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Influence of static cartoons combined with dynamic virtual environments on preoperative anxiety of preschool-aged children undergoing surgery

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World Journal of Clinical Cases 2024年第22期12卷 4947-4955页

作者： Ya-Lin Zhang Qi-ying Zhou Peng Zhang Lin-Feng Huang Li Jin zhi-Guo Zhou Department of Pediatrics Hangzhou Ninth People’s HospitalHangzhou 311225Zhejiang ProvinceChina Pediatric Intensive Care Unit Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Intensive Care Unit Hangzhou Ninth People’s HospitalHangzhou 311225Zhejiang ProvinceChina Department of Surgical Anesthesia Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Preschoolers become anxious when they are about to undergo anesthesia and surgery,warranting the development of more appropriate and effective *** To explore the effect of static cartoons combined with dynamic virtual environments on preoperative anxiety and anesthesia induction compliance in preschool-aged children undergoing *** One hundred and sixteen preschool-aged children were selected and assigned to the drug(n=37),intervention(n=40),and control(n=39)*** the children received routine preoperative checkups and nursing before being transferred to the preoperative preparation room on the day of the *** drug group received 0.5 mg/kg midazolam and the intervention group treatment consisting of static cartoons combined with dynamic virtual *** control group received no *** modified Yale Preoperative Anxiety Scale was used to evaluate the children’s anxiety level on the day before surgery(T0),before leaving the preoperative preparation room(T1),when entering the operating room(T2),and at anesthesia induction(T3).Compliance during anesthesia induction(T3)was evaluated using the Induction Compliance Checklist(ICC).Changes in mean arterial pressure(MAP),heart rate(HR),and respiratory rate(RR)were also recorded at each time *** The anxiety scores of the three groups increased variously at T1 and *** T3,both the drug and intervention groups had similar anxiety scores,both of which were lower than those in the control *** T1 and T2,MAP,HR,and RR of the three groups *** drug and control groups had significantly higher MAP and RR than the intervention group at *** T3,the MAP,HR,and RR of the drug group decreased and were significantly lower than those in the control group but were comparable to those in the intervention *** the drug and intervention groups had similar ICC scores and duration of anesthesia induction(T3),both of which were higher than those of t

关键词： Preschool Children Static cartoons combined with dynamic virtual environments Preoperative anxiety Compliance Anesthesia induction

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毛泽东思想在法语世界的深远影响——由《论持久战》法文版广泛传播谈起

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毛泽东邓小平理论研究 2024年第4期 99-107,F0003页

作者：龙治铭岳颖清华大学马克思主义学院

以《论持久战》为代表的毛泽东军事著作是中国人民克敌制胜的法宝,在世界范围内都受到特别关注。20世纪风起云涌的民族解放运动迫切需要科学理论指导,《论持久战》法文译本为法语世界的解放斗争提供了强大的理论武器,产生了重大回应与影... 详细信息

以《论持久战》为代表的毛泽东军事著作是中国人民克敌制胜的法宝,在世界范围内都受到特别关注。20世纪风起云涌的民族解放运动迫切需要科学理论指导,《论持久战》法文译本为法语世界的解放斗争提供了强大的理论武器,产生了重大回应与影响:29个国家和地区先后获得独立,法兰西第四共和国殖民体系瓦解,法兰西第五共和国成立并成为第一个与新中国友好建交的西方国家。中国共产党成功的革命道路、革命经验和革命智慧为全世界所有被压迫民族和被压迫人民带来新希望,极大推动了全世界的民族独立和人民解放运动,体现了中国化的马克思主义为世界社会主义运动和民族解放斗争作出的独特贡献。

关键词：《论持久战》毛泽东思想法语世界民族解放运动

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动态冲击下红砂岩蠕变特性及损伤本构模型

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岩土力学 2024年第6期45卷 1608-1622页

作者：樊赖宇吴志军储昭飞翁磊王智洋刘泉声陈结武汉大学土木建筑工程学院湖北武汉430072 武汉大学岩土与结构工程安全湖北省重点实验室湖北武汉430072 重庆大学资源与安全学院重庆400044

为研究岩石在动态扰动下的蠕变特性,在自行研发的冲击扰动蠕变试验装置上,对细粒红砂岩开展了多级冲击扰动蠕变试验,分析了不同蠕变应力与扰动能量下瞬时变形与蠕变行为,结合间接法得到了扰动能量对长期强度的影响。结果表明:动态扰动... 详细信息

为研究岩石在动态扰动下的蠕变特性,在自行研发的冲击扰动蠕变试验装置上,对细粒红砂岩开展了多级冲击扰动蠕变试验,分析了不同蠕变应力与扰动能量下瞬时变形与蠕变行为,结合间接法得到了扰动能量对长期强度的影响。结果表明:动态扰动在较低的蠕变应力下使试样致密,而当蠕变应力超过一定的应力阈值后加剧试样内部的损伤恶化,其引起的瞬时变形与蠕变应变则随蠕变应力表现出先减后增的规律;随着动态扰动能量的增加,试样的破坏应变越大,但长期强度越低;引入长期强度与扰动能量的相关性、动态扰动单元和扰动-损伤黏性元件,建立了黏塑性扰动损伤蠕变模型,结合试验数据验证了该模型的准确性,该模型可以准确地描述砂岩在静态恒载和动态扰动组合作用下的瞬态变形和蠕变行为。该研究成果对于钻爆法隧道的支护设计以及安全生产具有重要的理论意义与应用前景。

关键词：扰动蠕变试验蠕变特性动态扰动损伤蠕变模型

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Effect of Chinese Medicine in Patients with COVID-19: A Multi-center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第11期30卷 974-983页

作者： ZHAO Guo-zhen YAN Shi-yan LI Bo GUO Yu-hong SONG Shuang HU Ya-hui GUO Shi-qi HU Jing DU Yuan LU Hai-tian YE Hao-ran REN zhi-ying ZHU Ling-fei XU Xiao-long SU Rui LIU Qing-quan Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Institute of Traditional Chinese Medicine School of Clinical Medicine Beijing University of Chinese Medicine School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Integrated Chinese Medicine Tianjin University of Traditional Chinese Medicine

Objective: To evaluate the effectiveness and safety of Chinese medicine(CM) in the treatment of coronavirus disease 2019(COVID-19) in China. Methods: A multi-center retrospective cohort study was carried out, with cumulative CM treatment period of 3 days during hospitalization as exposure. Data came from consecutive inpatients from December 19, 2019 to May 16, 2020 in 4 medical centers in Wuhan, China. After data extraction, verification and cleaning, confounding factors were adjusted by inverse probability of treatment weighting(IPTW), and the Cox proportional hazards regression model was used for statistical analysis. Results:A total of 2,272 COVID-19 patients were included. There were 1,684 patients in the CM group and 588 patients in the control group. Compared with the control group, the hazard ratio(HR) for the deterioration rate in the CM group was 0.52 [95% confidence interval(CI): 0.41 to 0.64, Pying severity at admission, and the robustness of the results were confirmed by 3 sensitivity analyses. In addition, the HR for all-cause mortality in the CM group was 0.29(95% CI: 0.19 to 0.44, P<0.001).Regarding of safety, the proportion of patients with abnormal liver function or renal function in the CM group was smaller. Conclusion: This real-world study indicates that the combination of a full-course CM therapy on the basic conventional treatment, may safely reduce the deterioration rate and all-cause mortality of COVID-19patients. This result can provide the new evidence to support the current treatment of COVID-19. Additional prospective clinical trial is needed to evaluate the efficacy and safety of specific CM interventions.(Registration No. ChiCTR2200062917)

关键词： Chinese medicine all-cause mortality cohort study coronavirus disease 2019 deterioration rate

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Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3600-3623页

作者： Li-Li Yin Ping-Qian Qi Yun-Fei Hu Xiao-Jun Fu Rui-Shan He Meng-Meng Wang Yan-Juan Deng Su-Yi Xiong Qi-Wen Yu Jin-Ping Hu Lv Zhou zhi-Bin Zhou ying Xiong Huan Deng The Affiliated Rehabilitation Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Fourth Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second College of Clinical Medicine Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Tumor Immunology Institute Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of General Medicine The Second College of Clinical MedicineJiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina The Ministry of Education Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors Jiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina

BACKGROUND Colorectal polyps,which are characterized by a high recurrence rate,represent preneoplastic conditions of the *** to unclear mechanisms of pathogenesis,first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic *** recent studies suggest a mechanistic link between intestinal dysbiosis and polyps,the exact compositions and roles of bacteria in the mucosa around the lesions,rather than feces,remain *** To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal *** Mucosal samples were collected from four patients consistently with adenomatous polyps(Ade),seven consistently with non-Ade(Pol),ten with current Pol but previous Ade,and six healthy individuals,and bacterial patterns were evaluated by 16S rDNA *** discriminant analysis and Student’s t-tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp ***’s correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical *** The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy *** changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps,but also existed in histologically normal tissue 10 cm distal from the *** differences in bacterial diversity were observed in the mucosa from individuals with normal conditions,Pol,and *** abundance of Gram-negative bacteria,including Klebsiella,Plesiomonas,and Cronobacter,was observed in Pol group and Ade group,suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful ***,age and gender were linked to bacteria changes,indicating the potential involvement of sex hormone

关键词： Dysbiosis Biopsy Polyp Bacteria Colorectum

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海啸作用下跨海桥梁上部结构流-固耦合数值研究

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工程力学 2024年第9期41卷 111-122页

作者：杨志莹祝兵黄博张跃志殷瑞涛西南交通大学土木工程学院成都610031 重庆交通大学土木工程学院重庆400074

海啸是威胁跨海桥梁安全的主要灾害之一,深入研究海啸与桥梁上部结构耦合作用过程,明确桥梁上部结构波浪力以及桥梁支座受力状态对跨海桥梁安全具有重要意义。该文采用开源软件OpenFOAM建立二维数值水槽,以溃坝波模拟海啸,通过求解RANS... 详细信息

海啸是威胁跨海桥梁安全的主要灾害之一,深入研究海啸与桥梁上部结构耦合作用过程,明确桥梁上部结构波浪力以及桥梁支座受力状态对跨海桥梁安全具有重要意义。该文采用开源软件OpenFOAM建立二维数值水槽,以溃坝波模拟海啸,通过求解RANS方程来获取流体运动,并采用k-ε湍流模型解决RANS方程的封闭性问题,以弹簧-质量-阻尼体系模拟桥梁上部结构运动体系,通过流体与质量-弹簧-阻尼体系间实时数据传递,模拟海啸与桥梁上部结构之间的耦合效应。并利用溃坝波解析解及已有的试验数据验证了数值模型的可靠性。在此基础上,通过对比在水平方向采用刚性约束或不同刚度的弹性约束时上部结构的波浪力,研究了流-固耦合效应以及约束刚度对桥梁上部结构波浪力的影响,同时分析了在海啸作用过程中桥梁各支座的受力状态。结果表明:该文建立的数值模型能够准确地模拟海啸波浪与结构耦合作用过程;考虑流固耦合效应后,上部结构受到的最大波浪力明显减小,水平力最大值减小16.8%~21.0%,竖向力最大值减小15.5%~19.5%;相比于上部结构水平波浪力,支座承受的水平力波动更明显且其最大值达到上部结构水平力的1.25倍;迎浪侧支座在不同时刻存在拉和压两种不同工作状态,其最大拉力达到上部结构竖向波浪力最大值的90%以上;背浪侧支座仅承受压力,其最大压力约为迎浪侧支座最大压力的1.11倍~1.55倍。

关键词：跨海桥梁流固耦合数值模拟波浪力支座力

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Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai Yan-Yan Xue Weigang Ge Liang Yue Xiao-Yan Li Rong-Rong Lin Guo-Ping Peng Wenhao Jiang Sainan Li Kun-Mu Zheng Bin Jiang Jian-Ping Jia Tiannan Guo zhi-ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic *** ADspecific early diagnostic and disease staging biomarkers are *** this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 *** biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 *** quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,*** the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,*** 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,*** 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative ***,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD *** findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

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Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

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World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： Xuan Zhang Zhe Wang Gui-Ling Lin Fang-zhi Wei Yan-Ping Zhuang Wen-Lu Xu Qi Zhang Hui-Tao Wu Zi-Man He Xi-Yu Yin ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(Pying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

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高迁移率族蛋白B1对树突状细胞表型、吞噬功能及ERK/JNK/P38 MAPK信号通路的影响

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中国药理学通报 2024年第2期40卷 248-255页

作者：陈颖颖陈兰牟志向胡小龙张艺艳翁娇青吕佩瑜关天俊厦门大学附属中山医院肾内科福建厦门361004 厦门市血液透析质量控制中心福建厦门361004 厦门市卫生健康委员会医政处福建厦门361004 厦门大学附属中山医院药学部福建厦门361004

目的探究高迁移率族蛋白B1(high mobility group box 1,HMGB1)对硫酸吲哚酚(indoxyl sulfate,IS)诱导的树突状细胞(DCs)表型、吞噬功能及细胞外信号调节激酶(ERK)/氨基末端蛋白激酶(JNK)/丝裂原活化蛋白激酶P38抗体(P38 MAPK)信号通路... 详细信息

目的探究高迁移率族蛋白B1(high mobility group box 1,HMGB1)对硫酸吲哚酚(indoxyl sulfate,IS)诱导的树突状细胞(DCs)表型、吞噬功能及细胞外信号调节激酶(ERK)/氨基末端蛋白激酶(JNK)/丝裂原活化蛋白激酶P38抗体(P38 MAPK)信号通路的影响。方法分别以30、300、600μmol·L^(-1)IS干预人原代DC细胞24 h,分为Control组、IS-30组、IS-300组、IS-600组,通过流式细胞分析鉴定细胞表型并检测细胞吞噬功能;细胞经600μmol·L^(-1)IS干预24 h后加入1 mg·L^(-1)anti-HMGB1或经1 mg·L^(-1)HMGB1单独处理后分为Control组、IS组、HMGB1组、IS^(+)anti-HMGB1组,通过流式细胞分析鉴定细胞表型并检测细胞吞噬功能;Western blot和免疫荧光染色检测ERK/JNK/P38 MAPK信号通路相关蛋白表达。结果随IS浓度增加,CD83^(+)和CD86^(+)细胞数逐渐增加(P<0.01),DCs吞噬能力逐渐下降(P<0.01);与IS组相比,IS^(+)anti-HMGB1组的CD83^(+)和CD86^(+)细胞数明显减少(P<0.01),细胞吞噬能力增加(P<0.01)。此外,与Control组比较,IS或HMGB1组p-ERK/ERK、p-P38/P38、p-JNK/JNK的蛋白表达升高(均P<0.01);与IS组相比,IS^(+)anti-HMGB1组p-ERK/ERK、p-p38/p38、p-JNK/JNK的蛋白表达降低(均P<0.01)。结论拮抗HMGB1可抑制IS诱导的DCs表型及成熟并抑制ERK/JNK/P38 MAPK信号通路激活。

关键词：高迁移率族蛋白B1 树突状细胞硫酸吲哚酚表型吞噬功能

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低应变率冲击荷载下节理花岗岩的动力响应规律

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岩土力学 2024年第6期45卷 1755-1762,1777页

作者：王智德司莹莹李杰钱梦凡安佳兴武汉理工大学土木工程与建筑学院湖北武汉430070 武汉市勘察设计有限公司湖北武汉430000

岩体中节理面的存在是引起冲击应力波衰减的主要原因,会造成爆炸能量的衰减及降低爆破效果。为探讨低应变率下不同节理倾角花岗岩在冲击荷载作用下的动态力学性质、应力波传递规律和能量传递规律,利用分离式霍普金森压杆(split Hopkinso... 详细信息

岩体中节理面的存在是引起冲击应力波衰减的主要原因,会造成爆炸能量的衰减及降低爆破效果。为探讨低应变率下不同节理倾角花岗岩在冲击荷载作用下的动态力学性质、应力波传递规律和能量传递规律,利用分离式霍普金森压杆(split Hopkinson pressure bar,简称SHPB)试验装置对低应变率下3种不同冲击气压、4种不同倾角的节理花岗岩进行冲击试验。结果表明:(1)在含节理的岩样中,其峰值应力随节理倾角的增大呈下降趋势,随冲击荷载的增大呈上升趋势;(2)透射系数随节理倾角的增加先增大后减小,随冲击荷载的增大先减小后增大;(3)能量传递系数随节理倾角的增加先增高后降低,完整岩样、节理倾角θ=0º和45º的岩样,其能量传递系数都随着冲击荷载的增大而减小,而节理倾角θ=15º和30º的岩样,其能量传递系数随着冲击荷载的增大先减小后增大。

关键词：倾角节理花岗岩 SHPB冲击试验动力响应低应变率

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