检索结果-南通市图书馆

Overlapping syndrome of recurrent anti-N-methyl-D-aspartate receptor encephalitis and anti-myelin oligodendrocyte glycoprotein demyelinating diseases:A case report

引用

World Journal of Clinical Cases 2022年第18期10卷 6148-6155页

作者： Xue-Jing Yin Li-Fang Zhang Li-Hua Bao zhi-chao feng Jin-Hua Chen Bing-Xia Li Juan Zhang Department of Neurology Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Neurology Changzhi People's HospitalChangzhi 046000Shanxi ProvinceChina

BACKGROUND Anti-N-methyl-D-aspartate receptor encephalitis(NMDARe)is capable of presenting a relapsing course and coexisting with myelin oligodendrocyte glycoprotein antibody disease,whereas it has been relatively *** describe a man with no history of tumor who successively developed anti-NMDARe and anti-myelin oligodendrocyte glycoprotein antibody *** SUMMARY A 29-year-old man was initially admitted with headache,fever,intermittent abnormal behavior,decreased intelligence,limb twitching and loss of consciousness on July 16,*** admission,examination reported no *** his presentation,he experienced aggravated symptoms,and the reexamination of cranial magnetic resonance imaging(MRI)indicated punctate abnormal signals in the left parietal *** examination of cerebrospinal fluid and serum results revealed serum NMDAR antibody(Ab)(-),cerebrospinal fluid NMDAR-Ab(+)1:10 and Epstein-Barr virus capsid antigen antibody Ig G(+).Due to the imaging findings,anti-NMDARe was our primary *** patient was treated with methylprednisolone and gamma globulin pulse therapy,mannitol injection dehydration to reduce intracranial pressure,sodium valproate sustained-release tablets for anti-epilepsy and olanzapine and risperidone to mitigate psychiatric *** patient was admitted to the hospital for the second time for“abnormal mental behavior and increased limb movements”on December 14,***-examination of electroencephalography and cranial MRI showed no *** results of autoimmune encephalitis antibody revealed that serum NMDAR-Ab was weakly positive and cerebrospinal fluid NMDAR-Ab was *** comprehensive recurrent anti-NMDARe,the patient was treated with propylene-hormone pulse combined with immunosuppressive agents(mycophenolate mofetil),and the symptoms were *** patient was admitted for“hoarseness and double vision”for the third time on August 23,***-examination of cranial MRI showed ab

关键词： Autoimmune encephalitis Recurrent anti-N-methyl-D-aspartate receptor encephalitis Myelin oligodendrocyte glycoprotein Psoriasis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Altered expression of renal bumetanide-sensitive sodium-pota-ssium-2 chloride cotransporter and Cl- channel -K_2 gene in angiotensin Ⅱ-infused hypertensive rats

引用

Chinese Medical Journal 2005年第23期118卷 1945-1951页

作者： YE Tao LIU zhi-quan SUN chao-feng ZHENG Yong MA Ai-qun FANG Yuan Department of Cardiology First Hospital of Xi＇ an JiaotongUniversity Key Laboratory of Related-Genes to Environment ＆Disease of Education Ministry Xi＇ an 710061 China

Background Little information is available regarding the effect of angiotensin Ⅱ （Ang Ⅱ ） on the bumetanide-sensitive sodium-potassium-2 chloride cotransporter （NKCC2 ）, the thiazide-sensitive sodiumchloride cotransporter （ NCC）, and the Cl^- channel （ CLC ）-K2 at both mRNA and protein expression level in Ang Ⅱ-induced hypertensive rats. This study was conducted to investigate the influence of Ang Ⅱ with chronic subpressor infusion on nephron-specific gene expression of NKCC2, NCC and CLC-K2.Methods Sprague Dawleys rats were treated subcutaneously with either Ang Ⅱ （100 ng·kg^-1·min^-1） or vehicle for 14 days. Expression of NKCC2, NCC and CLC-K2 mRNA in kidneys was determined by real time polymerase chain reaction （PCR）. Western blotting analysis was used to measure NKCC2 and NCC protein expression.Results Ang Ⅱ significantly increased blood pressure and up-regulated NKCC2 mRNA and protein expression in the kidney. Expression of CLC-K2 mRNA in the kidney increased 1.6 fold （P 〈 0.05 ） . There were no changes in NCC mRNA or protein expression in AngⅡ-treated rats versus control.Conclusions Chronic subpressor Ang Ⅱ infusion can significantly alter NKCC2 and CLC-K2 mRNA expression in the kidney, and protein abundance of NKCC2 in kidney is positively regulated by Ang Ⅱ. These effects may contribute to enhanced renal Na^＋ and Cl^- reabsorption in response to Ang Ⅱ.

关键词： angiotensin Ⅱ·bumetanide-sensitive sodium-potassium-2 chloride cotransporter·thiazide-sensitive sodium-chloride cotransporter ·chloride channel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computer-Aided Simulation of Mastoidectomy

引用

Journal of Otology 2008年第2期3卷 113-115页

作者： CHEN He-xin, MA zhi-chao, Wang Zhang-feng, GUO Jie-bo, WEN Wei-ping, XU Geng Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat-sen University. Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou 510080, China Otorhinolaryngology Hospital of the First Affiliated Hospital of Sun Yat–sen University. Institute of Otorhinolaryngology Sun Yat–sen University Guangzhou 510080 China

Objective To establish a three-dimensional model of the temporal bone using CT scan images for study of temporal bone structures and simulation of mastoidectomy procedures. Methods CT scan images from 6 individuals (12 temporal bones) were used to reconstruct the Fallopian canal, internal auditory canal, cochlea, semicircular canals, sigmoid sinus, posterior fossa floor and jugular bulb on a computer platform. Their anatomical relations within the temporal bone were restored in the computed model. The same model was used to simulate mastoidectomy procedures. Results The reconstructed computer model provided accurate and clear three-dimensional images of temporal bone structures. Simulation of mastoidectomy using these images provided procedural experiences closely mimicking the real surgical procedure. Conclusion Computer-aided three dimensional reconstruction of temporal bone structures using CT scan images is a useful tool in surgical simulation and can aid surgical procedure planning.

关键词： three-dimension reconstruction CT scan surgery simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

氧在稀土酞菁上的电化学还原

引用

化学学报 1984年第7期42卷 727-730页

作者：王宝忱石志超中国科学院长春应用化学研究所中国科学院长春应用化学研究所!山东大学1983届毕业生

过渡金属大环配合物(例如酞菁和卟啉)对氧的电化学还原具有很高的催化活性,因而是目前电化学最活跃的研究领域之一.关于氧在过渡金属大环配合物上电化学还原机理,一般认为与过渡金属的价态变化有关.近年来,由于稀土双酞菁具有电致变色(e... 详细信息

过渡金属大环配合物(例如酞菁和卟啉)对氧的电化学还原具有很高的催化活性,因而是目前电化学最活跃的研究领域之一.关于氧在过渡金属大环配合物上电化学还原机理,一般认为与过渡金属的价态变化有关.近年来,由于稀土双酞菁具有电致变色(electrochromic)的特性,引起了人们极大的兴趣,并对它们的电化学行为进行了一系列的研究,但关于它们对氧的电化学还原作用却未见报道.我们利用循环伏安法研究了某些稀土单酞菁和双酞菁对氧的电化学还原的影响,并提出了氧的电化学还原的反应历程.

关键词：循环伏安曲线过渡金属预吸附过渡元素炭电极化学还原稀土金属电极表面电化学玻璃炭扫描速度

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Constructing quasi-2D perovskite to collect hot carriers to reduce open-circuit voltage loss for efficient inverted perovskite solar cells

引用

Science China Chemistry 2025年

作者： Lei Gu Xing Li chao Wu Yang feng Chunming Yang Lin Song Frontiers Science Center for Flexible Electronics Institute of Flexible Electronics Northwestern Polytechnical University Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences

Inverted perovskite solar cells （PSCs） have received great attention owing to the high certificated power conversion efficiency（PCE） reaching 26.7%. However, interfacial charge recombination is far superior to perovskite bulk charge recombination due to the use of fullerenes and their derivatives in inverted perovskite solar cells, which induces devastating open circuit voltage（VOC） losses. For this reason the present work attempts to use 4-chloropiperidine hydrochloride for the upper surface modification of perovskite to construct a quasi-two-dimensional （2D） structure with suitable 2D layer widths （n=2, 3 dominant）,which has a smaller electron carrier transport barrier without sacrificing short-circuit current （JSC） in the device. This strategy effectively passivates the interfacial defect states while promoting energy level alignment to achieve carrier dissociation and equilibrium transport at the interface, which in turn resulted in improved fill factor （FF）. In addition, additional energy levels are provided by 2D perovskites to collect hot carriers, resulting in improved device open circuit voltage （VOC）. As a result, the device PCE increases from 22.37%to 24.11%after the 4CPD treatment. In addition, the 4CPD-treated PSCs maintain 90%of the initial PCE after storage in an N2atmosphere at 50°C for 1,080 h, whereas the control devices show a 15%PCE loss under the same aging conditions. This work provides new opportunities to suppress interfacial charge recombination in inverted devices.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

豫东黄河故道湿地生态旅游开发探析

引用

特区经济 2009年第4期243卷 144-145页

作者：朱慧陈志超曾克峰中国地质大学地球科学学院湖北武汉430074

本文对豫东黄河故道湿地生态旅游资源进行评价,并从资源的开发与保护相结合、优化产品结构、分区分层开发等提出了开发湿地生态旅游资源的对策。

关键词：湿地生态旅游开发与保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

7-甲基-2-芳基-2H-吡唑[3,4-e]并-1,2,4-三嗪-3-醇的合成

引用

化学试剂 2016年第11期38卷 1133-1136页

作者：钞智锋鲁源云学英内蒙古医科大学药学院内蒙古呼和浩特010110

以寻找干扰嘌呤核酸代谢的抗肿瘤新药为目的,设计合成了嘌呤生物碱类似物。以3-甲基-5-氨基-4H-吡唑为原料,经重氮化偶合、氨解、关环等反应合成了9种新的标题类化合物,通过元素分析、1HNMR和质谱分析确定其结构。

关键词： 3-甲基-5-氨基-4H-吡唑吡唑[3,4-e]并-1,2,4-三嗪合成

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

咪唑[1,2-d]并-1,2,3,4-噻三唑衍生物的合成

引用

化学试剂 2016年第12期38卷 1231-1234页

作者：刘小红钞智锋杨慧鲁源内蒙古医科大学药学院内蒙古呼和浩特010110

为寻找CDC25B磷酸酯酶抑制剂,设计、合成咪唑[1,2-d]并-1,2,3,4-噻三唑衍生物。以溴代乙酰乙酸乙酯和5-氨基-1,2,3,4-噻三唑为原料,经过关环、肼解、缩合3步反应合成了5个目标化合物。通过元素分析、IR、1HNMR和MS分析确定了其结构。活... 详细信息

为寻找CDC25B磷酸酯酶抑制剂,设计、合成咪唑[1,2-d]并-1,2,3,4-噻三唑衍生物。以溴代乙酰乙酸乙酯和5-氨基-1,2,3,4-噻三唑为原料,经过关环、肼解、缩合3步反应合成了5个目标化合物。通过元素分析、IR、1HNMR和MS分析确定了其结构。活性结果表明,6-甲基咪唑[1,2-d]并-1,2,3,4-噻三唑-5-甲酰肼和N'-苄基-6-甲基咪唑并[1,2-d]并-1,2,3,4-噻三唑-5-甲酰肼对CDC25B有一定的抑制作用。

关键词：咪唑[1 2-d]并-1 2 3 4-噻三唑衍生物合成生物活性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

吡唑[5,1-c]并三嗪类CDC25B抑制剂的合成

引用

化学研究与应用 2017年第8期29卷 1220-1224页

作者：杨娜钞智锋成日青鲁源内蒙古医科大学附属医院药剂部内蒙古呼和浩特010050 内蒙古医科大学药学院内蒙古呼和浩特010059

CDC25B(cell division cyclin 25B)的过度表达与许多肿瘤的发生有关,被认为是新的很有潜力的抗肿瘤药物的靶点。为了寻找抑制CDC25B的抗肿瘤新药,以氰乙酸乙酯、苯肼及不同取代的芳香重氮盐为原料,经关环、重氮化、偶合和分子内环合等... 详细信息

CDC25B(cell division cyclin 25B)的过度表达与许多肿瘤的发生有关,被认为是新的很有潜力的抗肿瘤药物的靶点。为了寻找抑制CDC25B的抗肿瘤新药,以氰乙酸乙酯、苯肼及不同取代的芳香重氮盐为原料,经关环、重氮化、偶合和分子内环合等反应设计并合成了8个含有吡唑[5,1-c]并三嗪母核的嘌呤生物碱类似物。所得化合物均未见文献报道,通过元素分析、红外光谱、核磁氢谱及质谱确定了其结构,其中化合物4e、4f、4g、4h对CDC25B的抑制率(%抑制率)分别为93.5,92.6,94.5和92.1,具有较好的生物活性。

关键词： CDC25B 吡唑[5,1-c]并三嗪合成抗肿瘤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：