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Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-Yang Yan Hong lv Jing-Cheng Yang Chao You Zi-Ang Li Ding Ma Yi Xiao Jia Hu Wen-Tao Yang Yi-Zhou Jiang Jun Xu zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank P<0.001).Our prediction framework and neural network models were externally validated on the TNBC cases from TCGA(N=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

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Diagnosis of Pulmonary Artery Sling by Echocardiograpy

Diagnosis of Pulmonary Artery Sling by Echocardiograpy

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2012年浙江省超声医学学术年会

作者： lv zhi-su JIANG Guo-ping Department of Ultrasound the Children’s HospitalCollege of Medicine Zhejiang University

Objective: To investigate the characteristics and method of echocardiography in pulmonary artery sling (PAS). Methods: Using a routine and standard method ,echocardiographic assessment was performed .Observing the main pulmonary artery(MPA) and the origin of the left pulmonary artery(LPA),measuring the diameter of the MPA and left and right pulmonary artery(LPA and RPA) via the parasternal aortic short-axis views.

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Research on Pulmonary Stenosis in Complete Transposition of the Great Arteries by Echocardiography

Research on Pulmonary Stenosis in Complete Transposition of ...

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2012年浙江省超声医学学术年会

作者： lv zhi-su JIANG Guo-ping Department of Ultrasound the Children’s HospitalCollege of Medicine Zhejiang University

Objective To investigate the value of echocardiography in diagnosis of pulmonary stenosis in transposition of the great arteries (TGA). Methods Totally 107 children with TGA diagnosed by echocardiography and further confirmed by operation or cardiac catheter angiography were selected. Taking surgical and pathological findings as gold standard,all patients

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有色金属矿山测量常见问题改进措施分析

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世界有色金属 2023年第16期 41-43页

作者：吕治琦甘肃厂坝有色金属有限责任公司厂坝铅锌矿甘肃陇南742504

近年来,在新一轮工业化改革浪潮推动下,我国有色金属矿山企业普遍实施了互联网加改革、物联网改革,提高了测量效率与测量效果。当前,正值此类企业高质量发展阶段,需要持续提升测量水平,推动智能矿山建设工作。本文以此为出发点,概述了... 详细信息

近年来,在新一轮工业化改革浪潮推动下,我国有色金属矿山企业普遍实施了互联网加改革、物联网改革,提高了测量效率与测量效果。当前,正值此类企业高质量发展阶段,需要持续提升测量水平,推动智能矿山建设工作。本文以此为出发点,概述了有色金属矿山测量内容与特点,剖析了有色金属矿山测量中常见的问题。并在此基础上,分别从新理念、新技术、新人才三个层面提出了几点较有针对性的改进措施。

关键词：有色金属矿山测量问题改进措施

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社区卫生环境治理中民事责任与法律制度的应用研究

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四川环境 2023年第4期42卷 260-263页

作者：吕智霞陕西警官职业学院法律系西安710021

由于我国社区卫生环境治理法律体系不完善,使生活垃圾在处理过程中,一旦发生管辖纠纷,无法得到快速的处理,从而造成了环境污染。本文分析社区卫生环境治理中民事责任与法律制度的应用。明确当前社区卫生环境治理存在的民事责任与法律问... 详细信息

由于我国社区卫生环境治理法律体系不完善,使生活垃圾在处理过程中,一旦发生管辖纠纷,无法得到快速的处理,从而造成了环境污染。本文分析社区卫生环境治理中民事责任与法律制度的应用。明确当前社区卫生环境治理存在的民事责任与法律问题,根据民事责任与法律制度与社区卫生环境治理之间的反馈作用,建立民事责任与法律制度对社区卫生环境治理相关因素的对应关系,对相关因素分析,根据各因素之间的关系,确定其对社区卫生环境治理的监督与促进作用,完善社区卫生环境治理的民事责任与法律制度。

关键词：民事责任法律制度社区卫生环境环境治理

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浅析舱口盖结构的加工及安装

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科学与信息化 2022年第1期 126-128页

作者：吕志昊江南造船(集团)有限责任公司上海 201913

轮船的舱口盖是整个船身最为重要的一个部件,它能够最大限度地保证不管是在风暴天气还是暴雨天气下,都不会让船舱内的货物受到外界的影响,在船舱装卸货物的时候也应当保证船舱口能够随时开启和关闭,而本文便是主要对船舱口的整体结构加... 详细信息

轮船的舱口盖是整个船身最为重要的一个部件,它能够最大限度地保证不管是在风暴天气还是暴雨天气下,都不会让船舱内的货物受到外界的影响,在船舱装卸货物的时候也应当保证船舱口能够随时开启和关闭,而本文便是主要对船舱口的整体结构加工以及安装流程进行一个较为详细的阐述,在此基础上提出舱口盖安装前应该做出哪些准备工作、吊装盖板的工作以及舱口盖周边的零碎部件的安装等,这些合理的建议,更加有利于舱口盖发挥自身的作用.

关键词：舱口盖部件加工上船安装

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Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 159-170页

作者： Xiao-Mei Zhao zhi-Xin Wu Yan Wang Ying-Jie Xu Ye Xiu Xu Dong Jun-Jie Li Gui-Ji lv Si-Hao Wang Yu-Rong Li Zhao-Fang Bai Xiao-He Xiao Department of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Department of Military Patient Management The Fifth Medical Center of PLA General HospitalBeijingChina Department of Hepatology China Military Institute of Chinese Materia The Fifth Medical Center of PLA General HospitalBeijingChina Departmentof Hepatology National Key Laboratory of Kidney DiseasesBeijingChina

Background: Idiosyncratic drug-induced liver injury(IDILI) is a serious side effect of drugs, Epimedii Folium(EF) is unequivocally implicated in idiosyncratic liver injury onset, potentially due to its ability to perturb the NOD-like receptor family pyrin domain containing 3(NLRP3) inflammasome. Fructus Ligustri Lucidi(FLL), a frequently used medicinal combination with EF, has not yet been investigated for its ability to ameliorate EF-associated hepatotoxicity. Aims and Objectives: Study on the mechanism of compatibility of FLL to alleviate liver injury caused by EF. Materials and Methods: Western blot was used to determine the expression of related proteins, ELISA was used to detect the secretion of related inflammatory factors IL-1β, IL-18, IL-6 and TNF-α, liver injury indexes were detected and liver pathological tissue staining was used to evaluate the liver injury. Results: Our results demonstrated that EF exerted a particular augmenting effect on the stimulation of the NLRP3 inflammasome mediated by nigericin or ATP, whereas FLL suppressed the NLRP3 inflammasome stimulation. Furthermore, an equal EF to FLL ratio significantly reduced the stimulatory effects of EF. Moreover, EF has the potential to induce hepatic injury and augment pro-inflammatory cytokine synthesis in rats subjected to LPS. However, when combined with FLL, the detrimental effects of EF were mitigated. Conclusions: FLL possesses the capacity to attenuate EF-associated hepatotoxicity by suppressing EF-triggered NLRP3 inflammasome activation. Thus, FLL holds promise for improving the clinical safety profile of EF, shedding light on the potential of compatibility and detoxification theories in traditional Chinese medicine.

关键词： Epimedii Folium Fructus Ligustri Lucidi idiosyncratic drug-induced liver injury NOD-like receptor family pyrin domain containing 3 inflammasome traditional Chinese medicine

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Application of Wavelet Transform Modulus Maxima in Raman Distributed Temperature Sensors

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Photonic Sensors 2014年第2期4卷 142-146页

作者： Zongliang WANG Jun CHANG Sasa ZHANG Sha LUO Cuanwu JIA Boning SUN Shuo JIANG Yongning LIU Xiaohui LIU Guangping lv zhi LIU School of Information Science and Engineering and Shandong Provincial Key Laboratory of Laser Technology andApplieation Shandong University Jinan 250100 China

我们建议了并且示威小浪变换模量降噪方法减少的最大值(WTMM ) 温度错误。在这个计划，作文规模被 WTMM 振幅变化在 30 摯汵瑡潩 ? 整档楮畱与分解规模的生长简单地决定吗？

关键词：小波变换模模极大值温度传感器分布式小波分解系数喇曼应用去噪方法

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Clinical and molecular characteristics of Staphylococcus aureus isolated from Chinese children:association among the agr groups and genotypes,virulence genes and disease types

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World Journal of Pediatrics 2021年第2期17卷 180-188页

作者： Yan Xu Su-Yun Qian Kai-Hu Yao Fang Dong Wen-Qi Song Chen Sun Xin Yang Jing-Hui Zhen Xi-Qing Liu zhi-Yong lv Xi Yang Pediatric Intensive Care Unit National Center for Children's HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan-Li-Shi RoadBeijing 100045China Key Laboratory of Major Diseases in Children Ministry of EducationNational Key Discipline of Pediatrics(Capital Medical University)National Center for Children's HealthBeijing Pediatric Research Institute.Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Bacteriology Laboratory National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background This study was aimed to investigate the clinical and molecular epidemiology of Staphylococcus aureus(***)isolated from Chinese children and determine the possible relationship among the accessory gene regulator(agr)groups and genotypes,as well as among the virulence genes and disease *** *** strains were isolated from Beijing Children's Hospital between October 2017 and October *** isolates and 19 virulence genes were characterized using multi-locus sequence typing,staphylococcal protein A(spa),staphylococcal cassette chromosome mec,and agr *** A total of 191 non-repetitive *** clinical isolates were divided into 33 sequence types(STs),18 clonal com-plexes(CCs),and 59 spa ***59(39.8%),t437(37.7%),and agrⅠ(84.8%)were the predominant ***59,CC25,CC22,CC951,CC8,and CC398 belonged to agrⅠ.CC5 and CC15 were assigned to agrⅡ,and CC30 was characterized as agrⅢ.CC121 was classified under agrⅣ.The eta,etb,and bbp genes were more prevalent in agrⅣ(P0.05).Conclusions An association among the agr groups and genotypes,as well as specific toxin genes,was observed among the *** strains isolated from Chinese ***,a statistical correlation was not found among the agr groups and disease types.

关键词： Accessory gene regulator Chinese children Genotype Staphylococcus aureus Toxin gene

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医院消防应急广播系统设计探讨

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建筑电气 2022年第4期41卷 10-13页

作者：吕智谭杰华蓝设计(集团)有限公司南宁市530011 广西壮族自治区妇幼保健院南宁市530000

针对医院公共广播系统和消防应急广播系统合用时存在的问题进行分析探讨,根据医院主要公共场所环境噪声的实测数据,对医院特殊场所的扬声器设置提出建议,分析广播线路、功放及电源设计时容易忽视的问题并提出设计建议。

关键词：公共广播系统消防应急广播系统扬声器线路功放电源环境噪声大型医院

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