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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Leibniz Conformal Algebras of Rank Two

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Acta Mathematica Sinica,English Series 2020年第2期36卷 109-120页

作者： zhi Xiang wu School of Mathematical Sciences Zhejiang University

We classify all Leibniz conformal algebras of rank two.

关键词： Leibniz pseudoalgebra Lie conformal algebra Hopf algebra

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Control of vortex-induced vibrations of the cylinder by using split-ter plates immersed in the cylinder wake at low Reynolds number

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Journal of Hydrodynamics 2020年第5期32卷 942-952页

作者： zhi-qiang Xin zhi-huang wu Chui-jie wu Dan Huang The College of Mechanics and Materials HoHai UniversityNanjing 211100China State Key Laboratory of Structural Analysis for Industrial Equipment and School of Aeronautics and Astronautics Dalian University of TechnologyDalianChina

The vortex-induced vibrations of a cylinder with two plates symmetrically distributed along the centerline of the wake are studied by using the fluid-structure interaction simulations on the Arbitrary Lagrangian-Eulerian *** this study,the different geo-metrical distribution parameters of the splitter plates and inflow velocities are taken into *** physical mechanisms of vortex-induced vibration of the cylinder with symmetrical plates are revealed from the cylinder amplitude,hydrodynamic force characteristics,vortex shedding frequency,and flow pattern *** results show that the dynamic interaction between the vortex shed from the oscillation cylinder and plates is responsible for the wake stabilization mechanism,and the stable wake and the dynamic response reduction of the main cylinder can be achieved at a wide range of reduced velocities by placing sym-metrical sheets at suitable locations.

关键词： Cylinder vortex-induced vibrations splitter plates vibration control flow pattern

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Nichols algebras over weak Hopf algebras

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Applied Mathematics(A Journal of Chinese Universities) 2018年第1期33卷 107-126页

作者： wu zhi-xiang School of Mathematical Science Zhejiang University

In this paper, we study a Yetter-Drinfeld module V over a weak Hopf algebra *** the category of all left H-modules is not a braided tensor category, we can define a Yetter-Drinfeld module. Using this Yetter-Drinfeld modules V, we construct Nichols algebra B(V) over the weak Hopf algebra H, and a series of weak Hopf algebras. Some results of [8] are generalized.

关键词： quantum enveloping algebra Nichols algebra weak Hopf algebra

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Construct Weak Hopf Algebras by Using Borcherds Matrix

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Acta Mathematica Sinica,English Series 2009年第8期25卷 1337-1352页

作者： zhi Xiang wu Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

We define a new kind quantized enveloping algebra of a generalized Kac-Moody algebra by adding a new generator J satisfying jm = j for some integer m. We denote this algebra by wuqT（A）. This algebra is a weak Hopf algebra if and only if m = 2,3. In general, it is a bialgebra, and contains a Hopf subalgebra. This Hopf subalgebra is isomorphic to the usual quantum envelope algebra Uq （A） of a generalized Kac-Moody algebra A.

关键词： generalized Kac-Moody algebras irreducible representation weak Hopf algebra

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Effect of Stokes number on energy modulation of the fluid in turbulent particle-laden channel flows

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Journal of Hydrodynamics 2022年第3期34卷 510-521页

作者： zhi-feng wu Jian-zhao wu Bo-fu Wang zhi-ming Lu Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai Key Laboratory of Mechanics in Energy EngineeringShanghai UniversityShanghai200072China

The effect of Stokes number on the kinetic energy(KE)budget in particle-laden turbulent channel flows is examined by conducting two-way coupled direct numerical simulations using the Eulerian-Lagrangian *** friction Reynolds number of the single phase channel flow is Re_(τ)=180,the particle mass loading and volume fraction areφ_(m)=0.2,φ_(v)≈10−4,and the Stokes numbers range from St^(+)=14–*** statistics show that due to the presence of solid particles,the mean velocity is reduced in the vicinity of the wall but enhanced in the outer region,and the off-streamwise intensity of fluctuated velocity and the Reynolds stress are reduced in the whole *** analysis on the budgets of turbulent kinetic energy(TKE)finds that the presence of particles induces a significant reduction on both the production and dissipation *** increasing Stokes number St^(+),both the production and dissipation rates exhibit non-monotonical trends,i.e.,both initially decrease for St^(+)*** suggests that the particle-induced suppression on TKE production and dissipation is the strongest nearly at St^(+)=*** is also found that particles act as an additional sink/source term in the budgets of both mean-flow kinetic energy(MKE)and *** addition,we investigate the influence of St^(+)on the“zero point”which indicates the balance of exchanging energy between the particle and fluid *** is shown that with increasing St^(+),the“zero point”moves toward the wall,suggesting that the position of perfect following between particle and fluid is closer to the wall with larger St^(+).The present results reveal the Stokes number effects on the spatial transport mechanisms of MKE,TKE in turbulent channel flows laden with inertial particles.

关键词： Particle-laden flows two-way coupling Stokes numbers kinetic energy budgets

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Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

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Stabilization of coordinated motion for underwater vehicles

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Acta Mechanica Sinica 2011年第3期27卷 438-444页

作者： Fan wu zhi-Yong Geng State Key Laboratory for Turbulence and Complex Systems Peking University 100871 Beijing China

This paper presents a coordinating and stabilizing control law for a group of underwater vehicles with unstable dynamics. The coordinating law is derived from a potential that only depends on the relative configuration of the underwater vehicles. Being coordinated,the group behaves like one mechanical system with symmetry,and we focus on stabilizing a family of coordinated motions,called relative equilibria. The stabilizing law is derived using energy shaping to stabilize the relative equilibria which involve each vehicle translating along its longest（unstable） axis without spinning,while maintaining a relative configuration within the group. The proposed control law is physically motivated and avoids the linearization or cancellation of nonlinearities.

关键词： Underwater vehicles . Coordination .Relativeequilibria. Stabilization. Energy shaping

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Vortex definition and ＂vortex criteria＂

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Science China(Physics,Mechanics & Astronomy) 2018年第2期61卷 82-86页

作者： Jie-zhi wu State Key Laboratory for Turbulence and Complex Systems College of Engineering Peking University Beijing 100871 China

It is well known that the vorticity ω = △× u, where u is fluid velocity, has clear mathematic definition, but for vis- cous flow the definition of a vortex remains an open prob- lem for long [1,2], which has now evolved to a big confusion after many ＂vortex identification criteria＂（＂vortex criteria＂ for short） were proposed to identify various turbulent coher- ent structures observed experimentally and numerically. The present communication attempts to clarify this confusing situ- ation and provide a preliminary answer to the question： What is a vortex？1）

关键词： Vortex definition "vortex criteria"

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Line Aging Assessment in Distribution Network Based on Topology Verification and Parameter Estimation

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1658-1668页

作者： zhi wu Huan Long Chang Chen School of Electrical Engineering Southeast UniversityNanjing China IEEE Maintenance Branch Company State Grid Jiangsu Electric Power Company Ltd.Nanjing China

The aging of lines has a strong impact on the economy and safety of the distribution *** paper proposes a novel approach to conduct line aging assessment in the distribution network based on topology verification and parameter *** topology verification,the set of alternative topologies is firstly generated based on the switching *** best-matched topology is determined by comparing the difference between the actual measurement data and calculated voltage magnitude curves among the alternative ***,a novel parameter estimation approach is proposed to estimate the actual line parameters based on the measured active power,reactive power,and voltage magnitude *** includes two stages,i.e.,the fixed-step aging parameter(FSAP)iteration,and specialized Newton-Raphson(SNR)*** theoretical line parameters of the best-matched topology are taken as a warm start of FSAP,and the fitted result of FSAP is further renewed by the *** on the deviation between the renewed and theoretical line parameters,the aging severity risk level of each line is finally quantified through the risk assessment *** experiments on the modified IEEE 33-bus and 123-bus systems demonstrate that the proposed approach can effectively conduct line aging assessment in the distribution network.

关键词： Line aging topology verification parameter estimation risk assessment Newton-Raphson iteration

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