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Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-Na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

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Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

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Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang Xiang-Cui Liu Yu-Chao Wang Huan-Ran Zheng Jin-Xian Wang Jia-Yi Zheng Meng-Jie Liu Dan-Ni Deng Yu Bai Ying-Bi Chen tong Zhang zhi-ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

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脑血管重建术历史沿革

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中国现代神经疾病杂志 2024年第8期24卷 599-605页

作者：佟志勇广州医科大学附属第二医院神经外科 510260

脑血管重建术正在不断更新迭代,但仍面临诸多挑战,如定量调节桥血管血流量的方法,如何重建直径<0.5 mm的动脉穿支等问题。本文回顾血管重建术的诞生和脑血管重建术的发展历程,重点关注脑血管重建术的基本原理和创新技术、脑血管重建术... 详细信息

脑血管重建术正在不断更新迭代,但仍面临诸多挑战,如定量调节桥血管血流量的方法,如何重建直径<0.5 mm的动脉穿支等问题。本文回顾血管重建术的诞生和脑血管重建术的发展历程,重点关注脑血管重建术的基本原理和创新技术、脑血管重建术在复杂颅内动脉瘤治疗中的应用及疗效、脑血管重建术迭代的现状及发展趋势,旨在促进脑血管重建术的迭代及其在复杂颅内动脉瘤治疗中的应用。

关键词：颅内动脉瘤脑血管重建术医学史综述

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Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer

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World Journal of Gastroenterology 2024年第39期30卷 4281-4294页

作者： Jing-Zhao Zhang zhi-Wei Zhang Xin-Yi Guo Deng-Sheng Zhu Xiao-Rui Huang ming Cai tong Guo Ya-Hong Yu Department of Biliopancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina

BACKGROUND Ampullary cancer is a relatively rare malignant tumor in the digestive *** incidence has increased in recent *** for now,its biological characteristics have not been fully *** studies have primarily focused on the histological classification and genetic changes,but there are fewer investigations into the differences among site-specific *** clinicopathological charac-teristics of ampullary cancer occurring in different positions have not been ***,the role of adjuvant therapy in the treatment of patients with ampullary cancer remains *** cancer and explore the factors affecting *** A total of 356 patients who met the inclusion and exclusion criteria were *** were divided into ampulla of Vater cancer(AVC)and duodenal papilla cancer(DPC)based on the gross and microscopic *** data,admission examination results,and perioperative outcomes were collected and *** Kaplan-Meier curve was used for survival *** and multivariate analysis was performed to explore the independent risk factors affecting the overall survival(OS)of both *** The preoperative total bilirubin level in patients with AVC was significantly higher than those with DPC(P=0.04).The OS for patients with DPC was 58.90±38.74 months,significantly longer than 44.31±35.90 months for patients with AVC(Pmin level(P=0.009),total bilirubin level(P=0.017),and number of positive lymph nodes(P=0.005).For DPC,risk factors included:Age(P=0.004),tumor size(P=0.023),number of positive lymph nodes(P=0.010)and adjuvant treatment(P=0.020).Adjuvant therapy significantly improved the OS rate of patients with DPC,but not for those with *** Patients with AVC had a shorter OS compared to those with *** prognosis factors and the role of adjuvant therapy of two groups were diffe

关键词： Ampullary cancer Prognosis Risk factors Overall survival Adjuvant therapy

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Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening

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Current Medical Science 2024年第4期44卷 748-758页

作者： Shan-shan HU tong-yao WANG Lu NI Fan-xin HU Bo-wen YUE Ying ZHENG Tian-lun WANG Abhishek KUMAR Yan-yan WANG Jin-e WANG zhi-yong ZHOU Third-grade Pharmacological Laboratory of Traditional Chinese Medicine State Administration of Traditional Chinese MedicineChina Three Gorges UniversityYichang 443002China College of Medicine and Health Sciences China Three Gorges UniversityYichang 443002China College of Basic Medical Science China Three Gorges UniversityYichang 443002China

Objective Icariin(ICA)has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging *** dysfunction is associated with brain aging-related neurodegenerative *** opening of the mitochondrial permeability transition pore(mPTP)is a crucial factor in mitochondrial dysfunction and is associated with excessive *** study aimed to explore that ICA protects against neuronal injury by blocking the mPTP opening and down-regulating autophagy levels in a D-galactose(D-gal)-induced cell injury *** A cell model of neuronal injury was established in rat pheochromocytoma cells(PC12 cells)treated with 200 mmol/L D-gal for 48 *** this cell model,PC12 cells were pre-treated with different concentrations of ICA for 24 *** was used to detect cell *** associatedβ-galactosidase(SA-β-Gal)staining was used to observe cell *** blot analysis was performed to detect the expression levels of a senescence-related protein(p21),autophagy markers(LC3B,p62,Atg7,Atg5 and Beclin 1),mitochondrial fission and fusion-related proteins(Drp1,Mfn2 and Opa1),and mitophagy markers(Pink1 and Parkin).The changes of autophagic flow were detected by using mRFP-GFP-LC3 *** intracellular ultrastructure was observed by transmission electron *** was used to detect mPTP,mitochondrial membrane potential(MMP),mitochondrial reactive oxygen species(mtROS)and ROS *** and apoptosis levels were detected by flow *** D-gal treatment significantly decreased the viability of PC12 cells,and markedly increased the SA-β-Gal positive cells as compared to the control *** the D-gal stimulation,the expression of p21 was significantly ***,D-gal stimulation resulted in an elevated LC3B II/I ratio and decreased p62 ***,autophagosomes and autolysosomes were significantly increased,indicating abnormal activation of autophag

关键词： icariin neuronal injury mitochondrial dysfunction mitochondrial permeability transition pore autophagy

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： zhi-Wu tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-ming Ge Wen-Ying Zhuang Gang Hu Ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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颅内动脉瘤与脑血管重建术

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中国现代神经疾病杂志 2024年第8期24卷 595-598页

作者：佟志勇广州医科大学附属第二医院神经外科 510260

脑血管重建技术的迭代伴随“复杂颅内动脉瘤”概念的变迁,脑血管重建技术逐步改变动脉瘤的治疗策略。本文重点阐述颅内动脉瘤的治疗原则和常用显微外科技术、复杂颅内动脉瘤的概念变迁和治疗难点、脑血管重建术的发展趋势及其在复杂颅... 详细信息

脑血管重建技术的迭代伴随“复杂颅内动脉瘤”概念的变迁,脑血管重建技术逐步改变动脉瘤的治疗策略。本文重点阐述颅内动脉瘤的治疗原则和常用显微外科技术、复杂颅内动脉瘤的概念变迁和治疗难点、脑血管重建术的发展趋势及其在复杂颅内动脉瘤治疗中的应用及展望等,旨在促进脑血管重建术在颅内动脉瘤治疗中的高质量应用。

关键词：颅内动脉瘤脑血管重建术综述

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Amplified circularly polarized luminescence of chiral metal-organic frameworks via post-synthetic installing pillars

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Chinese Chemical Letters 2024年第10期35卷 485-489页

作者： Xue-zhi Wang Yi-tong Liu Chuang-Wei Zhou Bei Wang Dong Luo Mo Xie Meng-Ying Sun Yong-Liang Huang jie Luo Yan Wu Shuixing Zhang Xiao-Ping Zhou Dan Li Department of Radiology The First Afliated HospitalJinan UniversityGuangzhou 510632China College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinanUniversityGuangzhou510632China Department of Medicinal Chemistry Shantou University Medical CollegeShantou 515041China Department of Anesthesiology.The First Afliated Hospital of Sun Yat-sen University Guangzhou 50080China

Post-synthetic installation strategy is an effective approach to improve the functions of metal-organic frameworks(MOFs).Herein,a pair of chiral MOFs is successfully constructed through solvothermal subcomponent self-assembly and exhibit circularly polarized luminescence(CPL).These MOFs contain coordinatively unsaturated Zn sites and channels,which allow the installation of pyridyl-terminated pillars into the original *** a post-synthetic installation process reinforces the MOFs'rigidity and increases the photoluminescence quantum yields(PLQYs).Furthermore,the luminescence dissymmetry factors(glum)of these post-modified MOFs are amplified after installing the *** work provides an appealing strategy for boosting the CPL performance of chiral MOFs.

关键词： Chiral metal-organic frameworks Circularlypolarized luminescence Post-synthetic installation Pyridyl-terminated pillars Chirality transfer

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High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei miao Jiankun Xu michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu zhi Yao Jie mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

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Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy: tackling herpesvirus drug resistance

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Science China Life Sciences 2024年

作者： Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping Lan Hao Zhang Lu Shang Bo Zheng mi Wang Yingchun Liu Lifang Zhang Chenzhong Fei Wu tong Changlong Liu Ersheng Kuang Guangzhi tong Feng Gu Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural Affairs State Key Laboratory for Animal Disease Control and Prevention College of Veterinary Medicine Lanzhou University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Institute of Human Virology Zhongshan School of Medicine Sun Yat-Sen University School of Medicine Tsinghua University

The emergence of drug resistance to virus(i.e., acyclovir(ACV) to herpesviruses) has been termed one of the common clinical issues,emphasizing the discovery of new antiviral agents. To address it, a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR) screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV), an α-herpesvirus causing human and pig diseases. The results demonstrated that type 2 voltage-gated chloride channels(CLC-2) encoded by one of the identified genes, CLCN2, is a potential drug target for anti-herpesvirus therapy. CLC-2 inhibitors, omeprazole(OME) and 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid(DIDS), can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e., PRV, HSV and EBV), and effectively treat murine herpes simplex encephalitis(HSE). Additionally, DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly, both DIDS and OME were able to inhibit ACV-resistant HSV-1 strain infection. The study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug resistance. The discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

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