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Anticancer effect of Jinlongshe granules on in situ-transplanted human MKN-45 gastric cancer in nude mice and xenografted sarcoma 180 in Kunming mice and its mechanism

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World Journal of Gastroenterology 2006年第18期12卷 2890-2894页

作者： zhi-Hong Yu Pin-Kang Wei Ling xu zhi-Feng Qin Jun Shi Department of Traditional Chinese Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China

AIM： To study the antitumor effect of Chinese compound Jinlongshe （JLS） granules on sarcoma 180 and MKN-45 human gastric cancer cell lines in vivo and its mechanism. METHODS： After establishment of S180 sarcoma （S180） and MKN-45 gastric cancer model of nude mice, the tumor-bearing mice were divided into 5 groups at random. Three experimental groups were respectively given the aqueous extract of JLS granules at doses of 120 g, 60 g and 20 g/（kg per 6/wk,i.g） for 3 wk in S180 and 6 wk in nude mice model. Positive control was given cyclophosphamide （Cy） at a dose of 50 mg/（kg per 3/wk, i.g） for 3 wk in S180 models and 5-Fluorouracil （5-FU） 20 mg/（kg per 3/wk, i.g） for 3 wk in nude mice model. Negative control was given normal saline （NS） at a dose of 0.18 g/（kg per 6/wk, i.g） respectively. After 3 wk in mice bearing S180 tumor and 6 wk in nude mice model, the experimental animals were sacrificed and the masses of tumor were weighed, and the rates of tumor inhibition of each treated group were calculated respectively. To determine the antitumor mechanisms, the morphological changes, cell cycle and apoptosis were observed in MKN-45 nude mice model. Annexin V-FITC/PI double staining FCM assay was used to further determine the live cells, apoptotic cells, necrotic cells and debris. RESULTS： The inhibitory rates of JLS granules at the doses of 20 g/kg, 60 g/kg and 120 g/kg were 50.31%, 55.94% and 68.13% （P 〈 0.01） in nude mice models and 40.90%, 50.32% and 58.46% （P 〈 0.01） in S180 model. The inhibitory rate of Cy was 85.22% in S180 models and the inhibitory rate of 5-FU was 53.43% in nude mice model （P 〈 0.01）. Nuclear chromatin and margination were observed under a transmission electron microscope （TEM）. The G0/G1 phase was arrested, typical apoptotic peak appeared, the apoptotic rate was 22.81%-38.54% in three JLS granule-treated groups. Annexin V-FITC/PI double staining FCM assay showed that the apoptotic cells were 4.36%, 3.08% and 7.08% in three dosages, most cell

关键词： Jinlongshe granules Sarcoma 180 Human MKN-45 gastric cancer lines Traditional Chinese medicine

Large magnetic refrigerant capacity of HoFe_(1-x)Co_(x)Al(x=0,0.3)compounds

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Rare Metals 2021年第10期40卷 2868-2872页

作者： zhi-Yi xu zhi-Gao Zhang Rong-Li Gao Wen-Jie Gong Rui-Fen Hou An-Li Lin National Institute of Metrology(NIM) Beijing 100029China School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China

Magnetic and magnetocaloric properties of HoFe_(1-x)Co_(x)Al(x = 0, 0.3) were investigated. Both HoFeAl and HoFe_(0.7)Co_(0.3) Al undergo a second-order ferromagnetic(FIM) to paramagnetic(PM) transition at Curie temperatures(TC) of 87 and 82 K, respectively. The magnetocaloric effect is improved by the introduction of Co in HoFeAl compound. For a field change from 0 to 5 T,the maximum values of magnetic entropy change(﹣△SM)are 7.0 J·kg^(-1)·K^(-1) for HoFeAl and 8.6 J·kg^(-1)·K^(-1) for HoFe_(0.7)Co_(0.3) Al. In addition, the refrigerant capacity(RC)is enhanced largely from 416.2 J·kg^(-1) for HoFeAl to561.9 J·kg^(-1) for HoFe_(0.7)Co_(0.3) Al. This large RC is attributed to the large ﹣?SM and the wide temperature span of ?SM peak in HoFe_(0.7)Co_(0.3) Al compound. The physical mechanism of improvement in magnetocaloric effect by Co substitution in HoFeAl was also discussed in detail.

关键词： RTX compound Intermetallic compound Magnetocaloric effect Refrigerant capacity

An Efficient Framework for Multiple Subgraph Pattern Matching Models

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Journal of Computer Science & Technology 2019年第6期34卷 1185-1202页

作者： Jiu-Ru Gao Wei Chen Jia-Jie xu An Liu zhi-xu Li Hongzhi Yin Lei Zhao School of Computer Science and Technology Soochow UniversitySuzhou 215006China School of Information Technology and Electrical Engineering The University of QueenslandBrisbane 4072Australia

With the popularity of storing large data graph in cloud, the emergence of subgraph pattern matching on a remote cloud has been inspired. Typically, subgraph pattern matching is defined in terms of subgraph isomorphism, which is an NP-complete problem and sometimes too strict to find useful matches in certain applications. And how to protect the privacy of data graphs in subgraph pattern matching without undermining matching results is an important concern. Thus, we propose a novel framework to achieve the privacy-preserving subgraph pattern matching in cloud. In order to protect the structural privacy in data graphs, we firstly develop a k-automorphism model based method. Additionally, we use a cost-model based label generalization method to protect label privacy in both data graphs and pattern graphs. During the generation of the k-automorphic graph, a large number of noise edges or vertices might be introduced to the original data graph. Thus, we use the outsourced graph, which is only a subset of a k-automorphic graph, to answer the subgraph pattern matching. The efficiency of the pattern matching process can be greatly improved in this way. Extensive experiments on real-world datasets demonstrate the high efficiency of our framework.

关键词： subgraph pattern matching k-automorphism label generalization

A novel method for telescope polarization modeling based on an artificial neural network

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Research in Astronomy and Astrophysics 2021年第7期21卷 41-50页

作者： Jian-Guo Peng Shu Yuan Kai-Fan Ji zhi xu Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China

The polarization characteristics of an astronomical telescope is an important factor that affects polarimetry accuracy. Polarization modeling is an essential means to achieve high precision and efficient polarization measurement of the telescope, especially for the alt-azimuth mount telescope. At present, the polarization model for the telescope(i.e., the physical parametric model) is mainly constructed using the polarization parameters of each optical element. In this paper, an artificial neural network(ANN) is used to model the polarization characteristics of the telescope. The ANN model between the physical parametric model residual and the pointing direction of the telescope is obtained, which reduces the model deviation caused by the incompleteness of the physical parametric model. Compared with the physical parametric model, the model fitting and predictive accuracy of the New Vacuum Solar Telescope(NVST) is improved after adopting the ANN model. After using the ANN model, the polarization cross-talk from I to Q, U, and V can be reduced from 0.011 to 0.007, and the crosstalk among Q, U, and V can be reduced from 0.047 to 0.020, which effectively improves the polarization measurement accuracy of the telescope.

关键词： techniques:polarimetric telescopes polarization instrumentation:polarimeters

Preparation of calcium ferrite by flue gas desulfurization gypsum

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Journal of Iron and Steel Research International 2021年第11期28卷 1357-1365页

作者： Lin-cheng Liu Hai-bin Zuo Wen-guo Liu zhi-qiang xu State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

At present,the continuous accumulation of the flue gas desulfurization(FGD)gypsum in steel plants leads to the serious environmental issues and resource *** achieve green and sustainable development for the steel industry,it is significant to improve the usage of by-product *** the sintering FGD gypsum,ferric oxide,and graphite carbon as raw materials,the effects of the carbon content,reaction time,and molar ratio of CaO to Fe_(2)O_(3)on the desulfurization rate of gypsum were studied based on the orthogonal *** results show that the order of the three influencing factors on the desulfurization rate of FGD gypsum is:molar ratio of CaO to Fe_(2)O_(3)>reaction time>carbon *** the optimal conditions of 20 wt.%carbon content,4 h reaction time,and 1:1 molar ratio of CaO to Fe_(2)O_(3),the desulfurization rate of desulfurization gypsum is 95.79%,and 97.57 wt.%of calcium ferrite appears in the solid product,which can be used as sintering additive to increase the economic benefits of enterprises and realize the green ecological development mode of internal generation and internal digestion of solid waste in iron and steel enterprises.

关键词： Flue gas desulfurization gypsum Desulfurization rate Calcium ferrite Sintered ore Green production

Propagating slow sausage waves in a sunspot observed by the New Vacuum Solar Telescope

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Research in Astronomy and Astrophysics 2020年第8期20卷 157-162页

作者： Song Feng Zheng Deng Ding Yuan zhi xu Xiao Yang Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518055China Yunnan Observatories Chinese Academy of SciencesKunming 650011China

A sunspot is an ideal waveguide for a variety of magnetohydrodynamic waves,which carry a significant amount of energy to the upper atmosphere and could be used as a tool to probe the magnetic and thermal structure of a *** this study,we used the New Vacuum Solar Telescope and took highresolution image sequences simultaneously in both Ti O(7058±10?A)and Hα(6562±2.5?A)*** extracted the area and total emission intensity variations of sunspot umbra and analyzed the signals with synchrosqueezing *** found that the area and emission intensity varied with both three and five minute ***,the area and intensity oscillated in phase with each other,this fact hold in both Ti O and Hα*** interpret this oscillatory signal as a propagating slow sausage *** propagation speed is estimated at about 8 km s^-*** infer that this sunspot's umbra could have temperature as low as 2800–3500 K.

关键词： Sun:sunspot Sun:oscillations magnetohydrodynamics(MHD) methods:data analysis

An Anisotropic Biomimetic Lemongrass Flexible Piezoelectric Actuator-Inhibitory Regression

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Journal of Bionic Engineering 2024年第4期21卷 1817-1829页

作者： Tianwei Liang Yunhong Liang Jiru Wang Hu Huang zhi xu Hongwei Zhao Key Laboratory of CNC Equipment Reliability Ministry of EducationJilin UniversityChangchun130022China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130022China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China The Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun130025China

At present,the existing piezoelectric stick-slip actuators have an inherent back-slip problem,which greatly limits the development and application of stick-slip *** order to inhibit the regression phenomenon,a new bionic lemongrass stickslip actuator was prepared by using polymer PDMS to replicate natural biological *** surface microstructure of the grass was copied by PDMS,and the PDMS film was *** rigid and flexible bionic friction pair was further prepared,and the flexible anisotropic PDMS stick slip actuator was *** was found that the anisotropic friction characteristics of the surface microstructure of the grass inhibited the anti-sliding motion,and the elastic potential energy of the PDMS film improved the output characteristics of the *** adjusting the input voltage to control the contact between the drive foot and the rotor,the rigid and flexible hybrid drive can be realized and the backsliding phenomenon can be *** actuator is compact,lightweight and can achieve high speed and high resolution output without preloading force,which has important application value in the field of fast and accurate positioning with load limitation.

关键词： Piezoelectric actuator Bionic surface Friction Surface friction Flexible film

Multiparameter Numerical Investigation of Two Types of Moving Interactions Between the Deep-Sea Mining Vehicle Track Plate and Seabed Soil:Digging and Rotating Motions

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China Ocean Engineering 2024年第3期38卷 408-423页

作者： SUN Peng-fei LYU Hai-ning YANG Jian-min xu zhi-yong State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Yazhou Bay Institute of Deepsea SCI-TECH Shanghai Jiao Tong UniversitySanya 572024China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China

To ensure the safe performance of deep-sea mining vehicles(DSMVs),it is necessary to study the mechanical characteristics of the interaction between the seabed soil and the track *** rotation and digging motions of the track plate are important links in the contact between the driving mechanism of the DSMV and seabed *** this study,a numerical simulation is conducted using the coupled Eulerian–Lagrangian(CEL)large deformation numerical method to investigate the interaction between the track plate of the DSMV and the seabed soil under two working conditions:rotating condition and digging ***,a soil numerical model is established based on the elastoplastic mechanical characterization using the basic physical and mechanical properties of the seabed soil obtained by in situ ***,the soil disturbance mechanism and the dynamic mechanical response of the track plate under rotating and digging conditions are obtained through the analysis of the sensitivity of the motion parameters,the grouser structure,the layered soil features and the soil *** results indicate that the above parameters remarkably influence the interaction between the DSMV and the seabed ***,it is important to consider the rotating and digging motion of the DSMV in practical engineering to develop a detailed optimization design of the track plate.

关键词： deep-sea mining vehicle rotating motion digging motion track plate-seabed soil interaction CEL numerical method

Propagation of Few-Cycle Pulse Laser in Two-Level Atom Medium

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Chinese Physics Letters 2001年第7期18卷 912-914页

作者： XIAO Jian WANG Zhong-Yang xu zhi-Zhan Laboratory for High Intensity Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800

By comparing the numerical solutions of Maxwell-Bloch equations beyond and within the slowly-varying envelope approximation and the rotating-wave approximation for the propagation of few-cycle pulse laser in a resonant two-level atom medium,we found that both the Rabi flopping and the refractive index,and subsequently the carrier and the propagation velocity of the few-cycle pulse,are closely connected with the time-derivative behaviour of the electric *** is because of the Rabi flopping is such that soliton pulse splits during propagation and that a shorter pulse propagates faster than a broader one.

关键词： approximation soliton faster