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肠道黏膜、肠道免疫和微生物群在肠源性白念珠菌感染中的作用

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中国感染控制杂志 2024年第5期23卷 631-637页

作者：陈慧婷李家生徐志昌秦定梅张祎王睿睿云南省中医药大学中药学院分子药理教研室云南昆明650500 云南省民族特色养生理论与健康产品工程实验室云南昆明650500 省部共建生物资源保护与利用国家重点实验室云南昆明650500

肠源性白念珠菌感染是指肠道内定植的白念珠菌在一定条件下发生易位,突破肠道,造成组织感染,甚至引发侵袭性白念珠菌感染。肠道黏膜作为念珠菌第一接触位点,是抵抗白念珠菌定植或侵入的第一道防线,常通过物理屏障和激活宿主免疫抑制感... 详细信息

肠源性白念珠菌感染是指肠道内定植的白念珠菌在一定条件下发生易位,突破肠道,造成组织感染,甚至引发侵袭性白念珠菌感染。肠道黏膜作为念珠菌第一接触位点,是抵抗白念珠菌定植或侵入的第一道防线,常通过物理屏障和激活宿主免疫抑制感染。作为另一种防御机制,肠道内微生物群则通过调节pH,分泌抗菌肽和竞争黏附点共同抵抗白念珠菌侵袭感染。本综述总结肠道黏膜、肠道免疫和微生物群这三个关键因素在肠源性白念珠菌感染中的作用,为肠道定植引发侵袭性白念珠菌病的科学研究提供新思路。

关键词：肠源性白念珠菌感染肠道黏膜肠道免疫肠道微生物群白假丝酵母菌

Nanometer Stripe Microstructure of Supersaturated Solid Solution in Fe-Cu Alloy

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Journal of Iron and Steel Research International 2007年第1期14卷 64-68页

作者： REN Hui-ping WANG Hai-yan LIU Zong-chang AN zhi-guo College of Material and Metallurgy Engineering Inner Mongolia University of Science and TechnologyBaotou 014010 Inner Mongolia China

Strengthening due to precipitation of Cu in the a-Fe matrix is an important phenomenon utilized in the design of HSLA steels. In the present work, the microstructure of supersaturated solid solution in Fe-1.18%Cu binary alloy was investigated by means of high resolution electron microscopy. The results indicated that the solid solution was heterogeneous, there were lots of Cu atom clusters, which consisted of diffractive stripe microstructure similar to twin crystal. Orientation deviation was observed between two （110）o planes in diffractive stripes, which results in light and shade contrast. Furthermore, formation mechanisms of the nanometre stripe microstructure were discussed in terms of the interaction of Cu and Fe atoms in the Fe-Cu binary alloys.

关键词： Fe-Cu alloy supersaturated solid solution Cu-rich cluster nanometer stripe microstructure high resolution electron microscopy

小麦穗型相关生长素通路基因发掘及TaARF23-A与小穗数关联分析

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作物学报 2024年第2期50卷 506-513页

作者：谭丹陈家婷郜钰张晓军李欣闫贵云李锐陈芳常利芳张树伟郭慧娟畅志坚乔麟轶山西农业大学农学院/作物遗传与分子改良山西省重点实验室/农业农村部有机旱作农业重点实验室(部省共建) 山西太原030031

生长素是调控作物穗部形态的主要内源激素之一。为了发掘小麦中与穗型相关的生长素通路基因,本研究选择了纺锤穗型品系SY95-71和密穗品系CH7034,对其幼穗内源生长素含量进行了检测,结果显示SY95-71幼穗中的色胺含量显著高于CH7034。转... 详细信息

生长素是调控作物穗部形态的主要内源激素之一。为了发掘小麦中与穗型相关的生长素通路基因,本研究选择了纺锤穗型品系SY95-71和密穗品系CH7034,对其幼穗内源生长素含量进行了检测,结果显示SY95-71幼穗中的色胺含量显著高于CH7034。转录组测序结果表明,在高置信区间(P<0.01)范围内, SY95-71幼穗中富集到4个特有的生长素相关条目,并且色氨酸脱羧酶基因(负责将色氨酸转化为色胺)和生长素响应因子基因(Auxin Response Factors,ARFs)的转录水平均显著高于CH7034。对在SY95-71中高表达的2个ARF基因(TraesCS7A02G475700和TraesCS7A02G475600)作了进一步分析,结果显示二者是位于7A染色体长臂上的一对串联重复基因,根据小麦ARF家族成员编号,将其分别命名为TaARF23-A1和TaARF23-A2。qRT-PCR结果证实SY95-71幼穗中TaARF23-A1和TaARF23-A2的表达量极显著高于CH7034。测序结果显示TaARF23-A的外显子序列在SY95-71和CH7034间具有2个SNP和1个InDel。根据InDel位点开发分子标记,并将其与SY95-71和CH7034的RILs群体在6个大田环境下的穗部表型进行关联分析,结果显示TaARF23-A与小穗数显著相关(P<0.0001),其CH7034型等位变异比SY95-71型等位变异增加了1.67个小穗。本研究结果将为小穗发育机制解析提供参考,也为小麦理想穗型改良提供了分子标记。

关键词：小麦穗型生长素 TaARF23-A 小穗数分子标记

Non-fused medium bandgap electron acceptors for efficient organic photovoltaics

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Journal of Energy Chemistry 2022年第7期31卷 576-582,I0014页

作者： Tian-Jiao Wen Jiale Xiang Nakul Jain zhi-Xi Liu Zeng Chen Xinxin Xia Xinhui Lu Haiming Zhu Feng Gao chang-zhi Li State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina Department of Physics Chemistry and Biology(IFM) Link?ping UniversityLinköping SE-58183Sweden Department of Chemistry Zhejiang UniversityHangzhou 310027ZhejiangChina Department of Physics The Chinese University of Hong KongNew TerritoriesHong Kong 999077China

The cost-effective organic semiconductors are strongly needed in organic photovoltaics(OPVs). Herein,two medium bandgap(MBG) electron acceptors, TPT4F and TPT4Cl are developed via the new design of multi-noncovalent interaction assisted unfused core, flanked with two electron withdrawing end groups. These fullly non-fused MBG acceptors adapt the planar and rigid conformation in solid, therefore exhibiting the ordered face-on stacking and strong photoluminescence in films. As results, TPT4Cl^(-)based OPVs, upon blending with the PBDB-TF polymer donor, have achieved a power conversion efficiency of 10.16% with a low non-radiative loss of 0.27 e V, representing one of the best fullly non-fused medium bandgap acceptors with desirable cost-efficiency balance.

关键词： Organic photovoltaic Medium bandgap Electron withdrawing unit Non-covalent interaction

GATE REGULATION SPEED AND TRANSITION PROCESS OF UNSTEADY FLOW IN CHANNEL

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Journal of Hydrodynamics 2008年第2期20卷 231-238页

作者： TAN Guang-ming DING zhi-liang WANG chang-de YAO Xiong State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan 430072 China

The operation methods of channel and the speed of gate regulation have great influence on the transformation of flow in water conveyance channels. Based on characteristics method, a 1-D unsteady flow numerical model for gate regulation was established in this study. The process of water flow was simulated under different boundary conditions. The influence of gate regulation speed and channel operation methods on flow transition process was analyzed. The numerical results show that under the same conditions, with increasing regulation speed of the gate, the change rates of discharge and water level increase, while the response time of channel becomes shorter, and ultimately the discharge and water level will transit to the same equilibrium states. Moreover, the flow is easier to reach stable state, if the water level in front of the sluice is kept constant, instead of,behind the sluice. This study will be important to the scheme design of automatic operation control in water conveyance channels.

关键词： check gate regulation speed unsteady flow transition process numerical simulation

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南京晓庄学院学报 2024年第2期40卷 109-114页

作者：常直杨涂玮蔡安宁朱振峰南京晓庄学院科研处江苏南京211171 南京晓庄学院旅游与社会管理学院江苏南京211171 江苏省旅游发展研究中心江苏南京210009

开展旅游度假区多元主体治理模式的研究对于丰富旅游治理相关理论及创建世界级旅游度假区具有指导意义。以南京汤山温泉度假区为例,基于利益相关者理论,通过案例地调研及访谈,研究发现案例地“六元主体协同治理”模式业已形成。“六元... 详细信息

开展旅游度假区多元主体治理模式的研究对于丰富旅游治理相关理论及创建世界级旅游度假区具有指导意义。以南京汤山温泉度假区为例,基于利益相关者理论,通过案例地调研及访谈,研究发现案例地“六元主体协同治理”模式业已形成。“六元”主体包括政府、企业、协会、游客、社区居民、新闻媒体。“六元”主体协同方式包括明晰价值认同,推动长效发展;出台法律法规,保障统一管理;优化权责分配,实现共同治理;搭建沟通网络,降低运行风险四个方面。“六元”主体协同治理内容包括空间、生态、文化、社会等多维度治理内容。并提出“融入全球旅游伦理道德规范,建立高质量分级分类认证体系,更加突出旅游生态环境保护,提升文旅数智化发展水平,建立国际温泉文化人才学院,加强与上海合作组织的交流”等创建世界一流旅游度假区的路径。

关键词：利益相关多元主体协同治理汤山温泉旅游度假区

High-efficiency organic solar cells with low voltage-loss of 0.46 V

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Chinese Chemical Letters 2020年第7期31卷 1991-1996页

作者： zhi-Peng Yu Xue Li Chengliang He Di Wang Ran Qin Guanqing Zhou zhi-Xi Liu Thomas Rieks Andersen Haiming Zhu Hongzheng Chen chang-zhi Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization State Key Laboratory of Silicon MaterialsDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Chemistry Zhejiang UniversityHangzhou 310027China

The recent evolution of active components yielded brilliant progresses for organic solar cells(OSCs),yet the mechanism is needed to be clearly *** this wo rk,two electron acceptors,a linear SN6-2Br and a V-shaped BTP-2Br,are developed with nitrogen atoms introduced to replace the traditional sp3-hybridized carbon in the fused ***-2Br possesses an electron-de ficient central core,which exhibits slightly blue-shifted absorption as well as deepened HOMO-level compared with *** corresponding photovoltaic performance from V-shaped BTP-2Br based devices exhibit superior performance especially in short-circuit current(Jsc),despite an enhanced absorption and charge carrier mobilities for *** primary reason for the higher JSC from BTP-2Br is faster exciton diffusion and dissociation in ble nds,than those of *** a result,PBDB-TF:BTP-2Br based devices achieve a power conversion efficiency(PCE)of 13.84%with an voltage-loss of only 0.46 V,which is one of the lowest values ever ***,we fabricated semitransparent OSCs that exhibit an excellent PCE of 9.62%with average visible transparency of 20.1%.

关键词： Organic solar cells High efficiency Low voltage-loss Semitransparent OSCs Electron-defficient central core

CeO2@NiCo2O4 nanowire arrays on carbon textiles as high performance cathode for Li-O2 batteries

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Science China Chemistry 2017年第12期60卷 1540-1545页

作者： Zhen-Dong Yang zhi-Wen chang Ji-Jing Xu Xiao-Yang Yang Xin-Bo Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationDepartment of Materials Science and EngineeringJilin UniversityChangchun 130022China University of Chinese Academy of Sciences Beijing100049China

The successful development of Li-O_2 battery technology depends on developing a stable and efficient cathode. As an important step toward this goal, for the first time, we report the development of CeO_2 nanoparticles modified NiCo_2O_4 nanowire arrays(NWAs) grown on the carbon textiles as a new carbon-free and binder-free cathode system. In this study, the Li-O_2 battery with the CeO_2@NiCo_2O_4 NWAs has exhibited much reduced overpotentials, a high discharge capacity, an improved cycling stability,outperforming the Li-O_2 battery with NiCo_2O_4 NWAs. These improvements can be attributed to both the tailored morphology of discharge product and improved oxygen reduction reaction(ORR) and oxygen evolution reaction(OER) activity after CeO_2 NPs deposition. To a considerable extent, this idea of cathode construction including structure design and composition optimization can provide guidance for further researches in developing more powerful cathode for Li-O_2 battery.

关键词： Li-O2 battery efficient cathode design CeO2 nanoparticles NiCo2O4 nanowire arrays improved electrochemical performances

Last Deglaciation Climatic Fluctuation Record by the Palaeo-Daocheng Ice Cap, Southeastern Qinghai-Tibetan Plateau

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Acta Geologica Sinica(English Edition) 2014年第6期88卷 1863-1874页

作者： ZHANG zhigang XU Xiaobin WANG Jian ZHAO zhijun BAI Shibiao chang zhi Yang School of Geographical Sciences Nanjing Normal University Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Jiangsu Second Normal University Key Laboratory of Virtual Geographical Environment Nanjing Normal University Nanjing Institute of Tourism and Hospitality

The last deglaciation, a key period for understanding present and future climate changes, has long been the hot topic for palaeoclimatological study. The Qinghai-Tibetan Plateau（QTP） is often a target study area for understanding hemispheric, or even global environment changes. The glacial landforms on the QTP provide a unique perspective for its climate change. In order to investigate the onset of the last deglaciation at the QTP and its regional correlation, the terrestrial cosmogenic nuclides（TCN） 10 Be and 26 Al surface exposure dating was chosen to date the roche moutonnée, the polished surface and the moraine debris located at the palaeo-Daocheng Ice Cap（pDIC）, southeastern QTP. Our results show that the onset of the last deglaciation is at about 19 ka, followed by another warming event occurring around 15 ka in the p-DIC area. These timings agree well with other records, e.g. equivalent with a rapid sea level rise at 19 ka and the onset of B？lling warming event at about 15 ka. Thus, our new data can provide good reveal constraint on the climate evolution at the QTP.

关键词： Terrestrial Cosmogenic Nuclides Last Deglaciation Palaeo-Daocheng Ice Cap Qinghai Tibetan Plateau