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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang zhi-Lai Zhan Guang-Lu Chang Yan gao Xia Li Wen-Yuan gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： zhi-Min Lin Han-Yuan gao Shu-Han Shi Yue-Ting Li Department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGLT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGLT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGLT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

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大学生压力、领悟社会支持与压力后成长的关系研究

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凯里学院学报 2017年第2期35卷 155-157页

作者：周玉霞付志高广西师范大学教育学部广西桂林541004 凯里学院教育科学学院贵州凯里556011

探究大学生压力、领悟社会支持(PSSS)与压力后成长的关系,采用大学生压力源量表,领悟社会支持量表和大学生压力后成长量表进行问卷调查。结果表明:(1)领悟社会支持与压力后成长显著正相关,压力与压力后成长显著负相关,领悟社会支持与压... 详细信息

探究大学生压力、领悟社会支持(PSSS)与压力后成长的关系,采用大学生压力源量表,领悟社会支持量表和大学生压力后成长量表进行问卷调查。结果表明:(1)领悟社会支持与压力后成长显著正相关,压力与压力后成长显著负相关,领悟社会支持与压力显著负相关。(2)领悟社会支持对压力后成长有正向预测作用。结论:大学生压力和领悟社会支持对压力后成长有重要影响,能直接预测压力后成长水平。领悟社会支持在压力和压力后成长中起部分中介作用。

关键词：大学生压力后成长领悟社会支持

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin fu Peiyan Long Xiao gao Zhengwei Wang zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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高中教师的工作倦怠现状调查研究——以凯里市高中为例

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凯里学院学报 2017年第1期35卷 179-181页

作者：李玲付志高李林青凯里学院贵州凯里556011

由于高中招生规模的扩大,生源质量大大降低,教师在教学中成就感降低。加上近年来各种政策和社会现象的影响,导致部分教师产生职业倦怠感。而教师的工作倦怠对教师的发展和学生的成长有消极的影响。本研究以凯里市三所中学218位教师为研... 详细信息

由于高中招生规模的扩大,生源质量大大降低,教师在教学中成就感降低。加上近年来各种政策和社会现象的影响,导致部分教师产生职业倦怠感。而教师的工作倦怠对教师的发展和学生的成长有消极的影响。本研究以凯里市三所中学218位教师为研究对象,采用问卷调查法,分析中学教师的工作倦怠状况和产生的原因。研究发现:凯里市高中教师的工作倦怠为中等水平,随年龄增长而降低,重点高中教师的工作倦怠较低,性别及班主任工作等因素对其工作倦怠的影响较低。

关键词：高中教师工作倦怠热情枯竭精力枯竭职业成就感

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基于杉木退化人工林碳储量、生产力及其碳汇经济的阔叶树种选择研究

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林业科学研究 2024年第6期37卷 93-103页

作者：付志高李芬好肖以华朱火生许涵王焱贲春丽中国林业科学研究院热带林业研究所广东广州510520 乐昌市林业局广东乐昌510200 江西农业大学林学院江西南昌330006

[目的]杉木的纯林连续栽培导致土壤退化和生产力降低。阔叶树与杉木混交可以提升立地质量和林分生产力。本研究旨在探究不同阔叶树种与杉木混交模式下的碳储量、生产力和碳汇经济价值,为区域退化杉木人工林改造和高效碳汇林建设的树种... 详细信息

[目的]杉木的纯林连续栽培导致土壤退化和生产力降低。阔叶树与杉木混交可以提升立地质量和林分生产力。本研究旨在探究不同阔叶树种与杉木混交模式下的碳储量、生产力和碳汇经济价值,为区域退化杉木人工林改造和高效碳汇林建设的树种选择提供技术支持。[方法]选取了2004年种植的10种不同阔叶树种与杉木混交的造林林分,研究了不同混交模式下林分碳储量、生产力和碳汇经济价值的差异。[结果]表明:(1)10种阔叶树种的胸径(6.5~21.3 cm)、树高(8.0~22.6 m)和密度降幅(750~3119株·hm^(-2))均存在显著的差异,且均是米老排的值最大,且极显著高于深山含笑(p<0.01)。此外,大径木的比例最高的亦是米老排,其余9种树种则以中径木为主。(2)不同林分的干、枝、叶、根和总生物量分别为56.54~140.69t·hm^(-2)、13.22~43.97 t·hm^(-2)、2.72~9.17 t·hm^(-2)、3.22~80.35 t·hm^(-2)、82.78~274.18 t·hm^(-2),且均呈现显著的差异(p<0.01),这5种生物量指标中,最大的树种均是米老排,但最小树种不同,阴香的干、叶和总生物量最小,而枝和根生物量最小的分别是观光木和红锥。(3)10种树种的碳储量、生产力和碳汇经济价值分别为15.43~136.66 t·hm^(-2)、1.62~14.38 t·hm^(-2)·a^(-1)和0.18~2.39万元·hm^(-2)。碳储量表现为米老排极显著高于观光木和深山含笑(p<0.01)。生产力米老排极显著高于除木荷以外的其余树种(p<0.01),碳汇经济价值则是米老排极显著高于除木荷和枫香以外的其余树种(p<0.01)。[结论]在粤北地区退化杉木人工林改造中,建议优先选择米老排、木荷和枫香作为高效碳汇林的树种选项;而对于大径材林培育,则建议优先选择米老排、乐昌含笑、阴香和红锥。

关键词：杉木人工林退化碳储量生产力碳汇经济价值

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Synthesis and electromagnetic wave absorption properties of Gd-Co ferrite@carbon core-shell structure composites

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Rare Metals 2023年第1期42卷 254-262页

作者： Jing gao zhi-Jun Ma fu-Li Liu Xing-Yuan Weng School of Mining Liaoning Technical UniversityFuxin123000China

Developing high-performance electromagnetic absorbing materials remains a *** this work,Gd-Co ferrite@carbon core-shell structure composites were synthesized by a two-step hydrothermal *** effects of rare earth Gd doping amount on the microstructure and electromagnetic wave absorption properties of cobalt ferrite@carbon composites were mainly *** results show that an appropriate amount of Gd doping can refine the crystal grain size of cobalt ferrite@carbon ***,when the doping amount of Gd exceeds the solid solubility threshold,the secondary phase GdFeO_(3)will be generated and the grain size will *** the doping amount of Gd is x=0.04,the reflection loss(RL) of the CoFe_(1.96)Gd_(0.04)O_(4)@C composites reaches the minimum value of -9.26 dB at the absorption layer thickness of 2.0 mm and a frequency of 13.67 GHz,and the effective absorption band(EAB) is 5.01 GHz(10.95-15.96 GHz).Compared with the CoFe_(2)O_(4)@C composites,the RL of the CoFe_(1.96)Gd_(0.04)O_(4)@C composites is increased by 79.35%,and the EAB is broadened by 3.51%.Gd ions enhance the dielectric loss through the grain size effect,and the increase of magnetocrystalline anisotropy enhances the magnetic *** CoFe_(1.96)Gd_(0.04)O_(4)@C composites have excellent impedance matching,which relies on the strong magnetic loss of ferrite,the interface polarization,and dipole polarization formed by the carbon shell to attenuate electromagnetic waves.

关键词： Rare earth Gd Cobalt ferrite Core-shell structure composites Electromagnetic wave absorption

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Resonant current in coupled inertial Brownian particles with delayed-feedback control

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Frontiers of physics 2017年第6期12卷 33-41页

作者： Tian-fu gao zhi-Gang Zheng Jin-Can Chen College of Physical Science and Technology Shenyang Normal University Shenyang 110034 China College of Information Science and Engineering Huaqiao University Xiamen 361021 China Department of Physics Xiamen University Xiamen 361005 China

The transport of a walker in rocking feedback-controlled ratchets is investigated. The walker consists of two coupled ＂feet＂ that allow the interchange of the order of particles while the walker moves. In the underdamped case, tile deterministic dynamics of the walker in a tilted asymmetric ratchet with an external periodic force is considered. It is found that delayed feedback ratchets with a switching-on- and-off dependence of the states of the system can lead to absolute negative mobility. In such a novel phenomenon, the particles move against tile bias. Moreover, the walker can acquire a series of resonant steps for different values of the current. It is interesting to find that the resonant currents of the walker are induced by tile phase locked motion that corresponds to the synchronization of the motion with the change in the frequency of the external driving. These resonant steps can be well predicted in terms of time-space symmetry analysis, which is in good agreement with dynamics simulations. The transport performances can be optimized and controlled by suitably adjusting the parameters of tile delayed-feedback ratchets.

关键词： delayed-feedback control absolute negative mobility resonant steps phase locking

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Hot pressing sintering process and sintering mechanism of W-La_(2)O_(3)-Y_(2)O_(3)-ZrO_(2)

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Rare Metals 2021年第7期40卷 1949-1956页

作者： Bao-Gang fu Jian-Can Yang zhi-Kun gao Zuo-Ren Nie College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China

The W-La_(2)O_(3)-Y_(2)O_(3)-ZrO_(2)materials were prepared by vacuum hot pressing sintering *** microstructure was characterized by scanning electron microscopy(SEM).The effects of sintering temperature,sintering pressure,holding time and heating rate on relative density,hardness and microstructure were *** sintering activation energy of the powder was *** on the result,the best sintering parameters by vacuum hot pressing sintering are as follows:sintering temperature of 1600℃,sintering pressure of 60 MPa and holding time of 60 *** heating rate is 10℃·min^(-1)from room temperature to 1000℃and 4℃·min^(-1)from1000 to 1600℃.Using this process,the grain size is about3 lm in diameter with relative density at 99.7%,and the hardness is HV *** sintering characteristic index(n)of the specimen is 4,and the sintering mechanism mainly depends on the diffusion from the surface to the intragranular in the volume *** sintering activation energy of W-La_(2)O_(3)-Y_(2)O_(3)-ZrO_(2)material is286.2 k J·mol^(-1),which indicates that the powder has higher activity in sintering process.

关键词： W-La_(2)O_(3)-Y_(2)O_(3)-ZrO_(2) Hot pressing sintering Relative density Tungsten electrode Sintering mechanism

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Preparation and H_2S Gas-Sensing Performances of Coral-Like SnO_2–CuO Nanocomposite

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Acta Metallurgica Sinica(English Letters) 2015年第9期28卷 1190-1197页

作者： Chun gao zhi-Dong Lin Na Li Ping fu Xue-Hua Wang School of Materials Science and Engineering Wuhan Institute of Technology

Nanocomposites composed of SnO2 and CuO were prepared by hydrothermal method. The microstructures of obtained SnO2-CuO powders were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and nitrogen adsorption-desorption test. The results show that the nanocomposites exhibited coral-like nanostructure, and the average crystalline size of SnO2 was 12 nm. The specific surface area of the four samples, SnO2- 0.2CuO, SnO2-0.5CuO, SnO2-1.0CuO and SnO2-2.0CuO are 72.97, 58.77, 49.72 and 54.95 m2/g, respectively. The gas sensing performance of the four samples to ethanol, formaldehyde and H2S was studied. The sensor of SnOa-0.5CuO exhibited high response to hydrogen sulfide （4173 to 10 ppm H2S, where ppm represent 10-6）, and low response to ethanol and formaldehyde. The good selectivity exhibited that the SnO2-0.5CuO nanocomposite can be a promising candidate for highly sensitive and selective gas-sensing material to H2S.

关键词： Nanocomposite SnO2-CuO Gas sensor H2S

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