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Tribotronic triggers and sequential logic circuits

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Nano Research 2017年第10期10卷 3534-3542页

作者： Li Min Zhang zhi wei yang Yao Kun Pang Tao Zhou Chi Zhang Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences National Center for Nanoscience and Technology Beijing 100083 China School of Material Science and Engineering Georgia Institute of Technology Atlanta GA 30332-0245 USA

In this paper, a floating-gate tribotronic transistor （FGTT） based on a mobile triboelectric layer and a traditional silicon-based field-effect transistor （FET） is proposed. In the FGTT, the triboelectric charges in the layer created by contact electrification can be used to modulate charge carrier transport in the transistor. Based on the FGTTs and FETs, a tribotronic negated AND （NAND） gate that achieves mechanical-electrical coupled inputs, logic operations, and electrical level outputs is fabricated. By further integrating tribotronic NAND gates with traditional digital circuits, several basic units such as the tribotronic S-R trigger, D trigger, and T trigger have been demonstrated. Additionally, tribotronic sequential logic circuits such as registers and counters have also been integrated to enable external contact triggered storage and computation. In contrast to the conventional sequential logic units controlled by electrical signals, contact-triggered tribotronic sequential logic circuits are able to realize direct interaction and integration with the external environment. This development can lead to their potential application in micro/nano-sensors, electromechanical storage, interactive control, and intelligent instrumentation.

关键词： tribotronics tribotronic transistor triboelectric nanogenerator trigger sequential logic circuits

Intestinal Cckbr-specific knockout mouse as a novel model of salt-sensitive hypertension via sodium over-absorption

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Journal of Geriatric Cardiology 2023年第7期20卷 538-547页

作者： Qiong-Yu ZHANG Yan GUO Xiao-Liang JIANG Xing LIU Shu-Guang ZHAO Xian-Liang ZHOU zhi-wei yang Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Emergency Department Taihe County People’s HospitalTaihe CountyAnhui ProvinceChina Institute of Laboratory Animal Science Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical Collage(PUMC)BeijingChina

OBJECTIVES To investigate the value of CCKBR^(fl/fl)villin-Cre mice as a mouse model of salt-sensitive hypertension(SSH).METHODS In the first part,2-month-old CCKBR^(fl/fl)villin-Cre mice(CKO)and control CCKBR^(fl/fl)mice(WT)were fed with normal diet(0.4%NaCl)or high salt diet(4%NaCl),separately for 6 *** the rescue study,one week of hydrochlorothiazide or saline injection were treated with the CKO mice fed high salt *** blood pressure,biochemical indexes,and the expression of small intestinal sodium transporters(NHE3,NKCC1,eNaC)was *** organ injury markers(MMP2/MMP9)and the histopathological changes of kidneys were observed,whereas the changes of duodenal sodium absorption were detected by small intestinal perfusion in *** The CCKBR^(fl/fl)villin-Cre mice with high salt intake exhibited high blood pressure,increased duodenal sodium absorption and urinary sodium excretion,and with renal *** protein expression of NHE3,NKCC1 and eNaC were also significant increase in the intestine of CKO-HS *** with hydrochlorothiazide remarkably attenuated the elevated blood pressure by high salt absorption in the CCKBR^(fl/fl)villin-Cre mice,but no significant histopathological changes were *** These results support a crucial role of intestinal Cckbr deficiency on SSH development and the diuretic antihypertension effect in CCKBR^(fl/fl)villin-Cre *** CCKBR^(fl/fl)villin-Cre mice with the high salt intake may serve as a stable model of salt-sensitive hypertensive induced by sodium overloading.

关键词： hypertension intestine injection

Electromagnetic scattering and imaging simulation of extremely large-scale sea-ship scene based on GPU parallel technology

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Journal of Electronic Science and Technology 2024年第2期22卷 16-23页

作者： Cheng-wei Zhang zhi-Qin Zhao wei yang Li-Lai Zhou Hai-Yu Zhu Southwest China Institute of Electronic Technology Chengdu610036China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Tencent Company Shenzhen518054China

Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is *** the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing ***,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing *** using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as *** is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.

关键词： Multi graphics processing unit Radar imaging Sea-ship Shooting and bouncing rays

Viral-mediated gene therapy in pediatric neurological disorders

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World Journal of Pediatrics 2024年第6期20卷 533-555页

作者： Jing Peng wei-wei Zou Xiao-Lei Wang zhi-Guo Zhang Ran Huo Li yang Department of Pediatrics Clinical Research Center for Chidren Neurodevelopmental disablities of Hunan ProvinceXiangya HospitalCentral South UniversityChangsha 410008China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingChina

Background Due to the broad application of next-generation sequencing,the molecular diagnosis of genetic disorders in pediatric neurology is no longer an unachievable ***,treatments for neurological genetic disorders in children remain primarily *** the other hand,with the continuous evolution of therapeutic viral vectors,gene therapy is becoming a clinical *** this perspective,we wrote this review to illustrate the current state regarding viral-mediated gene therapy in childhood neurological *** sources We searched databases,including PubMed and Google Scholar,using the keywords"adenovirus vector,""lentivirus vector,"and"AAv"for gene therapy,and"immunoreaction induced by gene therapy vectors,""administration routes of gene therapy vectors,"and"gene therapy"with"NCL,""SMA,""DMD,""congenital myopathy,""MPS""leukodystrophy,"or"pediatric metabolic disorders".We also screened the database of *** using the keywords"gene therapy for children"and then filtered the results with the ones aimed at neurological *** time range of the search procedure was from the inception of the databases to the *** We presented the characteristics of commonly used viral vectors for gene therapy for pediatric neurological disorders and summarized their merits and drawbacks,the administration routes of each vector,the research progress,and the clinical application status of viral-mediated gene therapy on pediatric neurological *** Viral-mediated gene therapy is on the brink of broad clinical ***-mediated gene therapy will dramatically change the treatment pattern of childhood neurological disorders,and many children with incurable diseases will meet the dawn of a ***,the vectors must be optimized for better safety and efficacy.

关键词： Gene therapy Neurological disorders Pediatrics Viral vectors

Preclinical evaluation of herpes simplex virus armed with granulocyte-macrophage colony-stimulating factor in pancreatic carcinoma

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World Journal of Gastroenterology 2013年第31期19卷 5138-5143页

作者： Hao Liu Shou-Jun Yuan Ying-Tai Chen Yi-Bin Xie Liang Cui wei-zhi yang De-Xuan yang Yan-Tao Tian Department of Abdominal Surgery Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Pharmacological and Toxi-cological Laboratory Institute of Radiation Medicine Medical Radiobiology Laboratory Cancer Hospital Chinese Academy of Medical Science Peking Union Medical College

AIM: To investigate the therapeutic efficacy and mechanisms of action of oncolytic-herpes-simplex-virus encoding granulocyte-macrophage colony-stimulating factor(HSVGM-CSF) in pancreatic ***: Tumor blocks were homogenized in a sterile grinder in *** homogenate was injected into the right armpit of each *** vaccination,the mice were randomly assigned into four groups: a control group,a high dose HSVGM-CSFgroup [1 × 107plaque forming units(pfu)/tumor],a medium dose HSVGM-CSF group(5 × 106pfu/tumor) and a low dose HSVGM-CSF group(5 × 105pfu/tumor).After initiation of drug administration,body weights and tumor diameters were measured every 3 *** days later,after decapitation of the animal by cervical dislocation,each tumor was isolated,weighed and stored in 10% formaldehyde *** drug effectiveness was evaluated according to the weight,volume and relative volume change of each ***,GM-CSF protein levels in serum were assayed by enzyme-linked immunosorbent assays at 1,2,3 and 4 d after injection of ***: Injection of the recombinant mouse HSV encoding GM-CSF resulted in a significant reduction in tumor growth compared to the control group,and dosedependent effects were observed: the relative tumor proliferation rates of the low dose,medium dose and high dose groups on 15 d after injection were 45.5%,55.2% and 65.5%,*** inhibition rates of the tumor weights of the low,middle,and high dose groups were 41.4%,46.7% and 50.5%,***,the production of GM-CSF was significantly increased in the mice infected with *** increase in the GM-CSF level was more pronounced in the high dose group compared to the other two dose ***: Our study provides the first evidence that HSVGM-CSFcould inhibit the growth of pancreatic *** enhanced GM-CSF expression might be responsible for the phenomenon.

关键词： Pancreatic carcinoma Gene therapy Animal test Herpes-simplex-virus encoding granulocytemacrophage colony-stimulating factor

Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

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Petroleum Science 2024年第1期21卷 667-673页

作者： Yan-Wen Lin Tong Li Yi Zhang wei-wei Yan Xiao-Ming Chen zhi-Sen Zhang Jian-yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

Three-dimensional computed topography analysis of a patient with an unusual anatomy of the maxillary second and third molars

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International Journal of Oral Science 2011年第4期3卷 225-228页

作者： Jin Zhao Yan Li zhi-wei yang wei Wang Yan Meng Department of Stomatology First Affiliated Hospital of Xinjiang Medical University Urumqi 830054 China Department of Stomatology Fifth Affiliated Hospital of Xinjiang Medical University Urumqi 830011 China Information Technology Division of Urumqi Railway Bureau Urumqi 830011 China Xinjiang KeLi Advanced Manufacturing Technology Ltd. Urumqi 830000 China

We present a case of a patient with rare anatomy of a maxillary second molar with three mesiobuccal root canals and a maxillary third molar with four separate roots, identified using multi-slice computed topography （CT） and three-dimensional reconstruction techniques. The described case enriched/might enrich our knowledge about possible anatomical aberrations of maxillary molars. In addition, we demonstrate the role of multi-slice CT as an objective tool for confirmatory diagnosis and successful endodontic management.

关键词： maxillary second molar mesiobuccal root maxillary third molar multi-slice computed topography three-dimensional reconstruction

Intrahepatic portal venous systems in adult patients with cavernous transformation of portal vein: Imaging features and a new classification

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 481-486页

作者： Xin Huang Qian Lu Yue-wei Zhang Lin Zhang zhi-Zhong Ren Xiao-wei yang Ying Liu Rui Tang Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background: Cavernous transformation of the portal vein(CTPV) due to portal vein obstruction is a rare vascular anomaly defined as the formation of multiple collateral vessels in the hepatic hilum. This study aimed to investigate the imaging features of intrahepatic portal vein in adult patients with CTPV and establish the relationship between the manifestations of intrahepatic portal vein and the progression of CTPV. Methods: We retrospectively analyzed 14 CTPV patients in Beijing Tsinghua Changgung Hospital. All patients underwent both direct portal venography(DPV) and computed tomography angiography(CTA) to reveal the manifestations of the portal venous system. The vessels measured included the left portal vein(LPV), right portal vein(RPV), main portal vein(MPV) and the portal vein bifurcation(PVB). Results: Nine males and 5 females, with a median age of 40.5 years, were included in the study. No significant difference was found in the diameters of the LPV or RPV measured by DPV and CTA. The visualization in terms of LPV, RPV and PVB measured by DPV was higher than that by CTA. There was a significant association between LPV/RPV and PVB/MPV in term of visibility revealed with DPV( P = 0.01), while this association was not observed with CTA. According to the imaging features of the portal vein measured by DPV, CTPV was classified into three categories to facilitate the diagnosis and treatment. Conclusions: DPV was more accurate than CTA for revealing the course of the intrahepatic portal vein in patients with CTPV. The classification of CTPV, that originated from the imaging features of the portal vein revealed by DPV, may provide a new perspective for the diagnosis and treatment of CTPV.

关键词： Cavernous transformation of the portal vein Classification Direct portal venography Intrahepatic portal venous system

P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration

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World Journal of Gastroenterology 2020年第41期26卷 6361-6377页

作者： Xu Zhang Ming Zhu Xiao-Liang Jiang Xing Liu Xue Liu Pan Liu Xian-Xian Wu zhi-wei yang Tao Qin Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina Department of Hepato-Biliary-Pancreatic Surgery Zhengzhou University People’s Hospital&Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Zhongshan School of Medicine Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Institute of Laboratory Animal Science Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical Collage(PUMC)Beijing 100021China

BACKGROUND Acute pancreatitis(AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome(SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1(PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of *** To investigate the role and mechanism of PSGL-1 in the development of *** The PSGL-1 expression on leukocytes was detected in peripheral blood of AP patients and volunteers. Pancreatic injury, inflammatory cytokines expression, and inflammatory cell infiltration was measured in AP mouse models induced with PSGL-1 knockout(PSGL-1-/-) and wild-type(PSGL-1+/+) mice. Leukocyteendothelial cell adhesion was measured in a peripheral blood mononuclear cell(PBMC)-endothelial cell coculture *** The expression of PSGL-1 on monocytes and neutrophils was significantly increased in AP patients. Compared with PSGL-1+/+ mice, PSGL-1-/-AP mice induced by caerulein exhibited lower serum amylase, less Interleukin-1 beta(IL-1 beta) and Interleukin-6(IL-6) expression, less neutrophil and macrophage infiltration, and reduced peripheral neutrophil and monocyte accounts. PSGL-1 deficiency alleviated leukocyte-endothelial cell adhesion via IL-6 but not IL-1 *** PSGL-1 deficiency effectively inhibits the development of AP by preventing leukocyte-endothelial cell adhesion via IL-6 stimulation and may become a potential therapeutic target for treating AP.

关键词： P-selectin glycoprotein ligand 1 Acute pancreatitis Inflammation Leukocyte adhesion Interleukin-6