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Pars plana vitrectomy for retinal detachment using perfluoro-n-octane as intraoperative tamponade:a multicenter,randomized,non-inferiority trial

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 82-91页

作者： Xin Shi Wei-Jun Wang Ying fan Hai-Yun Liu Hong Wang Yu-Hui Chen Ao Rong zhi-Feng Wu Xun Xu Kun Liu Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200085China Shanghai Jieshi Medical Technology Co.Ltd. Shanghai 201201China Department of Ophthalmology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Ophthalmology Wuxi No.2 People’s Hospital(Jiangnan University Medical CenterJUMC)Wuxi 214002Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of perfluoro-n-octane(PFO)for ophthalmic surgery versus F-Octane as an intraoperative tamponade in pars plana vitrectomy(PPV)in management of retinal ***:This multicenter,prospective,randomized,double-masked,parallel-controlled,non-inferiority trial was conducted in three ophthalmology clinical centers in *** with retinal detachment,who were eligible for PPV were consecutively *** were assigned to PFO for ophthalmic surgery or F-Octane for intraocular tamponade in a 1:1 ***-corrected visual acuity(BCVA),intraocular pressure(IOP)measurement,and dilated fundus examination were performed preoperatively and at 1,7±1,28±3d *** primary outcome was complete retinal reattachment rate at postoperative day *** non-inferiority margin was set at 9.8%.The secondary outcomes included intraoperative retinal reattachment rate,and mean changes in IOP and BCVA from baseline to 1,7±1,28±3d postoperatively,*** analyses were presented for all randomly assigned participates in this ***:Totally 124 eligible patients completed the study between Mar.14,2016 and Jun.7,*** of them were randomly assigned to the PFO for ophthalmic surgery group,and 64 were assigned to the F-Octane *** characteristics were comparable between the two *** groups achieved 100%retinal reattachment at postoperative day one(difference 0,95%CI:-6.21%to 5.75%,P=1).The pre-defined noninferiority criterion was *** significant difference was observed in intraoperative retinal reattachment rate(difference 1.77%,P=0.61),mean changes in IOP(difference 0.36,-0.09,2.22 mm Hg at 1,7±1,28±3d postoperatively,with all P>0.05)and BCVA(difference 0.04,-0.02,0.06 logMAR at 1,7±1,28±3d postoperatively,all P>0.05)between the two *** apparent adverse events related to the utilization of PFO were ***:In patients with retinal detachment undergoing PPV,PFO

关键词： perfluoro-n-octane vitreoretinal surgery intraocular tamponade ophthalmic surgery retinal detachment

Highly sensitive diamond X-ray detector array for high-temperature applications

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Chip 2024年第3期3卷 43-49页

作者： Wenjie Dou Chaonan Lin Wei fan Xun Yang Chao fang Huaping Zang Shaoyi Wang Congxu Zhu zhi Zheng Weimin Zhou Chongxin Shan Henan Key Laboratory of Diamond Optoelectronic Material and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province College of Chemical and Materials EngineeringXuchang UniversityXuchang 461000China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou450046China

Diamond is a highly suitable material for X-ray detectors that can function effectively in harsh environments due to its unique properties such as ultrawide bandgap,high radiation resistance,excellent carrier mobility as well as remarkable chemical and thermal ***,the sensitivity of diamond X-ray detectors needs further improvement due to the relatively low X-ray absorption efficiency of diamond,and the exploration of singlecrystal diamond array imaging still remains *** the current work,a 10310 X-ray photodetector array was constructed from single-crystal *** improve the sensitivity of the diamond X-ray detector,an asymmetric sandwich electrode structure was ***,trenches were created through laser cutting to prevent crosstalk between adjacent *** diamond X-ray detector array exhibits exceptional performance,including a low detection limit of 4.9 nGy s^(-1),a sensitivity of 14.3 mC Gy^(-1) cm^(-2),and a light-dark current ratio of 18,312,which are among the most favorable values ever reported for diamond X-ray ***,these diamond X-ray detectors can operate at high temperatures up to 450℃,making them suitable for development in harsh environments.

关键词： Diamond X-ray detector array X-ray imaging Sensi-tivity Detection limit

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying Liu Yi-Yan Zhai Yi-Xuan Wang zhi-Shan Wu Antony Stalin Guo-Liang Cheng Bing Li Chao Wu zhi-Hong Huang Shan Lu Xiao-Tian fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

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惯性器件长期贮存性能可靠性灰色马氏链预测

上海交通大学学报 2004年第10期38卷 1761-1763,1767页

作者：钱峰田蔚风金志华樊春玲上海交通大学信息检测技术与仪器系上海200030

为了及时掌握武器系统惯性器件的性能,并为延长其使用寿命及维修提供依据,对其进行贮存可靠性评估和预测非常必要.讨论了一种灰色马氏链预测模型的建模方法,此方法兼具灰色模型和马氏链模型的优点,它不仅充分利用了灰色模型动态建模思想... 详细信息

为了及时掌握武器系统惯性器件的性能,并为延长其使用寿命及维修提供依据,对其进行贮存可靠性评估和预测非常必要.讨论了一种灰色马氏链预测模型的建模方法,此方法兼具灰色模型和马氏链模型的优点,它不仅充分利用了灰色模型动态建模思想,来预报可靠性数据总体趋势,并且根据此总体趋势,进行状态的划分,从而大大克服了马氏链状态矩阵运算量大的缺点,而且拓宽了灰色模型的应用范围,使其适合于波动性较大的随机数据列的预测.最后,对某型导弹速率陀螺仪贮存性能可靠性进行估计,并进行灰色马氏链预测.

关键词：惯性器件灰色模型马氏链可靠性预测

Development of 400-μW cryogen-free dilution refrigerators for quantum experiments

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Chinese Physics B 2024年第7期33卷 28-35页

作者：关翔樊洁边勇波程智刚姬忠庆 Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

We have successfully developed cryogen-free dilution refrigerators with medium cooling power that can be applied to quantum experiments. Breakthroughs have been made in some key technologies and components of heat switches and dilution units. Our prototype has been running continuously and stably for more than 100 hours below 10 m K, with a minimum temperature of 7.6 m K and a cooling power of 450 μW at 100 m K. At the same time, we have also made progress in the application of dilution refrigerators, such as quantum computing, low-temperature detector, and magnet integration. These indicators and test results indicate good prospects for application in physics, astronomy, and quantum information.

关键词： cryogen-free dilution refrigerator quantum computing low-temperature detector superconducting magnet

Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2031-2039页

作者： Xiang Liu Yi-Feng Wang Xiao-Hui Qi zhi-Lei Zhang Jiang-Yang Pan Xue-Li fan Yu Du Ying-Min Zhai Qi Wang Department of CT and MRI The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND The consistency of pancreatic apparent diffusion coefficient(ADC)values and intravoxel incoherent motion(IVIM)parameter values across different magnetic resonance imaging(MRI)devices significantly impacts the patient’s diagnosis and *** To explore consistency in image quality,ADC values,and IVIM parameter values among different MRI devices in pancreatic *** This retrospective study was approved by the local ethics committee,and informed consent was obtained from all *** total,22 healthy volunteers(10 males and 12 females)aged 24-61 years(mean,28.9±2.3 years)underwent pancreatic diffusion-weighted imaging using 3.0T MRI equipment from three *** independent observers subjectively scored image quality and measured the pancreas’s overall ADC values and signal-to-noise ratios(SNRs).Subsequently,regions of interest(ROIs)were delineated for the IVIM parameters(true diffusion coefficient,pseudo-diffusion coefficient,and perfusion fraction)using post-processing *** ROIs were on the head,body,and tail of the *** subjective image ratings were assessed using the kappa consistency *** correlation coefficients(ICCs)and mixed linear models were used to evaluate each device’s quantitative parameter ***,a pairwise analysis of IVIM parameter values across each device was performed using Bland-Altman *** The Kappa value for the subjective ratings of the different observers was 0.776(P0.05),and the ICCs for the ADC values from different devices were 0.870,0.707,and 0.808,respectively(P<0.05).Notably,only a few statistically significant inter-device agreements were observed for different IVIM parameters,and among t

关键词： Intravoxel incoherent motion Pancreas Image quality Consistency test

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元宇宙重构传媒:内在逻辑、挑战与规制

经济问题 2024年第8期 69-74页

作者：孙志凡北京城市学院北京100083

元宇宙深度融入传媒是必然的趋势。依托多元技术集成及更丰富的人际沟通方式,作为未来媒体集成模式的元宇宙丰富了传播场景,为重构传媒提供了可能性。现有的元宇宙传媒探索创造了更加多元精细媒体场景、拓宽了传统媒体经营业务模式、构... 详细信息

元宇宙深度融入传媒是必然的趋势。依托多元技术集成及更丰富的人际沟通方式,作为未来媒体集成模式的元宇宙丰富了传播场景,为重构传媒提供了可能性。现有的元宇宙传媒探索创造了更加多元精细媒体场景、拓宽了传统媒体经营业务模式、构建了新型“时空观”,同时也缔造了新型的“传播文化”。但是,现实或可能引致的问题也应重视:元宇宙传媒场景虚实相融带来的监管难题、当前体制下的数据保护问题及可能导致的伦理问题等。针对这些问题进行规范时,要实施前瞻性、动态性的多维度治理,加强对用户数据隐私和安全的保护,实现有效治理的“大局观”。

关键词：元宇宙传媒重构媒介治理

“Keyboard sign”and“coffee bean sign”in the prenatal diagnosis of ileal atresia:A case report

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World Journal of Clinical Cases 2024年第24期12卷 5622-5627页

作者： zhi-Hui Fei Qi-Yi Zhou Ling fan Chan Yin Department of Ultrasound Changde Maternal and Child Health Care HospitalChangde 415000Hunan ProvinceChina

BACKGROUND Ileal atresia is a congenital abnormality where there is significant stenosis or complete absence of a portion of the *** overall diagnostic accuracy of prenatal ultrasound in detecting jejunal and ileal atresia is *** report a case of ileal atresia diagnosed prenatally by ultrasound examination with the“keyboard sign”and“coffee bean sign”.CASE SUMMARY We report a case of ileal atresia diagnosed in utero at 31 weeks'of *** ultrasound examination revealed two rows of intestines arranged in an‘S’shape in the middle *** inner diameters were 1.7 cm and 1.6 cm,respectively.A typical“keyboard sign”was *** intestine canal behind the“keyboard sign”showed an irregular strong *** was no normal intestinal wall structure,showing a typical“coffee bean sign”.Termination of the pregnancy and autopsy findings confirmed the *** The prenatal diagnosis of ileal atresia is *** sonographic features of the“keyboard sign”and“coffee bean sign”are helpful in diagnosing the location of congenital jejunal and ileal atresia.

关键词： Ileal atresia The prenatal diagnosis Keyboard sign Coffee bean sign

Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex

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Protein & Cell 2024年第3期15卷 230-234页

作者： Yuxia Wang Lijie Wu Tian Wang Junlin Liu Fei Li Longquan Jiang Zhongbo fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua zhi-Jie Liu iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Molecular and Clinical Medicine Kunming Medical UniversityKunming 650500China

Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关键词： stimulation return