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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu zhi-Han yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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Infrared Characters of Host Galaxies with H_(2)O Megamaser

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Chinese Physics Letters 2001年第6期18卷 841-843页

作者： YU zhi-yao Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030 National Astronomical Observatories Chinese Academy of SciencesBeijing 100012

Infrared characters of all the host galaxies with H2O megamaser have been *** most striking feature is anticorrelation of S(60)/S(100)versus S(12)/S(25),and S(25)/S(60)versus S(12)/S(25).The anticorrelation in flux density ratio can been explained by coexistence of large and very small dust *** latter,which are heated by absorption of single photon,are believed to be resposible for bulk of 12μm *** the photon energy of the host galaxy is small,this implies large S(12)/S(25)and small S(60)/S(100).However,when photon energy density becomes larger,the infrared spectrum will peak at wavelengths≤100μm and enhance emission at 25μ*** a consequence small S(12)/S(25)and large S(60)/S(100)are observed.

关键词： galaxy striking galaxies

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Finite particle method for kinematically indeterminate bar assemblies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第5期10卷 669-676页

作者： Ying YU yao-zhi LUO Space Structures Research Center Zhejiang University Hangzhou 310058 China

This study presents a structural analysis algorithm called the finite particle method （FPM） for kinematically indeterminate bar assemblies. Different from the traditional analysis method, FPM is based on the combination of the vector mechanics and numerical calculations. It models the analyzed domain composed of finite particles. Newton＇s second law is adopted to describe the motions of all particles. A convected material flame and explicit time integration for the solution procedure is also adopted in this method. By using the FPM, there is no need to solve any nonlinear equations, to calculate the stiffness matrix or equilibrium matrix, which is very helpful in the analysis of kinematically indeterminate structures. The basic formulations for the space bar are derived, following its solution procedures for bar assemblies. Three numerical examples are analyzed using the FPM. Results obtained from both the straight pretension cable and the suspension cable assembly show that the FPM can produce a more accurate analysis result. The motion simulation of the four-bar space assembly demonstrates the capability of this method in the analysis ofkinematically indeterminate structures.

关键词： Finite particle method (FPM) Vector mechanics Convected material frame Explicit time integrations Kinematicallyindeterminate bar assemblies

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Reinforcement learning based adaptive control for uncertain mechanical systems with asymptotic tracking

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Defence Technology（防务技术） 2024年第4期34卷 19-28页

作者： Xiang-long Liang zhi-kai yao yao-wen Ge Jian-yong yao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China College of Automation&College of Artificial Intelligence Nanjing University of Post and TelecommunicationNanjing210023China

This paper mainly focuses on the development of a learning-based controller for a class of uncertain mechanical systems modeled by the Euler-Lagrange *** considered system can depict the behavior of a large class of engineering systems,such as vehicular systems,robot manipulators and *** these systems are often characterized by highly nonlinear characteristics,heavy modeling uncertainties and unknown perturbations,therefore,accurate-model-based nonlinear control approaches become *** by the challenge,a reinforcement learning(RL)adaptive control methodology based on the actor-critic framework is investigated to compensate the uncertain mechanical *** approximation inaccuracies caused by RL and the exogenous unknown disturbances are circumvented via a continuous robust integral of the sign of the error(RISE)control *** from a classical RISE control law,a tanh(·)function is utilized instead of a sign(·)function to acquire a more smooth control *** developed controller requires very little prior knowledge of the dynamic model,is robust to unknown dynamics and exogenous disturbances,and can achieve asymptotic output ***,co-simulations through ADAMS and MATLAB/Simulink on a three degrees-of-freedom(3-DOF)manipulator and experiments on a real-time electromechanical servo system are performed to verify the performance of the proposed approach.

关键词： Adaptive control Reinforcement learning Uncertain mechanical systems Asymptotic tracking

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Elevational patterns of temperature and humidity in the middle Tianshan Mountain area in Central Asia

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Journal of Mountain Science 2020年第2期17卷 397-409页

作者： Gheyur GHEYRET Anwar MOHAMMAT TANG zhi-yao Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface ProcessesPeking UniversityBeijing 100871China Key Laboratory of Biogeography and Bioresources in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

The vertical distribution of vegetation types along an elevational gradient in mountain areas largely depends on the elevational changes in air temperature and humidity. In this study, we presented the seasonal and diurnal variations in the elevational gradients of air temperature and humidity on the southern and northern slopes in the middle Tianshan Mountain Range using data collected throughout the year via HOBO data loggers. The measurements were conducted at 12 different elevations from 1548 to 3277 m from September 2004 to August 2005. The results showed that the annual mean air temperature decreased along the elevational gradients with temperature lapse rates of(0.71±0.20)°C/100 m and(0.59±0.05)°C/100 m on the northern and southern slopes, respectively. The annual mean absolute humidity significantly decreased with increasing elevation on the northern slope but showed no significant trend on the southern slope. The annual mean relative humidity did not show a significant trend on the northern slope but increased with increasing elevation on the southern slope. The mean air temperature lapse rate exhibited significant seasonal variation, which is steeper insummer and shallower in winter, and this value varied between 0.37°C/100 m and 0.75°C/100 m on the southern slope and between 0.30°C/100 m and 1.02°C/100 m on the northern slope. The mean absolute and relative humidity also exhibited significant seasonal variations on both slopes, with the maximum occurring in summer and the minimum occurring in winter or spring. The monthly diurnal range of air temperature on both slopes was higher in spring than in winter. The annual range of air temperature on the southern slope was higher than that on the northern slope. Our results suggest that significant spatiotemporal variations in humidity and temperature lapse rate are useful when analyzing the relationships between species range sizes and climate in mountain areas.

关键词： Temperature lapse rate Absolute humidity Relative humidity Annual range of temperature Diurnal range of temperature HOBO data loggers

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A generalization of Kempe’s linkages

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1084-1090页

作者： MAO De-can LUO yao-zhi YOU Zhong Space Structure Research Center Zhejiang University Hangzhou 310027 China Department of Engineering Science University of Oxford Oxford OX1 3PJ UK

A new, general type of planar linkages is presented, which extends the classical linkages developed by Kempe consisting of two single-looped kinematic chains of linkages, interconnected by revolute hinges. Together with a locking device, these new linkages have only one degree of freedom (DOF), which makes them ideal for serving as deployable structures for different purposes. Here, we start with a fresh matrix method of analysis for double-loop planar linkages, using 2D transformation matrices and a new symbolic notation. Further inspection for one case of Kempe’s linkages is provided. Basing on the inspection, by means of some novel algebraic and geometric techniques, one particularly fascinating solution was found. Physical models were built to show that the derivation in this paper is valid and the new mechanisms are correct.

关键词： Double-loop Kempe's linkages Transformation matrices Deployable structures

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Mobility and equilibrium stability analysis of pin-jointed mechanisms with equilibrium matrix SVD

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1091-1100页

作者： LU Jin-yu LUO yao-zhi LI Na Department of Civil Engineering Zhejiang University Hangzhou 310027 China

Under certain load pattern, the geometrically indeterminate pin-jointed mechanisms will present certain shapes to keep static equalization. This paper proposes a matrix-based method to determine the mobility and equilibrium stability of mechanisms according to the effects of the external loads. The first and second variations of the potential energy function of mechanisms under conservative force field are analyzed. Based on the singular value decomposition (SVD) method, a new crite- rion for the mobility and equilibrium stability of mechanisms can be concluded by analyzing the equilibrium matrix. The mobility and stability of mechanisms can be classified by unified matrix formulae. A number of examples are given to demonstrate the proposed criterion. In the end, criteria are summarized in a table.

关键词： Pin-jointed mechanisms Criteria for stability of equilibrium Criteria for mobility Potential energy function Equilibrium matrix. Singular value decomposition (SVD) method

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Cyclic behavior test of a new double-arch steel gate

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第11期8卷 1731-1739页

作者： LUO yao-zhi ZHU Shi-zhe CHEN Xi Space Structures Research Center Zhejiang University Hangzhou 310027 China School of Landscape Architecture and Art Zhejiang Forestry University Hangzhou 311300 China

A new double-arch structure for the gate used as tidal barrage and sluice was adopted in Caoe River Dam in China. It was a spatial structure made up of the right arch, the invert arch, the chord, etc., and was designed to bear bilateral loads. To research the cyclic behavior of the new double-arch structure, a scale-model cyclic test was conducted. First, the test setup and test method were presented in detail, and according to the test results, the cyclic behavior and failure characteristics of this structure were discussed. Then by analyzing the test cyclic envelope curve, it was found the curve was divided into three stages: the elastic stage, the local plastic stage and the failure stage at the local yield point and structural yield point. The gate model has local yield strength and structural yield strength, with both their values being bigger than that of the designing load. Therefore, the gate is safe enough for the projects. At last, dynamic property of the gate was analyzed considering additional mass of the water. It was found that the tidal bore shock would not cause resonance vibration of the gate.

关键词： Double-arch steel gate Cyclic behavior test Cyclic envelope curve Dynamic property

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Regulating Ni site in NiV LDH for efficient electrocatalytic production of formate and hydrogen by glycerol electrolysis

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Rare Metals 2022年第5期41卷 1583-1594页

作者： Lin Dong Guan-Ru Chang Yi Feng Xian-zhi yao Xin-yao Yu Key Laboratory of Structure and Functional Regulation of Hybrid Materials Institutes of Physical Science and Information TechnologyAnhui UniversityMinistry of Education.Hefei 230601China School of Chemistry and Chemical Engineering Huangshan UniversityHuangshan 245041China Department of Polymer Materials and Engineering Academy of Chemical EngineeringHebei University of TechnologyTianjin 300130China Ningbo Research Institute of Ecological and Environmental Sciences Ningbo 315000China Energy Materials and Devices Key Laboratory of Anhui Province for Photoelectric Conversion Anhui UniversityHefei 230601China

Energy-saving glycerol electrolysis with lower potential than water spitting endows a promising way for the concurrent production of value-added formate and high-purity hydrogen. However, there is still lack of efficient electrocatalysts at both anode and cathode for glycerol electrolysis. Herein, we report the activation of Ni site in NiV layered double hydroxide(LDH) by electrochemical and N_(2)/H_(2) plasma regulations for boosting the activity of glycerol oxidation reaction(GOR) and hydrogen evolution reaction(HER), respectively. Specifically, boosted GOR performance with a low overpotential(1.23 V at 10 mA·cm^(-2)) and a high Faradic efficiency(94%) is demonstrated by electrochemically regulated NiV LDH(ENiV LDH) with elevated valence state of Ni site. In situ Raman spectrum reveals the generation of Ni(Ⅲ) species by electrochemical regulation, and the highly active Ni(Ⅲ)can be regenerated with the process of electrochemical oxidation. Additionally, the possible reaction pathway is speculated based on the in situ Fourier transform infrared spectroscopy(FTIR) and high-performance liquid chromatography results. The plasma-regulated NiV LDH(PNiV LDH) with lower valence state of Ni site exhibits outstanding HER activity, displaying a low overpotential of 45 m V to deliver 10 mA·cm^(-2).When employing E-NiV LDH and P-NiV LDH as anode and cathode electrocatalyst, respectively, the assembled electrolyzer merely needs 1.25 V to achieve 10 m A·cm^(-2) for simultaneous production of formate and hydrogen, demonstrating remarkable 320 mV of lower potential than water electrolysis.

关键词： Glycerol electrolysis Glycerol oxidation reaction Hydrogen evolution reaction NiV LDH Formate

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Development and preliminary results of a large-pixel two-layer LaBr_(3) Compton camera prototype

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Nuclear Science and Techniques 2023年第8期34卷 100-114页

作者： Ming-Hao Dong zhi-Yang yao Yong-Shun Xiao Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Lanthanum bromide(LaBr_(3))crystal has a high energy resolution and time resolution and has been used in Compton cameras(CCs)over the past few ***,LaBr_(3) crystal arrays are difficult to process because LaBr_(3) is easy to crack and break;thus,few LaBr_(3)-based CC prototypes have been *** this study,we designed and fabricated a large-pixel LaBr_(3) CC prototype and evaluated its performance with regard to position,energy,and angular *** used two 10×10 LaBr_(3) crystal arrays with a pixel size of 5 mm×5 mm,silicon photomultipliers(SiPMs),and corresponding decoding circuits to construct our ***,a framework based on a Voronoi diagram and a lookup table was developed for list-mode projection data *** Carlo(MC)simulations based on Geant4 and experiments were conducted to evaluate the performance of our CC *** lateral position resolution was 5 mm,and the maximum deviation in the depth direction was 2.5 and 5 mm for the scatterer and absorber,*** corresponding measured energy resolu-tions were 7.65%and 8.44%,respectively,at 511 *** experimental results of ^(137)Cs point-like sources were consistent with the MC simulation results with regard to the spatial positions and full widths at half maximum(FWHMs).The angular resolution of the fabricated prototype was approximately 6°when a point-like ^(137)Cs source was centrally placed at a distance of 5 cm from the *** proposed and investigated a large-pixel LaBr_(3) CC for the first time and verified its feasibility for use in accurate spatial positioning of radiative sources with a high angular *** proposed CC can satisfy the requirements of radiative source imaging and positioning in the nuclear industry and medical applications.

关键词： Compton camera Large pixel Gamma camera LaBr_(3)detector Prototype evaluation

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