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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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油樟油副产物对细菌性皮肤致病菌的抑制作用

四川农业大学学报 2014年第1期32卷 53-58页

作者：黄彤游玲杜永华税之乎邓杰魏琴宜宾学院生命科学与食品工程学院/宜宾学院西南特色经济植物保护与利用重点实验室四川宜宾644007 发酵资源与应用四川省高校重点实验室四川宜宾644007

[目的]研究白樟油等几种油樟油副产物对4种常见细菌性皮肤致病菌的抑制作用.[方法]采用滤纸片扩散法和试管二倍稀释法测定白樟油等几种油樟油副产物对4种常见细菌性皮肤致病菌的最低抑菌浓度和最低杀菌浓度,并通过平板菌落计数法绘制抑... 详细信息

[目的]研究白樟油等几种油樟油副产物对4种常见细菌性皮肤致病菌的抑制作用.[方法]采用滤纸片扩散法和试管二倍稀释法测定白樟油等几种油樟油副产物对4种常见细菌性皮肤致病菌的最低抑菌浓度和最低杀菌浓度,并通过平板菌落计数法绘制抑菌曲线.[结果]白樟油等几种油樟油副产物对大肠杆菌、变形杆菌、金黄色葡萄球菌和痤疮杆菌有不同程度的抑制作用,属于浓度依赖型,其最低抑菌浓度（MIC）值在3.13～12.5 μL/mL,最低杀菌浓度（MBC）值在6.25～25 μL/mL.[结论]白樟油等几种油樟油副产物有较好的抑菌活性,具有治疗细菌性皮肤病的潜力.

关键词：油樟油副产物细菌性皮肤致病菌抑制作用

Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： TAN hui-qun hu zhi-shui DONG Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

Synthesis, Crystal Structure and Properties of a New Cd(II) Complex Based on Mixed 5-Hydroxy-isophthalic Acid and 1-(1H-imidazol-4-yl)-3-(4H-tetrazol-5-yl)benzene Ligands

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Chinese Journal of Structural Chemistry 2015年第6期34卷 899-905页

作者： hu zhi-Yong Zhu Juan-Juan CHEN shui-Sheng QIAO Rui College of Chemistry & Chemical Engineering Fuyang Normal College

A new coordination polymer [Cd2（5-IPA）（HL）2（H20）2]＇4H20 （1） was prepared under hydrothermal conditions based on 5-hydroxy-isophthalic acid （5-H2IPA） with multi-N-donor ligand 1-（1H-imidazol-4-yl）-3-（4H-tetrazol-5-yl）benzene （H2L）. The complex was characterized by IR spectroscopy, TGA, X-ray powder and single-crystal diffraction. It crystallizes in the monoclinic system, space group C2/e with a = 23.6291（18）, b = 9.9847（8）, c = 17.7244（14） A, fl = 124.6180（10）°, V = 3441.4（5） A3, Z = 4, C28H30N12O11Cd2, Mr = 935.44, Dc = 1.805 g/cm^3,μ= 1.313 mm^-1, S = 1.055, F（000） = 1864, the final R = 0.049 and wR = 0.1315 for 2985 observed reflections （I 〉 2σ（I））. The central metal Cd（II） atoms with octahedral coordination geometry are six-coordinated by three oxygen and three nitrogen atoms. The HL- ligands from the deprotonated HzL connect Cd（II） atoms to form two-dimensional （2D） double-layer fes networks which are further pillared by 5-IPA2- ligands into a rare binodal （3, 4）-connected three-dimensional （3D） architecture with a （4·6·8）（4·62·83） fse-3,4-C2/c topology. Solid state luminescent property and sorption property of 1 have been investigated.

关键词： synthesis crystal structure luminescence property

A Parallel Genetic Algorithm Based on Spark for Pairwise Test Suite Generation

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Journal of Computer Science & Technology 2016年第2期31卷 417-427页

作者： Rong-zhi Qi zhi-Jian Wang shui-Yan Li College of Computer and Information Hohai University Nanjing 211106 China CoUege of Science Hohai University Nanjing 211106 China

Pairwise testing is an effective test generation technique that requires all pairs of parameter values to be by at least one test case. It has been proven that generating minimum test suite is an NP-complete problem covered Genetic algorithms have been used for pairwise test suite generation by researchers. However, it is always a time-consuming process, which leads to significant limitations and obstacles for practical use of genetic algorithms towards large-scale test problems. Parallelism will be an effective way to not only enhance the computation performance but also improve the quality of the solutions. In this paper, we use Spark, a fast and general parallel computing platform, to parallelize the genetic algorithm to tackle the problem. We propose a two-phase parallelization algorithm including fitness evaluation parallelization and genetic operation parallelization. Experimental results show that our algorithm outperforms the sequential genetic algorithm and competes with other approaches in both test suite size and computational performance. As a result, our algorithm is a promising improvement of the genetic algorithm for pairwise test suite generation.

关键词： pairwise testing parallel genetic algorithm Spark test generation

Precision spectroscopy of atomic helium

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National Science Review 2020年第12期7卷 1818-1827页

作者： Yu R.Sun shui-Ming hu Hefei National Laboratory for Physical Sciences at Microscale iChem CenterUniversity of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China

Helium is a prototype three-body system and has long been a model system for developing quantum mechanics theory and computational *** fine-structure splitting in the 2;P state of helium is considered to be the most suitable for determining the fine-structure constant α in *** more than 50 years of efforts by many theorists and experimentalists,we are now working toward a determination ofα with an accuracy of a few parts per billion,which can be compared to the results obtained by entirely different methods to verify the self-consistency of quantum ***,the precision spectroscopy of helium allows determination of the nuclear charge radius,and it is expected to help resolve the ’proton radius puzzle’.In this review,we introduce the latest developments in the precision spectroscopy of the helium atom,especially the discrepancies among theoretical and experimental results,and give an outlook on future progress.

关键词： precision spectroscopy helium, quantum electrodynamics fine-structure constant nuclear charge radius

Two-dimensional extreme distribution for estimating mechanism reliability under large variance

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Advances in Manufacturing 2020年第3期8卷 369-379页

作者： zhi-hua Wang Zhong-Lai Wang shui Yu School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu611731People’s Republic of China Center for System Reliability and Safety University of Electronic Science and Technology of ChinaChengdu611731People’s Republic of China

The effective estimation of the operational reliability of mechanism is a significant challenge in engineering practices,especially when the variance of uncertain factors becomes *** this challenge,a novel mechanism reliability method via a two-dimensional extreme distribution is investigated in the *** time-variant reliability problem for the mechanism is first transformed to the time-invariant system reliability problem by constructing the two-dimensional extreme *** joint probability density functions(JPDFs),including random expansion points and extreme motion errors,are then obtained by combining the kernel density estimation(KDE)method and the copula ***,a multidimensional integration is performed to calculate the system time-invariant *** cases are investigated to demonstrate the effectiveness of the presented method.

关键词： Time-variant reliability Great variance Two-dimensional Extreme distribution Kernel density estimation(KDE) Multidimensional Integration

Relationship between red blood cell distribution width levels and atrial fibrillation in hypertensive patients

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Journal of Geriatric Cardiology 2020年第8期17卷 486-494页

作者： Li-hui ZHENG Shang-Yu LIU Feng hu zhi-Cheng hu Li-shui SHEN Ling-Min WU Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Information on the relationship between red blood cell distribution width(RDW)and atrial fibrillation(AF)in patients with essential hypertension are *** study aimed to assess the relationship between AF and RDW in hypertensive *** We enrolled 432 hypertensive patients,including 350 AF patients and 82 patients as ***'demographic,clinical,laboratory and echocardiographic characteristics were *** AF patients were further divided into the persistent and paroxysmal AF *** were monitored to identify the cardiac rhythm during blood sampling,and based on the rhythm,the paroxysmal AF group was categorized into the presence(with AF rhythm during blood sampling)and absence(with sinus rhythm during blood sampling)*** The AF group had elevated RDW levels than the controls(12.7%±0.8%vs.12.4%±0.7%,P=0.002),and the persistent AF subgroup had higher RDW levels than the paroxysmal AF subgroup(12.9%±0.8%vs.12.6%±0.8%,P=0.007).Furthermore,in the paroxysmal AF group,the presence group had higher RDW levels than the absence group(13.0%±0.6%vs.12.5%±0.9%,P=0.001).There was no significant difference in RDW levels between the persistent AF subgroup and presence group of the paroxysmal AF subgroup(P=0.533)and between the absence group of the paroxysmal AF subgroup and control group(P=0.262).In multivariate regression analysis,in hypertensive patients,the presence of AF rhythm is an independent predictor for increased RDW concentration(P=0.001).Conclusions The RDW may be associated with the presence of AF rhythm,which implies the importance of maintaining the sinus rhythm in hypertensive patients.

关键词： Atrial fibrillation Hypertension Inflammation Red blood cell distribution width

Hydrodynamic pressure on concrete face rockfill dams subjected to earthquakes

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Journal of Hydrodynamics 2019年第1期31卷 152-168页

作者： Zhong-zhi Fu Sheng-shui Chen Guo-ying Li Geotechnical Engineering Department Nanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Failure Mechanism and Safety Control Techniques of Earth-Rock Dams Ministry of Water ResourceNanjing 210029China

The hydrodynamic pressure is an important load on concrete face rockfill dams (CFRDs) subjected to earthquakes,the influence of which,however,is not clear as compared with that in concrete *** this paper,the coupling effect between the CFRDs and the reservoir water is studied based on two-dimensional finite element simulations by using a verified *** is found that neglecting the solid-fluid coupling effect not only results in an overestimation of the acceleration response within the rockfill materials but also makes an overestimation of the dynamical stresses in the concrete *** a reliable seismic response analysis of the CFRDs,therefore,the hydrodynamic pressure should be taken into account,particularly when the dam is subjected to a simultaneous excitation in both horizontal and vertical *** results show,however,that the compressibility of the water can be safely neglected in the seismic response analyses of the CFRDs even when the dam is as high as 300 m,except when the excitation is quite abundant in high frequency contents.

关键词： Concrete face rockfill dam hydrodynamic pressure seismic response earthquake