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Knowledge modeling based on interval-valued fuzzy rough set and similarity inference: prediction of welding distortion

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第8期15卷 636-650页

作者： zhi-qiang feng Cun-gen LIU Hu HUANG Maritime College Qinzhou University State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University

Knowledge-based modeling is a trend in complex system modeling technology. To extract the process knowledge from an information system, an approach of knowledge modeling based on interval-valued fuzzy rough set is presented in this paper, in which attribute reduction is a key to obtain the simplified knowledge model. Through defining dependency and inclusion functions, algorithms for attribute reduction and rule extraction are obtained. The approximation inference plays an important role in the development of the fuzzy system. To improve the inference mechanism, we provide a method of similaritybased inference in an interval-valued fuzzy environment. Combining the conventional compositional rule of inference with similarity based approximate reasoning, an inference result is deduced via rule translation, similarity matching, relation modification, and projection operation. This approach is applied to the problem of predicting welding distortion in marine structures, and the experimental results validate the effectiveness of the proposed methods of knowledge modeling and similarity-based inference.

关键词： Knowledge modeling Interval-valued fuzzy rough set Similarity-based inference Welding distortion prediction

Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors

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Chinese Chemical Letters 2006年第3期17卷 325-328页

作者： Chang Bin GUO Zhe feng CAI Zong Ru GUO zhi qiang feng feng Ming CHU Gui-Fang CHENG feng Ming CHU Gui Fang CHENG Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College Beijing 100050

A series of thiazole derivatives of ibuprofen, as cyclooxygenase-2 Inhibitors, were designed, synthesized and in vitro evaluated.

关键词： Cyclooxygenase-2 (COX-2) inhibitor ibuprofen thiazole derivative.

Synergistic effect of RhBMP-2 and bFGF on ectopic osteogenesis in mice

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Asian Pacific Journal of Tropical Medicine 2015年第1期8卷 53-59页

作者： Shu-Yuan Ma zhi-qiang feng Ren-Fa Lai zhi-Ying Zhou Zhong-Da Yin First Affiliated Hospital of Ji'nan University

Objective:To investigate the synergistic effect and mechanism of the combined application of recombinant human bone morphogenetic protein-2(rhBMP-2) and basic fibroblast growth factor(bFGF).Methods:24 KM male mice were randomly divided into 6 groups with 4 mice in each group,namely,Group A(control group),Group B(only treated with collagen),Group C(treated with2 ng bFGF+collagen).Group D(treated with 4μg rhBMP-2+collagen),Group E(treated with 4 μg rhBMP-2+2 ng bFGF+collagen) and Group F(treated with 4 μg rhBMP-2+4 ng bFGF+*** composites were implanted into the intermuscular septum of hind legs mice:whereas in control group,intermuscular septum of mice was separated and no implantation was *** observation,detection of concentration of calcium content,micro computed tomography(Micro-CT).three-dimensional reconstruction *** of bone mineral density(BMD).bone volume fraction(BVF) and trabecular thickness(***).as well as histological observation with HE staining and ALP and CD34 immumohistochemical staining were ***:Ectopic osteogenesis was found in Groups D.F and F *** difference in concentration of calcium contents was statistically significant between Groups D and E(P0.05).Micro-CT and three-dimensional reconstruction revealed continuous newborn bone substance in external surface of ectopic bone formation,and the center of bone formation did not show obvious substantial filling by bone *** differences in BMD,BVF and *** were statistically significant between Groups D and E or F(P<0.01 or <0.05).HE staining showed that in Groups D.E and *** bone substance was mainly located at the edge of ectopic bone formation,and the bone formation in Groups E and F was better than that in Group *** and CD34 immumohistochemical staining revealed the positive expression mainly at the edge of ectopic bone formation,and area of positive expression in Groups E and

关键词： BMP-2 bFCF Ectopic osteogenesis Micro-CT

Synthesis and in vitro cytotoxic activities of sorafenib derivatives

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Chinese Chemical Letters 2014年第5期25卷 702-704页

作者： Ke Wang Yan Li Li-Jing Zhang Xiao-Guang Chen zhi-qiang feng Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia MedicaChinese Academy of Medical Sciences &Peking Union Medical College State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences &Peking Union Medical College

A series of novel sorafenib derivatives have been designed and *** cytotoxic activities of these compounds were tested in three tumor cell *** of the compounds showed potent antiproliferative activity against the tested cell lines with IC50= 0–20 mmol/*** compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell *** them,compound 5g demonstrated significant inhibitory activity against A549,ACHN and MDAMB-231 cell lines with IC50values of 1.29,1.99,3.11 mmol/L,respectively.

关键词： Sorafenib Antiproliferative activity A549 ACHN MDA-MB-231

Effect of rhBMP-2 sustained-release nanocapsules on the ectopic osteogenesis process in Sprague-Dawley rats

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 884-888页

作者： Ren-Fa Lai Ze-Jian Li zhi-Ying Zhou zhi-qiang feng Qing-Tong Zhao Department of Oral & Maxillofacial Surgery First Affiliated HospitalJinan University

Objective:To explore the effect of sustained-release recombinant human bone morphogenetic protein-2(rhBMP-2) on ectopic osteogenesis in the muscle pouches of rats through preparing rhBMP-2 sustained-release capsules by wrapping morphogenesis protein bones-2(BMP-2)using chitosan nanoparticles,and compositing collagen ***:Twenty four SpragueDawley rats were randomly divided into four groups with six rats in each group,that is Group A(control group),Group B(only treated with collagen),Group C(rhBMP-2+collagen treated group) and Group D(rhBMP-2/cs+collagen treated group).The composite materials for each group were implanted in the bilateral peroneal muscle pouches in *** peroneal muscles were only separated without implanting any materials in control *** were sacrificed 2 weeks and 4 weeks post treatment and samples were cut off for general observation,Micro CT scans and histological ***:General observation showed no new bone formation in Groups A and B mice,while new bones were formed in Groups C and D *** weeks after treatment Micro CT scans showed that The bone volume fraction(BVF),trabecular thickness(Tb. Th),bone mineral density(BMD) in Group C mice were all higher than that in Group D(P<0.05). At the fourth week,the BVK,*** and BMD were significantly higher than that at the second week(P<0.01).Conclusions:The slow-release effect of rhBMP-2/cs sustained-release capsules can significantly promote ectopic *** bone formation effect is better than that of rhBMP-2 burst-release group.

关键词： BMP-2 Micro-CT Chitosan nanoparticles Polymeric drug-loading sustainedrelease capsules Ectopic osteogenesis

Applying the fractional derivative Zener model to fitting the time-dependent material viscoelasticity tested by nanoindentation

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Biosurface and Biotribology 2018年第2期4卷 58-67页

作者： Long Fei Wei Wei Li zhi qiang feng Jian Tao Liu School of Mechanical Engineering Southwest Jiaotong UniversityChendu 610031People's Republic of China Tribology Res earch Institute Key Laboratory for Advanced Technology of Materials of Ministry of EducationSouthwest Jiaotong UniversityChendu 610031People's Republic of China LMEE-UEVE Universite de Paris-Saclay40 rue du PelvouxEvry 91020France

Material viscoelasticity is of particular importance for polymers,biotissues and many others,due to the significant influence not only on the elastic response of structures,but also on their failure mechanism in actual *** this study,the experimental tests by nanoindentations are cate gorized according to the objective parameter combined with the indenter sha pe into four distinct cases,and the Fractional Derivative Zener model(FDZM)is employed to characterize this time-dependent *** explicit data-fitting formulas are derived to determine the relaxation modulus and creep compliance te sted with the conical and spherical inde ***,a fitting scheme is provided to facilitate the identification of these viscoelastic *** comparison with the general methods adopting the Prony series or empirical models,two silent merits present:(1)fewer model coefficients necessitate being determined based on the experimental data;(2)the relaxation modulus G(t)and the creep compliance J(t)can be obtained through one indentation test,and their exact interconversion is guaranteed as *** sets of experimental data are applied to examine the validity of the developed approach,and three more examples are adopted to demonstrate the exact interconversion between G(t)and J(t).A few concluding remarks are drawn eventually.

关键词： modulus relaxation exact

Zircon U-Pb-Hf isotopic and geochemical characteristics of the Xierzi biotite monzogranite pluton,Linxi,Inner Mongolia and its tectonic implications

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Geoscience Frontiers 2018年第2期9卷 505-516页

作者： Qing-Bin Guan Zheng-Hong Liu Xing-An Wang Bin Wang Shi-Jie Wang Yu-Song Chen zhi-qiang feng College of Earth Sciences Jilin UniversityChangchun 130061China College of Geographical Sciences Northeast Normal UniversityChangchun 130024China Shandong Provincial No.6 Exploration Institute of Geology and Mineral Resources Weihai 264209China Department of Earth Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

The opening, subduction and final closure of the Paleo-Asian Ocean led to the formation of the Central Asian Orogenic Belt. Controversy has long surrounded the timing of final closure of the Paleo-Asian Ocean. Here we present zircon U-Pb ages and petrological, geochemical and in situ Hf isotope data for the Xierzi biotite monzogranite pluton, Linxi, SE Inner Mongolia. U-Pb dating of zircon by LA-ICP-MS yields a middle Permian emplacement age(268.7 ± 2.3 Ma) for the Xierzi pluton that is dominated by biotite monzogranites with high SiO_2(71.2-72.8 wt.%),alkali(Na_2 O + K_2 O =8.05-8.44 wt.%), Al_2 O_3(14.4-15.2 wt.%) and Fe_2 O_3~T relative to low MgO contents, yielding Fe_2 O_3~T/MgO ratios of 2.87-3.44, and plotting within the high-K calc-alkaline field on a SiO_2 vs. K_2 O diagram. The aluminum saturation indexes(A/CNK) of the biotite monzogranites range from 1.06 to 1.19, corresponding to weakly to strongly peraluminous. They are enriched in rare earth elements(REE), high field strength elements(HFSEs; Zr,Hf). and large ion lithophile elements(LILEs; Rb, U, Th). The LREEs are enriched relative to the HREEs,with a distinct negative Eu anomaly in a chondrite-normalized REE diagram. Geochemically, the Xierzi biotite monzogranite is classified as an aluminous A-type granite, with all samples plotting within the A2-type granite field on a Y/Nb vs. Rb/Nb diagram. Zircon ε_(Hf)(t) values and two-stage modal ages of the zircons within the pluton range from +4.80 to +13.65 and from 983 to 418 Ma, respectively, indicating that the primary magma was generated through partial melting of felsic rocks from juvenile ***, these results demonstrate that the Xierzi pluton formed under the post-orogenic extensional setting after arc-continent collision in the middle Permian.

关键词： Linxi area A-type granite Zircon U-Pb dating Extensional tectonic setting Paleo-Asian Ocean Arc-continent collision

Design,synthesis and biological evaluation of novel glucokinase activators

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Chinese Chemical Letters 2011年第1期22卷 73-76页

作者： Yong qiang Li Yu Liang Zhang Sheng Quan Hu Yu Ling Wang Hong Rui Song zhi qiang feng Lei Lei Quan Liu Zhu Fang Shen Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.

关键词： Diabetes Glueokinase activators Benzamide derivatives

Magnetostratigraphy and paleoenvironmental record of late Cenozoic sediments in the Taiyuan Basin,North China

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Journal of Palaeogeography 2024年第4期13卷 971-992页

作者： zhi-qiang feng Qian Li Wei Han Kun-Yuan Ma Yong-Jiang Liu Rong-Zhu Wei Yan-Wei Du Yong Lei Guang-Hui Li College of Geoscience and Geomatics Engineering Taiyuan University of TechnologyTaiyuan 030024Shanxi ProvinceChina Shanxi Institute of Geological Survey Taiyuan 030006Shanxi ProvinceChina Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Lab of Submarine Geoscience and Prospecting TechniquesCollege of Marine GeosciencesOcean University of ChinaQingdao 266100Shandong ProvinceChina Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237Shandong ProvinceChina College of Resources and Environment Shanxi Agricultural UniversityTaigu 030801Shanxi ProvinceChina Department of Information Engineering Shanxi UniversityTaiyuan 030013Shanxi ProvinceChina

The Taiyuan Basin is of importance for intraplate tectonic deformation in North China and contains Cenozoic strata with a maximum thickness of 3800 m.A~853.5-m-deep borehole(ZK01)with an overall core recovery rate of 85.09%was drilled at Yuci(37°35'37?N,112°39'47?E)in the central Taiyuan Basin,to obtain high-resolution records of paleomagnetism,paleoclimatic and paleoenvironmental conditions,and depositional environment of the *** obtained magnetic polarity sequence consists of 13 normal and 12 reverse zones,which correspond to C1n-C4An.2n of the geomagnetic polarity time *** data show that the evolution of ZK01 core covers the interval from 8.1 Ma to the present,and the bottoms of Pliocene,Quaternary,and Middle Pleistocene were identified in Taiyuan Basin,with a sedimentary accumulation rate ranging from 62.5 m/Ma to 175.9 m/*** data reveal that the source rocks in the study area underwent intense weathering and the sediments mainly formed in a semi-arid and oxygen-rich *** addition,paleoclimatic changes occurred at~7 Ma,3.8 Ma,and 1.7 Ma,which can be closely related to the tectonic uplift of the Loess Plateau and Tibetan Plateau,as well as the variations in the Asian monsoon and associated regional and global climatic change.

关键词： Taiyuan Basin Core sediment Magnetostratigraphy Climate change Paleoenvironment Quaternary