocardial cells and fibers in CHF rats,leading to enhanced myocardial tissue morphology and notable advantages in combating myocardial *** can reduce the levels of BAX and Caspase3 and up-regulate the expression of BCL_(2),thereby inhibiting cardiomyocyte ***,QXHLF demonstrates inhibitory effects on the mRNA and protein expression levels of TGFβ_(1),TAK_(1),and p-p38 in the heart tissue of the CHF rat ***:These findings indicate that QXHLF has a therapeutic effect on CHF by inhibiting the p38-MAPK signaling pathway,reducing m

关键词： chronic heart failure Qiangxinhuoli prescription p38MAPK pathway H_(9)C_(2) Action mechanism

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Cellular senescence and metabolic reprogramming:Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment

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Cancer Communications 2024年第9期44卷 929-966页

作者： Fusheng Zhang Junchen Guo Shengmiao Yu Youwei zheng Meiqi Duan Liang Zhao YihanWang zhi Yang Xiaofeng Jiang Department of General Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Hepatobiliary and Pancreatic Surgery Peking University First HospitalBeijingP.R.China Department of Radiology The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoningP.R.China Outpatient Department The Fourth Affiliated HospitalChina Medical UniversityShenyangLiaoningP.R.China

The intrinsic oncogenic mechanisms and properties of the tumor microenvironment(TME)have been extensively *** features of the TME include metabolic reprogramming,hypoxia,chronic inflammation,and tumor *** studies suggest that senescence-associated secretory phenotypes that mediate intercellular information exchange play a role in the dynamic evolution of the ***,hypoxic adaptation,metabolic dysregulation,and phenotypic shifts in immune cells regulated by cellular senescence synergistically contribute to the development of an immunosuppressive microenvironment and chronic inflammation,thereby promoting the progression of tumor *** review provides a comprehensive summary of the processes by which cellular senescence regulates the dynamic evolution of the tumor-adapted TME,with focus on the complex mechanisms underlying the relationship between senescence and changes in the biological functions of tumor *** available findings suggest that components of the TME collectively contribute to the progression of tumor *** potential applications and challenges of targeted cellular senescence-based and combination therapies in clinical settings are further discussed within the context of advancing cellular senescence-related research.

关键词： cellular senescence metabolic reprogramming hypoxia chronic inflammation immunosuppressive tumor microenvironment tumor-targeted therapy

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A novel method for producing benzene polycarboxylic acids by electrochemical oxidation of Zhaotong lignite in aqueous NaCl solution

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Carbon Resources Conversion 2024年第2期7卷 88-94页

作者： Ze-zheng Li Wei-Jia Jiang Yu-Gao Wang zhi-Lei Wang Jun Shen Xian-Yong Wei College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024ShanxiChina School of Basic Medicine Shanxi University of Chinese MedicineJinzhong 030619China Institute of Environmental Science Shanxi UniversityTaiyuan 030031China Shanxi Huayang New Material Technology Group Co. Ltd.YangquanShanxi 045000China Key Laboratory of Coal Processing and Efficient Utilization Ministry of EducationChina University of Mining&TechnologyXuzhou 221116JiangsuChina

The development of a coal-based synthetic route to produce benzene polycarboxylic acids(BPCAs)is of great importance for the highly efficient utilization of *** this paper,aqueous NaCl^(-)electrolytic system was used to oxidize Zhaotong lignite to prepare *** electrochemical oxidation of lignite in aqueous NaCl solution could produce more BPCAs than that in aqueous NaOH *** aqueous NaCl electrolytic system could in-suit produce a stable OCl^(-),which was synthesized by the combination reaction between Cl_(2)and OH􀀀generated in the anode or cathode,*** in-suit produced OCl^(-)would degrade the organic structures of the lignite dispersing in the electrolyte to generate *** formation of BPCAs could be greatly affected by current density,electrolysis time and the addition amount of NaCl in the electrolytic system,which resulted from that the factors played an important role in the generation of OCl^(-).The coal related model compounds including anthracene and phenanthrene were used to investigate the electrochemical oxidation mechanism of the *** results indicated that the aromatic ring structures in the lignite were attacked by O_(2)•^(-)from the OCl^(-)to afford BPCAs.

关键词： Lignite Benzene polycarboxylic acids Electrochemical oxidation Aqueous NaCl electrolytic system Coal related model compounds

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Iron-based layered double hydroxide packed with metal-organic frameworks for enhanced overall water-splitting electrocatalysis

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Tungsten 2024年第4期6卷 859-868页

作者： Long Chen Yun Luo zhi-Peng Yu Yi-Kun Cheng Yang zheng Li He Jia-Hao Xiong Wen-Wen Kong Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical Engineering Shihezi University Institute of Scientific Research Luzhou North Chemistry Industry Co.Ltd International Iberian Nanotechnology Laboratory (INL) CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Key Laboratory of Electronic Information Materials and Devices Center of Materials Science and Optoelectronics Engineering Xinjiang Technical Institute of Physics and Chemistry of CAS

Designing hybrid materials with numerous catalytic active sites,high specific surface area,and interfacial interactions is an effective strategy to improve electrocatalytic *** this work,iron-based metal organic frameworks（Fe-MOFs）@（Co,Ni）Fe-layered double hydroxide（LDH） is successfully constructed using the similar "MOF growing on LDH" strategy for oxygen evolution reaction and hydrogen evolution reaction in the alkaline *** synthesized hybrid materials in this particular way show excellent electrochemical overall water-splitting performance with the cell voltage of 1.62 V at10 mA·cm-2in the alkaline environment due to the optimized adsorption/desorption properties of metal ions on oxygencontaining species and interfacial effects of hybrid ***-MOFs@（Co,Ni）Fe-LDH also exhibits excellent hydrogen and oxygen production efficiency of 370 and 175 μL·min-1,*** work draws on an effective approach to the fabrication of MOF@LDH structures and provides new insights into overall water-splitting in alkaline conditions.

关键词： Electrocatalysis Interfacial interactions Layered double hydroxide Metal–organic frameworks (MOFs) Water splitting

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Sex differences in the association between the muscle quality index and the incidence of depression: A cross-sectional study

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World Journal of Psychiatry 2024年第9期14卷 1335-1345页

作者： Gui-Ping Huang Li-Ping Mai zhi-Jie zheng Xi-Pei Wang Guo-Dong He Institute of Medical Research Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Depression presents significant challenges to mental health *** phy-sical activity is highly beneficial to mental and physical health,relatively few stu-dies have conducted on the relationship between *** To investigate the association between muscle quality index(MQI)and incidence of *** The data used in this cross-sectional study were obtained from the 2011-2014 National Health and Nutritional Examination Survey,which included informa-tion on MQI,depression,and confounding *** logistic regre-ssion models were employed,while taking into account the complex multi-stage sampling design.A restricted cubic spline model was utilized to investigate the non-linear relationship between the MQI and ***,subgroup analyses were performed to identify influential *** The prevalence of depression in this population was 8.44%.With the adjusted model,the MQI was associated with depression in females(odds ratio=0.68,95%confidence interval:0.49-0.95)but not in males(odds ratio=1.08,95%confidence interval:0.77-1.52).Restricted cubic spline adjustment of all covariates showed a significant negative non-linear relationship between depression and the MQI in *** observed trend indicated an 80%decrease in the risk of depression for each unit increase in MQI,until a value of ***,when the MQI exceeded 2.2,the prevalence of depression increased by 20%for every unit increase in the *** analyses further confirmed that the MQI was negatively associated with *** The MQI was inversely correlated with depression in females but not males,suggesting that females with a higher MQI might decrease the risk of depression.

关键词： Sex differences Muscle quality index Depression National Health and Nutrition Examination Survey Population-based study

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Sorely reducing emissions of non-methane short-lived climate forcers will worsen compound flood-heatwave extremes in the Northern Hemisphere

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Advances in Climate Change Research 2024年第4期15卷 737-750页

作者： Ying-Fang LI zhi-Li WANG Ya-Dong LEI Xiao-Chao YU Lin LIU Hui-zheng CHE Xiao-Ye ZHANG State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of China Meteorological Administration Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100190China

Non-methane short-lived climate forcer(SLCF)or near-term climate forcer(NTCF)emissions,as a significant driver of climate change,can be reduced to improve air *** reductions may contribute to additional warming of the climate system in the short term,thereby strongly affecting the likelihood of climate ***,there has been no quantitative assessment of the impact of non-methane SLCF mitigation on compound flood-heatwave extremes(CFHEs).This study quantitatively investigates the changes in future(2031-2050 versus 1995-2014)CFHEs and the resulting population exposure in the Northern Hemisphere(NH)due to non-methane SLCF *** used multi-model ensemble simulations under two future scenarios from the Aerosol and Chemistry Model Intercomparison Project(AerChemMIP)in the Coupled Model Intercomparison Project Phase 6(CMIP6).The two future scenarios share the same greenhouse gas(GHG)emissions but have weak(Shared Socioeconomic Pathway(SSP)3-7.0)versus strong(SSP3-7.0-lowNTCF)levels of air quality control *** results show that future non-methane SLCF reductions during 2031-2050 results in about a 7.3%±2.3%increase in grid exposure to CFHEs in the NH relative to the period *** frequency,intensity,and duration of CFHEs increase by varying *** the period 2031-2050,the frequency of CFHEs across the NH increases by 2.9±0.9 events per decade due to non-methane SLCF *** increases in CFHE frequency are more pronounced in East Asia,South Asia,Siberia,and northern and eastern North *** East and South Asia,the in-tensities of both heatwaves and floods corresponding to CFHEs increase markedly,where heatwave magnitude(HWM)increases by 0.3±0.2 K in East Asia and weighted average precipitation(WAP)increases by 18.3%±15.3%and 12.0%±4.5%in East Asia and South Asia,*** other regions,rising temperatures dominate the increase in *** regard to the duration of CFHEs,future reductions in non-methane SLC

关键词： Non-methane SLCFs CHFEs Cleaner air Population exposure

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Plate tectonics in the Archean:Observations versus interpretations

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Science China Earth Sciences 2024年第1期67卷 1-30页

作者： YongFei zheng School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Crust-Mantle Materials and Environment Chinese Academy of SciencesHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of SciencesHefei 230026China

Plate tectonics theory,established in the 1960s,has been successful in explaining many geological phenomena,processes and events that occurred in the ***,the theory has often struggled to provide a coherent framework in interpreting geological records in continental interior and Precambrian *** dealing with the relationship between plate tectonics and continental geology,continental interior tectonics was often separated from continental margin tectonics in the inheritance and development of their structure and *** separation led to the illusion that the plate tectonics theory is not applicable to Precambrian geology,particularly in explaining the fundamental geological characteristics of Archean *** this illusion does not mean that the Archean continental crust did not originate from a regime of plate tectonics,it led to the development of alternative tectonic models,often involving vertical movements under a regime of stagnant lid tectonics,including not only endogenous processes such as gravitational sagduction,mantle plumes and heat pipes but also exogenous processes such as bolide *** vertical processes were not unique to the Archean but persisted into the *** result from mantle poloidal convection at different depths,not specific to any particular *** the plate tectonics theory from the traditional kinematic model in the 20th century to a holistic kinematic-dynamic model in the 21st century and systematically examining the vertical transport of matter and energy at plate margins,it is evident that plate tectonics can explain the common geological characteristics of Archean cratons,such as lithological associations,structural patterns and metamorphic *** deciphering the structure and composition of convergent plate margins as well as their dynamics,the formation and evolution of continental crust since the Archean can be divided into ancient plate tectonics in the Preca

关键词： Plate tectonics Archean geology Continental origin Crustal reworking Plate interior Plate margin

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Degradation and biocompatibility of one-step electrodeposited magnesium thioctic acid/magnesium hydroxide hybrid coatings on ZE21B alloys for cardiovascular stents

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Journal of Magnesium and Alloys 2024年第1期12卷 120-138页

作者： Zhao-Qi Zhang Bing-zhi Li Pei-Duo Tong Shao-Kang Guan Li Wang zheng-Hui Qiu Cun-Guo Lin Rong-Chang Zeng School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou 450001China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China

Constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based ***,the steps for preparing composite coatings are usually complicated and ***,a novel composite coating,composed of bioactive magnesium thioctic acid(MTA)layer formed by deposition and corrosion-resistant magnesium hydroxide(Mg(OH)_(2))layer grown in situ,is simply fabricated on ZE21B alloys via one-step *** electron microscopy(SEM)shows that the electrodeposited coating has a compact and uniform *** the high adhesion of the MTA/Mg(OH)_(2)hybrid coating is also confirmed by the micro-scratch *** test,scanning kelvin probe(SKP),and hydrogen evolution measurement indicate that the hybrid coating effectively reduces the degradation rate of Mg *** experiment and cell culture trial detect that the composite coating is of fine ***,the preparation mechanism of MTA/Mg(OH)_(2)hybrid coatings is discussed and *** coating shows a great potential application for cardiovascular stents.

关键词： Magnesium alloy Corrosion resistance Hybrid coating Endothelialization Biocompatibility

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Energy band modulation of N-doped rutile/anatase TiO_(2) photoanode promoting charge separation toward prominent photoelectrochemical performance

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Rare Metals 2024年第8期43卷 3784-3797页

作者： Juan Gao Shi-Xuan Wang Jia-Le Deng Ping-Ping Wei Fu-Zhang Chen Ling-Cheng zheng Yue-Qin Wang Yang Li Yin Liu gang He School of Mechanics and Photoelectric Physics Anhui University of Science and TechnologyHuainan 232001China School of Materials Science and Engineering Anhui UniversityHefei230039China Tianneng Battery(Wuhu)Co. Ltd.Wuhu 241000China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001China

To solve the problem of high photogenerated carrier recombination rate and low photoelectric conversion efficiency of TiO_(2)-based materials,a simple N-doped anatase/rutile TiO_(2) heterophase nanorod film was designed by a low-temperature hydrothermal method in this *** enhanced separation and transport of photogenerated charges were facilitated by the smaller contact barrier and appropriate band matching between anatase TiO_(2)nanoparticles and rutile TiO_(2) *** introduction of N doping in anatase TiO_(2) resulted in an upward shift of the valence band and a narrowing of the band gap,consequently enhancing the efficiency of visible light *** combination of the heterophase junction and N-doping exhibited a synergistic effect,effectively suppressing the recombination of photogenerated charges and enhancing the photoelectric conversion efficiency of the *** AM 1.5G irradiation,the photocurrent density(J)of the A-TO(N)@R-TONR photoanode reached2.19 mA·cm^(-2)(V_(RHE,1.23 eV)).Additionally,the incident photon-electron conversion efficiency(IPCE)and the charge injection efficiency(η)reached 81.4%and 51.6%at320 ***,the J,IPCE,andηvalues of the A-TO(N)@R-TONR photoanode were 2.96,2.1 and 3.2times those of pure R-TONR photoanode,*** work presents a rational strategy for designing efficient TiO_(2)-based photoanodes.

关键词： TiO_(2) Heterophase junction Photoanode

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Enhanced electrical performance in CaBi_(4)Ti_(4)O_(15)ceramics through synergistic chemical doping and texture engineering

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Journal of Materiomics 2024年第2期10卷 471-479页

作者： Le Zhao Guohao Li Xiao Zhai Weijie Kuai Yuzhi Zhai gang Tian zhigang Gai Minglei Zhao Juan Du Hongjun Zhang Limei zheng School of Information and Automation Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan250100China Center for Optics Research and Engineering(CORE) Key Laboratory of Laser and Infrared System of Ministry of EducationShandong UniversityQingdaoShandong266237China College of Materials Science and Engineering Liaocheng UniversityLiaocheng252059China Functional Materials and Acoustooptic Instruments Institute School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin150080China

High-temperature piezoelectric materials with excellent piezoelectricity,low dielectric loss and large resistivity are highly desired for many industrial sectors such as aerospace,aircraft and nuclear *** a synergistic design strategy combining microstructural texture and chemical doping is employed to optimize CaBi 4Ti 4O15(CBT)ceramics with bismuth layer *** textured microstructure with an orientation factor of 80%e82%has been successfully achieved by the spark plasma sintering ***,by doping MnO_(2),both advantages of hard doping and sintering aids are used to obtain the excellent electrical performance of d_(33)=27.3 pC/N,tandδ-0.1%,Q_(31)~2,307 and electrical re-sistivityρ~6.5×10^(10)Ω·*** to 600℃,the 0.2%(in mass)Mn doped CBT ceramics still exhibit high performance of d_(33)=26.4 pC/N,r~1.5×10^(6)Ω·cm and tandδ~15.8%,keeping at an applicable level,thus the upper-temperature limit for practical application of the CBT ceramics is greatly *** work paves a new way for developing and fabricating excellent high-temperature piezoelectric materials.

关键词： CaBi_(4)Ti_(4)O_(15) Piezoelectricity Mechanical quality factor Resistivity

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