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Biomarkers for response to immunotherapy in hepatobiliary malignancies

Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 413-419页

作者： zhi-fei lin Lun-Xiu Qin Jin-Hong Chen Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China

Background:The advent of immune checkpoint inhibitors(ICIs)has revolutionized the therapeutic options of hepatobiliary ***,the clinical benefit provided by immunotherapy seems limited to a small subgroup of patients with hepatobiliary *** identification of reliable predictors of the response to immunotherapy is urgently *** sources:Literature search was conducted in Pub Med for relevant articles published up to May *** of clinical trials was obtained from https://***/.Results:Biomarkers for ICI response of hepatobiliary malignancies remain in the exploration stage and lack compelling *** programmed death-ligand 1(PD-L1)expression is the most widely studied biomarker in hepatocellular carcinoma(HCC)and biliary tract cancers(BTCs),but there are conflicting results on its predictive *** mutational burden(TMB)is generally low both in HCC and BTCs,and the clinical trials of TMB are rare in hepatobiliary ***,mismatch repair deficiency(dMMR)/high microsatellite instability(MSI-H)may be a predictive biomarker of response to antiPD-1 therapy in ***,some emerging biomarkers,such as gut microbiota,show predictive potential in the preliminary *** and liquid-biopsy biomarkers,including circulating tumor cells,circulating tumor DNA(ct DNA)and exosomal PD-L1 provide a quick and non-invasive approach for monitoring the ICI response,showing a new promising ***:Multiple potential biomarkers for predicting ICI response of hepatobiliary malignancies have been explored and tried to apply in *** there is no robust evidence to prove their clinical value in predicting immunotherapeutic response for patients with hepatobiliary *** identification of predictors for response to ICIs is an urgent need and major *** studies are warranted to validate the role of emerging biomarkers in predicting immunotherapeut

关键词： Biomarker Immunotherapy Hepatocellular carcinoma Biliary tract cancers

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Poland＇s syndrome in women： 24 cases study and literature review

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Chinese Medical Journal 2012年第18期125卷 3283-3287页

作者： ZHU lin ZENG Ang WANG Xiao-jun LIU zhi-fei ZHANG Hai-lin Plastic Surgery Department Peking Union Medical CollegeHospital Chinese Academy of Medical SciencesChina Beijing 100032

Background Since its first description in 1841, numerous variations and treatments of Poland＇s syndrome （congenital deficiency of the pectoralis major muscle associated with brachysyndactyly） have been reported. None of the reports, however, involved female Chinese patients. Methods A retrospective study of 24 female patients was conducted to guide the selection of methods of surgical reconstruction. The patients were divided into three groups according to the degree of thoracic tissue development. Type I （mild）： Limited tissue loss which can be treated with simple filling with autologous fat and/or an artificial breast implant. Type II （moderate）： Moderate thoracic tissue hypoplasia where the breast parenchyma can still offer adequate implant coverage. Mammoplasty using a latissimus dorsi muscular flap with an implant was performed in this group. The flap was used to fill the infraclavicular hollow, and the implant was placed in the dual-plane pocket. Type Ⅲ （severe）： Severe thoracic tissue hypoplasia, without sufficient parenchyma to offer implant coverage. A latissimus dorsi muscular flap was used to form a total submuscular pocket in which an implant was placed. Results The numbers of Type Ⅰ, Ⅱ, and Ⅲ patients were 15, 3, and 6, respectively. All of the flaps and injected fat demonstrated good survival. Satisfactory cosmetic results were exhibited during the follow-up period of 1 to 9 years. Conclusions Although this group of patients showed varied conditions, they can be roughly divided into three types according to the degree of thoracic tissue development. In our experience, this classification is simple and useful in choosing the breast reconstruction options.

关键词： Poland's syndrome pectoralis major muscle aplasia congenital breast malformation latissimus dorsi muscular flap

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不同添加剂对紫花苜蓿裹包青贮品质及菌群构成的影响

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中国草地学报 2017年第4期39卷 54-59页

作者：张志飞穆麟文昭竹龚梨霞魏仲珊李志才湖南农业大学农学院湖南长沙410128 湖南德人牧业科技有限公司湖南常德415921

以含水量60%的紫花苜蓿为材料进行添加剂裹包青贮,分析添加剂青贮紫花苜蓿的发酵品质、营养成分等,并利用Miseq高通量测序技术分析青贮料细菌群落的组成。结果表明:与对照相比,3种乳酸菌复合添加剂和1种防腐剂添加剂紫花苜蓿裹包青贮料... 详细信息

以含水量60%的紫花苜蓿为材料进行添加剂裹包青贮,分析添加剂青贮紫花苜蓿的发酵品质、营养成分等,并利用Miseq高通量测序技术分析青贮料细菌群落的组成。结果表明:与对照相比,3种乳酸菌复合添加剂和1种防腐剂添加剂紫花苜蓿裹包青贮料的发酵品质和营养品质都有所提高,其中植物乳杆菌复合制剂(A)及甲酸、甲酸铵、丙酸及苯甲酸钠防腐剂(D)添加青贮的综合效果最好。乳酸菌复合添加青贮料中乳酸菌含量较高,群落主要以乳杆菌、魏斯氏菌及片球菌为主;防腐型添加剂(D)青贮料中以乳杆菌为主,乳酸菌总量偏低,组成复杂的其他菌含量偏高,但都不是优势菌群;未添加的对照组青贮效果较差,乳酸菌总量极低。

关键词：紫花苜蓿青贮添加剂青贮品质 Miseq测序细菌菌群

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-lin Jiang Hui-Na Liu Yu-Fan Yang zhi-Cheng Zhang Qi Dai Xiao-Yan Bao lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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左卡尼汀对急性心肌梗死急诊PCI患者血清H-FABP及6MWT的影响

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中国急救医学 2017年第10期37卷 900-902页

作者：许明生张科芝杨林飞韩玉龙张建冯俊陈振飞高玉周江荣孙桂兰合肥市第二人民医院心内科安徽合肥230011

目的探讨急性心肌梗死（AMI）急诊PCI术后应用左卡尼汀，对血清心型脂肪酸结合蛋白（H-FABP）及近期预后的影响。方法选择AMI行急诊PCI患者102例，随机分为治疗组54例和对照组48例，实验组在急诊PCI中加用左卡尼汀3．0g＋0．9％生理盐水... 详细信息

目的探讨急性心肌梗死（AMI）急诊PCI术后应用左卡尼汀，对血清心型脂肪酸结合蛋白（H-FABP）及近期预后的影响。方法选择AMI行急诊PCI患者102例，随机分为治疗组54例和对照组48例，实验组在急诊PCI中加用左卡尼汀3．0g＋0．9％生理盐水250mL静脉滴注，以后每日1次，连续7d以上。对照组行急诊PCI治疗及常规药物治疗。比较两组血浆H-FABP、CK-MB、cTnI水平和住院期间LVEF值，随访90d后六分钟步行试验（6MWT）距离。结果实验组术后血浆H-FABP、CK-MB、cTnI水平较对照组明显降低，LVEF高于对照组（P〈0．05），随访90d后实验组6MWT距离明显高于对照组（P〈0．05）。结论AMI急诊PCI患者补充左卡尼汀对缺血心肌细胞有保护作用，可明显改善患者的心功能。

关键词：左卡尼汀经皮冠状动脉介入治疗(PCI) 心型脂肪酸结合蛋白六分钟步行试验

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粉质黏土和风化粉砂岩中变径抗浮锚杆高效绿色成孔关键技术

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山西建筑 2025年第1期51卷 80-83,133页

作者：林飞江苏省新能源地质调查大队江苏南京210041 江苏华东建设基础工程有限公司江苏南京210007

为了提高粉质黏土和全风化、强风化粉砂岩地层中变径抗浮锚杆的成孔工效,对长螺旋钻机进行了改进,使其具有送风功能,开发了长螺旋钻机引孔接力高压旋喷钻机扩孔下变径抗浮锚杆成孔关键技术,并提出了相应的施工参数。采用关键技术和施工... 详细信息

为了提高粉质黏土和全风化、强风化粉砂岩地层中变径抗浮锚杆的成孔工效,对长螺旋钻机进行了改进,使其具有送风功能,开发了长螺旋钻机引孔接力高压旋喷钻机扩孔下变径抗浮锚杆成孔关键技术,并提出了相应的施工参数。采用关键技术和施工参数,保证变径抗浮锚杆抗拔力达到设计要求外,与单一高压旋喷钻机进行变径抗浮锚杆成孔的常规工艺相比,减少了13%的工期。鉴于粉质黏土和全风化、强风化粉砂岩地层中,高压送风长螺旋钻机引孔时会产生扬尘,开发了配套的降尘结构,消除了扬尘引起的环境问题及对作业人员的危害,实现了绿色施工。

关键词：变径抗浮锚杆粉质黏土长螺旋钻机引孔扩孔

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三芯光纤复合海缆拉伸的有限元建模与仿真

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光通信研究 2016年第3期3期(25)卷 29-32页

作者：卢志飞林晓波郑新龙吕安强李世强张杰国网浙江省电力公司舟山供电公司浙江舟山316021 浙江舟山海洋输电研究院有限公司浙江舟山316021 华北电力大学电子与通信工程系河北保定071003

三芯光纤复合海底电缆(简称为"海缆")在运输、敷设和运行的过程中经常会产生拉伸的机械行为,对其进行拉伸建模仿真,可获得实体试验难以得到的应力、应变等数据。文章通过建立海缆拉伸有限元模型,模拟了海缆的拉伸过程。首先根据海缆拉... 详细信息

三芯光纤复合海底电缆(简称为"海缆")在运输、敷设和运行的过程中经常会产生拉伸的机械行为,对其进行拉伸建模仿真,可获得实体试验难以得到的应力、应变等数据。文章通过建立海缆拉伸有限元模型,模拟了海缆的拉伸过程。首先根据海缆拉伸的力学特点对结构进行简化,得到三芯海缆的几何模型;然后对其施加约束及速度载荷,控制沙漏能,仿真轴向拉伸过程;最后对数据进行有效提取和处理,获得海缆的应力与应变,为研究海缆的力学性能、判断海缆工作状态提供了参考。

关键词：三芯光纤复合海缆拉伸应力应变有限元

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Identification of Differentially Expressed Genes in the Salivary Gand of Rhipicephalus haemaphysaloides by the Suppression Subtractive Hybridization Approach

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Journal of Integrative Agriculture 2012年第9期11卷 1528-1544页

作者： XIANG fei-yu ZHOU Yong-zhi ZHOU Jin-lin Key Laboratory of Animal Parasitology Ministry of Agriculture~Shanghai Veterinary Research Institute Chinese Academy of AgriculturalSciences Shanghai 200241 P.R.China

For the purpose of screening and analyzing the differentially expressed genes from the salivary gland of Rhipicephalus haemaphysaloides, two salivary gland-subtracted cDNA libraries of partially fed female ticks and fed male ticks were constructed using suppression subtractive hybridization （SSH）. A total of 247 female expression sequence tags （ESTs） and 168 male ESTs were obtained from the two SSH cDNA libraries. It is predicted that 25 female ESTs and 44 female ESTs contain the 5＂ and 3＂ ends, respectively, and that 53 male ESTs and 74 male ESTs contain the 5＂ and 3＂ ends, respectively. To identify the subtraction rate of the two SSH cDNA libraries, the RT-PCR method was used to test 24 female ESTs and 21 male ESTs selected randomly but not repeatedly. The results showed that there were 13 upregulated or differentially expressed genes in the partially fed salivary gland of the female R. haemaphysaloides and that the differentially expressed rate was 54%. In addition, they indicated that there were 9 upregulated or differently expressed genes in the fed salivary gland of the male R. haemaphysaloides and that the differentially expressed rate was 43%. Putative translations of 141 （57%） female ESTs and 125 （74%） male ESTs had similarity to GenBank sequences, and 32 （23%） female ESTs and 29 （23%） male ESTs exhibited similarity to tick proteins, which showed that most of the proteins in the libraries were mainly related to the feeding blood physiology of the ticks.

关键词： Rhipicephalus haemaphysaloides salivary gland suppression subtractive hybridization (SSH) cDNA library expression sequence tag (EST)

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眼镜蛇毒组分C的抗瘤活性及其对肿瘤细胞存活率的影响

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蛇志 1998年第3期10卷 1-3页

作者：植飞赵路宁林振桃管锦霞广州蛇毒研究所

目的观察眼镜蛇毒组分Ｃ对ＢＡＬＢ／Ｃ型小鼠腹水型肝癌Ｈ２２的抑瘤作用及其体外对肝癌Ｈ２２细胞存活率的直接影响。方法通过半体内实验，观察眼镜蛇毒组分Ｃ对小鼠腹水型肝癌Ｈ２２的抑瘤率；通过细胞培养，以细胞存活率为指标观察... 详细信息

目的观察眼镜蛇毒组分Ｃ对ＢＡＬＢ／Ｃ型小鼠腹水型肝癌Ｈ２２的抑瘤作用及其体外对肝癌Ｈ２２细胞存活率的直接影响。方法通过半体内实验，观察眼镜蛇毒组分Ｃ对小鼠腹水型肝癌Ｈ２２的抑瘤率；通过细胞培养，以细胞存活率为指标观察中华眼镜蛇毒组分Ｃ对ＢＡＬＢ／Ｃ型小鼠腹水型肝癌Ｈ２２细胞在体外的直接杀伤作用。结果眼镜蛇毒组分Ｃ能明显抑制ＢＡＬＢ／Ｃ型小鼠腹水型肝癌Ｈ２２细胞的生长，其抑瘤作用随剂量增大而增强，ＩＣ５０为９５ｍｇ／Ｌ。在体外，眼镜蛇毒组分Ｃ的浓度对ＢＡＬＢ／Ｃ型小鼠腹水型肝癌Ｈ２２细胞存活率的影响随其作用剂量的增大而增强，ＩＣ５０为９ｍｇ／Ｌ；同时，这种影响还随其作用时间的延长而增强。结论眼镜蛇毒组分Ｃ对ＢＡＬＢ／Ｃ型小鼠腹水型肝癌Ｈ２２有显著的抑瘤作用。

关键词：中华眼镜蛇毒组分C 腹水型肝癌细胞细胞存活率

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