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Regulatory Effect of E2,IL-6 and IL-8 on the Growth of Epithelial Ovarian Cancer Cells

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Cellular & Molecular Immunology 2005年第5期2卷 365-372页

作者： Yue wang Jie Yang Yan Gao Yongrui du Leyuan Bao Wenyan Niu zhi Yao Department of Immunology Tianjin Medical University Tianjin 300070 China Department of Gynecologic Oncology Tianjin Women＇s Hospital Tianjin 300070 China Corresponding to： Dr. zhi Yao Department of Immunology Tianjin Medical University 22 Qixiangtai Road Tianjin 300070 China

To determine the regulatory effects of estrogen and cytokine IL-6 and IL-8 on the growth of epithelial ovarian cancer （OVCA）, we first examined the status of estrogen receptors （ERα and ERβ）, IL-6 receptor （IL-6Rα and gp130）, and IL-8 receptor （IL-8RA and IL-8RB） on five epithelial OVCA cell lines by semiquantitative RT-PCR and Western blot analysis. Results showed that the expressions of these receptors were variable on the five cells. Those OVCA ceUs expressing the receptors were selected to study related molecular mechanism. MTT assay was performed to observe the effects of 17β-estradiol （E2）, IL-6 and IL-8 on cell proliferation. We discovered that E2 markedly promoted the proliferation of CAOV-3 and OVCAR-3 cell in a time- and dose-dependent manner. Tamoxifen （Txf）, an ER inhibitor, completely blocked the proliferation of the E2-induced cells, and IL-6- or/and IL-8-neutralizing antibody only showed partially blocking activity. IL-6 and IL-8 were able to significantly stimulate CAOV-3 and OVCAR-3 cell proliferation in a time- and dose-dependent manner, which had a potential synergistic effect on CAOV-3 cells but not on OVCAR-3 cells. The cell proliferation induced by these two cytokines was abolished completely by their specific neutralizing antibodies, partially by Txf, but not by unrelated goat IgG. Taken together, our results suggested that estrogen, IL-6 and IL-8 could modulate OVCA growth by forming a reciprocal cascade with amplifying effect.

关键词： estrogen IL-6 IL-8 cell proliferation epithelial ovarian cancer

Predicting landslide scenes under potential earthquake scenarios in the Xianshuihe fault zone, Southwest China

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Journal of Mountain Science 2017年第7期14卷 1262-1278页

作者： ZHANG Yong-shuang YANG zhi-hua GUO Chang-bao wang Tao wang Dong-hui du Guo-liang China Institute of Geo-Environment Monitoring Institute of Geomechanics Chinese Academy of Geological Sciences Chengdu Center China Geological Survey

Earthquake-induced landslides can seriously aggravate the earthquake's destructive consequences and have caused widespread concern in recent decades. The Xianshuihe fault is a large active left-lateral strike-slip fault in the southeast margin of Qinghai-Tibet Plateau, Southwest China, where the frequent strong earthquakes have brought abundant geo-hazards. This study focuses mainly on exploring and predicting the landslide scenes induced by the potential earthquakes. Firstly, the sophisticated Newmark model is improved through landslide cases induced by the Ms7.9 Luhuo earthquake in 1973 to adapt the field seismotectonics of the Xianshuihe fault zone. Then, it is used to predict the landslide scenes under one speculated potential earthquake scenario with the similar focal mechanism with the Luhuo earthquake. The preliminary results show that the slope displacement resulted from Newmark model can reflect spatial distribution characteristics ofearthquake-induced landslides. The predicted potential earthquake-induced landslide scenes present an obvious extending trend along the Xianshuihe fault. The landslide hazard is greater in the northeast regions than southwest regions of the Xianshuihe fault, where there are more complex topographic conditions. The study procedure will be a helpful demonstration for exploration and prediction of landslide scenes under potential earthquakes in the regions with high seismic activity.

关键词： Qinghai-Tibet Plateau Xianshuihe fault Potential earthquake Landslide Newmark model

Lifts of Non-Compact Convex Sets and Cone Factorizations

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Journal of Systems Science & Complexity 2020年第5期33卷 1632-1655页

作者： wang Chu zhi Lihong Beijing Jinghang Computation and Communication Research Institute Beijing 100074China KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

This paper generalizes the factorization theorem of Gouveia,Parrilo and Thomas to a broader class of convex *** a general convex set,the authors define a slack operator associated to the set and its polar according to whether the convex set is full dimensional,whether it is a translated cone and whether it contains *** authors strengthen the condition of a cone lift by requiring not only the convex set is the image of an affine slice of a given closed convex cone,but also its recession cone is the image of the linear slice of the closed convex *** authors show that the generalized lift of a convex set can also be characterized by the cone factorization of a properly defined slack operator.

关键词： Cone factorization convex set lift nonnegative rank polyhedron positive semidefinite rank recession cone

Mechanism of Endogenous Peptide PDYBX1 and Precursor Protein YBX1 in Hirschsprung’s Disease

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Neuroscience Bulletin 2024年第6期40卷 695-706页

作者： Qiaochu Sun Zhengke zhi Chenglong wang Chunxia du Jie Tang Hongxing Li Weibing Tang Department of Pediatric Surgery Children’s Hospital of Nanjing Medical UniversityNanjing210008China

Endogenous peptides,bioactive agents with a small molecular weight and outstanding absorbability,regulate various cellular processes and ***,their role in the occurrence of Hirschsprung’s disease(HSCR)remains ***,we found that the expression of an endogenous peptide derived from YBX1(termed PDYBX1 in this study)was upregulated in the aganglionic colonic tissue of HSCR patients,whereas its precursor protein YBX1 was *** shown by Transwell and cytoskeleton staining assays,silencing YBX1 inhibited the migration of enteric neural cells,and this effect was partially reversed after treatment with ***,immunoprecipitation and immunofluorescence revealed that ERK2 bound to YBX1 and *** of YBX1 blocked the ERK1/2 pathway,but upregulation of PDYBX1 counteracted this effect by binding to ERK2,thereby promoting cell migration and *** together,the endogenous peptide PDYBX1 may partially alleviate the inhibition of the ERK1/2 pathway caused by the downregulation of its precursor protein YBX1 to antagonize the impairment of enteric neural ***1 may be exploited to design a novel potential therapeutic agent for HSCR.

关键词： Hirschsprung’s disease YBX1 Endogenous peptide PDYBX1 Enteric neural cell

Comparison of very-high-frequency ultrasound assessment of radial arterial wall layers after first and repeated transradial coronary procedures

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Journal of Geriatric Cardiology 2017年第4期14卷 245-253页

作者： Bei-Bei ZHANG Yu-Jie ZHOU Jie du Shi-Wei YANG zhi-Jiang wang Hua SHEN zhi-Ming ZHOU Bering Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing China

Background Transradial coronary procedure （TRP） traumatizes the radial artery （RA）, especially resulting in changes to arterial wall morphology. This study explored the significance of the early onset of traumatic effects to wall layers of the RA following the first TRP （FTRP） and repeat TRP （RTRP） using very-high-frequency ultrabiomicroscopy （VHFUBM）. Methods A total of 1431 patients that re- ceived TRP were divided into the FTRP group that comprised 781 patients and the RTRP group that comprised 650 patients depending on the number of procedures. Two-dimensional RA images were acquired by 30-55 MHz ultrasound one day before and one day after the pro- cedure. Results After TRP, the incidence of intimal tears, medial dissections and external elastic lamina fracture were greater in the RTRP （P 〈 0.001）. The RTRP group showed significantly thicker intimal thickness （IT）, media thickness （MT）, adventitia thickness and all complex layer thicknesses as compared with the FTRP group （P 〈 0.001）. Conclusions Multivariate linear regression analysis discovered that repeated TRP and other observations were independent predictors of increased IT in post-operative RA. VHFUBM provides an approach to study structural and histopathological injury in the wall layers of RA which showed increased trauma to the RA following RTRP.

关键词： Radial arterial wall morphology Transradial procedure Very-high-frequency ultrabiomicroscopy

Comprehensive evaluation of the optimal rates of irrigation and potassium application for strawberry

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 65-72页

作者： Xiaoqing Yang Rongcheng du Mengchi Zhang Huawei Feng Ziqing wang zhi Zhang College of Horticulture Northwest A&F UniversityYangling 712199ShaanxiChina

Accurate and effective management of irrigation and fertilization is essential for efficient greenhouse strawberry ***,the effects of the combined application of water and potassium on strawberry growth were evaluated by experimenting with 12 treatments,including four transpiration(ET_(c))-based irrigation levels(W1:100%ET_(c),W2:85%ET_(c),W3:70%ET_(c),and W4:55%ET_(c))and three potassium levels according to the target yield(K1:369.5 kg/hm^(2),K2:307.9 kg/hm^(2),and K3:246.3 kg/hm^(2)).Various indexes of strawberry yield,fruit quality,water and fertilizer utilization efficiency,and soil nutrient residues were *** and potassium application had significant effects on strawberry *** irrigation levels increased yield(Y),and moderate water and potassium application increased single fruit weight(SFW),water utilization efficiency(WUE),total soluble sugar(TSSC),and the sugar-acid ratio(SAR).While low-application of potassium increased the soluble protein content(SP),partial factor productivity of potassium(PFP_(K)),and reduce nutrient residues in soil effectively.A comprehensive system for evaluating strawberry growth and its benefits to the soil environment was *** FAHP and CRITIC methods were used to calculate the subjective weight and objective weight of each index,*** largest subjective weight was observed forY(0.200),and the largest objective weight was observed for soil-available potassium(0.101).The final weight was determined using Game theory;Y had the highest weight(0.185),and free amino acids(FAA)had the lowest weight(0.047).Grey relational analysis(GRA)was used to evaluate the optimal irrigation and potassium scheme for accomplishing multiple *** response of the comprehensive score of strawberries to irrigation and potassium exhibited a negative parabolic relationship,and the effect of irrigation was greater than the effect of potassium *** was a significant interaction bet

关键词： strawberry irrigation potassium FAHP CRITIC nutrient residues

Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第01期 257-263页

作者： Jiapian Huang Chenxin wang Xu wang Xiaoyu Zhou Wei Xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

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The effects of fertilization on the trait-abundance relationships in a Tibetan alpine meadow community

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Journal of Plant Ecology 2016年第2期9卷 144-152页

作者： Xiaolong Zhou Youshi wang Pengfei Zhang zhi Guo Chengjin Chu Guozhen du State Key Laboratory of Grassland and Agro-ecosystems School of Life SciencesLanzhou University222 Tianshui RoadLanzhou 730000GansuPeople's Republic of China Ministry of Education Key Laboratory of Western China’s Environmental Systems Research School of Arid Environment and Climate ChangeLanzhou University222 Tianshui RoadLanzhou 730000GansuPeople'Republic of China SYSU-Alberta Joint Lab for Biodiversity Conservation State Key Laboratory of Biocontrol and School of Life SciencesSun Yat-sen University135 Xingang RoadGuangzhou 510275GuangdongPeople'Republic of China

Aims Comparisons of the trait-abundance relationships from various habitat types are critical for community ecology,which can offer us insights about the mechanisms underlying the local community assembly,such as the relative role of neutral *** processes in shaping community ***,we explored the responses of trait-abundance relationships to nitrogen(N),phosphorus(P)and potassium(K)fertilization in an alpine *** Five fertilization treatments(an unfertilized control and additions of N,P,K and NPK respectively)were implemented using randomized block design in an alpine Tibetan *** relative abundance(SRA),plant above-ground biomass and species richness were measured in each *** 24 common species,we measured species functional traits:saturated height,specific leaf area(SLA)and leaf dry matter content(LDMC)in each treatment but seed size only in the unfertilized *** major axis(SMA)regression and phylogenetically independent contrasts(PICs)analysis were used to analyse species trait-abundance relationships in response to different fertilization *** Findings Positive correlations between SRA and saturated height were raised following N,P and NPK fertilizations,which indicated an increase in light competition in these *** P fertilized plots,SRA was also positively correlated with LDMC because tall grasses with a nutrients conservation strategy often have a relative competitive advantage in capturing limited light and soil *** K fertilized plots,neither the trait-abundance relationships nor above-ground biomass or species richness significantly differed from that in the control,which suggests that K was not a limiting resource in our study *** significant correlations between species traits and relative abundance in fertilized treatment suggest that trait-based selection plays an important role in determining species abundance within local communities in alpine meadows.

关键词： community structure community assembly functional trait non-neutral process species relative abundance

Soil Properties and Characteristics of Soil Aggregate in Marginal Farmlands of Oasis in the Middle of Hexi Corridor Region, Northwest China

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Agricultural Sciences in China 2007年第6期6卷 706-714页

作者： SUYong-zhong wang Fang ZHANG zhi-hui du Ming-wu Laboratory of Watershed Hydrology and Applied Ecology Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 P.R.China Linze Inland River Basin Research Station Chinese Ecosystem Research Network Lanzhou 730000 P.R.China

The composition and stability of soil aggregate are closely related to soil quality, soil erosion, and agricultural sustainability. In this study, 49 soil samples at the 0-10 cm surface layer were collected from four soil types （i.e., Ari-Sandic Primosols, Calci-Orthic Aridosols, Siltigi-Otrthic Anthrosols, and Ustic Cambosols） in the marginal farmland in the oasis of the middle Hexi Corridor region and was used to determine the characteristics of soil aggregates. The composition of dry- and wet- sieved aggregates and the physical and chemical properties （including soil particle distribution, soil organic carbon （SOC）, calcium carbonate （CaCO3）, and oxides of Fe^3＋ and Al^3＋） of the selected soils were analyzed. The results show that soil particle size distribution is dominated by fine sand fraction in most of soils except Ustic Cambosols. Soil organic carbon concentration is 5.88 ± 2.52 g kg^-1 on average, ranging from 4.75 g kg^-1 in Ari-Sandic Primosols to 10.51 g kg^-1 in Ustic Cambosols. The soils have high calcium carbonate （CaCO3） concentration, ranging from 84.7 to 164.8 g kg^-1, which is increased with soil fine particle and organic carbon content. The percentage of 〉0.25 mm dry aggregates ranges from 65.2% in Ari-Sandic Primosols to 94.6% in Ustic Cambosols, and large dry blocky aggregates （〉5 mm） is dominant in all soils. The mean weight diameter of dry aggregates （DMWD） ranges from 3.2 mm to 5.5 mm. The percentage of 〉0.25 mm water-stable aggregate is from 23.8% to 45.4%. The percentage of aggregate destruction （PAD） is from 52.4% to 66.8%, which shows a weak aggregate stability. Ari-Sandic Primosols has the highest PAD. The distribution and characteristics of soil aggregates are in favor of controlling soil wind erosion. However, the stability of aggregate of all soils is weak and soils are prone to disperse and harden after irrigation. The mass of macro-aggregates and DMWD are positively significantly correlated with the contents of soil clay and silt,

关键词： soil aggregate soil properties returning cropland to grassland marginal oasis Hexi Corridor region