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Tsinghua Science and Technology 2024年第3期29卷 874-882页

作者： Chao Wang Qiaoyun Hu Haonan Yao Sumin Wang zhi pei Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication Shanghai UniversityShanghai 200444China

This work is the first to determine that a real quantum computer(including generalized and specialized)can decipher million-scale RSA relying solely on quantum algorithms,showing the real attack potential of D-Wave *** influence of different column widths on RSA factorization results is studied on the basis of a multiplication table,and the optimal column method is determined by traversal *** traversal experiment of integer factorization within 10000 shows that the local field and coupling coefficients are 75%–93%lower than the research of Shanghai University in 2020 and more than 85%lower than that of Purdue University in *** low Ising model parameters are crucial to reducing the hardware requirements,prompting factoring 1245407 on the D-Wave 2000Q real machine.D-Wave advantage already has more than 5000 qubits and will be expanded to 7000 qubits during 2023–2024,with remarkable improvements in decoherence and *** machine is expected to promote the solution of large-scale combinatorial optimization *** of the contributions of this paper is the discussion of the long-term impact of D-Wave on the development of post-quantum cryptography standards.

关键词： quantum annealing RSA D-Wave 2000Q post-quantum cryptography

Interpretation and characterization of rate of penetration intelligent prediction model

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Petroleum Science 2024年第1期21卷 582-596页

作者： zhi-Jun pei Xian-zhi Song Hai-Tao Wang Yi-Qi Shi Shou-Ceng Tian Gen-Sheng Li College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Petroleum Resources and Prospecting Beijing102249China Kunlun Digital Technology Co. Ltd.Beijing102206China

Accurate prediction of the rate of penetration(ROP)is significant for drilling *** the intelligent ROP prediction model based on fully connected neural networks(FNN)outperforms traditional ROP equations and machine learning algorithms,its lack of interpretability undermines its *** study proposes a novel interpretation and characterization method for the FNN ROP prediction model using the Rectified Linear Unit(ReLU)activation *** leveraging the derivative of the ReLU function,the FNN function calculation process is transformed into vector *** FNN model is linearly characterized through further simplification,enabling its interpretation and *** proposed method is applied in ROP prediction scenarios using drilling data from three vertical wells in the Tarim *** results demonstrate that the FNN ROP prediction model with ReLU as the activation function performs exceptionally *** relative activation frequency curve of hidden layer neurons aids in analyzing the overfitting of the FNN ROP model and determining drilling data *** the well sections with similar drilling data,averaging the weight parameters enables linear characterization of the FNN ROP prediction model,leading to the establishment of a corresponding linear representation ***,the quantitative analysis of each feature's influence on ROP facilitates the proposal of drilling parameter optimization schemes for the current well *** established linear characterization equation exhibits high precision,strong stability,and adaptability through the application and validation across multiple well sections.

关键词： Fully connected neural network Explainable artificial intelligence Rate of penetration ReLU active function Deep learning Machine learning

Identification of male schizophrenia patients using brain morphology based on machine learning algorithms

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World Journal of Psychiatry 2024年第6期14卷 804-811页

作者： Tao Yu Wen-zhi pei Chun-Yuan Xu Chen-Chen Deng Xu-Lai Zhang Department of Clinical Nutrition Hefei Fourth People’s HospitalHefei 230032Anhui ProvinceChina Department of Psychiatry Hefei Fourth People’s HospitalHefei 230032Anhui ProvinceChina Department of Gynaecology Anhui Maternal and Child Health HospitalHefei 230032Anhui ProvinceChina

BACKGROUND Schizophrenia is a severe psychiatric disease,and its prevalence is ***,diagnosis of early-stage schizophrenia is still considered a challenging *** To employ brain morphological features and machine learning method to differentiate male individuals with schizophrenia from healthy *** The least absolute shrinkage and selection operator and t tests were applied to select important features from structural magnetic resonance images as input features for *** commonly used machine learning algorithms,the general linear model,random forest(RF),k-nearest neighbors,and support vector machine algorithms,were used to develop the classification *** performance of the classification models was evaluated according to the area under the receiver operating characteristic curve(AUC).RESULTS A total of 8 important features with significant differences between groups were considered as input features for the establishment of classification models based on the four machine learning *** to other machine learning algorithms,RF yielded better performance in the discrimination of male schizophrenic individuals from healthy controls,with an AUC of *** Our research suggests that brain morphological features can be used to improve the early diagnosis of schizophrenia in male patients.

关键词： Schizophrenia Machine learning Classification Structure Magnetic Resonance imaging

Chlorajaponins A—Q,Lindenane-Related Sesquiterpenoid Dimers from Chloranthus japonicus and Their Biological Activities

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Chinese Journal of Chemistry 2024年第11期42卷 1247-1259页

作者： Wei-Jiao Feng Yue Gu pei-zhi Huang Hong-Ying Yang Rui Zhang Yi-Lin He Ting-Hong Lv Ya Li Kun Gao State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu730000 China Research Institute Lanzhou Jiaotong UniversityLanzhouGansu730070 China

Seventeen undescribed lindenane-related sesquiterpenoid dimers,chlorajaponins A—Q(1—17),and 13 reported analogs(18—30)were isolated from Chloranthus japonicus *** 1 possesses an unprecedented 3/5/7/5/5/6/5/3 fused octacyclic scaffold,featuring a 6(5→4)-abeo-lindenane monomer,while 2 exhibits a 3/5/6/6/5/6/5/3 fused octacyclic *** structures were determined through a combination of spectroscopic analyses and X-ray *** 1,2,and 18 demonstrated significant inhibitory effects on lipid accumulation and effectively reduced the levels of triglycerides and total cholesterol,as well as the levels of aspartate aminotransferase and alanine aminotransferase in a HepG2 cell *** addition,compounds 1,2,and 18 significantly suppressed the protein expression of the fatty acid synthase(FASN)and the sterol regulatory element-binding protein 1(SREBP1).Moreover,the anti-inflammatory assay showed that compounds 19—22 and 25 inhibited the NO production induced by lipopolysaccharide in RAW 264.7 macrophages with IC50 values of 7.89±0.44,6.25±0.46,2.98±0.29,10.77±0.60,and 3.60±0.28μmol/L.

关键词： Chloranthus japonicus Lindenane-type sesquiterpenoid dimers Lipid-lowering activity Anti-inflammatory activity NMR spectroscopy Natural products X-ray diffraction

论中国共产党的理论自觉及其内容演进——以马克思世界历史理论为考察视角

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马克思主义研究 2024年第5期 122-134页

作者：裴植北京大学马克思主义学院北京大学教育部习近平新时代中国特色社会主义思想研究中心北京100871

马克思世界历史理论是我们考察近代以来殖民地半殖民地民族和国家历史命运的基本理论遵循。因之于理论自觉,中国共产党十分注重运用马克思世界历史理论来分析中国问题和把握中国国情。中国共产党的理论自觉因世界历史的主题演变而在不... 详细信息

马克思世界历史理论是我们考察近代以来殖民地半殖民地民族和国家历史命运的基本理论遵循。因之于理论自觉,中国共产党十分注重运用马克思世界历史理论来分析中国问题和把握中国国情。中国共产党的理论自觉因世界历史的主题演变而在不同阶段体现出不同的内容侧重,其中,明确以科学社会主义摆脱“资本主义-帝国主义”体系的束缚是中国共产党成立后在理论自觉方面的首要而直观的呈现,实现马克思主义中国属性与国际属性的统一是中国共产党通过总结实践中的经验教训而凝结出的为全党所接受的共识性认知,而赋予中国经验的理论提炼以世界历史意义则主要体现为不同时期的中国共产党人在尊重历史规律、把握历史主动过程中所凸显的理论自觉的核心内容。上述三个方面生动地彰显了马克思世界历史理论视阈下中国共产党理论自觉的内容演进。

关键词：马克思世界历史理论中国共产党理论自觉

基于代理模型技术的江海直达船体结构可靠性优化设计

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船舶力学 2024年第4期28卷 551-560页

作者：康煜晗裴志勇吴卫国武汉理工大学船海与能源动力工程学院武汉430063 武汉理工大学绿色智能江海直达船舶与邮轮游艇研究中心武汉430063 绿色智能江海直达船舶湖北省工程研究中心武汉430063

为提高船体结构可靠性优化设计这类多参数、高维度、高非线性优化问题的效率,弥补传统船体结构确定性优化设计对影响结构安全不确定性因素考虑的欠缺,本文以一艘江海直达船为研究对象,采用BP(Back Propagation)神经网络代理模型技术,结... 详细信息

为提高船体结构可靠性优化设计这类多参数、高维度、高非线性优化问题的效率,弥补传统船体结构确定性优化设计对影响结构安全不确定性因素考虑的欠缺,本文以一艘江海直达船为研究对象,采用BP(Back Propagation)神经网络代理模型技术,结合SMOTE(Synthetic Minority Oversampling Technique)过采样算法增加极限状态失效面附近样本点数量,实现以较少的样本点获得较高精度的船体舱段结构极限状态代理模型,进而利用蒙特卡洛抽样模拟方法编制船体结构可靠度计算程序,在结构可靠性分析的基础上以降低船体舱段结构重量为目标,采用模拟退火优化算法开展船体结构可靠性优化设计。本文建立了一套完整有效的、基于代理模型技术的船体结构可靠性优化设计系统,有效提高了优化设计的效率,对江海直达船体结构可靠性优化设计具有指导意义。

关键词：可靠性优化设计可靠度计算江海直达船代理模型 SMOTE算法蒙特卡洛抽样

善恶人类学:“暗黑人类学”与“关于善的人类学”何以共存

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青海民族研究 2024年第3期35卷 156-164页

作者：张志培冯莎厦门大学福建厦门363105

善与恶“势不两立”,“暗黑人类学”与“关于善的人类学”是否也是如此呢?人类学家雪莉·奥尔特纳(Sherry Ortner)总结20世纪80年代以来的人类学发展,并提出“暗黑理论”,关注人类苦难的经验。而在另外一派理论脉络中,人类学家则再次讨... 详细信息

善与恶“势不两立”,“暗黑人类学”与“关于善的人类学”是否也是如此呢?人类学家雪莉·奥尔特纳(Sherry Ortner)总结20世纪80年代以来的人类学发展,并提出“暗黑理论”,关注人类苦难的经验。而在另外一派理论脉络中,人类学家则再次讨论“良善”的问题,以“新道德人类学”为主力。表面上,两者好像是一种对立关系,并呈现出从“暗黑”向“良善”的单向转变,但对“暗黑人类学”与“关于善的人类学”的梳理讨论揭示出两者之间并非二元对立,而是构成一种多重且互相包含的关系,即“善恶人类学”。如果人类学家没能察觉到这种关系,有可能将研究对象“本质化”为“苦难”或“良善”的道德主体,只聚焦于主体在道德两难中的抉择,而忽视他们也在善与恶拉扯之间有意或无意的行动。

关键词：暗黑人类学暗黑理论关于善的人类学伦理/道德善恶

Phase I clinical trial of intracerebral injection of lentiviral-ABCD1 for the treatment of cerebral adrenoleukodystrophy

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Science Bulletin 2024年第16期69卷 2596-2603页

作者： Qiu-Hong Wang Jing Wanga zhi-pei Ling zhi-Qiang Cui Jie Gong Rui Zhang Shi-Jun Li Yang-Yang Wang Rui Yang De-Hui Huang Wen He Jing Gao Chen Feng pei-Li Hu Li-Ying Liu Lung-Ji Chang Li-Ping Zou Senior Department of Pediatrics Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Department of Neurosurgery Hainan Hospital of PLA General HospitalSanya 572013China Department of Neurosurgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054China Beijing Meikang Biotechnology Co. LTD.Beijing 100085China Department of Radiology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pediatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Shenzhen Geno-Immune Medical Institute Shenzhen 518057China Beijing Institute for Brain Disorders Center for Brain Disorders Research Capital Medical UniversityBeijing 100069China

This was a single-arm,multicenter,open-label phase I *** vectors(LV)carrying the ABCD1 gene(LV-ABCD1)was directly injected into the brain of patients with childhood cerebral adrenoleukodystrophy(CCALD),and multi-site injection was *** injection dose increased from 200 to 1600 lL(vector titer:1×10^(9) transduction units per mL(TU/mL)),and the average dose per kilogram body weight ranges from 8 to 63.6 lL/*** primary endpoint was safety,dose-exploration and immunogenicity and the secondary endpoint was initial evaluation of efficacy and the expression of ABCD1 protein.A total of 7 patients participated in this phase I study and were followed for 1 *** injectionrelated serious adverse event or death *** adverse events associated with the injection were irritability(71%,5/7)and fever(37.2-38.5℃,57%,4/7).Adverse events were mild and selflimited,or resolved within 3 d of symptomatic *** maximal tolerable dose is 1600 *** 5 cases(83.3%,5/6),no lentivirus associated antibodies were *** overall survival at 1-year was 100%.The ABCD1 protein expression was detected in neutrophils,monocytes and *** study suggests that the intracerebral injection of LV-ABCD1 for CCALD is safe and can achieve successful LV transduction in vivo;even the maximal dose did not increase the risk of adverse ***,the direct LV-ABCD1 injection displayed low *** addition,the effectiveness of intracerebral LV-ABCD1 injection has been preliminarily demonstrated while further investigation is *** study has been registered in the Chinese Clinical Trial Registry(https://***/,registration number:ChiCTR1900026649).

关键词： Adrenoleukodystrophy Lentiviral vectors ABCD1 Intracerebral injection

早发型帕金森病丘脑底核脑深部电刺激术后长期随访一例

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中国现代神经疾病杂志 2024年第7期24卷 555-558页

作者：何平徐欣凌至培南开大学医学院天津300071 解放军总医院第一医学中心神经外科医学部北京100853 解放军总医院海南医院神经外科三亚572013

患者男性,51岁,因肢体僵硬、运动减少8年,加重伴静止性震颤2年,于2016年3月13日收入解放军总医院第一医学中心。患者于2008年(36岁)发病,表现为左上肢活动减少,以手部动作不灵活为主,后逐渐进展至左下肢,出现行走困难,2010年外院诊断为... 详细信息

患者男性,51岁,因肢体僵硬、运动减少8年,加重伴静止性震颤2年,于2016年3月13日收入解放军总医院第一医学中心。患者于2008年(36岁)发病,表现为左上肢活动减少,以手部动作不灵活为主,后逐渐进展至左下肢,出现行走困难,2010年外院诊断为帕金森病,予以多巴丝肼187.50 mg/次(2次/d)和吡贝地尔50 mg/次(2次/d)口服,运动迟缓明显改善,四肢活动基本正常。

关键词：帕金森病深部脑刺激法丘脑底核苍白球病例报告

局域共振超材料表面波屏障带隙特性与隔振性能

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岩土力学 2024年第3期45卷 750-758,787页

作者：厉超庄培芝李利平张思峰周冲山东建筑大学交通工程学院山东济南250101 山东大学齐鲁交通学院山东济南250002 山东大学岩土与结构工程研究中心山东济南250061

为有效解决轨道交通运营引发的地面振动问题,基于声学超材料概念提出一种局域共振超材料表面波屏障(locally resonant metamaterial surface wave barrier,简称LRMB)隔振方法,并采用混凝土和橡胶垫层构造出屏障结构。根据半无限空间弹... 详细信息

为有效解决轨道交通运营引发的地面振动问题,基于声学超材料概念提出一种局域共振超材料表面波屏障(locally resonant metamaterial surface wave barrier,简称LRMB)隔振方法,并采用混凝土和橡胶垫层构造出屏障结构。根据半无限空间弹性动力学理论,推导LRMB带隙计算的解析式,分析橡胶垫、混凝土参数对LRMB带隙特性的影响规律。基于轨道交通地面振动实测数据,探讨LRMB的隔振效果。研究结果表明:LRMB表面波带隙产生主要与其竖向振动有关,基于该模式建立的带隙计算方法是准确的;LRMB橡胶垫厚度增大,带隙起始频率降低,带隙宽度增大;LRMB橡胶垫宽度增大,带隙起始频率升高,带隙宽度减小;LRMB混凝土质量增大,带隙起始频率降低,带隙宽度增大;LRMB原胞数量增多,隔振效率提升,隔振效率达到20~25 dB;以济南轨道交通1号线工程为例,采用LRMB后地面振动衰减可达70%~80%,验证了LRMB的良好隔振性能。

关键词：声学超材料表面波波屏障带隙特性隔振性能