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Wavelet and pain rating index for inhalation anesthesia: A randomized controlled trial

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World Journal of Clinical Cases 2020年第21期8卷 5221-5234页

作者： Jian-Wen Zhang zhi-Gan lv Ying Kong Chong-Fang Han Bao-Guo Wang Department of Anesthesiology Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Anesthesiology Shanxi Dayi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Wavelet index(WLi)and pain rating index(PRi)are new parameters for regulating general anesthesia depth based on wavelet *** To investigate the safety and efficacy of using WLi or PRi in sevoflurane *** This randomized controlled trial enrolled 66 patients scheduled for elective posterior lumbar interbody fusion surgery under sevoflurane anesthesia between September 2017 and February 2018.A random number generator was used to assign the eligible patients to three groups:Systolic blood pressure(SBP)monitoring group,WLi monitoring group,and PRi monitoring *** main anesthesiologist was aware of the patient grouping and intervention *** primary endpoint was anesthesia recovery *** endpoints included extubation time,sevoflurane consumption,number of unwanted events/interventions,number of adverse events and postoperative visual analogue scale for *** A total of 62 patients were included in the final analysis(SBP group,n=21;WLi group,n=21;and PRi group,n=20).There were no significant differences among the three groups in patient age,gender distribution,body mass index,American Society of Anesthesiologists class,duration of surgery,or duration of *** recovery time was shorter in the WLi and PRi groups than in the SBP group with no significant difference between the WLi and PRi *** time was shorter in the WLi and PRi groups than in the SBP *** consumption was lower in the WLi and PRi groups than in the SBP *** was more commonly needed to treat hypertension in the WLi and PRi groups than in the SBP *** Regulation of sevoflurane anesthesia depth with WLi or PRi reduced anesthesia recovery time,extubation time and sevoflurane consumption without intraoperative unwanted events.

关键词： Wavelet index Pain rating index Sevoflurane Depth of anesthesia Anesthesiology Systolic blood pressure

基于Hadoop技术的船舶柴油机大数据处理平台

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舰船科学技术 2023年第11期45卷 119-122页

作者：吕志峰江苏航运职业技术学院江苏南通226010

柴油机是船舶推进系统的重要组成部分,随着柴油机技术的不断发展,对柴油机相关参数进行监测并分析是必然发展趋势。柴油机的故障监测需要依赖大量的柴油机监测数据,而嵌入式处理器无法实现大量监测数据的实时采集和分析。本文提出一种基... 详细信息

柴油机是船舶推进系统的重要组成部分,随着柴油机技术的不断发展,对柴油机相关参数进行监测并分析是必然发展趋势。柴油机的故障监测需要依赖大量的柴油机监测数据,而嵌入式处理器无法实现大量监测数据的实时采集和分析。本文提出一种基于Hadoop技术的船舶柴油机大数据处理平台,对Hadoop技术的HDFS和MapReduce的实现原理进行详细分析。在此基础上设计系统的整体结构框图,并对多文件的写入速度和数据排序进行测试。本文基于Hadoop技术的船舶柴油机大数据平台可以满足船舶柴油机数据的存储和分析需求,并且具有较高的可靠性和扩展性。

关键词：大数据 Hadoop HDFS 柴油机船舶故障诊断

Enhanced activation of peroxymonosulfate on layered molybdenum disulfide loaded with Co–La bimetallic oxide for efficient degradation of chloramphenicol

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Rare Metals 2024年第9期43卷 4628-4635页

作者： Yu-Ning Fan Yun-Qiu Zhang San-Shuang Gao Zeng-Hui Bi Yin Wang Shu-Xing Zhou Qian Liu Tian-Ping lv Guang-zhi Hu Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan University Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and Science Institute for Advanced Study Chengdu University

The use of transition metal-activated peroxymonosulfate（PMS） as an advanced oxidation technology has gained recognition. This study developed a catalyst using cobaltDlanthanum bimetallic oxide supported on layered molybdenum disulfide （Mo S2） as a carrier. The CoDLa/Mo S2catalyst was synthesised through coprecipitation, followed by calcination with an optimised metal ratio of Co:La=2:1 to activate PMS and degrade trace chloramphenicol（CAP） in water. The chemical composition of the catalyst was confirmed using X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS）. At catalyst and PMS dosages of 0.1 and 0.5 g·L-1, respectively, the degradation rate of CAP was 95% with in 30 min. The catalyst exhibitedstrong resistance to most interfering anions and maintained a high degradation rate at p H 3D11. Liquid chromatographyDmass spectrometry analysis revealed the potential degradation pathways of CAP in the CoDLa/Mo S2（2:1）/PMS system. For other pollutants, such as oxytetracycline,complete degradation was achieved within 20 min,demonstrating the broad applicability of the CoDLa/Mo S2（2:1）/PMS system for the degradation and removal of antibiotic organic contaminants. This study offers a feasible approach for the degradation of antibiotic organic pollutants, including CAP, in natural water bodies.

关键词： Catalysts

基于文本信息的科技型中小企业信用风险识别信号博弈模型

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软科学 2022年第5期36卷 131-136页

作者：张目吕知远贵州财经大学大数据应用与经济学院贵阳550025 贵州财经大学贵州科技创新创业投资研究院贵阳550025

针对银行与科技型中小企业的信息不对称问题,运用信号博弈理论,以企业财务报表作为识别信用风险的信号构建基本模型,对分离均衡与混同均衡存在的条件进行分析;引入文本信息决策变量构建扩展模型,考察银行获取的文本信息水平对市场均衡... 详细信息

针对银行与科技型中小企业的信息不对称问题,运用信号博弈理论,以企业财务报表作为识别信用风险的信号构建基本模型,对分离均衡与混同均衡存在的条件进行分析;引入文本信息决策变量构建扩展模型,考察银行获取的文本信息水平对市场均衡的影响。结果表明,银行利用文本信息对企业进行信用核查,使得分离均衡更容易出现;在满足银行获取文本信息的成本约束条件下,当高风险企业付出的与文本信息水平相关的期望风险成本足够高时,引入文本信息决策可以有效遏制高风险企业的伪装行为。在大数据背景下,银行可以在企业财务报表的基础上引入文本信息决策,降低信息不对称,提高信用风险识别能力。

关键词：科技型中小企业信用风险信用风险识别文本信息信号博弈

Mechanism of fluidized chlorination reaction of Kenya natural rutile ore

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Rare Metals 2014年第4期33卷 485-492页

作者： Li-Ping Niu Pei-Yuan Ni Ting-An Zhang Guo-zhi lv Ai-Ping Zhou Xi-bin Liang De-long Meng School of Materials and Metallurgy Key Laboratory for Ecological Utilization of Multimetallic Mineral (Ministry of Education)Northeastern University Department of Material Science and Engineering KTH-Royal Institute of TechnologySE-100 44 StockholmSweden Titanium Plant Jinchuan Group Company Limited

In this paper, the thermodynamics and kinetics of nature rutile carbochlorination in a fluidized-bed were investigated. The thermodynamic calculations of TiO2-C- C12 system show that when C is excess in the solid phase, titanium tetrachloride and carbon monoxide can exist sta- bly. At high temperature, the reaction with CO as the product is the dominant reaction. The appropriate reaction conditions are as follows： reaction temperature of 950 ℃, reaction time of 40 min, carbon ratio of 30 wt% of rutile, natural rutile particle size of -96 μm, petroleum coke size of -150 μm, and chlorine flow of 0.036 m3.h-1. Under the above conditions, the reaction conversion rate of TiO2 can reach about 95 %. This paper proposed a reaction rate model, and got a rutile chlorination rate formula, which is generally consistent with the experimental data. For the TiO2-C-C12 system, the reaction rate is dependent on the initial radius of rutile particle, density, and the partial pressures of C12. From 900 to 1,000 ℃, the apparent activation energy is 10.569 ***1-1, and the mass diffu- sion is found to be the main reaction-controlling step. The expression for the chlorine reaction rate in the C-C12 sys- tem is obtained, and it depends on the degree of reaction, the partial pressure of C12, and the size of rutile particle.

关键词： Natural rutile Gas-solid reaction Fluidized-bed Carbochlorination Particle

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熔融转炉铜渣贫化法回收铜

Transactions of Nonferrous Metals Society of China 2023年第8期33卷 2511-2522页

作者：王坤刘燕郝君豆志河吕国志张廷安东北大学冶金学院沈阳110819 多金属共生矿生态冶金教育部重点实验室沈阳110819

为了从铜渣中回收铜,提出熔融铜渣贫化回收铜的新方法。首先计算贫化过程的热力学和FeO−SiO_(2)二元相图,然后研究实验参数对Fe_(3)O_(4)还原和铜回收率的影响规律,分析贫化机理。结果表明:氧化硅的加入可以明显降低黄铁矿还原磁铁矿的... 详细信息

为了从铜渣中回收铜,提出熔融铜渣贫化回收铜的新方法。首先计算贫化过程的热力学和FeO−SiO_(2)二元相图,然后研究实验参数对Fe_(3)O_(4)还原和铜回收率的影响规律,分析贫化机理。结果表明:氧化硅的加入可以明显降低黄铁矿还原磁铁矿的初始反应温度。最优条件下,铜渣中的Fe_(3)O_(4)和铜含量分别降低至2.45%和0.39%(质量分数),铜回收率为92.52%。贫化后,超过94%的银和99%的金沉降在铜锍中。大约72%的锌和75%的铅挥发进入烟气。由于磁铁矿的还原,铜渣的黏度从0.68 Pa·s降低到了0.12 Pa·s,并且机械搅拌可以强化铜锍液滴的沉降。

关键词：铜渣铜回收贫化磁铁矿还原机械搅拌

PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3049-3067页

作者： Jianming Yang Yawen Xiao Ningning Zhao Geng Pei Yan Sun Xinyu Sun Kaiyuan Yu Chunhui Miao Ran Liu Junqiang lv Hongyu Chu Lu Zhou Bangmao Wang zhi Yao Quan Wang Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Institute of ImmunologyState Key Laboratory of Experimental Hematologythe Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of ImmunologySchool of Basic Medical SciencesTianjin Institute of Urologythe Second Hospital of Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyTianjin Medical UniversityTianjin 300070China Department of Pathology Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center of Cancer/Key Laboratory of Cancer Prevention and TherapyTianjin/Tianjin’s Clinical Research Center of CancerTianjin 30060China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300070China

The mucosal barrier is crucial for intestinal homeostasis,and goblet cells are essential for maintaining the mucosal barrier *** proviral integration site for Moloney murine leukemia virus-1(PIM1)kinase regulates multiple cellular functions,but its role in intestinal homeostasis during colitis is ***,we demonstrate that PIM1 is prominently elevated in the colonic epithelia of both ulcerative colitis patients and murine models,in the presence of intestinal *** PIM1 leads to decreased goblet cells,thus impairing resistance to colitis and colitis-associated colorectal cancer(CAC)in ***,PIM1 modulates goblet cell differentiation through the Wnt and Notch signaling ***,PIM1 interacts with histone deacetylase 2(HDAC2)and downregulates its level via phosphorylation,thereby altering the epigenetic profiles of Wnt signaling pathway ***,these findings investigate the unknown function of the PIM1-HDAC2 axis in goblet cell differentiation and ulcerative colitis/CAC pathogenesis,which points to the potential for PIM1-targeted therapies of ulcerative colitis and CAC.

关键词： PIM1 HDAC2 Goblet cell Gut microbiota Intestinal homeostasis Epigenetic modification Ulcerative colitis CAC

Exponential distance distribution of connected neurons in simulations of two-dimensional in vitro neural network development

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Frontiers of physics 2017年第3期12卷 133-138页

作者： zhi-Song lv Chen-Ping Zhu Pei Nie Jing Zhao Hui-Jie Yang Yan-Jun Wang Chin-Kun Hu Department of Physics in Science College Nanjing University of Aeronautics and Astronautics Nanjing 210016 Research Center of Complex Systems Science University of Shanghai for Science and Technology Shanghai 200093 Department of Mathematics College-of Logistic-Engineering of PLANanjing 210016 College of Civil Aviation Nanjing University of Aeronautics and Astronautics Nanjing 210016 Institute of Physics Academia Sinica Nankang Taipei 11529 National Center for Theoretical Sciences Tsing Hua University Hsinchu 30013

The distribution of the geometric distances of connected neurons is a practical factor underlying neural networks in the brain. It can affect the brain＇s dynamic properties at the ground level. Karbowski derived a power-law decay distribution that has not yet been verified by experiment. In this work, we check its validity using simulations with a phenomenological model. Based on the in vitro two- dimensional development of neural networks in culture vessels by Ito, we match the synapse number saturation time to obtain suitable parameters for the development process, then determine the distri-bution of distances between connected neurons under such conditions. Our simulations obtain a clear exponential distribution instead of a power-law one, which indicates that Karbowski＇s conclusion is invalid, at least for the case of in vitro neural network development in two-dimensional culture vessels.

关键词： distance distribution connected neurons development exponential power-law neuralnetworks complex systems

Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3605-3623页

作者： Zehui Tan Ning Guo zhi Cao Shuyu Liu Jiayu Zhang Deyi Ma Jiahao Zhang Wencai lv Nan Jiang Linghe Zang Lihui Wang Xin Zhai Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacology Shenyang Pharmaceutical UniversityShenyang 110016China

Recent research certified that DOT1L and its mutations represented by R231Q were potential targets for the treatment of lung ***,a series of adenosine-containing derivatives were identified with DOT1LR231Q inhibition through antiproliferation assay and Western blot analysis in the H460R231Q *** most promising compound 37 significantly reduced DOT1LR231Q mediated H3K79 methylation and effectively inhibited the proliferation,self-renewal,migration,and invasion of lung cancer cell lines at low micromolar *** cell permeability and cellular target engagement of 37 were verified by both CETSA and DARTS *** the H460R231Q OE cell-derived xenograft(CDX)model,37 displayed pronounced tumor growth inhibition after intraperitoneal administration at 20 mg/kg dose for 3 weeks(TGI=54.38%),without obvious toxicities.A pharmacokinetic study revealed that 37 possessed tolerable properties(t_(1/2)=1.93±0.91 h,F=97.2%)after intraperitoneal administration in *** study confirmed that 37 suppressed malignant phenotypes of lung cancer carrying R231Q gain-of-function mutation via the MAPK/ERK signaling ***,analysis of the binding modes between molecules and DOT1LWT/R231Q proteins put forward the“Induced-fit”allosteric model in favor to the discovery of potent DOT1L candidates.

关键词： DOT1L R231Q mutation Lung cancer Adenosine-containing inhibitors Epigenetics